The Outliyr Index: Weekly Edition

Edition 2 · Week 2026-W27

Published 2026-07-06. This edition is an immutable snapshot: it never changes after publication.

What changed on The Outliyr Index in week 2026-W27?

147 interventions were on the board this week: 10 notable movers, 0 new entries, 0 departures. Biggest mover: Shilajit (momentum climbed from 5.4% to 64.8% while holding Proven).

Notable movers

Shilajit: rising

momentum climbed from 5.4% to 64.8% while holding Proven Full entry.

HRV Biofeedback: rising

momentum climbed from 0.3% to 56.3% while holding Proven Full entry.

Blood-Flow Restriction Training: rising

momentum climbed from 0.6% to 55.5% while holding Proven Full entry.

Earthing: rising

momentum climbed from 2.8% to 57.0% while holding Promising Full entry.

SNAP-8 (Acetyl Octapeptide-3): rising

momentum climbed from 0.0% to 52.8% while holding Promising Full entry.

Hyaluronic Acid: rising

momentum climbed from 6.2% to 56.6% while holding Promising Full entry.

Orforglipron (Foundayo): rising

momentum climbed from 18.5% to 66.7% while holding Promising Full entry.

Tesamorelin: rising

momentum climbed from 8.0% to 55.4% while holding Promising Full entry.

CJC-1295 DAC: rising

momentum climbed from 0.0% to 41.7% while holding Experimental Full entry.

GHRP-2 (Pralmorelin): rising

momentum climbed from 0.0% to 41.7% while holding Experimental Full entry.

New on the Index

No new interventions entered the board this week.

The board this week

Proven 46

Astaxanthin
Score
7.8/10
Momentum
35.2%
Trend
↑ Trend Up
Astaxanthin is a 7.8 / 10 fit for people weighing antioxidant, inflammation control, and skin resilience, especially when the goal is a tracked experiment with clear endpoints. The…
Blood-Flow Restriction Training
Score
8.2/10
Momentum
55.5%
Trend
↑ Trend Up
Blood-Flow Restriction Training is a 8.2 / 10 fit for muscle growth, geriatric, recovery repair, especially for readers who can match the protocol to load management, cuff pressure…
BPC-157
Score
7.5/10
Momentum
41.4%
Trend
↑ Trend Up
BPC-157 is a 7.5 / 10 fit for adults considering an investigational recovery peptide after basic rehab, sleep, protein, and load management are already handled, not a proven human…
Bromantane (Ladasten)
Score
7.1/10
Momentum
29.2%
Trend
↑ Trend Up
The practical verdict on Bromantane is that it is a reasonable adjunct for asthenic recovery and stress resilience in someone willing to accept gray-market sourcing, willing to use…
Coenzyme Q10 (CoQ10 / Ubiquinol)
Score
7.1/10
Momentum
16.7%
Trend
↑ Trend Up
CoQ10 is a strong-recommend supplement at 7.1/10 for the right person: a cheap, very safe mitochondrial cofactor with genuine hard-outcome evidence in heart failure and real sympto…
Collagen Peptides
Score
7.6/10
Momentum
36.7%
Trend
↑ Trend Up
Collagen Peptides is a 7.6 / 10 fit for people considering skin beauty, bone joint, recovery repair, sleep quality, with the strongest case in the populations already represented b…
Creatine Monohydrate
Score
8.7/10
Momentum
40.2%
Trend
↑ Trend Up
Creatine Monohydrate is a 8.7 / 10 fit for people weighing strength and power, muscle growth, and cognition and focus, especially when the goal is a tracked experiment with clear e…
Electrolytes
Score
8.8/10
Momentum
39.3%
Trend
↓ Trend Down
Electrolytes is a 8.8 / 10 fit for people losing fluid through heat, sweat, diarrhea, low-carb dieting, sauna, endurance work, or heavy training, because electrolytes solve a real…
Essential Amino Acids
Score
8/10
Momentum
33.9%
Trend
↑ Trend Up
Essential Amino Acids is a 8.0 / 10 fit for people weighing muscle growth, recovery and repair, and geriatric, especially when the goal is a tracked experiment with clear endpoints…
Full-Body EMS
Score
7.3/10
Momentum
11.1%
Trend
↑ Trend Up
Full-Body EMS is a 7.3 / 10 fit for people considering geriatric, body composition, strength power, chronic pain, with the strongest case in the populations already represented by…
GHK-Cu
Score
7.4/10
Momentum
34.5%
Trend
↑ Trend Up
GHK-Cu is a 7.4 / 10 fit for skin beauty, wound healing, recovery repair, especially for readers who can match the protocol to topical route, copper sensitivity, wound status, and…
Glycine
Score
7.9/10
Momentum
36.1%
Trend
↑ Trend Up
Glycine is a 7.9 / 10 fit for people who want a low-cost sleep, recovery, and glutathione-support tool with a better safety profile than most biohacker compounds, not a stand-alone…
Grass-Fed Whey Protein
Score
8.3/10
Momentum
29.2%
Trend
↑ Trend Up
Grass-Fed Whey Protein is a strong, practical protein source, and most of its value comes from dose and leucine rather than the grass-fed label. It earns its score when the goal is…
HRV Biofeedback
Score
9/10
Momentum
56.3%
Trend
↑ Trend Up
HRV Biofeedback is a 9.0 / 10 fit for hrv vagal tone, stress resilience, anxiety, especially for readers who can match the protocol to breathing cadence, adherence, baseline HRV, a…
Infrared Sauna
Score
7.4/10
Momentum
29.7%
Trend
↑ Trend Up
Infrared Sauna is a 7.4 / 10 fit for people who want passive heat for vascular conditioning, pain relief, mood support, or heat acclimation without harder training stress, because…
KPV (Lys-Pro-Val)
Score
7.1/10
Momentum
29.2%
Trend
↑ Trend Up
KPV (Lys-Pro-Val) is a 7.1 / 10 fit for people weighing gut health, inflammation control, and immune function, especially when the goal is a tracked experiment with clear endpoints…
L-Theanine
Score
7.9/10
Momentum
46.3%
Trend
↑ Trend Up
L-Theanine is a 7.9 / 10 fit for people considering cognition focus, stress resilience, sleep quality, anxiety, with the strongest case in the populations already represented by th…
Lactoferrin
Score
7.3/10
Momentum
30.0%
Trend
↑ Trend Up
Lactoferrin is a 7.3 / 10 fit for immune function, gut health, anti inflammatory, especially for readers who can match the protocol to iron status, dairy allergy, infection risk, a…
Lion's Mane
Score
7.2/10
Momentum
35.6%
Trend
↑ Trend Up
Lion's Mane is a 7.2 / 10 fit for people testing a gentle cognition or mood mushroom with realistic expectations and enough patience for multi-week tracking, not a guaranteed nerve…
Magnesium
Score
8.7/10
Momentum
32.9%
Trend
↓ Trend Down
Magnesium is a 8.7 / 10 fit for people with low intake, stress load, poor sleep, blood-pressure concerns, migraines, or glucose issues who want a practical mineral correction, not…
Melatonin
Score
8.2/10
Momentum
47.5%
Trend
↑ Trend Up
Melatonin is one of the more useful low-cost supplements when the target is circadian timing, jet lag, delayed sleep phase, or carefully selected sleep-onset support. It is far les…
Molecular Hydrogen
Score
8/10
Momentum
47.6%
Trend
↓ Trend Down
Molecular Hydrogen is a 8.0 / 10 fit for people weighing inflammation control, antioxidant, and recovery and repair, especially when the goal is a tracked experiment with clear end…
NAC (N-Acetylcysteine)
Score
8/10
Momentum
22.9%
Trend
↑ Trend Up
NAC is an 8.0 / 10 strong recommend: a cheap, broad, deeply-evidenced glutathione precursor with a genuinely life-saving core use and a benign safety record. The practical verdict…
Neurofeedback
Score
8.3/10
Momentum
29.0%
Trend
↑ Trend Up
Neurofeedback is a 8.3 / 10 fit for cognition focus, neuroplasticity, and TBI support when the protocol, practitioner quality, session dose, and objective tracking all line up. The…
Norwegian 4x4
Score
8.5/10
Momentum
36.0%
Trend
↑ Trend Up
Norwegian 4x4 delivers measurable VO2max gains for fit adults who can handle brief, high-intensity work and who need a time-efficient protocol. The evidence supports a roughly 7% i…
PEMF (Pulsed Electromagnetic Field Therapy)
Score
7.5/10
Momentum
19.8%
Trend
↑ Trend Up
PEMF (Pulsed Electromagnetic Field Therapy) is a 7.5 / 10 fit for people considering bone joint, acute pain, chronic pain, injury recovery, with the strongest case in the populatio…
Phosphatidylserine
Score
7.3/10
Momentum
37.0%
Trend
↑ Trend Up
Phosphatidylserine is a 7.3 / 10 fit for cognition focus, memory, stress resilience, especially for readers who can match the protocol to cortisol pattern, cognitive baseline, trai…
Polyphenols (Dietary)
Score
7.6/10
Momentum
6.5%
Trend
↓ Trend Down
Dietary polyphenols are a 7.6 / 10, a strong recommendation built on an unusual combination: large, consistent population evidence and an excellent safety, cost, and reversibility…
Red Light Therapy
Score
8/10
Momentum
28.0%
Trend
↑ Trend Up
Red Light Therapy is a 7/10 BioHarmony intervention for people who want a low-risk tool for skin aging, hair density, pain, recovery, wound support, and mitochondrial signaling, pr…
Rucking (Weighted Walking)
Score
7.3/10
Momentum
29.2%
Trend
↑ Trend Up
Rucking earns a 7.3 and a strong-recommend tier because it is a cheap, accessible, low-risk way to stack aerobic conditioning, weight-bearing loading, and a higher calorie burn ont…
Saffron
Score
8/10
Momentum
43.9%
Trend
↑ Trend Up
Saffron is a 8.0 / 10 fit for people using mood, depression, and sleep quality as a measured experiment, not a belief-based staple. The best anchors are [Kell et al. 2017](https://…
Semax
Score
7.1/10
Momentum
22.4%
Trend
↑ Trend Up
Semax is a 7.1 / 10 fit for people considering cognition focus, neuroprotection, memory, stress resilience, with the strongest case in the populations already represented by the ev…
Shilajit
Score
7.4/10
Momentum
64.8%
Trend
↑ Trend Up
Shilajit is a 7.4 / 10 fit for men testing fertility, testosterone, energy, or mineral-resin support with a purified, contaminant-tested product, not a universal adaptogen or detox…
Spermidine
Score
7.6/10
Momentum
31.9%
Trend
↑ Trend Up
Spermidine is a 6/10 fit for people interested in food-based autophagy and healthy-aging signals, especially when they can track diet and biomarkers, because spermidine has solid m…
Spirulina
Score
7/10
Momentum
46.8%
Trend
↑ Trend Up
Spirulina earns a strong-recommend at 7.0 because it delivers a replicated cluster of cardiometabolic benefits at food-grade safety and an unusually low cost. The practical verdict…
Taurine
Score
8.1/10
Momentum
38.9%
Trend
↑ Trend Up
Taurine is a 8.1 / 10 fit for people weighing cardiovascular, metabolic health, and sleep quality, especially when the goal is a tracked experiment with clear endpoints. The strong…
TB-500 (Thymosin Beta-4 Fragment)
Score
7.5/10
Momentum
29.2%
Trend
↑ Trend Up
TB-500 (Thymosin Beta-4 Fragment) is a 7.9 / 10 fit for people considering recovery repair, injury recovery, wound healing, eye vision, with the strongest case in the populations a…
Thymosin Alpha-1
Score
7.3/10
Momentum
16.7%
Trend
↑ Trend Up
Thymosin Alpha-1 is a 7.3 / 10 fit for people discussing immune modulation with a clinician, especially in hospital-adjacent or immune-compromised contexts, not a casual immune boo…
Thymosin Beta-4 (Tβ4)
Score
7.2/10
Momentum
41.7%
Trend
↑ Trend Up
Thymosin beta-4 lands in the Worth trying band because it is the most clinically tested peptide in its class with a clean Phase 1 IV safety record, one Phase 3 primary-endpoint win…
Tongkat Ali
Score
7/10
Momentum
37.5%
Trend
↑ Trend Up
Tongkat Ali is a 7.0 / 10 fit for men with low-normal testosterone, stress-linked libido issues, or training goals who can verify product quality and labs, because Tongkat Ali has…
Traditional Sauna (Finnish Dry-Heat)
Score
7.7/10
Momentum
29.2%
Trend
↑ Trend Up
Traditional Finnish sauna is a strong-recommend practice at 7.7 out of 10 for one core reason: it offers a large, dose-dependent, real-world cardiovascular and longevity signal wit…
Vagus Nerve Stimulation
Score
7.7/10
Momentum
38.8%
Trend
↑ Trend Up
Vagus Nerve Stimulation is a 7.7 / 10 fit for hrv vagal tone, stress resilience, mood, especially for readers who can match the protocol to device type, stimulation site, autonomic…
Vitamin C (Ascorbic Acid)
Score
7.7/10
Momentum
44.6%
Trend
↑ Trend Up
Vitamin C is a 7.7 out of 10 because the floor is so high and the downside so small: it is essential, decisively effective for deficiency, very safe, and nearly free, with modest r…
Vitamin D3 + K2
Score
7.8/10
Momentum
25.1%
Trend
↑ Trend Up
Vitamin D3 + K2 is a 7.8 / 10 fit for deficient adults, winter indoor workers, postmenopausal women, and people pairing vitamin D with calcium or bone goals, not a guaranteed benef…
Whole-Body Vibration
Score
7.3/10
Momentum
29.7%
Trend
↑ Trend Up
Whole-Body Vibration is a low-impact modality that can modestly improve bone density, reduce chronic low-back pain, and enhance balance in older adults when applied in calibrated s…
Zone 2 Cardio
Score
8.3/10
Momentum
19.8%
Trend
↑ Trend Up
Zone 2 Cardio is a 8.3 / 10 fit for people willing to build aerobic capacity through repeatable, low-drama training they can sustain for years, because cardiorespiratory fitness is…

Promising 69

Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga)
Score
5.8/10
Momentum
29.2%
Trend
↑ Trend Up
Adaptogenic mushrooms are a 5.8 out of 10, a Worth trying class for the right person and goal. Reishi is the standout, with real human evidence for immune-marker shifts and fatigue…
AHK-Cu (Copper Tripeptide)
Score
6.5/10
Momentum
29.2%
Trend
↑ Trend Up
AHK-Cu sits at Neutral because it pairs a plausible mechanism and a clean safety profile with an almost empty human-evidence file. The practical verdict: it is a reasonable, low-ri…
Aniracetam
Score
6.4/10
Momentum
36.1%
Trend
↑ Trend Up
Aniracetam earns a 6.4 because its strongest case is narrow and real: a fat soluble racetam that fine tunes AMPA receptors and is studied for memory, verbal fluency, and connecting…
Apigenin
Score
6.7/10
Momentum
19.7%
Trend
↑ Trend Up
Apigenin is a 5/10 fit for people who want a gentle calming option, not a heavy sleep drug or a longevity shortcut. The best human signal still comes from chamomile extract trials,…
ARA-290 (Cibinetide)
Score
6.5/10
Momentum
29.2%
Trend
↑ Trend Up
ARA-290 sits at Neutral because it is the strongest peptide in this repair group on human-trial rigor, yet it is hemmed in by a narrow indication, small trials, no Phase 3, a defun…
Ashwagandha
Score
6.8/10
Momentum
32.7%
Trend
↑ Trend Up
Ashwagandha is a 6.8 / 10 fit for people using stress resilience, anxiety, and sleep quality as a measured experiment, not a belief-based staple. The best anchors are [Arumugam et…
Berberine
Score
6.8/10
Momentum
21.4%
Trend
↑ Trend Up
Berberine is a 6.8 / 10 fit for people considering blood sugar, metabolic health, cardiovascular, liver detox, with the strongest case in the populations already represented by the…
Ca-AKG (Calcium Alpha-Ketoglutarate)
Score
6.5/10
Momentum
29.2%
Trend
↑ Trend Up
Ca-AKG (Calcium Alpha-Ketoglutarate) is a 6.5 / 10 fit for people treating aging biology as a tracked experiment, especially bone turnover, frailty, inflammation, or methylation-ag…
Cagrilintide (AM833)
Score
5.8/10
Momentum
29.2%
Trend
↑ Trend Up
Cagrilintide lands at a neutral score because it is a legitimate, Phase 3-validated drug whose best use is not the one this report scores. As monotherapy it delivers real weight lo…
Celebrex (Celecoxib)
Score
5.8/10
Momentum
25.8%
Trend
↑ Trend Up
Celebrex (Celecoxib) is a 5.8 / 10 fit for people using anti inflammatory, acute pain, and chronic pain as a measured experiment, not a belief-based staple. The best anchors are [D…
Cerebrolysin
Score
6.3/10
Momentum
34.6%
Trend
↑ Trend Up
Cerebrolysin lands at Neutral because it pairs the largest human trial base of any nootropic-adjacent peptide with an evidence story that independent reviewers do not confirm, plus…
Chlorella
Score
6.5/10
Momentum
47.2%
Trend
↑ Trend Up
Chlorella is a worth-trying whole-food supplement at 6.5/10: a cheap, safe, broadly nutritious green algae with real but modest human evidence for lower cholesterol, lower blood pr…
CJC-1295 No DAC (Mod GRF 1-29)
Score
5.8/10
Momentum
29.2%
Trend
↑ Trend Up
CJC-1295 No DAC sits in caution because it pairs a clean, physiological mechanism with an almost empty human outcomes file and a form that has never been tested in people. If you w…
Cold Plunge
Score
6.3/10
Momentum
28.5%
Trend
↑ Trend Up
Cold plunge earns a 6.3 / 10 Neutral score because the acute-mood evidence corpus is genuine but the broader health claims outpace the durable-benefit data, and the practice-as-dis…
Colostrum
Score
6.8/10
Momentum
39.3%
Trend
↑ Trend Up
Colostrum is a 6.8 / 10 fit for immune function, gut health, recovery repair, especially for readers who can match the protocol to dairy tolerance, immune stress, gut barrier conte…
DSIP (Delta Sleep-Inducing Peptide)
Score
6.1/10
Momentum
29.2%
Trend
↑ Trend Up
DSIP sits at a low Neutral because it pairs a famous, overselling name with weak independent sleep evidence, a clean tolerability record, and one genuinely interesting but unproven…
Dynamine (Methylliberine)
Score
5.8/10
Momentum
29.2%
Trend
↑ Trend Up
Dynamine (methylliberine) earns a 5.8 because it does one thing well: deliver a fast, short burst of energy, focus, and reaction time, with thin evidence for anything beyond that.…
Earthing
Score
6.8/10
Momentum
57.0%
Trend
↑ Trend Up
Earthing appears most useful for adults who want a low-cost, low-risk way to nudge sleep depth, reduce mild pain after exercise, or modestly improve post-surgical recovery, while a…
Epitalon
Score
6.7/10
Momentum
30.7%
Trend
↑ Trend Up
Epitalon is a 6.7 / 10 fit for people using longevity, sleep quality, and healthspan as a measured experiment, not a belief-based staple. The best anchors are [Al-dulaimi et al. 20…
Ergothioneine
Score
6.6/10
Momentum
41.4%
Trend
↑ Trend Up
Ergothioneine is a 6.6 out of 10 fit for the longevity-minded person who eats few mushrooms and wants a cheap, very safe, tissue-retained antioxidant while the human outcome trials…
Exogenous Ketones
Score
5.9/10
Momentum
33.9%
Trend
↑ Trend Up
Exogenous ketones earn a 5.9 / 10, worth trying, but only for a person whose goal matches the narrow slice of evidence that is actually real. They are fast, intrinsically safe, and…
Fisetin
Score
6.8/10
Momentum
34.0%
Trend
↑ Trend Up
The 5.5 Neutral score reflects a real mechanism with thin and partly negative human translation. Fisetin is worth a structured 3-cycle trial for older adults with documented inflam…
Fucoidan (Brown Seaweed Polysaccharide)
Score
6.4/10
Momentum
16.7%
Trend
↑ Trend Up
Fucoidan is worth trying at 6.4 out of 10 for the right person: someone who wants a cheap, very safe immune and anti-inflammatory adjunct from a whole-food source and who keeps the…
Full-Spectrum Hemp (CBD)
Score
6.5/10
Momentum
20.8%
Trend
↑ Trend Up
Full-spectrum hemp is a 6.5 out of 10, worth-trying intervention for people who want a low-dependency, well-tolerated option and who keep their expectations matched to the evidence…
Glutathione (GSH)
Score
6.2/10
Momentum
36.4%
Trend
↑ Trend Up
Glutathione is a 6.2 out of 10, worth trying for the right person and easy to overrate for everyone else. The practical verdict is to treat it as a targeted, tracked experiment rat…
GlyNAC (Glycine + N-Acetylcysteine)
Score
6.7/10
Momentum
29.2%
Trend
↑ Trend Up
GlyNAC is a 6.7 out of 10, worth trying and arguably the best-evidenced way to raise glutathione, while still carrying an honest asterisk about replication. The practical verdict i…
Gonadorelin (GnRH)
Score
6.3/10
Momentum
26.1%
Trend
↑ Trend Up
Gonadorelin lands at Neutral because it pairs a genuinely strong foundation with a borrowed headline and finicky execution. It is a real, formerly FDA-approved drug with a textbook…
High-Dose Melatonin
Score
6.7/10
Momentum
29.2%
Trend
↑ Trend Up
High-dose melatonin is worth trying for advanced users with a clear reason, a conservative dose plan, and real monitoring for sedation, glucose, blood pressure, mood, and endocrine…
Hyaluronic Acid
Score
6.8/10
Momentum
56.6%
Trend
↑ Trend Up
Hyaluronic acid is a 6.83 out of 10, worth-trying pick for people targeting skin hydration, mild joint comfort, or dry eye who want a cheap, near-foolproof, very safe add-on and ar…
Hyperbaric Oxygen Therapy
Score
6.2/10
Momentum
30.1%
Trend
↑ Trend Up
Hyperbaric Oxygen Therapy delivers oxygen at 2.0-2.4 ATA and shows the strongest evidence for medically indicated conditions such as decompression illness, carbon monoxide poisonin…
Ipamorelin
Score
6.2/10
Momentum
44.3%
Trend
↑ Trend Up
Ipamorelin sits at neutral because it pairs a clean, well-understood mechanism with an almost empty human outcomes file. If you want a selective growth-hormone secretagogue, accept…
Kava (Piper methysticum)
Score
6/10
Momentum
29.2%
Trend
↑ Trend Up
Kava is a 6.0 / 10 Neutral: a real, fast-acting, non-addictive anxiolytic with a strong short-term and traditional evidence base, pulled down to the middle by one specific intrinsi…
Ketogenic Diet
Score
6.6/10
Momentum
23.5%
Trend
↓ Trend Down
Ketogenic Diet is a 6.6 / 10 fit for people using metabolic health, blood sugar, and body composition as a measured nutrition experiment. The body-composition signal is real: [Leun…
Kisspeptin-10
Score
6.4/10
Momentum
36.3%
Trend
↑ Trend Up
Kisspeptin-10 sits at Neutral because it pairs a first-rate, mechanistically elegant research program with a thin direct data set for the exact form people buy and impractical kine…
Melanotan I (Afamelanotide)
Score
6.2/10
Momentum
29.2%
Trend
↑ Trend Up
Melanotan I is worth trying when the goal is real photoprotection or pigment support and you can verify your source, not as a casual tanning shortcut. The 6.2 score reflects a comp…
Metformin
Score
6.9/10
Momentum
36.1%
Trend
↑ Trend Up
Metformin offers clinically proven glucose lowering for overweight adults with type 2 diabetes and can modestly lower the risk of progressing from prediabetes to diabetes, making i…
Methylene Blue
Score
6.1/10
Momentum
25.9%
Trend
↑ Trend Up
Methylene Blue is a 6.1 / 10 fit for advanced users who understand that methylene blue is a drug-like redox compound, not a casual blue nootropic, because the strongest evidence is…
Modafinil
Score
5.9/10
Momentum
32.6%
Trend
↑ Trend Up
Modafinil is a 5.9 / 10 fit for people using cognition focus, energy, and mood as a measured experiment, not a belief-based staple. The best anchors are [Caldwell JA et al. 2004](h…
MOTS-c
Score
6.5/10
Momentum
22.3%
Trend
↑ Trend Up
MOTS-c is a 6.5 / 10 fit for people considering mitochondrial, metabolic health, blood sugar, energy, with the strongest case in the populations already represented by the evidence…
NMN (Nicotinamide Mononucleotide)
Score
6.3/10
Momentum
37.5%
Trend
↑ Trend Up
NMN is a 6.3 / 10 fit for older or metabolically strained adults who want an NAD+ precursor trial with measured endpoints, not a reliable anti-aging shortcut for already healthy ad…
NR (Nicotinamide Riboside)
Score
6.1/10
Momentum
26.3%
Trend
↑ Trend Up
NR (Nicotinamide Riboside) is a 6.1 / 10 fit for people who want a measured NAD+ experiment, especially older adults or those tracking vascular, metabolic, or neurologic markers, b…
Omega-3
Score
6.8/10
Momentum
33.5%
Trend
↑ Trend Up
Omega-3 is a 6.8 / 10 fit for people using cardiovascular, anti inflammatory, and metabolic health as a measured experiment, not a belief-based staple. The best anchors are [Kavian…
Orforglipron (Foundayo)
Score
5.8/10
Momentum
66.7%
Trend
↑ Trend Up
Orforglipron sits at the bottom of the worth-trying tier because it pairs genuinely strong, deep evidence and unmatched oral convenience with an effect size that loses to the injec…
Oxiracetam
Score
6.4/10
Momentum
33.1%
Trend
↑ Trend Up
Oxiracetam earns a middle-of-the-road score because the mechanism is real but the modern human evidence is thin and sourcing is now genuinely hard. It positively modulates AMPA glu…
Oxytocin (Intranasal)
Score
6.5/10
Momentum
29.2%
Trend
↑ Trend Up
Intranasal oxytocin lands at Neutral because it pairs an outstanding safety record with genuinely inconsistent efficacy for the very uses it is marketed for. If you are curious, ev…
Paraxanthine (Enfinity)
Score
6.5/10
Momentum
29.2%
Trend
↑ Trend Up
Paraxanthine is a strong fit for caffeine users who want the focus and energy without as much of the jitter, chest tightness, or crash. The best evidence sits in acute cognition, r…
Pinealon (Glu-Asp-Arg)
Score
6.4/10
Momentum
29.2%
Trend
↑ Trend Up
Pinealon sits in caution because it pairs an interesting laboratory mechanism with an almost empty human evidence file. The cell and animal work is coherent, the safety read is mil…
Piracetam (Nootropil)
Score
6.5/10
Momentum
29.2%
Trend
↑ Trend Up
Piracetam is the granddaddy of nootropics and the most studied racetam, but its proven wins sit in clinical lanes like cortical myoclonus, post-stroke aphasia support, and narrow p…
Quercetin
Score
6.8/10
Momentum
32.9%
Trend
↑ Trend Up
The 5.5 Neutral score reflects honest tension between a wide mechanistic story and a narrow band of replicated human signals. Quercetin earns its supplement shelf space for allergi…
Quinton Marine Plasma (Seawater Minerals)
Score
5.9/10
Momentum
29.2%
Trend
↑ Trend Up
Quinton Marine Plasma is a clean, benign, full-spectrum electrolyte and trace-mineral source that earns a worth-trying 5.9 mostly on safety and mechanism, not on product-specific p…
Rapamycin
Score
6.8/10
Momentum
34.7%
Trend
↑ Trend Up
Rapamycin is a 6.8 / 10 fit for medically supervised longevity experimenters who understand mTOR tradeoffs and can monitor labs, not a casual supplement or proven human lifespan dr…
Sabroxy (Oroxylum indicum Extract)
Score
6.6/10
Momentum
29.2%
Trend
↑ Trend Up
Sabroxy is a standardized Oroxylum indicum extract worth a focused trial if you want clean, dopamine-leaning attention support and you understand the human evidence is essentially…
Selank
Score
6.9/10
Momentum
38.1%
Trend
↑ Trend Up
Selank is a 6.9 / 10 fit for people weighing anxiety, mood, and stress resilience, especially when the goal is a tracked experiment with clear endpoints. The strongest evidence anc…
Semaglutide
Score
6/10
Momentum
27.3%
Trend
↓ Trend Down
Semaglutide is a high-efficacy prescription metabolic lever for people with obesity, type 2 diabetes, established cardiovascular disease, diabetic kidney disease, or MASH, but Sema…
Senolytics
Score
6.6/10
Momentum
31.0%
Trend
↑ Trend Up
Senolytics is a 6.6 / 10 fit for longevity, healthspan, cellular senescence, especially for readers who can match the protocol to age, disease context, drug interactions, and wheth…
Sermorelin (GHRH 1-29)
Score
5.9/10
Momentum
29.2%
Trend
↑ Trend Up
Sermorelin earns its Neutral score by being the most credentialed peptide in a thinly-proven class, not by having strong adult outcome data. If you are an older adult with document…
SNAP-8 (Acetyl Octapeptide-3)
Score
6.2/10
Momentum
52.8%
Trend
↑ Trend Up
SNAP-8 lands in the lower Neutral band because it is harmless but essentially unproven, and proven alternatives make it a weak use of money. If you already run a solid routine and…
Sprinting (Sprint Interval Training)
Score
6.9/10
Momentum
25.0%
Trend
↑ Trend Up
Sprinting, done as structured sprint interval training, is a high-leverage tool for the right person: a near-maximal VO2max and metabolic stimulus in minutes per week, at zero cost…
SS-31 (Elamipretide)
Score
6/10
Momentum
29.2%
Trend
↑ Trend Up
SS-31 (Elamipretide) is a 6.0 / 10 fit for people using mitochondrial, antioxidant, and cardiovascular as a measured experiment, not a belief-based staple. The best anchors are [Zh…
Sulforaphane
Score
6.8/10
Momentum
28.7%
Trend
↑ Trend Up
The practical verdict on sulforaphane is that it is a reasonable food-level intervention for cruciferous vegetable enthusiasts and a selective supplement for metabolic-health and p…
Tesamorelin
Score
6.2/10
Momentum
55.4%
Trend
↑ Trend Up
Tesamorelin is a 6.2 / 10 fit for body composition, hormonal, metabolic health, especially for readers who can match the protocol to HIV lipodystrophy context, IGF-1 monitoring, gl…
Thymalin
Score
5.9/10
Momentum
33.4%
Trend
↑ Trend Up
Thymalin sits at Neutral because it pairs a genuinely intriguing, decades-deep immune-restoration signal, headlined by the 2 to 4 fold elderly mortality drop in Khavinson 2003, wit…
Thymulin (Zinc-Thymulin)
Score
6.6/10
Momentum
29.2%
Trend
↑ Trend Up
Thymulin earns a Neutral score because it pairs unusually well-defined biology with an unusually thin human-treatment file. If you understand zinc status, want a chemically defined…
Time-Restricted Eating
Score
6.9/10
Momentum
18.9%
Trend
↑ Trend Up
Time-Restricted Eating is a 6.9 / 10 fit for people using metabolic health, blood sugar, and body composition as a measured experiment, not a belief-based staple. The best anchors…
Tirzepatide
Score
6.1/10
Momentum
25.4%
Trend
↑ Trend Up
Tirzepatide delivers clinically meaningful weight loss and glycemic improvement for adults with obesity or type 2 diabetes, but the benefits depend on ongoing weekly injections. Th…
TUDCA (Tauroursodeoxycholic Acid)
Score
6.7/10
Momentum
29.2%
Trend
↑ Trend Up
TUDCA earns its score on a narrow, real strength: hepatobiliary support, bile flow, and a single solid metabolic signal, with weaker proof everywhere else. It makes sense when you…
Urolithin A
Score
6.5/10
Momentum
39.7%
Trend
↑ Trend Up
Urolithin A is a 6.5 / 10 fit for people considering mitochondrial, muscle growth, endurance cardio, anti inflammatory, with the strongest case in the populations already represent…
Vilon (Lys-Glu)
Score
6.4/10
Momentum
29.2%
Trend
↑ Trend Up
Vilon sits in caution because it pairs a coherent, single-source mechanism with an almost empty human outcomes file and zero independent confirmation. If you are a curious experime…
VK2735 (Viking Therapeutics)
Score
5.8/10
Momentum
29.2%
Trend
↑ Trend Up
VK2735 lands in the middle because it pairs a strong, validated short-term signal with the earliest-stage evidence file in the next-generation incretin batch. If you are tracking t…

Experimental 32

5-Amino-1MQ
Score
4.9/10
Momentum
35.2%
Trend
↑ Trend Up
5-Amino-1MQ earns a Caution score because the mechanism and animal data are promising while the human evidence is absent and the supply chain is unregulated. It is reasonable to co…
AOD-9604
Score
4.6/10
Momentum
35.4%
Trend
↑ Trend Up
AOD-9604 lands in caution for an unusual reason: it is safe but it does not appear to work for what it is sold for. The fat-loss mechanism is real and consistent in rodents, per He…
C15 (Pentadecanoic Acid)
Score
4.9/10
Momentum
29.2%
Trend
↑ Trend Up
C15 (Pentadecanoic Acid) is a 4.9 / 10 fit for people using metabolic health, liver detox, and cardiovascular as a measured experiment, not a belief-based staple. The best anchors…
C60 (Buckminsterfullerene)
Score
4.9/10
Momentum
41.7%
Trend
↑ Trend Up
C60 (Buckminsterfullerene) shows modest antioxidant activity but the evidence does not support oral longevity claims for most users. The only reproducible human data come from a sm…
CagriSema (Cagrilintide + Semaglutide)
Score
5.1/10
Momentum
29.2%
Trend
↑ Trend Up
CagriSema lands at Neutral because it pairs the strongest weight effect in this incretin batch with the weakest set of supporting facts around it. The potency is real: about 22.7%…
CJC-1295
Score
5.5/10
Momentum
39.2%
Trend
↑ Trend Up
CJC-1295 is a 5.5 / 10 fit for people weighing body composition, sleep quality, and recovery and repair, especially when the goal is a tracked experiment with clear endpoints. The…
CJC-1295 DAC
Score
4.8/10
Momentum
41.7%
Trend
↑ Trend Up
CJC-1295 with DAC sits in caution, and a step below the no-DAC form, because its one real edge, more human mechanism data and once-weekly convenience, is outweighed by a sustained…
Dihexa
Score
4.4/10
Momentum
32.5%
Trend
↑ Trend Up
Dihexa is a 4.4 / 10 fit for experimenters looking at cognition through a high-risk research-chemical lens, not people who want a normal nootropic, not a clinically proven memory d…
Ephedrine
Score
5.3/10
Momentum
42.6%
Trend
↑ Trend Up
Ephedrine is a 5.3 / 10 fit for people considering body composition, energy, respiratory, endurance cardio, with the strongest case in the populations already represented by the ev…
FOXO4-DRI
Score
4.1/10
Momentum
44.4%
Trend
↑ Trend Up
FOXO4-DRI sits in Caution at 4.2 because it pairs one of the most elegant senolytic mechanisms and the most dramatic mouse result in the category with zero human evidence and grey-…
GHRP-2 (Pralmorelin)
Score
5.5/10
Momentum
41.7%
Trend
↑ Trend Up
GHRP-2 lands at Neutral because it pairs genuine strengths, a strong growth-hormone pulse and a one-of-a-kind diagnostic approval, with genuine weaknesses, lower selectivity and an…
GHRP-6
Score
5.1/10
Momentum
39.6%
Trend
↑ Trend Up
GHRP-6 sits in caution because it pairs a real, fast, historically important mechanism with an empty human outcomes file and the heaviest side-effect load of its group. It is one o…
Humanin
Score
5.5/10
Momentum
28.8%
Trend
↑ Trend Up
Humanin is one of the more biologically interesting longevity peptides on the board, and it lands at Neutral because fascinating biology cannot outrun an empty human file. It is a…
LL-37 (Cathelicidin)
Score
4.7/10
Momentum
16.7%
Trend
↑ Trend Up
The practical verdict is simple: LL-37 is a fascinating molecule with one promising topical use and a genuine double-edge, which is exactly why it sits in caution rather than highe…
Mazdutide (IBI362)
Score
5.6/10
Momentum
29.2%
Trend
↑ Trend Up
Mazdutide earns a neutral score because the science is strong but the access and cardiac questions are not yet resolved. If your specific goal is liver fat, mazdutide posts the bes…
Melanotan II
Score
4.6/10
Momentum
42.8%
Trend
↑ Trend Up
Melanotan II is a caution-tier compound: effective enough to tempt use, risky enough to demand restraint. It reliably tans skin, blunts appetite, and drives libido, but it does all…
MK-677 (Ibutamoren)
Score
4.9/10
Momentum
29.2%
Trend
↑ Trend Up
MK-677 sits at a Neutral 4.8 because it is the best-evidenced growth-hormone secretagogue you can name and still not a clear win, which is an unusual place to land. The practical r…
NAD+ (Direct)
Score
5/10
Momentum
37.5%
Trend
↑ Trend Up
NAD+ (Direct) sits at the bottom of Neutral because it pairs an undisputed, central biology with a nearly empty direct-delivery evidence file and a real IV burden. The molecule mat…
Ozone Therapy
Score
5.1/10
Momentum
26.0%
Trend
↑ Trend Up
Ozone Therapy is a 5.1 / 10 fit for people weighing acute pain, chronic pain, and wound healing, especially when the goal is a tracked experiment with clear endpoints. The stronges…
P21 (P021)
Score
5/10
Momentum
47.2%
Trend
↑ Trend Up
P21 (P021) sits in caution because it pairs the cleanest, broadest rodent neurogenesis-and-tau dataset of any grey-market neurogenic peptide with a completely empty human file and…
PE-22-28
Score
4.9/10
Momentum
35.1%
Trend
↑ Trend Up
PE-22-28 sits in caution because it pairs one of the cleaner mechanisms in the grey-market peptide world with a completely empty human file. The TREK-1 to depression link is real a…
Pentosan Polysulfate (Elmiron)
Score
4.7/10
Momentum
29.2%
Trend
↑ Trend Up
Pentosan polysulfate sits in Caution because it pairs a genuinely approved, trial-backed drug with a modest, contested benefit and a serious eye toxicity that can be partly permane…
Phenylpiracetam (Phenotropil)
Score
5.5/10
Momentum
29.2%
Trend
↑ Trend Up
Phenylpiracetam is the most stimulating member of the racetam family, and it earns a middling score because the effect is real but narrow, fades fast with use, and rides on thin in…
Pine Pollen
Score
5.7/10
Momentum
36.7%
Trend
↑ Trend Up
Pine pollen is neutral at 5.7 out of 10: a cheap, low-risk, nutrient-dense whole food with a long traditional record, weighed against a famous testosterone claim that no human evid…
PT-141 (Bremelanotide)
Score
5.4/10
Momentum
16.7%
Trend
↑ Trend Up
PT-141 lands at caution because it pairs the best evidence base in the peptide world with a modest payoff and a heavy nausea burden. If you are a premenopausal woman with diagnosed…
Resveratrol
Score
5.6/10
Momentum
33.6%
Trend
↑ Trend Up
Resveratrol may be worth a trial for postmenopausal women focused on modest cognitive or cerebrovascular gains and for high-risk adults who need a cheap, low-effort supplement to s…
Retatrutide
Score
5.6/10
Momentum
42.0%
Trend
↑ Trend Up
Retatrutide is a 5.6 / 10 fit for people following obesity, diabetes, liver-fat, or cardiometabolic drug development under medical supervision, because retatrutide has unusually la…
SLU-PP-332
Score
4.7/10
Momentum
26.2%
Trend
↑ Trend Up
SLU-PP-332 may provide modest increases in mitochondrial oxidative capacity and treadmill endurance for highly controlled self-experiments, yet the evidence is limited to rodent mo…
Survodutide (BI 456906)
Score
5.1/10
Momentum
29.2%
Trend
↑ Trend Up
Survodutide lands at neutral because it pairs a genuinely exciting liver mechanism with an unfinished, investigational file and a grey-market-only supply. The practical read: if yo…
Tesofensine
Score
5/10
Momentum
39.0%
Trend
↑ Trend Up
Tesofensine sits in caution because it pairs genuinely strong Phase 2 weight loss with a cardiovascular signal that stalled its own development and a regulatory record that never c…
TRT (Testosterone Replacement Therapy)
Score
5.7/10
Momentum
25.0%
Trend
↑ Trend Up
TRT (Testosterone Replacement Therapy) is a 4/10 fit for people weighing hormonal, libido, and energy, especially when the goal is a tracked experiment with clear endpoints. The st…
VIP (Vasoactive Intestinal Peptide)
Score
5.4/10
Momentum
26.0%
Trend
↑ Trend Up
VIP lands at Neutral because it pairs a genuine, well-mapped anti-inflammatory and immune mechanism, and a larger registered-trial footprint than most grey-market peptides, with a…

Overhyped/Fading 0

No board interventions in this ring this week.

The crowd’s calls

Early scout calls are locked in Results publish as calls resolve.

How to cite this edition

The Outliyr Index, Edition 2 (Week 2026-W27). Outliyr, 2026. https://outliyr.com/health-optimization-index/2026-W27

Permanent URL: https://outliyr.com/health-optimization-index/2026-W27

Content hash (verifies this snapshot byte-for-byte): sha256:b3f382caba6b657b5b2cb1c73bbe5b0ef4c198803f8084193d74988d17b61a87

Each edition is a versioned, immutable, content-hashed dataset snapshot, structured for archival deposit (e.g. a Zenodo DOI per edition) at public launch.