All BioHarmony Ratings
The Outliyr BioHarmony Score is a 0–10 rating that weighs every intervention across 6 upside dimensions (efficacy, evidence, durability, speed, breadth, bioindividuality) and 7 downside dimensions (safety, side effects, cost, effort, dependency, reversibility). Scores fall into 6 tiers, from Top Tier down to Skip. Every rating below is sorted by score by default and filterable by tier, category, or use case.
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Tier
Category
Use case
Density
| Compare | Tried? | Intervention | Category | Score / 10 | Tier | Best for |
|---|---|---|---|---|---|---|
| HRV Biofeedback | Wearable & Tracker | 9.0/10 | ✅ Top-tier | High-stress individuals with low baseline vagal tone, anyone with anxiety or stress-related issues, athletes optimizing recovery and pre-competition readiness, people with PTSD (especially hyperarousal symptoms), hypertensives looking for non-pharmacological blood-pressure support, those new to breathwork who benefit from objective feedback, and biohackers who want to quantify and train their autonomic nervous system directly. Newer evidence from [Eddie 2025](https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2839605) extends the population to substance use disorder. | ||
| Electrolytes | Vitamin & Mineral & Nutrient | 8.3/10 | 💪 Strong recommend | Athletes, keto or low-carb dieters, fasters, hot-climate residents, sauna users, hikers, hot-yoga practitioners, people recovering from diarrhea or acute fluid loss with oral rehydration solution, and anyone with fatigue, cramps, headaches, dizziness, or poor performance that reliably improves after a salted drink. Best used as contextual replacement for sweat, illness, fasting, or low-carb sodium loss, not as a universal daily upgrade for sedentary people already eating a high-sodium processed-food diet. | ||
| Norwegian 4×4 | Cardiovascular | 8.3/10 | 💪 Strong recommend | Adults optimizing VO2max as a core health marker; time-constrained exercisers who can tolerate hard intervals; middle-aged and older adults rebuilding aerobic capacity with a gradual ramp; metabolic-syndrome patients pursuing cardiorespiratory and insulin-sensitivity gains; stable heart-failure or coronary-disease patients only inside supervised cardiac rehab after graded exercise testing; endurance athletes using 4x4 as the high-intensity layer inside a polarized training plan. | ||
| Creatine Monohydrate | Vitamin & Mineral & Nutrient | 8.3/10 | 💪 Strong recommend | Strength and muscle-growth athletes (the core indication). Adults over 50 for muscle preservation, bone density, and cognitive support. Vegetarians and vegans (amplified response from low baseline muscle creatine stores). Cognitive workers under sleep deprivation. Anyone seeking the highest evidence-to-cost ratio supplement. | ||
| Magnesium | Vitamin & Mineral & Nutrient | 8.2/10 | 💪 Strong recommend | Adults targeting sleep quality, anxiety, blood pressure, depression, migraine prevention, or athletic recovery. Vegetarians, athletes (high sweat losses), PPI users, and the deficient majority of the population (~50% per NHANES). Form choice should match the goal: glycinate or ionic for sleep and anxiety; threonate for cognitive applications; malate for daytime energy; topical for acute muscle tension. | ||
| Neurofeedback | Neurostimulation & Neurofeedback | 8.2/10 | 💪 Strong recommend | Adults with ADHD who want a non-drug adjunct and can commit to 30-40 sessions; PTSD patients using neurofeedback alongside trauma-informed therapy; treatment-resistant epilepsy patients considering SMR neurofeedback as adjunct care; athletes or high performers with prior concussion history; meditation practitioners who want measurable brain-state training; knowledge workers prioritizing durable self-regulation over acute stimulation. | ||
| Blood-Flow Restriction Training | Resistance & Strength | 8.2/10 | 💪 Strong recommend | Adults who want muscle growth or muscle preservation without heavy joint loading; post-surgical rehab patients using BFR under clinician supervision; adults over 60 who cannot tolerate heavy loading; athletes during deloads, travel, or in-season maintenance; injured trainees who still need a hypertrophy stimulus; and time-constrained lifters who want a short accessory block after conventional strength work. | ||
| Molecular Hydrogen | Vitamin & Mineral & Nutrient | 8.1/10 | 💪 Strong recommend | People with elevated oxidative stress or chronic inflammation, including metabolic syndrome, autoimmune-leaning inflammatory load, high training volume, or poor gut-derived hydrogen production. Also relevant as an adjunct discussion for radiotherapy quality-of-life support, post-cardiac-arrest care in clinical settings, and athletes seeking a low-burden recovery tool. Best fit is quality-verified tablets or properly engineered low-concentration inhalation, not cheap bottles or oxyhydrogen devices. | ||
| Zone 2 Cardio | Cardiovascular | 8.1/10 | 💪 Strong recommend | Adults optimizing cardiovascular health, metabolic flexibility, mitochondrial capacity, and long-term healthspan; sedentary adults building an aerobic base; middle-aged adults addressing cardiorespiratory decline; metabolic syndrome or prediabetes populations using moderate aerobic work alongside nutrition and resistance training; endurance athletes building base volume; and people who cannot tolerate frequent high-intensity training because of joint, recovery, or medical constraints. | ||
| Taurine | Vitamin & Mineral & Nutrient | 8.1/10 | 💪 Strong recommend | Adults over 40 with low-animal-food intake or age-related taurine decline; people with prehypertension or mild cardiometabolic risk who want a cheap adjunct; heart-failure patients only under cardiology supervision; type 2 diabetics or metabolic-syndrome patients using taurine alongside medical care; endurance athletes seeking a legal low-cost ergogenic; vegans and vegetarians with low dietary taurine; sleep optimizers who respond to mild GABAergic support. | ||
| Red Light Therapy | Light Therapy | 7.9/10 | 💪 Strong recommend | Adults seeking visible photoaging reduction over 8-12 weeks of consistent use; men and women with early-stage androgenetic alopecia; anyone with chronic joint pain, tendinopathy, or post-exercise recovery demands; shift workers and indoor-dominant lifestyles needing mitochondrial and circadian reinforcement; Hashimoto's patients exploring complementary interventions under clinical supervision; athletes targeting recovery; post-surgical wound-healing acceleration with medical clearance. | ||
| Essential Amino Acids | Amino Acid | 7.8/10 | 💪 Strong recommend | Travelers bridging protein gaps, fasted trainers who want muscle protein synthesis with minimal food volume, adults 60+ fighting anabolic resistance, vegans with lower-leucine protein patterns, people in calorie deficits trying to preserve lean mass, and post-surgical or immobilized adults using EAAs as adjunct nutrition under clinician guidance. | ||
| Melatonin | Exogenous Metabolite | 7.8/10 | 💪 Strong recommend | Circadian timing problems, jet lag, delayed sleep phase, autism-related insomnia under supervision, and users who care about antioxidant biology. | ||
| Glycine | Vitamin & Mineral & Nutrient | 7.8/10 | 💪 Strong recommend | Adults 50+ seeking sleep consolidation, glutathione restoration, or sarcopenia support; vegans, vegetarians, and low-collagen diets needing more connective-tissue substrate; shift workers and frequent travelers using 3 g pre-bed for off-cycle sleep quality; collagen peptide users who want to correct the glycine gap; and adults exploring GlyNAC with clinician oversight for aging-related oxidative stress. Psychiatric use belongs under prescriber supervision, especially when antipsychotics are involved. | ||
| L-Theanine | Amino Acid | 7.5/10 | 💪 Strong recommend | Adults who get caffeine jitters but still want focus; stress-prone people before presentations, difficult conversations, travel, or sleep onset; meditators looking for a relaxed-attention state; people who tolerate prescription anxiolytics poorly; and users building a low-risk sleep stack where the goal is lowering activation rather than forcing sedation. | ||
| Astaxanthin | Vitamin & Mineral & Nutrient | 7.4/10 | 💪 Strong recommend | Adults 40+ seeking broad antioxidant support with human RCT evidence; heavy screen users with eye fatigue; endurance athletes with high oxidative load; people with visible photoaging who still use topical SPF; dyslipidemic or prediabetic adults wanting modest adjunctive support; women pursuing ART where clinician-approved antioxidant support is appropriate; users who can source verified natural Haematococcus pluvialis extract and take it with fat. | ||
| Thymosin Alpha-1 | Immune Peptide | 7.4/10 | 💪 Strong recommend | Adults over 40 with age-related immune decline; frequent travelers facing elevated pathogen exposure; people recovering from illness, surgery, chemotherapy-associated immune suppression, or severe infection under clinician supervision; older adults exploring vaccine-response support; patients with documented low T-cell counts or immune markers; and cancer or chronic viral hepatitis patients only as an adjunct with their treating physician. | ||
| BPC-157 | Growth & Repair Peptide | 7.2/10 | 💪 Strong recommend | Healthy adults with acute tendon, ligament, muscle, or wound-repair goals who understand that BPC-157 remains an investigational gray-market peptide; people using short, scoped injury cycles alongside rehab, sleep, protein, and load management; gut-healing experimenters choosing oral arginine salt after conventional care has failed; non-tested athletes and recovery-focused users who can verify product purity and accept regulatory uncertainty. | ||
| Collagen Peptides | Amino Acid | 7.2/10 | 💪 Strong recommend | Post-menopausal women seeking modest skin and bone-density support; aging adults with knee or hip discomfort who understand collagen is adjunctive, not guideline-level osteoarthritis treatment; athletes pairing tendon-loading rehab with gelatin or collagen plus vitamin C; poor sleepers using collagen as a glycine vehicle; older adults resistance training for sarcopenia support; and anyone who wants extra glycine, proline, and hydroxyproline without replacing complete protein. | ||
| Grass-Fed Whey Protein | Vitamin & Mineral & Nutrient | 7.2/10 | 💪 Strong recommend | Protein-gap filling, resistance training, sarcopenia prevention, and convenient amino-acid delivery when brand testing is strong. | ||
| PEMF (Pulsed Electromagnetic Field Therapy) | PEMF | 7.2/10 | 💪 Strong recommend | Adults with nonunion fractures or spinal-fusion contexts using prescription medical devices; people with knee or hand osteoarthritis seeking adjunct pain relief; post-surgical patients using surgeon-cleared devices for pain, swelling, or soft-tissue recovery; people with chronic low-back or joint pain who can test a high-quality device consistently for 4-8 weeks; biohackers using a mat as a passive pre-bed wind-down tool while staying realistic about thin wellness evidence. | ||
| Infrared Sauna | Sauna & Heat Therapy | 7.2/10 | 💪 Strong recommend | Adults with cardiovascular risk factors who can tolerate heat and want a repeatable passive-heating practice; people with chronic inflammatory pain or stiffness; adults using sauna as a mood, sleep, and stress-downshift ritual; athletes targeting heat acclimation or recovery timing; people building a sweat-based environmental-toxin reduction protocol; and heart-failure patients only when Waon-style therapy is supervised by a cardiology team. | ||
| Saffron | Botanical Extract (non-adaptogenic) | 7.2/10 | 💪 Strong recommend | Adults with mild-to-moderate low mood, stress sensitivity, PMS or PMDD symptoms, sleep fragmentation, early dry AMD, or a low-risk mood stack needing serotonergic support without typical SSRI side effects. Best used as a standardized, third-party-tested extract and as an adjunct rather than a replacement for clinician-guided psychiatric, retinal, or metabolic care. | ||
| Lactoferrin | Substance | 7.1/10 | 💪 Strong recommend | Iron-deficient adults who want a gentler iron-adjacent option; people using lactoferrin as an adjunct to standard H. pylori eradication therapy; mild-to-moderate acne users willing to run the lactoferrin + zinc + vitamin E stack for 8-12 weeks; older adults exploring immune-marker modulation; carefully supervised neonatal settings where clinicians already use enteral lactoferrin protocols; adults with gut-barrier or high-exposure immune contexts who understand that adult respiratory infection prevention remains mixed. | ||
| Shilajit | Adaptogenic Herb | 7.1/10 | 💪 Strong recommend | Adults seeking a broad-spectrum mineral and fulvic-acid supplement with the best available human signal in testosterone support, male fertility, bone-density preservation, collagen turnover, strength retention, and steady baseline energy. Best suited to people willing to buy purified, standardized material with current heavy-metal testing and treat shilajit as a slow 8-48 week maintenance supplement rather than an acute stimulant. | ||
| Phosphatidylserine | Vitamin & Mineral & Nutrient | 7.1/10 | 💪 Strong recommend | Adults 55+ with age-associated memory complaints, chronically stressed adults with elevated HPA-axis tone, athletes experimenting with cortisol management during heavy training blocks, and children with ADHD only as an adjunct discussed with a clinician, especially when omega-3 intake is already addressed. | ||
| Full-Body EMS | Resistance & Strength | 7.1/10 | 💪 Strong recommend | Frequent travelers and remote workers who need a full-body strength dose without gym access; sarcopenic or frail older adults who cannot tolerate heavy conventional resistance training; chronic nonspecific low back pain sufferers who have plateaued on standard back-strengthening programs; athletes using WB-EMS for supervised neuromuscular re-education after injury; people preserving lean mass during a calorie deficit; sedentary adults who will actually commit to a 20-minute weekly minimum effective dose. | ||
| TB-500 (Thymosin Beta-4 Fragment) | Peptide | 7.0/10 | 💪 Strong recommend | Active adults recovering from acute soft-tissue injuries who already understand injectable peptide risk; post-surgical recovery contexts where the surgical team is aware; chronic tendinopathy or joint irritation after conservative rehab has stalled; users comparing TB-500 with BPC-157 for a broader systemic repair signal; and ophthalmology-adjacent readers tracking full-length topical thymosin beta-4 research rather than injected TB-500. | ||
| Earthing | Practice & Lifestyle | 7.0/10 | 💪 Strong recommend | Adults with sleep disruption, post-exercise soreness, mild pain, or recovery goals who can test free outdoor barefoot grounding before buying products; users who want a low-cost practice that stacks with morning sunlight, walking, breathwork, and sleep routines; post-surgical recovery users only as supportive care with clinician awareness; electrosensitivity-symptomatic users who prefer outdoor rod methods over outlet-grounded products. | ||
| Vagus Nerve Stimulation | Neurostimulation & Neurofeedback | 7.0/10 | 💪 Strong recommend | People with low baseline HRV, chronic stress, autonomic dysregulation, or post-concussion autonomic symptoms who want a passive recovery tool; migraine or cluster-headache patients considering an FDA-cleared non-invasive cervical device with clinician guidance; treatment-resistant epilepsy or depression patients discussing implanted VNS with a specialist; and biohackers who already do breathwork, sleep basics, and HRV biofeedback but want a device-based add-on. | ||
| Vitamin D3 + K2 | Vitamin & Mineral & Nutrient | 7.0/10 | 💪 Strong recommend | Adults living above 35° latitude, indoor workers, anyone with serum 25(OH)D below 30 ng/mL, postmenopausal women, and those targeting cardiovascular calcification prevention. | ||
| Whole-Body Vibration | Other Device | 7.0/10 | 💪 Strong recommend | Postmenopausal or osteopenic women using low-magnitude high-frequency platforms for bone maintenance; frail, sarcopenic, or very old adults using supervised vibration for strength, balance, and fall-risk support; chronic non-specific low back pain patients adding WBV to physical therapy; Parkinson's patients using it as a rehab adjunct rather than a disease treatment; children with cerebral palsy under pediatric PT supervision; lifters using pivotal platforms for warm-up, BFR stacking, or recovery flushing; travelers and remote workers needing a minimum-effective movement stimulus. | ||
| Melanotan I (Afamelanotide) | Neuropeptide | 6.9/10 | 👍 Worth trying | Photosensitive EPP patients under specialty care and fair-skinned self-experimenters who prioritize UV tolerance over convenience. | ||
| Epitalon | Peptide | 6.8/10 | 👍 Worth trying | Adults over 55 with documented age-related sleep disruption, low nighttime melatonin, or interest in Russian peptide-bioregulator protocols; advanced longevity self-experimenters who already have sleep, exercise, nutrition, metabolic health, and better-studied geroprotective strategies dialed in; people comparing cyclical pineal-axis protocols against nightly melatonin; and researchers comfortable treating Epitalon as a low-confidence, gray-market peptide with mostly Russian and in vitro support. | ||
| Spermidine | Vitamin & Mineral & Nutrient | 6.7/10 | 👍 Worth trying | Healthy adults over 40 who want a low-effort, food-derived autophagy lever with a long human dietary mortality signal; people whose TruDiagnostic, Function Health, or similar panels flag low polyamine status; cardiovascular-risk populations not on active antitumor therapy; post-menopausal women concerned about hair density; and stackers pairing spermidine with resveratrol, urolithin A, NMN, NR, or clinician-supervised rapamycin protocols. | ||
| GHK-Cu | Growth & Repair Peptide | 6.6/10 | 👍 Worth trying | Topical use on photoaged skin, 40+ thinning skin, post-procedure redness recovery, early androgenic thinning with intact follicles, diabetic or chronic wound-healing support under clinician oversight, and peptide-community users who understand that systemic injection evidence remains mechanistic and anecdotal rather than RCT-proven. | ||
| KPV (Lys-Pro-Val) | Immune Peptide | 6.6/10 | 👍 Worth trying | Adults already working with a clinician on gut inflammation, IBD-adjacent symptoms, inflammatory IBS patterns, or atopic skin issues who understand that KPV is an experimental peptide with strong preclinical rationale and no completed human efficacy trials. Best reserved for structured n-of-1 experiments after diagnostic workup, conventional first-line care, and lower-risk gut supports have been addressed. | ||
| NMN (Nicotinamide Mononucleotide) | Exogenous Metabolite | 6.5/10 | 👍 Worth trying | Adults over 40 with suspected NAD+ decline, especially those with insulin resistance, higher BMI, age-related physical decline, or poor lifestyle NAD+ inputs. Best considered after exercise, sleep, protein intake, fasting rhythm, sauna, and metabolic fundamentals are already in place. | ||
| Senolytics | Botanical Extract (non-adaptogenic) | 6.5/10 | 👍 Worth trying | Adults over 50 with signs of age-related decline, chronic low-grade inflammation, fibrotic conditions, or high senescence burden who want a low-cost OTC senolytic experiment; people considering prescription D+Q only with clinician supervision; post-chemotherapy or accelerated-aging users only with medical clearance. | ||
| NR (Nicotinamide Riboside) | Exogenous Metabolite | 6.5/10 | 👍 Worth trying | Adults 50+ who want the most regulated oral NAD+ precursor with FDA GRAS and New Dietary Ingredient history; people already covering exercise, sleep, protein, and meal timing who want an add-on NAD+ repletion experiment; Parkinson's or peripheral artery disease patients discussing adjunctive NR with clinicians; users who value Niagen quality control more than price; and longevity users building a broader NAD+ strategy instead of expecting NR alone to create obvious day-to-day effects. | ||
| Ca-AKG (Calcium Alpha-Ketoglutarate) | Vitamin & Mineral & Nutrient | 6.4/10 | 👍 Worth trying | Adults over 50 with elevated epigenetic age, postmenopausal women with osteopenia who understand the calcium-load tradeoff, and disciplined longevity-stack builders who are comfortable making a low-cost mechanism bet while waiting for controlled human biological-age data. | ||
| Urolithin A | Exogenous Metabolite | 6.4/10 | 👍 Worth trying | Older adults, sedentary adults, or people with suspected mitochondrial bottlenecks who want a low-effort mitophagy supplement; especially the estimated 60% of adults who are low or non-producers of urolithin A from pomegranate, walnuts, and other ellagitannin foods. Best run as a 12-16 week trial using Mitopure rather than generic capsules, with realistic expectations that biomarker shifts are more reliable than felt energy or performance changes. | ||
| Ashwagandha | Adaptogenic Herb | 6.4/10 | 👍 Worth trying | Chronically stressed adults with elevated perceived stress or cortisol-linked symptoms; adults with mild anxiety or insomnia who want a non-prescription option; men with stress-suppressed vitality or testosterone where lifestyle foundations are already addressed; subclinical hypothyroid patients only with clinician monitoring; athletes looking for modest recovery, strength, or VO2max support; users willing to choose third-party-tested standardized extracts and cycle use to reduce mood-blunting risk. | ||
| Berberine | Botanical Extract (non-adaptogenic) | 6.4/10 | 👍 Worth trying | Adults with diagnosed type 2 diabetes, prediabetes, metabolic syndrome, insulin-resistant PCOS, NAFLD with elevated ALT, dyslipidemia, or short-course gut antimicrobial protocols who can use berberine under clinician or pharmacist oversight, especially when metformin is not tolerated or accessible. | ||
| Omega-3 | Vitamin & Mineral & Nutrient | 6.4/10 | 👍 Worth trying | People with documented low Omega-3 Index below 5%; patients with elevated triglycerides who are using clinician-directed prescription omega-3 or carefully selected supplement protocols; adults using EPA-dominant omega-3 as an adjunct for unipolar depression; rheumatoid arthritis patients seeking modest pain reduction; people with NAFLD or chronic inflammatory patterns; pregnant or lactating women using purified DHA or algae oil under clinician guidance; vegans who need direct EPA/DHA rather than relying on ALA conversion. | ||
| Semax | Peptide | 6.4/10 | 👍 Worth trying | Biohackers and nootropic users seeking acute focus or processing-speed support with a low side-effect burden; adults exploring neuroprotection with physician awareness; researchers and clinicians in countries where Semax is legally available; older adults interested in post-stroke or neurorecovery-adjacent mechanisms; and users willing to accept that the strongest human evidence remains Russian and post-Soviet rather than independently replicated in U.S. or EU trials. | ||
| MOTS-c | Other Peptide | 6.4/10 | 👍 Worth trying | Metabolically unhealthy, sedentary, or aging adults who understand that MOTS-c remains a research peptide with no published human interventional efficacy RCTs. Most relevant for people tracking fasting glucose, insulin resistance, body composition, and mitochondrial energy who cannot fully express exercise adaptations through training alone. Tested athletes should avoid it because WADA lists MOTS-c under prohibited AMPK activators. | ||
| Colostrum | Vitamin & Mineral & Nutrient | 6.3/10 | 👍 Worth trying | Athletes under heavy training loads seeking fewer upper respiratory symptom days and better gut-barrier resilience; frequent travelers, parents of young children, and healthcare workers during sick season; heavy NSAID users who need gut-barrier support; people with permeability-type gut symptoms who can tolerate dairy; and users willing to take 10-20 g/day of IgG-standardized powder rather than low-dose social-media protocols. | ||
| Tesamorelin | Growth & Repair Peptide | 6.3/10 | 👍 Worth trying | Adults with HIV-associated abdominal lipodystrophy using the FDA-labeled indication; central visceral adiposity confirmed by imaging or waist metrics; HIV-associated NAFLD or early MASH under specialist care; older adults or MCI patients with low-normal IGF-1 who understand the cognitive evidence is still early; metabolically monitored users who can afford prescription Egrifta SV and are willing to track IGF-1, fasting glucose, HbA1c, cancer history, and retinopathy risk. | ||
| High-Dose Melatonin | Exogenous Metabolite | 6.3/10 | 👍 Worth trying | Experienced users targeting mitochondrial, antioxidant, immune, or oncology-adjacent research questions with clinician-aware monitoring. | ||
| Semaglutide | Other Pharmaceutical | 6.2/10 | 👍 Worth trying | Adults with obesity plus type 2 diabetes, established cardiovascular disease, diabetic chronic kidney disease, obesity-related heart failure symptoms, knee osteoarthritis driven by mechanical load, or biopsy-confirmed noncirrhotic MASH with fibrosis who can access branded prescription semaglutide, tolerate GI effects, and pair treatment with resistance training, protein targets, and long-term medical monitoring. | ||
| Tirzepatide | Peptide | 6.2/10 | 👍 Worth trying | Adults with BMI >=35 where time-to-intervention-effect genuinely matters; type 2 diabetics with poor glycemic control despite standard therapy; obesity with prediabetes where diabetes prevention is the clinical objective; obesity-associated HFpEF; adults with obesity-related obstructive sleep apnea using tirzepatide as adjunctive chronic disease care; people who have accepted the long-term therapy model and paired the drug with resistance training, high protein intake, creatine, and monitoring for lean-mass and bone-health risk. | ||
| Thymosin Beta-4 (Tβ4) | Growth & Repair Peptide | 8.8/10 | ||||
| Time-Restricted Eating | Practice & Lifestyle | 6.1/10 | 👍 Worth trying | Adults with metabolic dysfunction, prediabetes, type 2 diabetes, metabolic syndrome, or body-composition goals who find eating-window discipline easier than calorie counting; people willing to use earlier eating windows for stronger metabolic alignment; PCOS patients exploring TRE as an alternative to continuous calorie restriction under clinician supervision; biohackers trialing TRE in 8 to 12 week phases with body-composition and biomarker tracking; and people seeking a zero-cost, fully reversible dietary timing protocol. | ||
| Tongkat Ali | Adaptogenic Herb | 6.1/10 | 👍 Worth trying | Men over 35 with measured low or borderline testosterone, high SHBG, elevated stress load, or age-related libido decline who have already handled sleep, resistance training, body composition, and nutrition; athletes who need a reversible stress-and-androgen support tool but can verify supplement quality; and peri/post-menopausal women only if they understand the evidence is new, formulation-specific, and not a pregnancy or lactation tool. | ||
| Orforglipron (Foundayo) | Other Pharmaceutical | 6.1/10 | 👍 Worth trying | Adults with obesity or weight-related metabolic disease who want an effective GLP-1 option without injections, cold-chain storage, or the strict fasting that oral semaglutide demands, who accept that it is meaningfully less powerful than the injectables and that weight returns when treatment stops. | ||
| Lion’s Mane | Functional Mushroom | 6.0/10 | 👍 Worth trying | Adults with subjective cognitive decline, early MCI, or aging-related memory complaints; adults experimenting with sustained focus support where modest effects are acceptable; menopausal women with low-grade mood symptoms; users recovering from peripheral nerve injury under clinician guidance; and supplement-literate adults buying verified fruiting body extract or erinacine-standardized mycelium while cycling and stopping immediately if libido, mood, or anhedonia symptoms appear. | ||
| TUDCA (Tauroursodeoxycholic Acid) | Exogenous Metabolite | 6.0/10 | 👍 Worth trying | Liver, bile-flow, insulin-sensitivity, and carefully framed neuroprotection research where TUDCA is kept distinct from UDCA and AMX0035 combination-drug evidence. | ||
| Selank | Peptide | 5.9/10 | 👍 Worth trying | Acutely anxious adults who understand that Selank has Russian clinical evidence but no Western approval; users seeking a non-sedating anxiolytic alternative to benzodiazepine-like effects; self-experimenters willing to prioritize third-party-tested sourcing and stop if nasal irritation, fatigue, mood destabilization, or drug-interaction concerns appear. | ||
| SS-31 (Elamipretide) | Other Peptide | 5.9/10 | 👍 Worth trying | Diagnosed Barth syndrome patients who qualify for prescription Forzinity, weigh at least 30 kg, and are monitored by a mitochondrial-disease specialist. SS-31 is also a research-interest option for adults with documented mitochondrial disease or objective mitochondrial dysfunction who can access a clinical trial or legitimate prescription channel. It is a weak fit for healthy longevity users without measured mitochondrial impairment. | ||
| Bromantane (Ladasten) | Other Pharmaceutical | 5.8/10 | 👍 Worth trying | Knowledge workers and high-output executives running 30 mg pulsed in the morning (not daily) who want an actoprotector that does not feel like a classic stimulant, are willing to source from a gray-market channel with HPLC verification, and accept that the human safety record stops at 28 days. | ||
| ARA-290 (Cibinetide) | Other Peptide | 5.8/10 | 👍 Worth trying | People with refractory small-fiber neuropathy or sarcoidosis-associated nerve pain who want the most evidence-backed peptide in this niche, who accept it is investigational with no Phase 3 and a defunct sponsor, and who can source verified material and work with a clinician on monitoring. | ||
| Paraxanthine (Enfinity) | Stimulant & Methylxanthine | 5.8/10 | 👍 Worth trying | Caffeine-sensitive users testing focus and energy alternatives while recognizing the industry-funded evidence base. | ||
| Rapamycin | Pharmaceutical & Drug | 5.7/10 | ⚖️ Neutral | Adults 50+ with measurable age-related immune decline who understand off-label pharmaceutical risk, have access to a longevity-oriented prescriber, and will commit to regular blood work. Best fit is older, data-literate users who are comfortable treating rapamycin as an experimental geroscience intervention rather than a proven anti-aging medication. | ||
| Quercetin | Botanical Extract (non-adaptogenic) | 5.7/10 | ⚖️ Neutral | Older adults with allergic rhinitis, mild hypertension, chronic pelvic pain, or hyperuricemia who can afford a phytosome or EMIQ form. | ||
| Kisspeptin-10 | Neuropeptide | 5.7/10 | ⚖️ Neutral | Curious researchers and fertility-clinic settings who want the master upstream switch of the reproductive axis, who understand that most strong human data used kisspeptin-54 rather than the kisspeptin-10 form on sale, who accept a minutes-long half-life that demands frequent dosing or infusion, and who can source verified material while treating it as investigational rather than proven. | ||
| Piracetam (Nootropil) | Racetam | 5.6/10 | ⚖️ Neutral | Narrow historical-research contexts such as cortical myoclonus, aphasia adjuncts, and breath-holding-spell literature. | ||
| Retatrutide | Other Pharmaceutical | 5.6/10 | ⚖️ Neutral | Adults with severe obesity, type 2 diabetes, MASLD/MASH, knee osteoarthritis, or obstructive sleep apnea who are enrolled in Lilly-run TRIUMPH or TRANSCEND clinical trials with manufactured product, formal titration, laboratory monitoring, adverse-event tracking, protein/resistance-training support, and physician oversight. If approved with a clean label, the strongest fit is metabolically high-risk obesity, not cosmetic cutting or longevity experimentation. | ||
| CJC-1295 | Growth & Repair Peptide | 5.6/10 | ⚖️ Neutral | Healthy adults 30-50 seeking growth hormone optimization for body composition, sleep quality, and training recovery who understand that CJC-1295 is not FDA-approved, accept subcutaneous injections, use baseline and follow-up IGF-1 labs, avoid the DAC variant when sustained IGF-1 exposure is a concern, and prefer the shorter-acting Mod-GRF 1-29 plus ipamorelin format over gray-market weekly DAC use. | ||
| Survodutide (BI 456906) | Other Peptide | 5.5/10 | ⚖️ Neutral | People focused on fatty liver disease who want the most direct hepatic mechanism in the GLP-1 class, who accept that survodutide is investigational and only reachable through grey-market channels with no quality guarantee, and who can monitor liver enzymes, glucose, and heart rate while waiting for the Phase 3 liver readout. | ||
| Sulforaphane | Botanical Extract (non-adaptogenic) | 5.5/10 | ⚖️ Neutral | People with elevated air pollution exposure or dysregulated fasting glucose who can source a glucoraphanin product paired with active myrosinase, will track fasting glucose or hs-CRP for 8 to 12 weeks, and accept that broad NRF2 marketing claims have outrun the human evidence. | ||
| Apigenin | Botanical Extract (non-adaptogenic) | 5.5/10 | ⚖️ Neutral | Anxious-baseline adults who already respond well to chamomile or mild GABAergic calm; people testing a low-dose sleep stack and willing to isolate variables; users who want a standardized chamomile-adjacent compound rather than tea; cautious experimenters starting at 25-50 mg pre-bed; readers interested in the CD38/NAD+ hypothesis who understand it remains mouse and cell evidence, not a validated human longevity protocol. | ||
| Metformin | Other Pharmaceutical | 5.5/10 | ⚖️ Neutral | Adults with type 2 diabetes, especially overweight or insulin-resistant patients who tolerate metformin and can monitor kidney function and B12; selected prediabetes cases with BMI >=30, higher fasting glucose, prior gestational diabetes, or age under 60 after lifestyle-first care; insulin-resistant PCOS where ovulation, androgen, and metabolic endpoints matter; metabolically unhealthy adults using metformin under clinician supervision rather than healthy athletes chasing non-diabetic longevity. | ||
| Methylene Blue | Pharmaceutical & Drug | 5.5/10 | ⚖️ Neutral | Adults with suspected mitochondrial dysfunction, chronic fatigue, post-viral fatigue, or metabolic dysfunction who are not taking serotonergic drugs; cognitively demanding knowledge workers using occasional microdoses for acute mental clarity; adults over 50 exploring mitochondrial support alongside NAD+ precursors; biohackers pairing pharmaceutical-grade methylene blue with red light therapy; patients receiving FDA-approved IV methylene blue for acquired methemoglobinemia under medical care; procedure-specific local analgesia or shock use only under clinician supervision. | ||
| Humanin | Other Peptide | 8.8/10 | ||||
| Thymulin (Zinc-Thymulin) | Immune Peptide | 5.4/10 | ⚖️ Neutral | Researchers and experienced self-experimenters who already understand zinc status, want a chemically defined thymic hormone rather than an undefined extract, accept that no modern human trial supports injected thymulin, and can source verified material with a certificate of analysis. | ||
| Gonadorelin (GnRH) | Neuropeptide | 5.4/10 | ⚖️ Neutral | TRT users with an intact pituitary who want to keep their testes working and protect fertility, who will dose in frequent small pulses and accept that hCG has the better-tested track record, plus clinicians managing genuine hypothalamic amenorrhea or male hypogonadotropic hypogonadism through pulsatile delivery. | ||
| Mazdutide (IBI362) | Other Peptide | 5.3/10 | ⚖️ Neutral | People focused on body composition and liver fat who want the strongest published incretin liver data, who accept that all trials ran in Chinese adults with no Western or cardiovascular outcomes data, and who can source verified pharmaceutical-grade material rather than grey-market powder. | ||
| CagriSema (Cagrilintide + Semaglutide) | Other Peptide | 5.3/10 | ⚖️ Neutral | People researching the strongest dual-mechanism obesity injectable on the horizon who can wait for FDA approval, who want amylin plus GLP-1 rather than the GIP-based path, and who accept a high gastrointestinal load, no long-term safety record, and a gray-market-only access route until launch. | ||
| VIP (Vasoactive Intestinal Peptide) | Neuropeptide | 8.8/10 | ||||
| Ketogenic Diet | Practice & Lifestyle | 5.3/10 | ⚖️ Neutral | Medically supervised type 2 diabetes reversal programs with medication adjustment; refractory pediatric epilepsy under neurology and dietitian care; 8-12 week elimination or metabolic-reset phases; hyperandrogenic PCOS when fertility and endocrine markers are monitored; APOE3 cognitive-aging experiments using Mediterranean-keto or MCT-heavy variants; and ultra-endurance athletes who have completed a long adaptation block. | ||
| Hyperbaric Oxygen Therapy | Device & Technology | 5.3/10 | ⚖️ Neutral | Patients with UHMS-accepted medical indications under clinician supervision; older adults with documented cognitive complaints who can access hard-chamber 2.0 ATA protocols and understand the cost; chronic post-stroke and fibromyalgia patients considering adjunctive care; selected wound-care patients in medical settings; serious experimenters who have already optimized sleep, aerobic training, cardiometabolic risk, nutrition, and recovery basics. | ||
| Cerebrolysin | Other Pharmaceutical | 5.2/10 | ⚖️ Neutral | People investigating acute neuro-recovery (severe stroke or moderate-to-severe brain injury motor recovery) who can access a clinic for supervised infusion courses, who understand that the strongest evidence comes from manufacturer-funded trials and the independent reviews disagree, and who can source verified pharmaceutical-grade product rather than grey-market vials. | ||
| Cagrilintide (AM833) | Other Peptide | 5.2/10 | ⚖️ Neutral | Researchers and self-experimenters who understand cagrilintide is an investigational amylin analogue best understood as the amylin half of CagriSema, who want a separate satiety mechanism with a cleaner tolerability profile than GLP-1 drugs, and who can source pharmaceutical-grade material with a verified certificate of analysis and accept that no monotherapy approval or cardiovascular safety data exists. | ||
| DSIP (Delta Sleep-Inducing Peptide) | Neuropeptide | 8.8/10 | ||||
| Oxytocin (Intranasal) | Neuropeptide | 8.8/10 | ||||
| AHK-Cu (Copper Tripeptide) | Other Peptide | 8.8/10 | ||||
| Thymalin | Immune Peptide | 5.1/10 | ⚖️ Neutral | Researchers curious about the Khavinson peptide-bioregulator program who understand the entire human case is single-source and unreplicated, who can verify a clean bovine-derived injectable, and who treat thymalin as an experiment rather than a proven immune therapy. | ||
| Sermorelin (GHRH 1-29) | Growth & Repair Peptide | 5.1/10 | ⚖️ Neutral | Older adults with documented low IGF-1 or age-related somatopause who want the GHRH-class peptide with the most regulatory pedigree and real human trial history, who accept that modern adult anti-aging data is thin and mixed, who will dose pre-sleep and fasted, and who can source pharmaceutical-grade compounded material with a verified certificate of analysis. | ||
| Aniracetam | Racetam | 5.1/10 | ⚖️ Neutral | Mechanism-curious readers comparing racetams, not people seeking well-replicated human anxiety evidence. | ||
| Oxiracetam | Racetam | 5.0/10 | ⚖️ Neutral | Occasional logical-work experiments where sourcing constraints and weak modern replication are acceptable. | ||
| Modafinil | Eugeroic (wakefulness agent) | 5.0/10 | ⚖️ Neutral | Adults with diagnosed narcolepsy or idiopathic hypersomnia under a sleep clinician; obstructive sleep apnea patients with residual sleepiness after airway treatment; shift-work patients using clinician-directed timing; and selective off-label adults using infrequent, low-dose travel or sleep-debt rescue. Best fit is acute wakefulness, vigilance, and convergent focus when sleep pressure is high, not daily cognitive enhancement in rested healthy adults. | ||
| Sabroxy (Oroxylum indicum Extract) | Botanical Extract (non-adaptogenic) | 4.9/10 | ⚖️ Neutral | Short cognitive experiments with attention to MAO-B theory, sleep timing, and limited 28-day human safety data. | ||
| NAD+ (Direct) | Exogenous Metabolite | 8.8/10 | ||||
| GHRP-2 (Pralmorelin) | Growth & Repair Peptide | 4.9/10 | ⚖️ Neutral | Experienced peptide users who want a stronger growth-hormone pulse than ipamorelin, who accept that the human evidence is acute and diagnostic rather than outcome-based, who can tolerate the appetite, cortisol, and prolactin off-targets, and who can source verified pharmaceutical-grade material with a certificate of analysis. | ||
| Dihexa | Research Compound | 4.9/10 | ⚖️ Neutral | Researchers and unusually risk-tolerant self-experimenters studying neurodegenerative mechanisms who understand that dihexa has no human trials, no human pharmacokinetics, no validated dosing, and a serious c-Met growth-factor pathway concern. The only defensible human context is short-cycle, non-routine use with medical oversight, third-party identity and purity testing, and explicit avoidance in anyone with cancer risk, pregnancy, pediatrics, competitive sport exposure, or prescription-medication complexity. | ||
| SNAP-8 (Acetyl Octapeptide-3) | Other Peptide | 8.8/10 | ||||
| Dynamine (Methylliberine) | Stimulant & Methylxanthine | 4.8/10 | ⚖️ Neutral | Short stimulant trials where caffeine co-use, sleep timing, and limited independent replication are explicit constraints. | ||
| VK2735 (Viking Therapeutics) | Other Peptide | 4.8/10 | ⚖️ Neutral | Researchers and self-experimenters tracking the next-generation incretin class who understand that VK2735 is the earliest-stage option in the batch, that all of its data is short-duration, and that the only way to obtain it today is the grey market with unverified purity. | ||
| Ipamorelin | Growth & Repair Peptide | 4.8/10 | ⚖️ Neutral | Researchers and clinicians who want a selective growth-hormone secretagogue with a clean side-effect profile, who accept that the human efficacy data for body composition, recovery, and sleep is essentially absent, and who can source pharmaceutical-grade material and monitor IGF-1 and glucose. | ||
| MK-677 (Ibutamoren) | Research Compound | 4.8/10 | ⚖️ Neutral | Experienced users who want oral convenience over injections, who care more about deeper sleep and lean-mass support than proven strength or function, who have clean blood sugar and no cardiac history, and who will monitor fasting glucose and IGF-1 on a verified, third-party-tested product. | ||
| Cold Plunge | Cold Exposure | 4.8/10 | ⚖️ Neutral | Practitioners who treat cold plunge as a mindset and discipline practice rather than a wellness add-on, and who already have stress fundamentals in place | ||
| C15 (Pentadecanoic Acid) | Vitamin & Mineral & Nutrient | 4.7/10 | ⚖️ Neutral | Adults who do not consume dairy fat, follow vegan or very low-dairy diets, have objectively low circulating C15:0 on a validated fatty-acid panel, and want a time-limited 12-week experiment with pre and post lipid panel, ALT, AST, GGT, glucose, insulin, and a clear stop rule. People with documented NAFLD should treat C15:0 as an experimental adjunct to diet, not as the driver of liver-fat improvement. | ||
| Pentosan Polysulfate (Elmiron) | Other Pharmaceutical | 4.6/10 | ⚖️ Neutral | Interstitial cystitis patients who want the one FDA-approved oral option and will commit to baseline plus regular dilated-eye screening; clinically supervised osteoarthritis users in countries where injectable pentosan is approved who can keep cumulative dose low; people who value a real regulated drug with published trials over an unapproved research peptide and accept modest, contested benefit; anyone who can rule out bleeding risk and will stop at the first sign of vision change. | ||
| SLU-PP-332 | Research Compound | 4.6/10 | ⚖️ Neutral | Advanced biohackers with medical supervision who are studying exercise-mimetic pharmacology as a research interest, have already optimized structured training, nutrition, sleep, and creatine, and explicitly accept that SLU-PP-332 remains a preclinical research compound with no validated human dose, no human safety margin, no FDA approval, and substantial gray-market product-identity risk. | ||
| LL-37 (Cathelicidin) | Immune Peptide | 4.6/10 | ⚖️ Neutral | Researchers and clinicians studying host-defense peptides who want to understand LL-37's mechanism, plus people specifically interested in the one evidence-backed route, topical wound care, who accept that systemic injectable use has zero human efficacy data and a genuine autoimmune and pro-tumor double-edge. | ||
| PT-141 (Bremelanotide) | Neuropeptide | 4.6/10 | ⚖️ Neutral | Premenopausal women with diagnosed low sexual desire who want the one FDA-approved option and can tolerate nausea; men or women who did not respond to Viagra-type drugs alone and want a central, desire-driven mechanism to stack; people who can rule out cardiovascular contraindications and source pharmaceutical-grade material. | ||
| AOD-9604 | Other Peptide | 4.6/10 | ⚖️ Neutral | Almost no one as a standalone bet, given that the lead human trial failed and no positive human study exists; the closest fit is an experienced user who already runs better-evidenced repair peptides, wants a low-harm add-on, accepts it may do nothing, and can source verified, contamination-free material. | ||
| Phenylpiracetam (Phenotropil) | Racetam | 4.5/10 | ⚖️ Neutral | Occasional research-only stimulant comparison where WADA status, sourcing uncertainty, and rapid tolerance are understood. | ||
| Ozone Therapy | Therapy & Modality | 4.5/10 | ⚖️ Neutral | Adults with a narrow, indication-specific reason to consider ozone therapy: refractory discogenic low back pain under fluoroscopy-guided specialist care; selected dental, periodontal, oral-ulcer, or wound-care adjuncts; carefully screened users choosing rectal insufflation for antimicrobial experimentation; and chronic illness users who understand that systemic MAH, EBOO, and direct IV routes carry serious route-specific safety and regulatory issues. | ||
| CJC-1295 No DAC (Mod GRF 1-29) | Growth & Repair Peptide | 4.5/10 | ⚖️ Neutral | Experienced users who want a short-acting, physiological growth-hormone pulse to pair with ipamorelin, who accept that no human outcome trial supports the stack and that the no-DAC form itself has never been tested in people, and who can source pharmaceutical-grade material with a verified certificate of analysis. | ||
| P21 (P021) | Neuropeptide | 8.8/10 | ||||
| PE-22-28 | Neuropeptide | 8.8/10 | ||||
| GHRP-6 | Growth & Repair Peptide | 4.4/10 | ⚠️ Caution | Experienced users who want the strongest, oldest growth-hormone-releasing peptide and who actively want its appetite-boosting effect during a hard bulking phase, who accept that no human outcome trial backs the body-composition use and that newer selective options do the same growth-hormone job with fewer side effects. | ||
| Vilon (Lys-Glu) | Immune Peptide | 8.8/10 | ||||
| Tesofensine | Other Pharmaceutical | 8.8/10 | ||||
| 5-Amino-1MQ | Research Compound | 4.3/10 | ⚠️ Caution | Lean health optimizers on a calorie deficit who understand they are paying for a promising but unproven preclinical compound, dose it orally at 50 to 150 mg, source it carefully, and track their own response. | ||
| Pinealon (Glu-Asp-Arg) | Neuropeptide | 4.2/10 | ⚠️ Caution | Peptide-bioregulator hobbyists already running the Khavinson protocol who accept that no rigorous independent human trial supports Pinealon, want a low-drama cell-and-animal-stage compound to track with an N-of-1 mindset, and can source verified material with a certificate of analysis. | ||
| Resveratrol | Botanical Extract (non-adaptogenic) | 4.2/10 | ⚠️ Caution | Older adults with impaired glucose tolerance who want a low-cost adjunct alongside lifestyle modification; postmenopausal women targeting cerebrovascular and cognitive endpoints; patients with active cardiovascular risk markers seeking modest endothelial improvement at clinically studied doses while a clinician manages CYP2C9, BCRP, anticoagulant, renal, and hormone-sensitive-cancer risks. | ||
| Celebrex (Celecoxib) | Other Pharmaceutical | 4.2/10 | ⚠️ Caution | People with moderate-to-severe osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain, or primary dysmenorrhea who need prescription anti-inflammatory pain relief after lower-risk options have been considered; patients with elevated gastrointestinal risk where celecoxib may be preferable to a nonselective NSAID; and CYP2C9 normal metabolizers without established cardiovascular disease, active ulcer disease, severe kidney or liver impairment, late pregnancy, post-CABG surgery, or warfarin-like bleeding risk. | ||
| Ephedrine | Pharmaceutical & Drug | 4.2/10 | ⚠️ Caution | Time-bound cutting protocols (4-8 weeks) in screened adults without cardiovascular risk factors, MAOI/SSRI/TCA exposure, hyperthyroidism, or exercise-in-heat scenarios. Pharmaceutical-grade ephedrine HCl behind the pharmacy counter, never gray-market herbal ephedra. | ||
| TRT (Testosterone Replacement Therapy) | Pharmaceutical & Drug | 4.1/10 | ⚠️ Caution | Men 35+ with documented symptomatic hypogonadism on two separate morning testosterone tests; men with primary hypogonadism where lifestyle will not restore production; older hypogonadal men with sarcopenia, anemia, low libido, low bone density, or persistent depressive symptoms; hypogonadal men with type 2 diabetes or metabolic syndrome when treatment goals are symptom relief rather than glucose control; and men who can commit to fertility planning, hematocrit and PSA monitoring, blood-pressure checks, and a clinician who does not prescribe reflexive aromatase inhibitors. | ||
| FOXO4-DRI | Other Peptide | 8.8/10 | ||||
| CJC-1295 DAC | Growth & Repair Peptide | 3.9/10 | ⚠️ Caution | Users who specifically want once-weekly convenience over the daily no-DAC schedule, who accept a sustained and non-physiological growth-hormone elevation, who have no cardiovascular risk factors, and who understand a side effect cannot be reversed for 6 to 8 days; for most people the short-acting no-DAC form is the better choice. | ||
| C60 (Buckminsterfullerene) | Research Compound | 3.7/10 | ⚠️ Caution | High-stress endurance athletes and self-experimenters who understand that oral C60 has no human longevity RCT, can source vacuum-baked or sublimated product, can refrigerate and store it away from light, and are treating it as a speculative recovery experiment rather than a proven longevity supplement. | ||
| Melanotan II | Neuropeptide | 3.3/10 | ⚠️ Caution | High-risk-tolerant users seeking short-cycle tanning or libido effects who already understand dermatology and emergency red flags. |
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