The Outliyr Index: Weekly Edition

Edition 10 · Week 2026-W35

Published 2026-08-31. This edition is an immutable snapshot: it never changes after publication.

What changed on The Outliyr Index in week 2026-W35?

402 interventions were on the board this week: 22 notable movers, 37 new entries, 0 departures. Biggest mover: Ergothioneine (moved from Promising to Overhyped/Fading; momentum 63.0% to 14.7%).

Notable movers

Ergothioneine: fading

moved from Promising to Overhyped/Fading; momentum 63.0% to 14.7% Full entry.

Ipamorelin: rising

moved from Overhyped/Fading to Promising; momentum 17.5% to 17.5% Full entry.

Red light / near-infrared light therapy: fading

moved from Promising to Overhyped/Fading; momentum 80.4% to 2.1% Full entry.

Semaglutide: fading

moved from Promising to Overhyped/Fading; momentum 27.4% to 18.1% Full entry.

Thymalin: fading

moved from Promising to Overhyped/Fading; momentum 37.8% to 8.0% Full entry.

BEAM Minerals: rising

moved from Overhyped/Fading to Experimental; momentum 19.8% to 21.0% Full entry.

Bioregulators: fading

moved from Experimental to Overhyped/Fading; momentum 57.1% to 9.6% Full entry.

Blue-Light-Blocking Glasses: fading

moved from Experimental to Overhyped/Fading; momentum 28.6% to 18.0% Full entry.

CJC-1295: rising

moved from Overhyped/Fading to Experimental; momentum 12.5% to 21.5% Full entry.

Clomiphene: rising

moved from Overhyped/Fading to Experimental; momentum 21.6% to 29.6% Full entry.

Creatine: fading

moved from Experimental to Overhyped/Fading; momentum 37.5% to 18.4% Full entry.

Epithalon: rising

moved from Overhyped/Fading to Experimental; momentum 24.8% to 19.6% Full entry.

GHK-Cu (copper peptide): rising

moved from Overhyped/Fading to Experimental; momentum 0.0% to 22.5% Full entry.

GLP-1 agonists: rising

moved from Overhyped/Fading to Experimental; momentum 22.4% to 23.1% Full entry.

GLP-1 Receptor Agonists: fading

moved from Experimental to Overhyped/Fading; momentum 24.7% to 21.0% Full entry.

Humic / fulvic acid: fading

moved from Experimental to Overhyped/Fading; momentum 39.3% to 1.6% Full entry.

Kegels: rising

moved from Overhyped/Fading to Experimental; momentum 23.7% to 29.4% Full entry.

KPV peptide: rising

moved from Overhyped/Fading to Experimental; momentum 0.0% to 46.3% Full entry.

LYMA Laser: fading

moved from Experimental to Overhyped/Fading; momentum 28.1% to 12.0% Full entry.

Nicotine pouches: fading

moved from Experimental to Overhyped/Fading; momentum 29.0% to 14.5% Full entry.

P21 (P021): fading

moved from Experimental to Overhyped/Fading; momentum 57.0% to 19.1% Full entry.

Red / near-infrared light therapy (photobiomodulation): fading

moved from Experimental to Overhyped/Fading; momentum 62.5% to 11.0% Full entry.

New on the Index

Ayurvedic digestive spice blend (Gentle Digest) entered at Experimental Share card
Blue lotus (Nymphaea caerulea) entered at Experimental Share card
CBD / hemp flower entered at Experimental Share card
Dihydroberberine (DHB) entered at Experimental Share card
Dual N-Back brain training entered at Experimental Share card
Faraday / EMF-shielding bag entered at Experimental Share card
Finasteride entered at Experimental Share card
Meditation / mindfulness entered at Experimental Share card
Methylfolate entered at Experimental Share card
Minimalist / barefoot shoes (Peluva) entered at Experimental Share card
Morning sunlight viewing entered at Experimental Share card
Multivitamin entered at Experimental Share card
NOVOS Core (longevity supplement) entered at Experimental Share card
OneSkin OS-01 (topical senolytic peptide) entered at Experimental Share card
Physiological sigh / resonance breathing entered at Experimental Share card
Prebiotic fibers (acacia, guar gum, larch arabinogalactan) entered at Experimental Share card
Racetams / Piracetam entered at Experimental Share card
SiPore (silica GLP-1 alternative) entered at Experimental Share card
Somatic experiencing entered at Experimental Share card
Strength / resistance training entered at Experimental Share card
ThymoQuin (thymoquinone / black seed) entered at Experimental Share card
Vagus nerve stimulation (Truvaga) entered at Experimental Share card
VO2 max / cardiorespiratory training entered at Experimental Share card
Water filter (AquaTru) entered at Experimental Share card
Wild dagga (Leonotis leonurus) entered at Experimental Share card
Yohimbine entered at Experimental Share card
ZBiotics pre-alcohol probiotic entered at Experimental Share card
7,8-Dihydroxyflavone entered at Overhyped/Fading Share card
Choline entered at Overhyped/Fading Share card
Cold exposure entered at Overhyped/Fading Share card
Fasting entered at Overhyped/Fading Share card
Grounding / earthing entered at Overhyped/Fading Share card
MCT oil entered at Overhyped/Fading Share card
Pitolisant entered at Overhyped/Fading Share card
Progressive muscle relaxation entered at Overhyped/Fading Share card
Rasagiline entered at Overhyped/Fading Share card
Safinamide entered at Overhyped/Fading Share card

The board this week

Proven 46

Astaxanthin
Score
7.8/10
Momentum
27.8%
Trend
↑ Trend Up
Astaxanthin is a 7.8 / 10 fit for people weighing antioxidant, inflammation control, and skin resilience, especially when the goal is a tracked experiment with clear endpoints. The…
Blood-Flow Restriction Training
Score
8.2/10
Momentum
24.6%
Trend
↑ Trend Up
Blood-Flow Restriction Training is a 8.2 / 10 fit for muscle growth, geriatric, recovery repair, especially for readers who can match the protocol to load management, cuff pressure…
BPC-157
Score
7.5/10
Momentum
37.8%
Trend
↑ Trend Up
BPC-157 is a 7.5 / 10 fit for adults considering an investigational recovery peptide after basic rehab, sleep, protein, and load management are already handled, not a proven human…
Bromantane (Ladasten)
Score
7.1/10
Momentum
16.3%
Trend
↑ Trend Up
The practical verdict on Bromantane is that it is a reasonable adjunct for asthenic recovery and stress resilience in someone willing to accept gray-market sourcing, willing to use…
Coenzyme Q10 (CoQ10 / Ubiquinol)
Score
7.1/10
Momentum
16.3%
Trend
↑ Trend Up
CoQ10 is a strong-recommend supplement at 7.1/10 for the right person: a cheap, very safe mitochondrial cofactor with genuine hard-outcome evidence in heart failure and real sympto…
Collagen Peptides
Score
7.6/10
Momentum
22.7%
Trend
↑ Trend Up
Collagen Peptides is a 7.6 / 10 fit for people considering skin beauty, bone joint, recovery repair, sleep quality, with the strongest case in the populations already represented b…
Creatine Monohydrate
Score
8.7/10
Momentum
24.7%
Trend
↓ Trend Down
Creatine Monohydrate is a 8.7 / 10 fit for people weighing strength and power, muscle growth, and cognition and focus, especially when the goal is a tracked experiment with clear e…
Electrolytes
Score
8.8/10
Momentum
26.3%
Trend
↑ Trend Up
Electrolytes is a 8.8 / 10 fit for people losing fluid through heat, sweat, diarrhea, low-carb dieting, sauna, endurance work, or heavy training, because electrolytes solve a real…
Essential Amino Acids
Score
8/10
Momentum
29.7%
Trend
↑ Trend Up
Essential Amino Acids is a 8.0 / 10 fit for people weighing muscle growth, recovery and repair, and geriatric, especially when the goal is a tracked experiment with clear endpoints…
Full-Body EMS
Score
7.3/10
Momentum
32.4%
Trend
↑ Trend Up
Full-Body EMS is a 7.3 / 10 fit for people considering geriatric, body composition, strength power, chronic pain, with the strongest case in the populations already represented by…
GHK-Cu
Score
7.4/10
Momentum
20.1%
Trend
↑ Trend Up
GHK-Cu is a 7.4 / 10 fit for skin beauty, wound healing, recovery repair, especially for readers who can match the protocol to topical route, copper sensitivity, wound status, and…
Glycine
Score
7.9/10
Momentum
23.5%
Trend
↑ Trend Up
Glycine is a 7.9 / 10 fit for people who want a low-cost sleep, recovery, and glutathione-support tool with a better safety profile than most biohacker compounds, not a stand-alone…
Grass-Fed Whey Protein
Score
8.3/10
Momentum
26.3%
Trend
↑ Trend Up
Grass-Fed Whey Protein is a strong, practical protein source, and most of its value comes from dose and leucine rather than the grass-fed label. It earns its score when the goal is…
HRV Biofeedback
Score
9/10
Momentum
35.0%
Trend
↑ Trend Up
HRV Biofeedback is a 9.0 / 10 fit for hrv vagal tone, stress resilience, anxiety, especially for readers who can match the protocol to breathing cadence, adherence, baseline HRV, a…
Infrared Sauna
Score
7.4/10
Momentum
16.1%
Trend
↓ Trend Down
Infrared Sauna is a 7.4 / 10 fit for people who want passive heat for vascular conditioning, pain relief, mood support, or heat acclimation without harder training stress, because…
KPV (Lys-Pro-Val)
Score
7.1/10
Momentum
16.3%
Trend
↑ Trend Up
KPV (Lys-Pro-Val) is a 7.1 / 10 fit for people weighing gut health, inflammation control, and immune function, especially when the goal is a tracked experiment with clear endpoints…
L-Theanine
Score
7.9/10
Momentum
50.0%
Trend
↑ Trend Up
L-Theanine is a 7.9 / 10 fit for people considering cognition focus, stress resilience, sleep quality, anxiety, with the strongest case in the populations already represented by th…
Lactoferrin
Score
7.3/10
Momentum
22.5%
Trend
↓ Trend Down
Lactoferrin is a 7.3 / 10 fit for immune function, gut health, anti inflammatory, especially for readers who can match the protocol to iron status, dairy allergy, infection risk, a…
Lion's Mane
Score
7.2/10
Momentum
13.9%
Trend
↓ Trend Down
Lion's Mane is a 7.2 / 10 fit for people testing a gentle cognition or mood mushroom with realistic expectations and enough patience for multi-week tracking, not a guaranteed nerve…
Magnesium
Score
8.7/10
Momentum
24.6%
Trend
↑ Trend Up
Magnesium is a 8.7 / 10 fit for people with low intake, stress load, poor sleep, blood-pressure concerns, migraines, or glucose issues who want a practical mineral correction, not…
Melatonin
Score
8.2/10
Momentum
21.3%
Trend
↓ Trend Down
Melatonin is one of the more useful low-cost supplements when the target is circadian timing, jet lag, delayed sleep phase, or carefully selected sleep-onset support. It is far les…
Molecular Hydrogen
Score
8/10
Momentum
15.9%
Trend
↓ Trend Down
Molecular Hydrogen is a 8.0 / 10 fit for people weighing inflammation control, antioxidant, and recovery and repair, especially when the goal is a tracked experiment with clear end…
NAC (N-Acetylcysteine)
Score
8/10
Momentum
15.7%
Trend
↑ Trend Up
NAC is an 8.0 / 10 strong recommend: a cheap, broad, deeply-evidenced glutathione precursor with a genuinely life-saving core use and a benign safety record. The practical verdict…
Neurofeedback
Score
8.3/10
Momentum
31.4%
Trend
↑ Trend Up
Neurofeedback is a 8.3 / 10 fit for cognition focus, neuroplasticity, and TBI support when the protocol, practitioner quality, session dose, and objective tracking all line up. The…
Norwegian 4x4
Score
8.5/10
Momentum
36.9%
Trend
↑ Trend Up
Norwegian 4x4 delivers measurable VO2max gains for fit adults who can handle brief, high-intensity work and who need a time-efficient protocol. The evidence supports a roughly 7% i…
PEMF (Pulsed Electromagnetic Field Therapy)
Score
7.5/10
Momentum
22.5%
Trend
↑ Trend Up
PEMF (Pulsed Electromagnetic Field Therapy) is a 7.5 / 10 fit for people considering bone joint, acute pain, chronic pain, injury recovery, with the strongest case in the populatio…
Phosphatidylserine
Score
7.3/10
Momentum
20.8%
Trend
↑ Trend Up
Phosphatidylserine is a 7.3 / 10 fit for cognition focus, memory, stress resilience, especially for readers who can match the protocol to cortisol pattern, cognitive baseline, trai…
Polyphenols (Dietary)
Score
7.6/10
Momentum
15.9%
Trend
↑ Trend Up
Dietary polyphenols are a 7.6 / 10, a strong recommendation built on an unusual combination: large, consistent population evidence and an excellent safety, cost, and reversibility…
Red Light Therapy
Score
8/10
Momentum
22.4%
Trend
↑ Trend Up
Red Light Therapy is a 7/10 BioHarmony intervention for people who want a low-risk tool for skin aging, hair density, pain, recovery, wound support, and mitochondrial signaling, pr…
Rucking (Weighted Walking)
Score
7.3/10
Momentum
20.1%
Trend
↑ Trend Up
Rucking earns a 7.3 and a strong-recommend tier because it is a cheap, accessible, low-risk way to stack aerobic conditioning, weight-bearing loading, and a higher calorie burn ont…
Saffron
Score
8/10
Momentum
19.7%
Trend
↓ Trend Down
Saffron is a 8.0 / 10 fit for people using mood, depression, and sleep quality as a measured experiment, not a belief-based staple. The best anchors are [Kell et al. 2017](https://…
Semax
Score
7.1/10
Momentum
21.4%
Trend
↑ Trend Up
Semax is a 7.1 / 10 fit for people considering cognition focus, neuroprotection, memory, stress resilience, with the strongest case in the populations already represented by the ev…
Shilajit
Score
7.4/10
Momentum
15.8%
Trend
↓ Trend Down
Shilajit is a 7.4 / 10 fit for men testing fertility, testosterone, energy, or mineral-resin support with a purified, contaminant-tested product, not a universal adaptogen or detox…
Spermidine
Score
7.6/10
Momentum
20.7%
Trend
↑ Trend Up
Spermidine is a 6/10 fit for people interested in food-based autophagy and healthy-aging signals, especially when they can track diet and biomarkers, because spermidine has solid m…
Spirulina
Score
7/10
Momentum
28.8%
Trend
↑ Trend Up
Spirulina earns a strong-recommend at 7.0 because it delivers a replicated cluster of cardiometabolic benefits at food-grade safety and an unusually low cost. The practical verdict…
Taurine
Score
8.1/10
Momentum
28.5%
Trend
↑ Trend Up
Taurine is a 8.1 / 10 fit for people weighing cardiovascular, metabolic health, and sleep quality, especially when the goal is a tracked experiment with clear endpoints. The strong…
TB-500 (Thymosin Beta-4 Fragment)
Score
7.5/10
Momentum
16.3%
Trend
↑ Trend Up
TB-500 (Thymosin Beta-4 Fragment) is a 7.9 / 10 fit for people considering recovery repair, injury recovery, wound healing, eye vision, with the strongest case in the populations a…
Thymosin Alpha-1
Score
7.3/10
Momentum
22.5%
Trend
↑ Trend Up
Thymosin Alpha-1 is a 7.3 / 10 fit for people discussing immune modulation with a clinician, especially in hospital-adjacent or immune-compromised contexts, not a casual immune boo…
Thymosin Beta-4 (Tβ4)
Score
7.2/10
Momentum
10.0%
Trend
↓ Trend Down
Thymosin beta-4 lands in the Worth trying band because it is the most clinically tested peptide in its class with a clean Phase 1 IV safety record, one Phase 3 primary-endpoint win…
Tongkat Ali
Score
7/10
Momentum
27.6%
Trend
↑ Trend Up
Tongkat Ali is a 7.0 / 10 fit for men with low-normal testosterone, stress-linked libido issues, or training goals who can verify product quality and labs, because Tongkat Ali has…
Traditional Sauna (Finnish Dry-Heat)
Score
7.7/10
Momentum
16.3%
Trend
↑ Trend Up
Traditional Finnish sauna is a strong-recommend practice at 7.7 out of 10 for one core reason: it offers a large, dose-dependent, real-world cardiovascular and longevity signal wit…
Vagus Nerve Stimulation
Score
7.7/10
Momentum
22.2%
Trend
↑ Trend Up
Vagus Nerve Stimulation is a 7.7 / 10 fit for hrv vagal tone, stress resilience, mood, especially for readers who can match the protocol to device type, stimulation site, autonomic…
Vitamin C (Ascorbic Acid)
Score
7.7/10
Momentum
7.3%
Trend
↓ Trend Down
Vitamin C is a 7.7 out of 10 because the floor is so high and the downside so small: it is essential, decisively effective for deficiency, very safe, and nearly free, with modest r…
Vitamin D3 + K2
Score
7.8/10
Momentum
22.5%
Trend
↑ Trend Up
Vitamin D3 + K2 is a 7.8 / 10 fit for deficient adults, winter indoor workers, postmenopausal women, and people pairing vitamin D with calcium or bone goals, not a guaranteed benef…
Whole-Body Vibration
Score
7.3/10
Momentum
22.2%
Trend
↑ Trend Up
Whole-Body Vibration is a low-impact modality that can modestly improve bone density, reduce chronic low-back pain, and enhance balance in older adults when applied in calibrated s…
Zone 2 Cardio
Score
8.3/10
Momentum
22.5%
Trend
↑ Trend Up
Zone 2 Cardio is a 8.3 / 10 fit for people willing to build aerobic capacity through repeatable, low-drama training they can sustain for years, because cardiorespiratory fitness is…

Promising 68

Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga)
Score
5.8/10
Momentum
16.3%
Trend
↑ Trend Up
Adaptogenic mushrooms are a 5.8 out of 10, a Worth trying class for the right person and goal. Reishi is the standout, with real human evidence for immune-marker shifts and fatigue…
AHK-Cu (Copper Tripeptide)
Score
6.5/10
Momentum
16.3%
Trend
↑ Trend Up
AHK-Cu sits at Neutral because it pairs a plausible mechanism and a clean safety profile with an almost empty human-evidence file. The practical verdict: it is a reasonable, low-ri…
Aniracetam
Score
6.4/10
Momentum
19.0%
Trend
↑ Trend Up
Aniracetam earns a 6.4 because its strongest case is narrow and real: a fat soluble racetam that fine tunes AMPA receptors and is studied for memory, verbal fluency, and connecting…
Apigenin
Score
6.7/10
Momentum
22.9%
Trend
↑ Trend Up
Apigenin is a 5/10 fit for people who want a gentle calming option, not a heavy sleep drug or a longevity shortcut. The best human signal still comes from chamomile extract trials,…
ARA-290 (Cibinetide)
Score
6.5/10
Momentum
22.5%
Trend
↑ Trend Up
ARA-290 sits at Neutral because it is the strongest peptide in this repair group on human-trial rigor, yet it is hemmed in by a narrow indication, small trials, no Phase 3, a defun…
Ashwagandha
Score
6.8/10
Momentum
14.1%
Trend
↓ Trend Down
Ashwagandha is a 6.8 / 10 fit for people using stress resilience, anxiety, and sleep quality as a measured experiment, not a belief-based staple. The best anchors are [Arumugam et…
Berberine
Score
6.8/10
Momentum
46.7%
Trend
↑ Trend Up
Berberine is a 6.8 / 10 fit for people considering blood sugar, metabolic health, cardiovascular, liver detox, with the strongest case in the populations already represented by the…
Ca-AKG (Calcium Alpha-Ketoglutarate)
Score
6.5/10
Momentum
16.3%
Trend
↑ Trend Up
Ca-AKG (Calcium Alpha-Ketoglutarate) is a 6.5 / 10 fit for people treating aging biology as a tracked experiment, especially bone turnover, frailty, inflammation, or methylation-ag…
Cagrilintide (AM833)
Score
5.8/10
Momentum
16.3%
Trend
↑ Trend Up
Cagrilintide lands at a neutral score because it is a legitimate, Phase 3-validated drug whose best use is not the one this report scores. As monotherapy it delivers real weight lo…
Celebrex (Celecoxib)
Score
5.8/10
Momentum
16.3%
Trend
↑ Trend Up
Celebrex (Celecoxib) is a 5.8 / 10 fit for people using anti inflammatory, acute pain, and chronic pain as a measured experiment, not a belief-based staple. The best anchors are [D…
Cerebrolysin
Score
6.3/10
Momentum
26.2%
Trend
↑ Trend Up
Cerebrolysin lands at Neutral because it pairs the largest human trial base of any nootropic-adjacent peptide with an evidence story that independent reviewers do not confirm, plus…
Chlorella
Score
6.5/10
Momentum
19.9%
Trend
↓ Trend Down
Chlorella is a worth-trying whole-food supplement at 6.5/10: a cheap, safe, broadly nutritious green algae with real but modest human evidence for lower cholesterol, lower blood pr…
CJC-1295 No DAC (Mod GRF 1-29)
Score
5.8/10
Momentum
16.3%
Trend
↑ Trend Up
CJC-1295 No DAC sits in caution because it pairs a clean, physiological mechanism with an almost empty human outcomes file and a form that has never been tested in people. If you w…
Cold Plunge
Score
6.3/10
Momentum
27.1%
Trend
↑ Trend Up
Cold plunge earns a 6.3 / 10 Neutral score because the acute-mood evidence corpus is genuine but the broader health claims outpace the durable-benefit data, and the practice-as-dis…
Colostrum
Score
6.8/10
Momentum
23.9%
Trend
↑ Trend Up
Colostrum is a 6.8 / 10 fit for immune function, gut health, recovery repair, especially for readers who can match the protocol to dairy tolerance, immune stress, gut barrier conte…
Curcumin
Score
6.5/10
Momentum
20.4%
Trend
↓ Trend Down
Curcumin earns a 6.5 as a solid, benign anti-inflammatory with one strong use case and a lot of marketing noise around it. Take it for osteoarthritis, where it performs comparably…
DSIP (Delta Sleep-Inducing Peptide)
Score
6.1/10
Momentum
16.3%
Trend
↑ Trend Up
DSIP sits at a low Neutral because it pairs a famous, overselling name with weak independent sleep evidence, a clean tolerability record, and one genuinely interesting but unproven…
Dynamine (Methylliberine)
Score
5.8/10
Momentum
16.3%
Trend
↑ Trend Up
Dynamine (methylliberine) earns a 5.8 because it does one thing well: deliver a fast, short burst of energy, focus, and reaction time, with thin evidence for anything beyond that.…
Earthing
Score
6.8/10
Momentum
24.9%
Trend
↑ Trend Up
Earthing appears most useful for adults who want a low-cost, low-risk way to nudge sleep depth, reduce mild pain after exercise, or modestly improve post-surgical recovery, while a…
Epitalon
Score
6.7/10
Momentum
17.9%
Trend
↑ Trend Up
Epitalon is a 6.7 / 10 fit for people using longevity, sleep quality, and healthspan as a measured experiment, not a belief-based staple. The best anchors are [Al-dulaimi et al. 20…
Exogenous Ketones
Score
5.9/10
Momentum
27.1%
Trend
↑ Trend Up
Exogenous ketones earn a 5.9 / 10, worth trying, but only for a person whose goal matches the narrow slice of evidence that is actually real. They are fast, intrinsically safe, and…
Fisetin
Score
6.8/10
Momentum
21.8%
Trend
↑ Trend Up
The 5.5 Neutral score reflects a real mechanism with thin and partly negative human translation. Fisetin is worth a structured 3-cycle trial for older adults with documented inflam…
Fucoidan (Brown Seaweed Polysaccharide)
Score
6.4/10
Momentum
28.7%
Trend
↑ Trend Up
Fucoidan is worth trying at 6.4 out of 10 for the right person: someone who wants a cheap, very safe immune and anti-inflammatory adjunct from a whole-food source and who keeps the…
Full-Spectrum Hemp (CBD)
Score
6.5/10
Momentum
10.5%
Trend
↑ Trend Up
Full-spectrum hemp is a 6.5 out of 10, worth-trying intervention for people who want a low-dependency, well-tolerated option and who keep their expectations matched to the evidence…
Glutathione (GSH)
Score
6.2/10
Momentum
30.9%
Trend
↑ Trend Up
Glutathione is a 6.2 out of 10, worth trying for the right person and easy to overrate for everyone else. The practical verdict is to treat it as a targeted, tracked experiment rat…
GlyNAC (Glycine + N-Acetylcysteine)
Score
6.7/10
Momentum
16.3%
Trend
↑ Trend Up
GlyNAC is a 6.7 out of 10, worth trying and arguably the best-evidenced way to raise glutathione, while still carrying an honest asterisk about replication. The practical verdict i…
Gonadorelin (GnRH)
Score
6.3/10
Momentum
17.4%
Trend
↑ Trend Up
Gonadorelin lands at Neutral because it pairs a genuinely strong foundation with a borrowed headline and finicky execution. It is a real, formerly FDA-approved drug with a textbook…
High-Dose Melatonin
Score
6.7/10
Momentum
16.3%
Trend
↑ Trend Up
High-dose melatonin is worth trying for advanced users with a clear reason, a conservative dose plan, and real monitoring for sedation, glucose, blood pressure, mood, and endocrine…
Hyaluronic Acid
Score
6.8/10
Momentum
15.7%
Trend
↑ Trend Up
Hyaluronic acid is a 6.83 out of 10, worth-trying pick for people targeting skin hydration, mild joint comfort, or dry eye who want a cheap, near-foolproof, very safe add-on and ar…
Hyperbaric Oxygen Therapy
Score
6.2/10
Momentum
29.1%
Trend
↑ Trend Up
Hyperbaric Oxygen Therapy delivers oxygen at 2.0-2.4 ATA and shows the strongest evidence for medically indicated conditions such as decompression illness, carbon monoxide poisonin…
Ipamorelin
Score
6.2/10
Momentum
17.5%
Trend
↑ Trend Up
Ipamorelin sits at neutral because it pairs a clean, well-understood mechanism with an almost empty human outcomes file. If you want a selective growth-hormone secretagogue, accept…
Kava (Piper methysticum)
Score
6/10
Momentum
10.0%
Trend
↓ Trend Down
Kava is a 6.0 / 10 Neutral: a real, fast-acting, non-addictive anxiolytic with a strong short-term and traditional evidence base, pulled down to the middle by one specific intrinsi…
Ketogenic Diet
Score
6.6/10
Momentum
26.8%
Trend
↑ Trend Up
Ketogenic Diet is a 6.6 / 10 fit for people using metabolic health, blood sugar, and body composition as a measured nutrition experiment. The body-composition signal is real: [Leun…
Kisspeptin-10
Score
6.4/10
Momentum
19.8%
Trend
↑ Trend Up
Kisspeptin-10 sits at Neutral because it pairs a first-rate, mechanistically elegant research program with a thin direct data set for the exact form people buy and impractical kine…
Melanotan I (Afamelanotide)
Score
6.2/10
Momentum
16.3%
Trend
↑ Trend Up
Melanotan I is worth trying when the goal is real photoprotection or pigment support and you can verify your source, not as a casual tanning shortcut. The 6.2 score reflects a comp…
Metformin
Score
6.9/10
Momentum
24.6%
Trend
↑ Trend Up
Metformin offers clinically proven glucose lowering for overweight adults with type 2 diabetes and can modestly lower the risk of progressing from prediabetes to diabetes, making i…
Methylene Blue
Score
6.1/10
Momentum
21.5%
Trend
↑ Trend Up
Methylene Blue is a 6.1 / 10 fit for advanced users who understand that methylene blue is a drug-like redox compound, not a casual blue nootropic, because the strongest evidence is…
Modafinil
Score
5.9/10
Momentum
28.0%
Trend
↑ Trend Up
Modafinil is a 5.9 / 10 fit for people using cognition focus, energy, and mood as a measured experiment, not a belief-based staple. The best anchors are [Caldwell JA et al. 2004](h…
MOTS-c
Score
6.5/10
Momentum
23.2%
Trend
↑ Trend Up
MOTS-c is a 6.5 / 10 fit for people considering mitochondrial, metabolic health, blood sugar, energy, with the strongest case in the populations already represented by the evidence…
NMN (Nicotinamide Mononucleotide)
Score
6.3/10
Momentum
26.3%
Trend
↑ Trend Up
NMN is a 6.3 / 10 fit for older or metabolically strained adults who want an NAD+ precursor trial with measured endpoints, not a reliable anti-aging shortcut for already healthy ad…
NR (Nicotinamide Riboside)
Score
6.1/10
Momentum
30.6%
Trend
↑ Trend Up
NR (Nicotinamide Riboside) is a 6.1 / 10 fit for people who want a measured NAD+ experiment, especially older adults or those tracking vascular, metabolic, or neurologic markers, b…
Omega-3
Score
6.8/10
Momentum
39.1%
Trend
↑ Trend Up
Omega-3 is a 6.8 / 10 fit for people using cardiovascular, anti inflammatory, and metabolic health as a measured experiment, not a belief-based staple. The best anchors are [Kavian…
Orforglipron (Foundayo)
Score
5.8/10
Momentum
10.0%
Trend
↓ Trend Down
Orforglipron sits at the bottom of the worth-trying tier because it pairs genuinely strong, deep evidence and unmatched oral convenience with an effect size that loses to the injec…
Oxiracetam
Score
6.4/10
Momentum
17.4%
Trend
↑ Trend Up
Oxiracetam earns a middle-of-the-road score because the mechanism is real but the modern human evidence is thin and sourcing is now genuinely hard. It positively modulates AMPA glu…
Oxytocin (Intranasal)
Score
6.5/10
Momentum
35.0%
Trend
↑ Trend Up
Intranasal oxytocin lands at Neutral because it pairs an outstanding safety record with genuinely inconsistent efficacy for the very uses it is marketed for. If you are curious, ev…
Paraxanthine (Enfinity)
Score
6.5/10
Momentum
16.3%
Trend
↑ Trend Up
Paraxanthine is a strong fit for caffeine users who want the focus and energy without as much of the jitter, chest tightness, or crash. The best evidence sits in acute cognition, r…
Pinealon (Glu-Asp-Arg)
Score
6.4/10
Momentum
16.3%
Trend
↑ Trend Up
Pinealon sits in caution because it pairs an interesting laboratory mechanism with an almost empty human evidence file. The cell and animal work is coherent, the safety read is mil…
Piracetam (Nootropil)
Score
6.5/10
Momentum
16.3%
Trend
↑ Trend Up
Piracetam is the granddaddy of nootropics and the most studied racetam, but its proven wins sit in clinical lanes like cortical myoclonus, post-stroke aphasia support, and narrow p…
Quercetin
Score
6.8/10
Momentum
26.2%
Trend
↑ Trend Up
The 5.5 Neutral score reflects honest tension between a wide mechanistic story and a narrow band of replicated human signals. Quercetin earns its supplement shelf space for allergi…
Quinton Marine Plasma (Seawater Minerals)
Score
5.9/10
Momentum
16.3%
Trend
↑ Trend Up
Quinton Marine Plasma is a clean, benign, full-spectrum electrolyte and trace-mineral source that earns a worth-trying 5.9 mostly on safety and mechanism, not on product-specific p…
Rapamycin
Score
6.8/10
Momentum
27.6%
Trend
↑ Trend Up
Rapamycin is a 6.8 / 10 fit for medically supervised longevity experimenters who understand mTOR tradeoffs and can monitor labs, not a casual supplement or proven human lifespan dr…
Sabroxy (Oroxylum indicum Extract)
Score
6.6/10
Momentum
16.3%
Trend
↑ Trend Up
Sabroxy is a standardized Oroxylum indicum extract worth a focused trial if you want clean, dopamine-leaning attention support and you understand the human evidence is essentially…
Selank
Score
6.9/10
Momentum
19.6%
Trend
↑ Trend Up
Selank is a 6.9 / 10 fit for people weighing anxiety, mood, and stress resilience, especially when the goal is a tracked experiment with clear endpoints. The strongest evidence anc…
Senolytics
Score
6.6/10
Momentum
21.8%
Trend
↓ Trend Down
Senolytics is a 6.6 / 10 fit for longevity, healthspan, cellular senescence, especially for readers who can match the protocol to age, disease context, drug interactions, and wheth…
Sermorelin (GHRH 1-29)
Score
5.9/10
Momentum
16.3%
Trend
↑ Trend Up
Sermorelin earns its Neutral score by being the most credentialed peptide in a thinly-proven class, not by having strong adult outcome data. If you are an older adult with document…
SNAP-8 (Acetyl Octapeptide-3)
Score
6.2/10
Momentum
16.3%
Trend
↑ Trend Up
SNAP-8 lands in the lower Neutral band because it is harmless but essentially unproven, and proven alternatives make it a weak use of money. If you already run a solid routine and…
Sodium Butyrate
Score
6/10
Momentum
21.2%
Trend
↑ Trend Up
Sodium butyrate earns a 6.0 as a benign, mechanistically sound gut-support tool with thin human evidence. Take it as a colon-targeted add-on for ulcerative colitis or IBS, use a co…
Sprinting (Sprint Interval Training)
Score
6.9/10
Momentum
12.1%
Trend
↓ Trend Down
Sprinting, done as structured sprint interval training, is a high-leverage tool for the right person: a near-maximal VO2max and metabolic stimulus in minutes per week, at zero cost…
SS-31 (Elamipretide)
Score
6/10
Momentum
6.3%
Trend
↓ Trend Down
SS-31 (Elamipretide) is a 6.0 / 10 fit for people using mitochondrial, antioxidant, and cardiovascular as a measured experiment, not a belief-based staple. The best anchors are [Zh…
Sulforaphane
Score
6.8/10
Momentum
38.2%
Trend
↑ Trend Up
The practical verdict on sulforaphane is that it is a reasonable food-level intervention for cruciferous vegetable enthusiasts and a selective supplement for metabolic-health and p…
Tesamorelin
Score
6.2/10
Momentum
14.3%
Trend
↓ Trend Down
Tesamorelin is a 6.2 / 10 fit for body composition, hormonal, metabolic health, especially for readers who can match the protocol to HIV lipodystrophy context, IGF-1 monitoring, gl…
Thymulin (Zinc-Thymulin)
Score
6.6/10
Momentum
16.3%
Trend
↑ Trend Up
Thymulin earns a Neutral score because it pairs unusually well-defined biology with an unusually thin human-treatment file. If you understand zinc status, want a chemically defined…
Time-Restricted Eating
Score
6.9/10
Momentum
37.8%
Trend
↑ Trend Up
Time-Restricted Eating is a 6.9 / 10 fit for people using metabolic health, blood sugar, and body composition as a measured experiment, not a belief-based staple. The best anchors…
Tirzepatide
Score
6.1/10
Momentum
12.2%
Trend
↓ Trend Down
Tirzepatide delivers clinically meaningful weight loss and glycemic improvement for adults with obesity or type 2 diabetes, but the benefits depend on ongoing weekly injections. Th…
TUDCA (Tauroursodeoxycholic Acid)
Score
6.7/10
Momentum
28.7%
Trend
↑ Trend Up
TUDCA earns its score on a narrow, real strength: hepatobiliary support, bile flow, and a single solid metabolic signal, with weaker proof everywhere else. It makes sense when you…
Urolithin A
Score
6.5/10
Momentum
12.6%
Trend
↓ Trend Down
Urolithin A is a 6.5 / 10 fit for people considering mitochondrial, muscle growth, endurance cardio, anti inflammatory, with the strongest case in the populations already represent…
Vilon (Lys-Glu)
Score
6.4/10
Momentum
16.3%
Trend
↑ Trend Up
Vilon sits in caution because it pairs a coherent, single-source mechanism with an almost empty human outcomes file and zero independent confirmation. If you are a curious experime…
VK2735 (Viking Therapeutics)
Score
5.8/10
Momentum
16.3%
Trend
↑ Trend Up
VK2735 lands in the middle because it pairs a strong, validated short-term signal with the earliest-stage evidence file in the next-generation incretin batch. If you are tracking t…

Experimental 265

12-minute sprint/recovery workout
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
5-Amino-1MQ
Score
4.9/10
Momentum
42.3%
Trend
↑ Trend Up
5-Amino-1MQ earns a Caution score because the mechanism and animal data are promising while the human evidence is absent and the supply chain is unregulated. It is reasonable to co…
Alpha-GPC
Score
Not Scored
Momentum
23.0%
Trend
↑ Trend Up
Amanita Muscaria (muscimol)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Amygdalin (Vitamin B17 / Laetrile)
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
Anthros Chair (postural support device)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Anti-Gray Hair Serum
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
AOD-9604
Score
4.6/10
Momentum
17.6%
Trend
↑ Trend Up
AOD-9604 lands in caution for an unusual reason: it is safe but it does not appear to work for what it is sold for. The fat-loss mechanism is real and consistent in rodents, per He…
Apollo Neuro (nervous-system wearable)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
ARC PEMF device
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Aromatase inhibitor / estradiol management
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Ayurvedic digestive spice blend (Gentle Digest)
Score
Not Scored
Momentum
6.3%
Trend
↑ Trend Up
Bakuchiol
Score
Not Scored
Momentum
17.2%
Trend
↑ Trend Up
BEAM Minerals
Score
Not Scored
Momentum
21.0%
Trend
↑ Trend Up
Beef tallow
Score
Not Scored
Momentum
10.9%
Trend
↓ Trend Down
Beetroot nitrate
Score
Not Scored
Momentum
41.3%
Trend
↑ Trend Up
Bemotrizinol (sunscreen filter)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Beta-Alanine
Score
Not Scored
Momentum
20.9%
Trend
↑ Trend Up
Betaine HCl
Score
Not Scored
Momentum
28.2%
Trend
↑ Trend Up
BioPurify
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Bioregulators (peptide bioregulators)
Score
Not Scored
Momentum
10.0%
Trend
↓ Trend Down
Black seed / ThymoQuin
Score
Not Scored
Momentum
14.5%
Trend
↑ Trend Up
Blue lotus (Nymphaea caerulea)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Blushield (EMF mitigation)
Score
Not Scored
Momentum
36.3%
Trend
↑ Trend Up
Blushield EMF protection
Score
Not Scored
Momentum
36.3%
Trend
↑ Trend Up
BoomBoom nasal inhaler
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Boswellia Serrata
Score
Not Scored
Momentum
30.1%
Trend
↑ Trend Up
BPC-157 / TB-500
Score
Not Scored
Momentum
27.5%
Trend
↑ Trend Up
Breathwork
Score
Not Scored
Momentum
24.4%
Trend
↑ Trend Up
Bromelain
Score
Not Scored
Momentum
21.8%
Trend
↑ Trend Up
C15 (Pentadecanoic Acid)
Score
4.9/10
Momentum
10.0%
Trend
↓ Trend Down
C15 (Pentadecanoic Acid) is a 4.9 / 10 fit for people using metabolic health, liver detox, and cardiovascular as a measured experiment, not a belief-based staple. The best anchors…
C60 (Buckminsterfullerene)
Score
4.9/10
Momentum
10.0%
Trend
↑ Trend Up
C60 (Buckminsterfullerene) shows modest antioxidant activity but the evidence does not support oral longevity claims for most users. The only reproducible human data come from a sm…
C8 MCT oil
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
CagriSema (Cagrilintide + Semaglutide)
Score
5.1/10
Momentum
10.0%
Trend
↑ Trend Up
CagriSema lands at Neutral because it pairs the strongest weight effect in this incretin batch with the weakest set of supporting facts around it. The potency is real: about 22.7%…
Calcium
Score
Not Scored
Momentum
23.2%
Trend
↑ Trend Up
Carnivore diet
Score
Not Scored
Momentum
35.4%
Trend
↑ Trend Up
CBD / hemp flower
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
Citicoline
Score
Not Scored
Momentum
16.3%
Trend
↓ Trend Down
Citrulline
Score
Not Scored
Momentum
20.9%
Trend
↑ Trend Up
Citrus bergamot
Score
Not Scored
Momentum
27.5%
Trend
↑ Trend Up
CJC-1295
Score
5.5/10
Momentum
21.5%
Trend
↑ Trend Up
CJC-1295 is a 5.5 / 10 fit for people weighing body composition, sleep quality, and recovery and repair, especially when the goal is a tracked experiment with clear endpoints. The…
CJC-1295 / Ipamorelin
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
CJC-1295 DAC
Score
4.8/10
Momentum
6.3%
Trend
↓ Trend Down
CJC-1295 with DAC sits in caution, and a step below the no-DAC form, because its one real edge, more human mechanism data and once-weekly convenience, is outweighed by a sustained…
Clomiphene
Score
Not Scored
Momentum
29.6%
Trend
↑ Trend Up
Cocoa flavanols
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
Cold therapy / cold exposure
Score
Not Scored
Momentum
18.3%
Trend
↑ Trend Up
Collagen
Score
Not Scored
Momentum
21.9%
Trend
↑ Trend Up
Consistent meal timing
Score
Not Scored
Momentum
20.0%
Trend
↑ Trend Up
Continuous Glucose Monitor (CGM)
Score
Not Scored
Momentum
25.3%
Trend
↑ Trend Up
Coronary artery calcium (CAC) scoring
Score
Not Scored
Momentum
13.8%
Trend
↑ Trend Up
Curcumin / Turmeric
Score
Not Scored
Momentum
60.0%
Trend
↑ Trend Up
D-Ribose
Score
Not Scored
Momentum
17.9%
Trend
↓ Trend Down
Daily walking
Score
Not Scored
Momentum
21.0%
Trend
↑ Trend Up
DGL / licorice root
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Dichloroacetate
Score
Not Scored
Momentum
18.3%
Trend
↓ Trend Down
Dietary fiber
Score
Not Scored
Momentum
23.3%
Trend
↑ Trend Up
Dihexa
Score
4.4/10
Momentum
15.6%
Trend
↓ Trend Down
Dihexa is a 4.4 / 10 fit for experimenters looking at cognition through a high-risk research-chemical lens, not people who want a normal nootropic, not a clinically proven memory d…
Dihydroberberine (DHB)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Dispenza-style meditation
Score
Not Scored
Momentum
17.1%
Trend
↑ Trend Up
DMSO
Score
Not Scored
Momentum
12.3%
Trend
↓ Trend Down
Dry fasting
Score
Not Scored
Momentum
14.2%
Trend
↓ Trend Down
Dual N-Back brain training
Score
Not Scored
Momentum
42.5%
Trend
↑ Trend Up
Dual N-Back Training
Score
Not Scored
Momentum
32.5%
Trend
↑ Trend Up
DunedinPACE epigenetic age test
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
Echinacea
Score
Not Scored
Momentum
16.7%
Trend
↓ Trend Down
Electrolytes (LMNT)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Eleuthero
Score
Not Scored
Momentum
19.4%
Trend
↑ Trend Up
EmWave2 (HRV biofeedback device)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Ephedrine
Score
5.3/10
Momentum
19.0%
Trend
↑ Trend Up
Ephedrine is a 5.3 / 10 fit for people considering body composition, energy, respiratory, endurance cardio, with the strongest case in the populations already represented by the ev…
Epithalon
Score
Not Scored
Momentum
19.6%
Trend
↑ Trend Up
Essential oils (scent-anchor aromatherapy)
Score
Not Scored
Momentum
16.3%
Trend
↓ Trend Down
Estradiol
Score
Not Scored
Momentum
15.7%
Trend
↓ Trend Down
Estradiol / bioidentical HRT
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Exogenous Ketones (R3HBG)
Score
Not Scored
Momentum
19.4%
Trend
↑ Trend Up
Exosome therapy
Score
Not Scored
Momentum
8.5%
Trend
↑ Trend Up
Faraday / EMF-shielding bag
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Fatty15 (C15:0)
Score
Not Scored
Momentum
10.0%
Trend
↑ Trend Up
Fecal microbiota transplant (FMT)
Score
Not Scored
Momentum
29.1%
Trend
↑ Trend Up
Finasteride
Score
Not Scored
Momentum
27.3%
Trend
↓ Trend Down
Fish oil / omega-3
Score
Not Scored
Momentum
36.7%
Trend
↑ Trend Up
FLGR-242
Score
Not Scored
Momentum
10.2%
Trend
↓ Trend Down
Follistatin
Score
Not Scored
Momentum
20.1%
Trend
↑ Trend Up
FOXO4-DRI
Score
4.1/10
Momentum
27.7%
Trend
↑ Trend Up
FOXO4-DRI sits in Caution at 4.2 because it pairs one of the most elegant senolytic mechanisms and the most dramatic mouse result in the category with zero human evidence and grey-…
Full-body MRI screening
Score
Not Scored
Momentum
6.3%
Trend
↓ Trend Down
Fulvic/Humic Acid Minerals
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Garlic (cold remedy)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Ghee
Score
Not Scored
Momentum
24.7%
Trend
↑ Trend Up
GHK-Cu (copper peptide)
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
GHK-Cu peptide
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
GHRP-2 (Pralmorelin)
Score
5.5/10
Momentum
16.3%
Trend
↑ Trend Up
GHRP-2 lands at Neutral because it pairs genuine strengths, a strong growth-hormone pulse and a one-of-a-kind diagnostic approval, with genuine weaknesses, lower selectivity and an…
GHRP-6
Score
5.1/10
Momentum
27.5%
Trend
↑ Trend Up
GHRP-6 sits in caution because it pairs a real, fast, historically important mechanism with an empty human outcomes file and the heaviest side-effect load of its group. It is one o…
GLP-1 agonists
Score
Not Scored
Momentum
23.1%
Trend
↑ Trend Up
GLP-1 agonists (microdosed)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
GLP-1 agonists (semaglutide/tirzepatide, Ozempic/Mounjaro)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Graceful Aging (Aetherea energetic tincture)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Guardian Oral Care Device (red/NIR mouthpiece)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Guggul (Commiphora mukul)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Hair Tissue Mineral Analysis
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Hair Tissue Mineral Analysis (HTMA)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Hair-mineral-analysis mineral balancing
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
High-protein intake
Score
Not Scored
Momentum
18.3%
Trend
↑ Trend Up
Hiya kids multivitamin
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Honey (cold remedy)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Hormone Replacement Therapy (HRT)
Score
Not Scored
Momentum
32.1%
Trend
↑ Trend Up
Horny Goat Weed (Epimedium)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Humanin
Score
5.5/10
Momentum
29.2%
Trend
↑ Trend Up
Humanin is one of the more biologically interesting longevity peptides on the board, and it lands at Neutral because fascinating biology cannot outrun an empty human file. It is a…
Hydroxyapatite toothpaste
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
Hyperbaric Oxygen Therapy (HBOT)
Score
Not Scored
Momentum
35.0%
Trend
↑ Trend Up
Hypochlorous acid
Score
Not Scored
Momentum
27.8%
Trend
↑ Trend Up
Inhaled probiotics
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
Inspiratory muscle trainer
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Intermittent Fasting
Score
Not Scored
Momentum
23.5%
Trend
↑ Trend Up
Iodine
Score
Not Scored
Momentum
26.4%
Trend
↑ Trend Up
Just Thrive probiotics
Score
Not Scored
Momentum
10.0%
Trend
↓ Trend Down
Kegels
Score
Not Scored
Momentum
29.4%
Trend
↑ Trend Up
Ketamine
Score
Not Scored
Momentum
19.6%
Trend
↓ Trend Down
Ketone Ester (R3HBG)
Score
Not Scored
Momentum
18.6%
Trend
↑ Trend Up
Kineon Move+ Pro
Score
Not Scored
Momentum
13.1%
Trend
↓ Trend Down
Klotho
Score
Not Scored
Momentum
45.4%
Trend
↑ Trend Up
KPV peptide
Score
Not Scored
Momentum
46.3%
Trend
↑ Trend Up
L-Tyrosine
Score
Not Scored
Momentum
24.7%
Trend
↑ Trend Up
LL-37 (Cathelicidin)
Score
4.7/10
Momentum
22.5%
Trend
↑ Trend Up
The practical verdict is simple: LL-37 is a fascinating molecule with one promising topical use and a genuine double-edge, which is exactly why it sits in caution rather than highe…
LONGEVEX (stem cell supplement)
Score
Not Scored
Momentum
14.1%
Trend
↑ Trend Up
LYMA Power Youth serum & cream (skincare)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Mangosteen (xanthones)
Score
Not Scored
Momentum
28.7%
Trend
↑ Trend Up
Manjistha
Score
Not Scored
Momentum
19.6%
Trend
↑ Trend Up
Manuka honey (Manukora)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Marine Phytoplankton
Score
Not Scored
Momentum
29.9%
Trend
↑ Trend Up
Marine phytoplankton (Oceans Alive)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Mastic gum
Score
Not Scored
Momentum
17.3%
Trend
↑ Trend Up
Mazdutide (IBI362)
Score
5.6/10
Momentum
10.0%
Trend
↓ Trend Down
Mazdutide earns a neutral score because the science is strong but the access and cardiac questions are not yet resolved. If your specific goal is liver fat, mazdutide posts the bes…
Meditation / mindfulness
Score
Not Scored
Momentum
20.0%
Trend
↑ Trend Up
Mediterranean diet
Score
Not Scored
Momentum
18.9%
Trend
↓ Trend Down
Melanotan II
Score
4.6/10
Momentum
17.5%
Trend
↑ Trend Up
Melanotan II is a caution-tier compound: effective enough to tempt use, risky enough to demand restraint. It reliably tans skin, blunts appetite, and drives libido, but it does all…
Melatonin (jet lag)
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
Methylfolate
Score
Not Scored
Momentum
29.0%
Trend
↓ Trend Down
Mimio
Score
Not Scored
Momentum
23.1%
Trend
↑ Trend Up
Mindful chewing (mastication)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Minimalist / barefoot shoes (Peluva)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
MK-677 (Ibutamoren)
Score
4.9/10
Momentum
16.3%
Trend
↑ Trend Up
MK-677 sits at a Neutral 4.8 because it is the best-evidenced growth-hormone secretagogue you can name and still not a clear win, which is an unusual place to land. The practical r…
Molecular hydrogen therapy (Brown's Gas)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Morning sunlight / circadian light exposure
Score
Not Scored
Momentum
10.0%
Trend
↓ Trend Down
Morning sunlight viewing
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Multivitamin
Score
Not Scored
Momentum
32.2%
Trend
↓ Trend Down
Muse EEG headband
Score
Not Scored
Momentum
10.5%
Trend
↑ Trend Up
NAD+
Score
Not Scored
Momentum
48.4%
Trend
↑ Trend Up
NAD+ (Direct)
Score
5/10
Momentum
22.9%
Trend
↑ Trend Up
NAD+ (Direct) sits at the bottom of Neutral because it pairs an undisputed, central biology with a nearly empty direct-delivery evidence file and a real IV burden. The molecule mat…
NAD+ / NMN precursors
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
NAD+ booster (NOVOS Boost)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Nasal breathing
Score
Not Scored
Momentum
14.7%
Trend
↓ Trend Down
Nattokinase
Score
Not Scored
Momentum
21.1%
Trend
↓ Trend Down
Navitoclax
Score
Not Scored
Momentum
26.7%
Trend
↑ Trend Up
Near-infrared sauna
Score
Not Scored
Momentum
24.7%
Trend
↑ Trend Up
Nicotine (cognitive enhancer)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
NMR lipoprotein (LDL-P) blood analysis
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Noopept
Score
Not Scored
Momentum
19.8%
Trend
↑ Trend Up
Nootropics
Score
Not Scored
Momentum
22.9%
Trend
↑ Trend Up
NOVOS (biological age test + longevity supplement)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
NOVOS Core
Score
Not Scored
Momentum
19.1%
Trend
↑ Trend Up
NOVOS Core (longevity supplement)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Olive oil
Score
Not Scored
Momentum
20.1%
Trend
↓ Trend Down
Omega-3 (fish oil)
Score
Not Scored
Momentum
43.4%
Trend
↑ Trend Up
Omega-3 (fish/krill oil)
Score
Not Scored
Momentum
6.3%
Trend
↓ Trend Down
OneSkin OS-01 (topical senolytic peptide)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
OS-01 peptide (OneSkin)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Oura Ring
Score
Not Scored
Momentum
40.7%
Trend
↑ Trend Up
Ozone Therapy
Score
5.1/10
Momentum
24.3%
Trend
↑ Trend Up
Ozone Therapy is a 5.1 / 10 fit for people weighing acute pain, chronic pain, and wound healing, especially when the goal is a tracked experiment with clear endpoints. The stronges…
PE-22-28
Score
4.9/10
Momentum
17.6%
Trend
↓ Trend Down
PE-22-28 sits in caution because it pairs one of the cleaner mechanisms in the grey-market peptide world with a completely empty human file. The TREK-1 to depression link is real a…
Pelargonium sidoides
Score
Not Scored
Momentum
18.0%
Trend
↑ Trend Up
Pentosan Polysulfate (Elmiron)
Score
4.7/10
Momentum
22.5%
Trend
↑ Trend Up
Pentosan polysulfate sits in Caution because it pairs a genuinely approved, trial-backed drug with a modest, contested benefit and a serious eye toxicity that can be partly permane…
Peptide bioregulators
Score
Not Scored
Momentum
10.0%
Trend
↓ Trend Down
Peptides (Follistatin/Klotho/Ipamorelin)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Perfect Iodine / iodine
Score
Not Scored
Momentum
16.3%
Trend
↓ Trend Down
Phenylpiracetam (Phenotropil)
Score
5.5/10
Momentum
16.3%
Trend
↑ Trend Up
Phenylpiracetam is the most stimulating member of the racetam family, and it earns a middling score because the effect is real but narrow, fades fast with use, and rides on thin in…
Phospholipid Membrane Support (TUDCA/butyrate)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Physiological sigh / resonance breathing
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Pine Pollen
Score
5.7/10
Momentum
19.2%
Trend
↓ Trend Down
Pine pollen is neutral at 5.7 out of 10: a cheap, low-risk, nutrient-dense whole food with a long traditional record, weighed against a famous testosterone claim that no human evid…
Positive Muscle Failure (PMF) training
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Post-Cycle Therapy (PCT)
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
Post-meal walking
Score
Not Scored
Momentum
8.8%
Trend
↓ Trend Down
PQQ
Score
Not Scored
Momentum
39.6%
Trend
↑ Trend Up
Prebiotic fibers (acacia, guar gum, larch arabinogalactan)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Prenuvo MRI scan
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Progesterone
Score
Not Scored
Momentum
21.3%
Trend
↑ Trend Up
Prolonged fasting
Score
Not Scored
Momentum
18.3%
Trend
↑ Trend Up
Psychedelic-assisted therapy
Score
Not Scored
Momentum
17.5%
Trend
↓ Trend Down
PT-141 (Bremelanotide)
Score
5.4/10
Momentum
16.3%
Trend
↑ Trend Up
PT-141 lands at caution because it pairs the best evidence base in the peptide world with a modest payoff and a heavy nausea burden. If you are a premenopausal woman with diagnosed…
Quiet Mode (sleep/nervous-system formula)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Racetams / Piracetam
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Red yeast rice
Score
Not Scored
Momentum
24.0%
Trend
↑ Trend Up
Resistance / strength training for longevity
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Resistance / weight-bearing exercise
Score
Not Scored
Momentum
12.5%
Trend
↑ Trend Up
Resistance training
Score
Not Scored
Momentum
19.4%
Trend
↑ Trend Up
Resistance training + protein protocol (40+)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Resveratrol
Score
5.6/10
Momentum
31.7%
Trend
↑ Trend Up
Resveratrol may be worth a trial for postmenopausal women focused on modest cognitive or cerebrovascular gains and for high-risk adults who need a cheap, low-effort supplement to s…
Retatrutide
Score
5.6/10
Momentum
21.1%
Trend
↑ Trend Up
Retatrutide is a 5.6 / 10 fit for people following obesity, diabetes, liver-fat, or cardiometabolic drug development under medical supervision, because retatrutide has unusually la…
Rhodiola
Score
Not Scored
Momentum
17.1%
Trend
↓ Trend Down
Rolfing
Score
Not Scored
Momentum
15.8%
Trend
↑ Trend Up
Saline Nasal Rinse
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Sauna
Score
Not Scored
Momentum
19.4%
Trend
↓ Trend Down
Seed DS-01 synbiotic
Score
Not Scored
Momentum
16.3%
Trend
↓ Trend Down
Selank (N-Acetyl Selank Amidate)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Selenium
Score
Not Scored
Momentum
17.5%
Trend
↓ Trend Down
Semaglutide (GLP-1)
Score
Not Scored
Momentum
29.0%
Trend
↑ Trend Up
Semax & Selank
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Semax (N-Acetyl Semax Amidate)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Semen retention
Score
Not Scored
Momentum
25.0%
Trend
↓ Trend Down
Senolytics (senolytic stack)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
SiPore (silica GLP-1 alternative)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Sleep
Score
Not Scored
Momentum
18.5%
Trend
↑ Trend Up
Sleep supplements (magnesium / glycine / melatonin)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
SlimAssist
Score
Not Scored
Momentum
23.1%
Trend
↑ Trend Up
Slippery elm (prebiotic)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
SLU-PP-332
Score
4.7/10
Momentum
27.8%
Trend
↑ Trend Up
SLU-PP-332 may provide modest increases in mitochondrial oxidative capacity and treadmill endurance for highly controlled self-experiments, yet the evidence is limited to rodent mo…
Somatic experiencing
Score
Not Scored
Momentum
45.9%
Trend
↓ Trend Down
Spore-forming probiotics
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
Standing meditation
Score
Not Scored
Momentum
23.6%
Trend
↑ Trend Up
Stem cell therapy
Score
Not Scored
Momentum
26.6%
Trend
↑ Trend Up
Stomach pulling massage (Ayurvedic)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Strength / resistance training
Score
Not Scored
Momentum
6.3%
Trend
↑ Trend Up
Strength Training
Score
Not Scored
Momentum
26.6%
Trend
↑ Trend Up
Structured/cellular hydration protocol
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Sunlight / circadian light exposure (blue-light blocking)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Survodutide (BI 456906)
Score
5.1/10
Momentum
22.5%
Trend
↑ Trend Up
Survodutide lands at neutral because it pairs a genuinely exciting liver mechanism with an unfinished, investigational file and a grey-market-only supply. The practical read: if yo…
Synbiotic
Score
Not Scored
Momentum
24.7%
Trend
↓ Trend Down
Tadalafil (Cialis / PDE5 inhibitors)
Score
Not Scored
Momentum
35.0%
Trend
↑ Trend Up
Tesamorelin / Ipamorelin
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Tesofensine
Score
5/10
Momentum
18.6%
Trend
↑ Trend Up
Tesofensine sits in caution because it pairs genuinely strong Phase 2 weight loss with a cardiovascular signal that stalled its own development and a regulatory record that never c…
Testosterone (TRT)
Score
Not Scored
Momentum
15.9%
Trend
↓ Trend Down
Testosterone / HRT
Score
Not Scored
Momentum
32.0%
Trend
↑ Trend Up
Testosterone Cycling / TRT
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Tetrahydrocurcumin
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
ThymoQuin (thymoquinone / black seed)
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
ThymoQuin (thymoquinone)
Score
Not Scored
Momentum
25.6%
Trend
↑ Trend Up
Tocotrienols (Vitamin E)
Score
Not Scored
Momentum
41.3%
Trend
↑ Trend Up
Topical exosome serum
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Trace minerals / electrolyte remineralization
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
TRT (Testosterone Replacement Therapy)
Score
5.7/10
Momentum
14.2%
Trend
↓ Trend Down
TRT (Testosterone Replacement Therapy) is a 4/10 fit for people weighing hormonal, libido, and energy, especially when the goal is a tracked experiment with clear endpoints. The st…
TruDiagnostic epigenetic age test
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
TrueDark Glasses (blue-light blocking)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Tyrosine
Score
Not Scored
Momentum
24.7%
Trend
↑ Trend Up
Vagus nerve stimulation (Truvaga)
Score
Not Scored
Momentum
16.7%
Trend
↑ Trend Up
Viome Full Body Intelligence Test
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Viome microbiome/RNA testing
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
VIP (Vasoactive Intestinal Peptide)
Score
5.4/10
Momentum
14.7%
Trend
↑ Trend Up
VIP lands at Neutral because it pairs a genuine, well-mapped anti-inflammatory and immune mechanism, and a larger registered-trial footprint than most grey-market peptides, with a…
Vitamin B12 (methylcobalamin)
Score
Not Scored
Momentum
35.0%
Trend
↑ Trend Up
Vitamin C (cold remedy)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Vitamin D
Score
Not Scored
Momentum
24.7%
Trend
↑ Trend Up
Vitamin K2
Score
Not Scored
Momentum
28.8%
Trend
↑ Trend Up
Vitamin K2 + D3
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
VivaRays circadian glasses
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
VO2 max / cardiorespiratory training
Score
Not Scored
Momentum
6.3%
Trend
↑ Trend Up
Water filter (AquaTru)
Score
Not Scored
Momentum
18.3%
Trend
↑ Trend Up
Weighted vest
Score
Not Scored
Momentum
35.4%
Trend
↑ Trend Up
WeNatal prenatal (for her & him)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Whey protein powder
Score
Not Scored
Momentum
10.5%
Trend
↑ Trend Up
White rice (over brown)
Score
Not Scored
Momentum
26.3%
Trend
↑ Trend Up
Whole-food herbal supplements
Score
Not Scored
Momentum
22.5%
Trend
↑ Trend Up
Wild dagga (Leonotis leonurus)
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Wim Hof breathing
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Yohimbine
Score
Not Scored
Momentum
27.9%
Trend
↓ Trend Down
ZBiotics pre-alcohol probiotic
Score
Not Scored
Momentum
16.3%
Trend
↑ Trend Up
Zeolite
Score
Not Scored
Momentum
35.4%
Trend
↑ Trend Up
Zinc
Score
Not Scored
Momentum
18.4%
Trend
↓ Trend Down
Zinc (lozenges)
Score
Not Scored
Momentum
27.0%
Trend
↑ Trend Up

Overhyped/Fading 23

7,8-Dihydroxyflavone
Score
Not Scored
Momentum
16.7%
Trend
↓ Trend Down
Bioregulators
Score
Not Scored
Momentum
9.6%
Trend
↓ Trend Down
Blue-Light-Blocking Glasses
Score
Not Scored
Momentum
18.0%
Trend
↓ Trend Down
Choline
Score
Not Scored
Momentum
22.2%
Trend
↓ Trend Down
Cold exposure
Score
Not Scored
Momentum
15.1%
Trend
↓ Trend Down
Creatine
Score
Not Scored
Momentum
18.4%
Trend
↓ Trend Down
Ergothioneine
Score
6.6/10
Momentum
14.7%
Trend
↓ Trend Down
Ergothioneine is a 6.6 out of 10 fit for the longevity-minded person who eats few mushrooms and wants a cheap, very safe, tissue-retained antioxidant while the human outcome trials…
Fasting
Score
Not Scored
Momentum
20.4%
Trend
↓ Trend Down
GLP-1 Receptor Agonists
Score
Not Scored
Momentum
21.0%
Trend
↓ Trend Down
Grounding / earthing
Score
Not Scored
Momentum
9.0%
Trend
↓ Trend Down
Humic / fulvic acid
Score
Not Scored
Momentum
1.6%
Trend
↓ Trend Down
LYMA Laser
Score
Not Scored
Momentum
12.0%
Trend
↓ Trend Down
MCT oil
Score
Not Scored
Momentum
20.0%
Trend
↓ Trend Down
Nicotine pouches
Score
Not Scored
Momentum
14.5%
Trend
↓ Trend Down
P21 (P021)
Score
5/10
Momentum
19.1%
Trend
↓ Trend Down
P21 (P021) sits in caution because it pairs the cleanest, broadest rodent neurogenesis-and-tau dataset of any grey-market neurogenic peptide with a completely empty human file and…
Pitolisant
Score
Not Scored
Momentum
16.6%
Trend
↓ Trend Down
Progressive muscle relaxation
Score
Not Scored
Momentum
15.0%
Trend
↓ Trend Down
Rasagiline
Score
Not Scored
Momentum
23.3%
Trend
↓ Trend Down
Red / near-infrared light therapy (photobiomodulation)
Score
Not Scored
Momentum
11.0%
Trend
↓ Trend Down
Red light / near-infrared light therapy
Score
Not Scored
Momentum
2.1%
Trend
↓ Trend Down
Safinamide
Score
Not Scored
Momentum
24.4%
Trend
↓ Trend Down
Semaglutide
Score
6/10
Momentum
18.1%
Trend
↓ Trend Down
Semaglutide is a high-efficacy prescription metabolic lever for people with obesity, type 2 diabetes, established cardiovascular disease, diabetic kidney disease, or MASH, but Sema…
Thymalin
Score
5.9/10
Momentum
8.0%
Trend
↓ Trend Down
Thymalin sits at Neutral because it pairs a genuinely intriguing, decades-deep immune-restoration signal, headlined by the 2 to 4 fold elderly mortality drop in Khavinson 2003, wit…

The crowd’s calls

Early scout calls are locked in Results publish as calls resolve.

How to cite this edition

The Outliyr Index, Edition 10 (Week 2026-W35). Outliyr, 2026. https://outliyr.com/health-optimization-index/2026-W35

Permanent URL: https://outliyr.com/health-optimization-index/2026-W35

Content hash (verifies this snapshot byte-for-byte): sha256:c54e55ccb8dbb866db3ee5297c71b6b5a154b3000edcc396d5a09c76f0fc00c5

Each edition is a versioned, immutable, content-hashed dataset snapshot, structured for archival deposit (e.g. a Zenodo DOI per edition) at public launch.