Every intervention Outliyr has scored for wound healing, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for wound healing; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
31 of 98 evaluated interventions score 3.0+ out of 10 for wound healing · 9 comparisons
Vasireddi 2025 anchors the most relevant signal. BPC-157 fits wound healing when the target is tissue repair, vascular recruitment, or inflammation control, but the case still rests mostly on preclinical models. Theā¦
Hamblin 2017 summarizes angiogenesis, collagen, and inflammatory pathways that make photobiomodulation biologically credible. The evidence is strongest for selected superficial wounds and clinical protocols, not every burn or surgical scenario. Pradal 2025ā¦
Pickart et al. 2015 supports the core mechanism. GHK-Cu keeps an 8 because topical wound evidence is clinically meaningful, especially Mulder 1994, where diabetic plantar ulcers had 98.5% median area closure versusā¦
Hyperbaric Oxygen Therapy is most often evaluated as an adjunct to standard wound care, where it appears to increase oxygen delivery to hypoxic tissue and support fibroblast activity. The evidence tier remainsā¦
Full-length Tbeta4 has credible wound and corneal-healing evidence: Dunn 2010 reported compassionate-use corneal healing, and Sosne 2023 found 6 of 10 RGN-259 subjects healed versus 1 of 8 placebo, a trend thatā¦
Maglia 2024 reports Verified audit Track 1 source; 12 clinical studies, oral-ulcer size and pain reduction versus placebo, limited evidence quality. Lima 2024 points in the same direction, but route, dose, baselineā¦
Hagiyama 2024 reports 12 RCTs; 622 patients; low-certainty improvement in patient-reported outcomes and very-low-certainty strength signal after lower-limb surgeries. Wittholz 2024 points in the same direction, but route, dose, baseline status, andā¦
Holecek 2025 anchors the most relevant signal. Glycine fits wound healing because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the endpoint. The score stays bounded becauseā¦
Postoperative wound and edema data support a moderate wound-healing rating. Stocchero 2015 found fewer healing complications after third molar extraction, while Rohde 2015 found reduced wound exudate and inflammation after breast reconstruction.ā¦
Collagen deposition is the structural backbone of healing tissue, and vitamin C is the obligatory cofactor for the hydroxylase enzymes that stabilize collagen, so deficiency directly impairs wound closure and reopens healedā¦
Dhillon 2024 reports 25-article systematic review; mixed preliminary clinical evidence, heterogeneity, and need for stronger trials. Zhou 2024 points in the same direction, but route, dose, baseline status, and outcome tracking decideā¦
Wu 2025 anchors the most relevant signal. Thymosin Alpha-1 fits wound healing when immune modulation is medically relevant and monitored rather than casually guessed. The score stays bounded because the best evidenceā¦
Berthon et al. 2022 gives the strongest anchor. Wound-healing remains modest because lactoferrin has immune and antimicrobial mechanisms, but oral supplement RCTs for wound closure are limited. The score reflects mechanistic supportā¦
Collagen is central to wound matrix formation, and oral collagen has emerging support for surgical wound and scar quality. The evidence is smaller than skin, joint, and tendon endpoints. That makes Collagenā¦
Whole-Body Vibration may improve peripheral circulation, which can support the early phases of tissue repair. However, randomized trials that directly measure wound closure rates are few and show inconsistent results. Anti-inflammatory effectsā¦
Metformin's primary action is lowering blood sugar, which can indirectly support wound-healing in people with diabetes by reducing hyperglycemia-driven inflammation. Direct trials of Metformin as a topical or systemic wound-healing agent inā¦
Filip 2007 is the cleanest verified anchor for this report. The existing rationale points to this narrower claim: No direct consumer Ca-AKG wound-healing evidence. Burn-care OKG and AKG literature is adjacent, heterogeneous,ā¦
Wound healing is the most-tested human application for TĪ²4 outside the eye, and the data are real but mixed. The RGN-137 topical gel Phase 2 program covered pressure ulcers, venous stasis ulcers,ā¦
Improved circulation and glucose control can support wound healing over time. This is an indirect support effect. People with diabetic ulcers, vascular disease, or surgical wounds need clinical wound care rather thanā¦
HA is a genuine extracellular-matrix component and topical and dressing forms are used clinically for wounds, but high-quality oral-supplement outcome data for everyday wound healing is thin. Mechanistically plausible and used inā¦
Androgen replacement may support protein synthesis and tissue repair in deficient men, but direct human wound-healing evidence is limited. Surgical clearance and standard wound care matter more.
Wound healing is the one use case with real human evidence, which is why it scores highest. In a first-in-human topical trial of 34 people with hard-to-heal venous leg ulcers, LL-37 atā¦
Improved glycemic control may help diabetic wound biology, but appetite suppression and inadequate nutrition can impair healing.
Animal wound-healing rationale exists, but no human wound-healing RCT support was verified.
Antioxidant support for healing is reasonable but dedicated wound-healing RCT evidence is limited.
KPV may support a lower-inflammatory repair environment through NF-kB modulation, and Xiao 2017 found nanoparticle KPV accelerated mucosal healing in a mouse UC model. Direct human wound-healing evidence is absent.
Better glycemic control can support wound risk in diabetes. Calorie restriction, low protein intake, dehydration, and nausea can impair healing. There is no tirzepatide wound healing trial. Keep low and reserve anyā¦
Improved blood-flow dynamics after cuff release are theoretical support, but direct wound-healing evidence is limited.
Colostrum growth factors can support epithelial repair models, and topical uses appear in reviews, but oral bovine colostrum is not established as a human wound-healing intervention.
Wound and tissue-repair data are animal and in-vitro only.
GH can support tissue repair, but tesamorelin-specific wound-healing trials are absent. This rating remains low-moderate because the intervention is not clinically established for wounds.
Nothing matches those filters.
Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 11 of 31 are not priced yet; those cells are left blank rather than guessed.
| Intervention | Monthly cost | At dose | How you get it |
|---|---|---|---|
| BPC-157 | $40ā$80 | 250 to 500 mcg SC 1 to 2x/day near injury site | Grey market |
| Red Light Therapy | $17ā$43 | 10-20 min at 6-12 inches, full chest/face/back rotation | Over the counter |
| GHK-Cu | $30ā$100 | 0.5-3% topical serum or cream | Over the counter |
| Hyperbaric Oxygen Therapy | $3,000ā$6,000 | 2.0 ATA for 90 minutes with air breaks | In clinic |
| TB-500 (Thymosin Beta-4 Fragment) | Not priced yet | ||
| Ozone Therapy | $520ā$2,600 | 20-30 mcg/mL ozone, roughly 1,000-1,500 mcg total per session | In clinic |
| Essential Amino Acids | Not priced yet | ||
| Glycine | $2ā$3 | 3 g oral glycine | Over the counter |
| PEMF (Pulsed Electromagnetic Field Therapy) | $3ā$117 | 20-30 min mat session | Over the counter |
| Vitamin C (Ascorbic Acid) | Not priced yet | ||
| Molecular Hydrogen | Not priced yet | ||
| Thymosin Alpha-1 | $100ā$400 | 1.6 mg subcutaneous | Prescription |
| Lactoferrin | $25ā$50 | 250-300 mg apolactoferrin | Over the counter |
| Collagen Peptides | $8ā$40 | 2.5-10 g hydrolyzed collagen peptides | Over the counter |
| Whole-Body Vibration | $50ā$100 | 30 Hz, roughly 0.3g, 10-20 min standing | Over the counter |
| Metformin | $4ā$30 | 500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as tolerated | Prescription |
| Ca-AKG (Calcium Alpha-Ketoglutarate) | $15ā$30 | 1 g/day generic Ca-AKG oral | Over the counter |
| Thymosin Beta-4 (TĪ²4) | Not priced yet | ||
| Zone 2 Cardio | Not priced yet | Over the counter | |
| Hyaluronic Acid | Not priced yet | ||
| TRT (Testosterone Replacement Therapy) | $50ā$300 | Clinician-selected formulation at the lowest dose likely to restore physiologic testosterone | Prescription |
| LL-37 (Cathelicidin) | Not priced yet | ||
| Semaglutide | $199ā$349 | 0.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onward | Prescription |
| Spermidine | $40ā$90 | 1-3 mg/day oral WGE | Over the counter |
| Astaxanthin | Not priced yet | ||
| KPV (Lys-Pro-Val) | $40ā$100 | 250-500 mcg/day oral | Grey market |
| Tirzepatide | $299ā$449 | 2.5 to 5 to 7.5 to 10 to 12.5 to 15 mg | Prescription |
| Blood-Flow Restriction Training | Not priced yet | ||
| Colostrum | $60ā$80 | 20 g/day powder, split AM/PM if tolerated | Over the counter |
| Fucoidan (Brown Seaweed Polysaccharide) | Not priced yet | ||
| Tesamorelin | $250ā$500 | 2 mg subcutaneous daily in the evening | Prescription |
Head-to-head reports and category rankings that name a winner on this use case.
This page ranks by the live wound healing subrating, not the overall BioHarmony score. BPC-157 leads at 8.5ā9.0/10, with GHK-Cu close behind at 8.0ā8.5/10, backed by this category'sā¦
BPC-157 wins for acute tendon or muscle injuries, gut healing, and cost-sensitive use. TB-500 wins for cardiac tissue repair and systemic post-surgical recovery. BPC-157 scores 7.5ā8.0/10 and TB-500ā¦
GHK-Cu wins this on evidence. It has human wound and skin data behind it. AHK-Cu has one unreplicated dish study and no human trial at all. Use GHK-Cuā¦
BPC-157 for structural repair, KPV for inflammation you cannot afford to stimulate. BPC-157 scores gut health 9.0ā9.5/10 against KPV's 7.0ā7.5/10 and wins nearly every other row, because itā¦
Buy the panel. Red light therapy scores 7.5ā8.0/10 against HBOT's 5.5ā6.0/10, costs $17 to $43 a month against $3,000 to $6,000, and does not lose a single useā¦
Red light therapy scores 7.5ā8.0/10 and PEMF 7.0ā7.5/10, so the panel is the better first buy for most people. PEMF wins on bone and joint pain, where aā¦
Thymulin scores 6.5ā7.0/10, thymalin 5.5ā6.0/10, and they are not interchangeable. Thymulin is a defined zinc-dependent peptide with receptor-level science, stronger inflammation data and a much cheaper course. Thymalinā¦
HBOT scores 5.5ā6.0/10 and ozone 5.0ā5.5/10, but ozone wins several use cases outright. Pick HBOT for wounds, cognition and neuro recovery, at $3,000 to $6,000 a month. Pickā¦
Metformin scores 6.5ā7.0/10 and rapamycin 6.5ā7.0/10, which settles nothing. Rapamycin owns the aging-biology rows: longevity 8.0/10, autophagy 8.5/10, senescence 7.8/10, plus replicated mouse lifespan data. Metformin owns everydayā¦
BPC-157, at 8.5ā9.0 out of 10 for wound healing. Vasireddi 2025 anchors the most relevant signal.
Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 7.0ā7.5 out of 10 for wound healing.
31 of the 98 interventions evaluated for wound healing score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
