Every intervention Outliyr has scored for libido, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for libido; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
27 of 100 evaluated interventions score 3.0+ out of 10 for libido · 8 comparisons
Cochrane 2024 reports 43 studies, 11,419 participants; conservative counterweight for sexual-dysfunction claims outside classical primary or secondary hypogonadism. Snyder 2016 points in the same direction, but route, dose, baseline status, and outcome…
Leisegang 2022 is the cleanest verified anchor for this report. The existing rationale points to this narrower claim: the cited study used the correct the indexed paper for phytoandrogenic review support, while…
Red Light Therapy may support libido indirectly through sleep, mood, testosterone-linked pathways, and male fertility biology, but direct libido RCTs are thin. Salman Yazdi 2014 supports sperm motility effects, not desire. The…
Melanotan II has one of the more direct human libido and erection signals among gray-market peptides. In men with organic erectile dysfunction, MT-II produced 12 erections across 19 treated episodes versus 1…
Kihara 2002 is the cleanest verified anchor for this report. The existing rationale points to this narrower claim: Libido effects are inconsistent: relaxation and improved sleep may help, while chronic high heat…
Tirzepatide consistently reduces body weight, improves insulin sensitivity, and can normalize testosterone in obese men, which are mechanistic pathways that may enhance libido. However, the tier of evidence remains low because these…
Biswas 2010 anchors the most relevant signal. Shilajit fits libido when purified resin is matched to hormones, sperm parameters, strength fatigue, bone markers, or energy tracking. The score stays bounded because most…
The evidence points to a plausible use case without proving a universal response. Zhang et al. 2025 is the best anchor here because it reports 25 randomized trials, 1486 participants and improved…
The evidence points to a plausible use case without proving a universal response. Fatima et al. 2024 is the best anchor here because it reports five randomized trials, 254 participants and reduced…
Semaglutide can improve sexual function indirectly through weight loss and insulin improvement, but it can also reduce drive through low calories, reward dampening, nausea, or fatigue. Moiz 2024 supports the weight-loss pathway,…
Libido is the one use with real human evidence. PT-141 is FDA-approved for acquired low sexual desire in premenopausal women, where two Phase 3 trials in about 1,267 women improved desire and…
Lang 2024 makes the claim plausible but incomplete. The existing rationale points to this narrower claim: Better cardiovascular health, body composition, energy, and mood can support libido. Excess endurance volume, low energy…
Potential benefit is indirect through metabolic and hormonal improvements; no verified libido trial exists for F+Q or D+Q.
Libido is the strongest non-fertility signal and the main reason people seek kisspeptin-10, though the trial evidence used kisspeptin-54 rather than the kisspeptin-10 form on sale. In men with hypoactive sexual desire…
No direct libido evidence was verified. Any sexual-health effect would be indirect through body composition, training, or overall nutrition.
No direct libido evidence; indirect benefit could come through sleep quality.
No direct libido evidence. Secondary effects through energy, circulation, and confidence remain anecdotal.
No direct libido evidence exists. PCOS responders may see indirect hormonal normalization, but metformin is not a sexual-performance drug.
No direct libido evidence. Any performance benefit does not translate into sexual-function evidence.
Erectile function evidence appears vascular and angiogenic rather than broad libido modulation. Hadanny 2018 reports vascular endothelial gains with HBOT. Score modestly and avoid implying hormonal libido enhancement. Patients with vascular erectile…
Libido sits at a moderate score because the pathway is plausible but the direct evidence is thin and confounded. Restoring endogenous LH and testosterone should support libido in theory, and some users…
INSUFFICIENT_EVIDENCE for libido benefit and reproductive-axis warnings argue for caution.
Erectile function is, paradoxically, the use with the strongest randomized evidence in the entire VIP file, but it is narrow and route-specific. A multicentre double-blind placebo-controlled trial of intracavernosal VIP plus phentolamine…
Libido is part of the marketed androgen story but has no human evidence; any effect would depend on a testosterone change that has never been demonstrated in people.
Exercise can support sexual health through vascular and metabolic pathways. Overtraining or poor recovery can blunt libido, so the net effect depends on dose.
Animal data: Khamidova 2005 showed restoration of stress-impaired spermatogenesis and fertilizing capacity in male rats (PMID 16047676) and Kuzubova 2004 reported dose-dependent proceptivity and receptivity changes (PMID 15341065). No human libido RCT.
GH restoration may indirectly support sexual function in deficient or metabolically impaired adults, but tesamorelin has no direct libido trial evidence. The score stays exploratory.
Nothing matches those filters.
Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 6 of 27 are not priced yet; those cells are left blank rather than guessed.
| Intervention | Monthly cost | At dose | How you get it |
|---|---|---|---|
| TRT (Testosterone Replacement Therapy) | $50–$300 | Clinician-selected formulation at the lowest dose likely to restore physiologic testosterone | Prescription |
| Tongkat Ali | $20–$40 | 200 mg/day Physta standardized extract | Over the counter |
| Red Light Therapy | $17–$43 | 10-20 min at 6-12 inches, full chest/face/back rotation | Over the counter |
| Melanotan II | $25–$55 | Variable | Research use only |
| Infrared Sauna | $36–$73 | 55-60 degrees C, 20-30 min | Over the counter |
| Tirzepatide | $299–$449 | 2.5 to 5 to 7.5 to 10 to 12.5 to 15 mg | Prescription |
| Shilajit | $25–$50 | 500 mg purified shilajit | Over the counter |
| Saffron | Not priced yet | ||
| Ashwagandha | $15–$30 | 300 mg KSM-66 with breakfast and 300 mg with dinner | Over the counter |
| Semaglutide | $199–$349 | 0.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onward | Prescription |
| PT-141 (Bremelanotide) | $80–$200 | 1.75 mg | Prescription |
| Zone 2 Cardio | Not priced yet | Over the counter | |
| Senolytics | Not priced yet | ||
| Kisspeptin-10 | $25–$65 | 100 to 200 mcg per subcutaneous shot | Grey market |
| Essential Amino Acids | Not priced yet | ||
| Glycine | $2–$3 | 3 g oral glycine | Over the counter |
| Whole-Body Vibration | $50–$100 | 30 Hz, roughly 0.3g, 10-20 min standing | Over the counter |
| Metformin | $4–$30 | 500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as tolerated | Prescription |
| Ca-AKG (Calcium Alpha-Ketoglutarate) | $15–$30 | 1 g/day generic Ca-AKG oral | Over the counter |
| Hyperbaric Oxygen Therapy | $3,000–$6,000 | 2.0 ATA for 90 minutes with air breaks | In clinic |
| Gonadorelin (GnRH) | $50–$150 | Roughly 100 to 300 mcg | Prescription |
| Rapamycin | $15–$50 | 3 mg | Prescription |
| VIP (Vasoactive Intestinal Peptide) | Not priced yet | ||
| Pine Pollen | $20–$45 | 5 to 10 g powder per day | Over the counter |
| Norwegian 4×4 | Not priced yet | Over the counter | |
| Bromantane (Ladasten) | $12–$30 | 30 mg | Grey market |
| Tesamorelin | $250–$500 | 2 mg subcutaneous daily in the evening | Prescription |
Head-to-head reports and category rankings that name a winner on this use case.
This page ranks by hormonal fit, not overall BioHarmony score. TRT leads at 9.0–9.5/10. Phosphatidylserine sits fifth at 5.5–6.0/10 despite the second highest overall score here, 7.0–7.5/10. That…
The scores tie at 6.0–6.5/10 and 6.0–6.5/10 and every shared subrating sits within half a point, so the numbers decide nothing. Access and evidence decide it. Gonadorelin is…
Kisspeptin-10 scores 6.0–6.5/10 and TRT 5.5–6.0/10, and TRT still wins 13 of the 15 use cases both reports score. The higher number reflects dependency and reversibility, not effect.…
Melanotan I is the safer tanning peptide and it scores higher, 6.0–6.5/10 against 4.5–5.0/10. Both darken skin through the same receptor. Melanotan II hits three more receptors, which…
They solve different problems and the scores hide that. Oxytocin scores 6.5–7.0/10 against PT-141's 5.0–5.5/10, mostly on safety and cost. PT-141 still wins libido 5.5/10 against 2.5/10. Oxytocin…
Shilajit scores 7.0–7.5/10 and ashwagandha 6.5–7.0/10, but that gap is the least useful number here. These two do different jobs. Shilajit is the mineral and androgen play: male…
Ashwagandha scores 6.5–7.0/10 and tongkat ali 6.5–7.0/10, so the overall numbers do not decide it. Pick ashwagandha when stress, anxiety, or sleep is the complaint: its subratings there…
PT-141 scores 5.0–5.5/10 and melanotan II 4.5–5.0/10, and both land in the neutral tier. PT-141 is the defensible one. It targets the brain receptor that drives desire, it…
TRT (Testosterone Replacement Therapy), at 8.0–8.5 out of 10 for libido. Cochrane 2024 reports 43 studies, 11,419 participants; conservative counterweight for sexual-dysfunction claims outside classical primary or secondary hypogonadism.
Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 4.5–5.0 out of 10 for libido.
27 of the 100 interventions evaluated for libido score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
