Berberine: fading
moved from Promising to Overhyped; momentum 46.7% to 9.4% Full entry.
The Outliyr Index: Weekly Edition
Published 2026-09-07. This edition is an immutable snapshot: it never changes after publication.
438 interventions were on the board this week: 33 notable movers, 36 new entries, 0 departures. Biggest mover: Berberine (moved from Promising to Overhyped; momentum 46.7% to 9.4%).
moved from Promising to Overhyped; momentum 46.7% to 9.4% Full entry.
moved from Overhyped to Promising; momentum 14.7% to 21.3% Full entry.
moved from Overhyped to Promising; momentum 1.6% to 87.5% Full entry.
moved from Promising to Overhyped; momentum 23.2% to 21.0% Full entry.
moved from Promising to Overhyped; momentum 19.6% to 16.8% Full entry.
moved from Overhyped to Promising; momentum 18.1% to 8.6% Full entry.
moved from Promising to Overhyped; momentum 38.2% to 0.2% Full entry.
moved from Overhyped to Promising; momentum 8.0% to 23.7% Full entry.
moved from Promising to Overhyped; momentum 37.8% to 0.2% Full entry.
moved from Overhyped to Experimental; momentum 16.7% to 21.9% Full entry.
moved from Overhyped to Experimental; momentum 9.6% to 17.5% Full entry.
moved from Overhyped to Experimental; momentum 18.0% to 21.9% Full entry.
moved from Overhyped to Experimental; momentum 22.2% to 23.9% Full entry.
moved from Overhyped to Experimental; momentum 15.1% to 14.3% Full entry.
moved from Overhyped to Experimental; momentum 18.4% to 21.3% Full entry.
moved from Experimental to Overhyped; momentum 42.5% to 0.0% Full entry.
moved from Overhyped to Experimental; momentum 20.4% to 14.2% Full entry.
moved from Experimental to Overhyped; momentum 36.7% to 16.3% Full entry.
moved from Overhyped to Experimental; momentum 21.0% to 9.9% Full entry.
moved from Overhyped to Experimental; momentum 9.0% to 11.5% Full entry.
moved from Experimental to Overhyped; momentum 45.4% to 4.8% Full entry.
moved from Overhyped to Experimental; momentum 12.0% to 15.6% Full entry.
moved from Overhyped to Experimental; momentum 20.0% to 35.2% Full entry.
moved from Experimental to Overhyped; momentum 48.4% to 14.0% Full entry.
moved from Overhyped to Experimental; momentum 14.5% to 45.2% Full entry.
moved from Overhyped to Experimental; momentum 19.1% to 23.4% Full entry.
moved from Overhyped to Experimental; momentum 16.6% to 15.3% Full entry.
moved from Overhyped to Experimental; momentum 15.0% to 8.6% Full entry.
moved from Overhyped to Experimental; momentum 23.3% to 8.6% Full entry.
moved from Overhyped to Experimental; momentum 2.1% to 22.5% Full entry.
moved from Overhyped to Experimental; momentum 11.0% to 22.5% Full entry.
moved from Overhyped to Experimental; momentum 24.4% to 8.6% Full entry.
moved from Experimental to Overhyped; momentum 45.9% to 12.5% Full entry.
Astaxanthin is a {{bh_score}} fit for people weighing antioxidant, inflammation control, and skin resilience, especially when the goal is a tracked experiment with clear endpoints.…
Blood-Flow Restriction Training is a {{bh_score}} fit for muscle growth, geriatric, recovery repair, especially for readers who can match the protocol to load management, cuff pres…
BPC-157 is a {{bh_score}} fit for adults considering an investigational recovery peptide after basic rehab, sleep, protein, and load management are already handled, not a proven hu…
The practical verdict on Bromantane is that it is a reasonable adjunct for asthenic recovery and stress resilience in someone willing to accept gray-market sourcing, willing to use…
CoQ10 is a {{bh_tier}} supplement at {{bh_score}} for the right person: a cheap, very safe mitochondrial cofactor with genuine hard-outcome evidence in heart failure and real sympt…
Collagen Peptides is a {{bh_score}} fit for people considering skin beauty, bone joint, recovery repair, sleep quality, with the strongest case in the populations already represent…
Creatine Monohydrate is a {{bh_score}} fit for people weighing strength and power, muscle growth, and cognition and focus, especially when the goal is a tracked experiment with cle…
Electrolytes is a {{bh_score}} fit for people losing fluid through heat, sweat, diarrhea, low-carb dieting, sauna, endurance work, or heavy training, because electrolytes solve a r…
Essential Amino Acids is a {{bh_score}} fit for people weighing muscle growth, recovery and repair, and geriatric, especially when the goal is a tracked experiment with clear endpo…
Full-Body EMS is a {{bh_score}} fit for people considering geriatric, body composition, strength power, chronic pain, with the strongest case in the populations already represented…
GHK-Cu is a {{bh_score}} fit for skin beauty, wound healing, recovery repair, especially for readers who can match the protocol to topical route, copper sensitivity, wound status,…
Glycine is a {{bh_score}} fit for people who want a low-cost sleep, recovery, and glutathione-support tool with a better safety profile than most biohacker compounds, not a stand-a…
Grass-Fed Whey Protein is a strong, practical protein source, and most of its value comes from dose and leucine rather than the grass-fed label. It earns its score when the goal is…
HRV Biofeedback is a {{bh_score}} fit for hrv vagal tone, stress resilience, anxiety, especially for readers who can match the protocol to breathing cadence, adherence, baseline HR…
Infrared Sauna is a {{bh_score}} fit for people who want passive heat for vascular conditioning, pain relief, mood support, or heat acclimation without harder training stress, beca…
KPV (Lys-Pro-Val) is a {{bh_score}} fit for people weighing gut health, inflammation control, and immune function, especially when the goal is a tracked experiment with clear endpo…
L-Theanine is a {{bh_score}} fit for people considering cognition focus, stress resilience, sleep quality, anxiety, with the strongest case in the populations already represented b…
Lactoferrin is a {{bh_score}} fit for immune function, gut health, anti inflammatory, especially for readers who can match the protocol to iron status, dairy allergy, infection ris…
Lion's Mane is a {{bh_score}} fit for people testing a gentle cognition or mood mushroom with realistic expectations and enough patience for multi-week tracking, not a guaranteed n…
Magnesium is a {{bh_score}} fit for people with low intake, stress load, poor sleep, blood-pressure concerns, migraines, or glucose issues who want a practical mineral correction,…
Melatonin is one of the more useful low-cost supplements when the target is circadian timing, jet lag, delayed sleep phase, or carefully selected sleep-onset support. It is far les…
Molecular Hydrogen is a {{bh_score}} fit for people weighing inflammation control, antioxidant, and recovery and repair, especially when the goal is a tracked experiment with clear…
NAC scores {{bh_score}}, {{bh_tier}}: a cheap, broad, deeply-evidenced glutathione precursor with a genuinely life-saving core use and a benign safety record. The practical verdict…
Neurofeedback is a {{bh_score}} fit for cognition focus, neuroplasticity, and TBI support when the protocol, practitioner quality, session dose, and objective tracking all line up.…
Norwegian 4x4 delivers measurable VO2max gains for fit adults who can handle brief, high-intensity work and who need a time-efficient protocol. The evidence supports a roughly 7% i…
PEMF (Pulsed Electromagnetic Field Therapy) is a {{bh_score}} fit for people considering bone joint, acute pain, chronic pain, injury recovery, with the strongest case in the popul…
Phosphatidylserine is a {{bh_score}} fit for cognition focus, memory, stress resilience, especially for readers who can match the protocol to cortisol pattern, cognitive baseline,…
Dietary polyphenols score {{bh_score}} ({{bh_tier}}), based on an unusual combination: large, consistent population evidence and an excellent safety, cost, and reversibility profil…
Red Light Therapy is a {{bh_score}} BioHarmony intervention for people who want a low-risk tool for skin aging, hair density, pain, recovery, wound support, and mitochondrial signa…
Rucking earns a 7.3 and a strong-recommend tier because it is a cheap, accessible, low-risk way to stack aerobic conditioning, weight-bearing loading, and a higher calorie burn ont…
Saffron is a {{bh_score}} fit for people using mood, depression, and sleep quality as a measured experiment, not a belief-based staple. The best anchors are [Kell et al. 2017](http…
Semax is a {{bh_score}} fit for people considering cognition focus, neuroprotection, memory, stress resilience, with the strongest case in the populations already represented by th…
Shilajit is a {{bh_score}} fit for men testing fertility, testosterone, energy, or mineral-resin support with a purified, contaminant-tested product, not a universal adaptogen or d…
Spermidine is a {{bh_score}} fit for people interested in food-based autophagy and healthy-aging signals, especially when they can track diet and biomarkers, because spermidine has…
Spirulina earns a strong-recommend at 7.0 because it delivers a replicated cluster of cardiometabolic benefits at food-grade safety and an unusually low cost. The practical verdict…
Taurine is a {{bh_score}} fit for people weighing cardiovascular, metabolic health, and sleep quality, especially when the goal is a tracked experiment with clear endpoints. The st…
TB-500 (Thymosin Beta-4 Fragment) is a {{bh_score}} fit for people considering recovery repair, injury recovery, wound healing, or corneal healing, with the strongest case in acute…
Thymosin Alpha-1 is a {{bh_score}} fit for people discussing immune modulation with a clinician, especially in hospital-adjacent or immune-compromised contexts, not a casual immune…
Thymosin beta-4 lands in the Strong recommend band because it is the most clinically tested peptide in its repair class, with the cleanest Phase 1 intravenous safety record among t…
Tongkat Ali is a {{bh_score}} fit for men with low-normal testosterone, stress-linked libido issues, or training goals who can verify product quality and labs, because Tongkat Ali…
Traditional Finnish sauna is a strong-recommend practice at 7.7 out of 10 for one core reason: it offers a large, dose-dependent, real-world cardiovascular and longevity signal wit…
Vagus Nerve Stimulation is a {{bh_score}} fit for hrv vagal tone, stress resilience, mood, especially for readers who can match the protocol to device type, stimulation site, auton…
Vitamin C scores {{bh_score}} because the floor is so high and the downside so small: it is essential, decisively effective for deficiency, very safe, and nearly free, with modest…
Vitamin D3 + K2 is a {{bh_score}} fit for deficient adults, winter indoor workers, postmenopausal women, and people pairing vitamin D with calcium or bone goals, not a guaranteed b…
Whole-Body Vibration is a low-impact modality that can modestly improve bone density, reduce chronic low-back pain, and enhance balance in older adults when applied in calibrated s…
Zone 2 Cardio is a {{bh_score}} fit for people willing to build aerobic capacity through repeatable, low-drama training they can sustain for years, because cardiorespiratory fitnes…
Adaptogenic mushrooms are a 5.8 out of 10, a Worth trying class for the right person and goal. Reishi is the standout, with real human evidence for immune-marker shifts and fatigue…
AHK-Cu pairs a plausible mechanism and a clean safety profile with an almost empty human-evidence file. The practical verdict: it is a reasonable, low-risk add-on to a real hair pr…
Aniracetam earns {{bh_score}} because its strongest case is narrow and real: a fat soluble racetam that fine tunes AMPA receptors and is studied for memory, verbal fluency, and con…
Apigenin is a {{bh_score}} fit for people who want a gentle calming option, not a heavy sleep drug or a longevity shortcut. The best human signal still comes from chamomile extract…
ARA-290 is the strongest peptide in this repair group on human-trial rigor, yet it is hemmed in by a narrow indication, small trials, no Phase 3, a defunct sponsor, and grey-market…
Ashwagandha is a {{bh_score}} fit for people using stress resilience, anxiety, and sleep quality as a measured experiment, not a belief-based staple. The best anchors are [Arumugam…
Ca-AKG (Calcium Alpha-Ketoglutarate) is a {{bh_score}} fit for people treating aging biology as a tracked experiment, especially bone turnover, frailty, inflammation, or methylatio…
It is a legitimate, Phase 3-validated drug whose best use is not the one this report scores. As monotherapy it delivers real weight loss of about 11.8 percent with a cleaner tolera…
Celebrex (Celecoxib) is a {{bh_score}} fit for people using anti inflammatory, acute pain, and chronic pain as a measured experiment, not a belief-based staple. The best anchors ar…
It pairs the largest human trial base of any nootropic-adjacent peptide with an evidence story that independent reviewers do not confirm, plus a heavy infusion burden. If you are i…
Chlorella is a {{bh_tier}} whole-food supplement at {{bh_score}}: a cheap, safe, broadly nutritious green algae with real but modest human evidence for lower cholesterol, lower blo…
It pairs a clean, physiological mechanism with an almost empty human outcomes file and a form that has never been tested in people. If you want a short-acting growth-hormone pulse…
Cold plunge earns a {{bh_score}} {{bh_tier}} score because the acute-mood evidence corpus is genuine but the broader health claims outpace the durable-benefit data, and the practic…
Colostrum is a {{bh_score}} fit for immune function, gut health, recovery repair, especially for readers who can match the protocol to dairy tolerance, immune stress, gut barrier c…
Curcumin earns {{bh_score}} as a solid, benign anti-inflammatory with one strong use case and a lot of marketing noise around it. Take it for osteoarthritis, where it performs comp…
DSIP pairs a famous, overselling name with weak independent sleep evidence, a clean tolerability record, and one genuinely interesting but unproven withdrawal signal. The honest su…
Dynamine (methylliberine) earns a 5.8 because it does one thing well: deliver a fast, short burst of energy, focus, and reaction time, with thin evidence for anything beyond that.…
Earthing appears most useful for adults who want a low-cost, low-risk way to nudge sleep depth, reduce mild pain after exercise, or modestly improve post-surgical recovery, while a…
Epitalon is a {{bh_score}} fit for people using longevity, sleep quality, and healthspan as a measured experiment, not a belief-based staple. The best anchors are [Al-dulaimi et al…
Ergothioneine is a 6.6 out of 10 fit for the longevity-minded person who eats few mushrooms and wants a cheap, very safe, tissue-retained antioxidant while the human outcome trials…
Exogenous ketones earn {{bh_score}}, {{bh_tier}}, but only for a person whose goal matches the narrow slice of evidence that is actually real. They are fast, intrinsically safe, an…
The 5.5 Neutral score reflects a real mechanism with thin and partly negative human translation. Fisetin is worth a structured 3-cycle trial for older adults with documented inflam…
Fucoidan is worth trying at 6.4 out of 10 for the right person: someone who wants a cheap, very safe immune and anti-inflammatory adjunct from a whole-food source and who keeps the…
Full-spectrum hemp is a 6.5 out of 10, worth-trying intervention for people who want a low-dependency, well-tolerated option and who keep their expectations matched to the evidence…
Glutathione is a 6.2 out of 10, worth trying for the right person and easy to overrate for everyone else. The practical verdict is to treat it as a targeted, tracked experiment rat…
GlyNAC scores {{bh_score}}, {{bh_tier}}, and is arguably the best-evidenced way to raise glutathione, while still carrying an honest asterisk about replication. The practical verdi…
It pairs a genuinely strong foundation with a borrowed headline and finicky execution. It is a real, formerly FDA-approved drug with a textbook-clear, reversible mechanism, and it…
High-dose melatonin is worth trying for advanced users with a clear reason, a conservative dose plan, and real monitoring for sedation, glucose, blood pressure, mood, and endocrine…
Hyaluronic acid is a {{bh_score}}, {{bh_tier}} pick for people targeting skin hydration, mild joint comfort, or dry eye who want a cheap, near-foolproof, very safe add-on and are w…
Hyperbaric Oxygen Therapy delivers oxygen at 2.0-2.4 ATA and shows the strongest evidence for medically indicated conditions such as decompression illness, carbon monoxide poisonin…
Ipamorelin pairs a clean, well-understood mechanism with an almost empty human outcomes file. If you want a selective growth-hormone secretagogue, accept that the popular benefits…
Kava is a real, fast-acting, non-addictive anxiolytic with a strong short-term and traditional evidence base, limited by one specific intrinsic safety problem rather than by weak e…
Ketogenic Diet is a {{bh_score}} fit for people using metabolic health, blood sugar, and body composition as a measured nutrition experiment. The body-composition signal is real: […
Kisspeptin-10 pairs a first-rate, mechanistically elegant research program with a thin direct data set for the exact form people buy and impractical kinetics. If you are a curious…
Melanotan I is worth trying when the goal is real photoprotection or pigment support and you can verify your source, not as a casual tanning shortcut. The 6.2 score reflects a comp…
Metformin offers clinically proven glucose lowering for overweight adults with type 2 diabetes and can modestly lower the risk of progressing from prediabetes to diabetes, making i…
Methylene Blue is a {{bh_score}} fit for advanced users who understand that methylene blue is a drug-like redox compound, not a casual blue nootropic, because the strongest evidenc…
Modafinil is a {{bh_score}} fit for people using cognition focus, energy, and mood as a measured experiment, not a belief-based staple. The best anchors are [Caldwell JA et al. 200…
NMN is a {{bh_score}} fit for older or metabolically strained adults who want an NAD+ precursor trial with measured endpoints, not a reliable anti-aging shortcut for already health…
NR (Nicotinamide Riboside) is a {{bh_score}} fit for people who want a measured NAD+ experiment, especially older adults or those tracking vascular, metabolic, or neurologic marker…
Omega-3 is a {{bh_score}} fit for people using cardiovascular, anti inflammatory, and metabolic health as a measured experiment, not a belief-based staple. The best anchors are [Ka…
Orforglipron sits at the bottom of the worth-trying tier because it pairs genuinely strong, deep evidence and unmatched oral convenience with an effect size that loses to the injec…
Oxiracetam earns a middle-of-the-road score because the mechanism is real but the modern human evidence is thin and sourcing is now genuinely hard. It positively modulates AMPA glu…
It pairs an outstanding safety record with genuinely inconsistent efficacy for the very uses it is marketed for. If you are curious, even-keeled, and want a low-risk, low-cost acut…
Paraxanthine is a strong fit for caffeine users who want the focus and energy without as much of the jitter, chest tightness, or crash. The best evidence sits in acute cognition, r…
It pairs an interesting laboratory mechanism with an almost empty human evidence file. The cell and animal work is coherent, the safety read is mild, and an outside lab confirmed t…
Piracetam is the granddaddy of nootropics and the most studied racetam, but its proven wins sit in clinical lanes like cortical myoclonus, post-stroke aphasia support, and narrow p…
The {{bh_score}}, {{bh_tier}} score reflects honest tension between a wide mechanistic story and a narrow band of replicated human signals. Quercetin earns its supplement shelf spa…
Quinton Marine Plasma is a clean, benign, full-spectrum electrolyte and trace-mineral source that earns a worth-trying 5.9 mostly on safety and mechanism, not on product-specific p…
Rapamycin is a {{bh_score}} fit for medically supervised longevity experimenters who understand mTOR tradeoffs and can monitor labs, not a casual supplement or proven human lifespa…
Sabroxy is a standardized Oroxylum indicum extract worth a focused trial if you want clean, dopamine-leaning attention support and you understand the human evidence is essentially…
Semaglutide is a high-efficacy prescription metabolic lever for people with obesity, type 2 diabetes, established cardiovascular disease, diabetic kidney disease, or MASH, but Sema…
Senolytics is a {{bh_score}} fit for longevity, healthspan, cellular senescence, especially for readers who can match the protocol to age, disease context, drug interactions, and w…
Sermorelin earns its score by being the most credentialed peptide in a thinly-proven class, not by having strong adult outcome data. If you are an older adult with documented low I…
It is harmless but essentially unproven, and proven alternatives make it a weak use of money. If you already run a solid routine and want to add a low-cost, zero-risk peptide serum…
Sodium butyrate earns {{bh_score}} as a benign, mechanistically sound gut-support tool with thin human evidence. Take it as a colon-targeted add-on for ulcerative colitis or IBS, u…
Sprinting, done as structured sprint interval training, is a high-leverage tool for the right person: a near-maximal VO2max and metabolic stimulus in minutes per week, at zero cost…
SS-31 (Elamipretide) is a {{bh_score}} fit for people using mitochondrial, antioxidant, and cardiovascular as a measured experiment, not a belief-based staple. The best anchors are…
Tesamorelin is a {{bh_score}} fit for body composition, hormonal, metabolic health, especially for readers who can match the protocol to HIV lipodystrophy context, IGF-1 monitoring…
Thymalin pairs a genuinely intriguing, decades-deep immune-restoration signal, headlined by the 2 to 4 fold elderly mortality drop in Khavinson 2003, with an evidence base that no…
Thymulin pairs unusually well-defined biology with an unusually thin human-treatment file. If you understand zinc status, want a chemically defined thymic hormone rather than an un…
Tirzepatide delivers clinically meaningful weight loss and glycemic improvement for adults with obesity or type 2 diabetes, but the benefits depend on ongoing weekly injections. Th…
TUDCA earns its score on a narrow, real strength: hepatobiliary support, bile flow, and a single solid metabolic signal, with weaker proof everywhere else. It makes sense when you…
Urolithin A is a {{bh_score}} fit for people considering mitochondrial, muscle growth, endurance cardio, anti inflammatory, with the strongest case in the populations already repre…
It pairs a coherent, single-source mechanism with an almost empty human outcomes file and zero independent confirmation. If you are a curious experimenter who already accepts you a…
VK2735 pairs a strong, validated short-term signal with the earliest-stage evidence file in the next-generation incretin batch. If you are tracking this class closely, the peer-rev…
5-Amino-1MQ earns its score because the mechanism and animal data are promising while the human evidence is absent and the supply chain is unregulated. It is reasonable to consider…
AOD-9604 is unusual: it is safe but it does not appear to work for what it is sold for. The fat-loss mechanism is real and consistent in rodents, per Heffernan 2000, but the one co…
C15 (Pentadecanoic Acid) is a {{bh_score}} fit for people using metabolic health, liver detox, and cardiovascular as a measured experiment, not a belief-based staple. The best anch…
C60 (Buckminsterfullerene) shows modest antioxidant activity but the evidence does not support oral longevity claims for most users. The only reproducible human data come from a sm…
CagriSema lands at Neutral because it pairs the strongest weight effect in this incretin batch with the weakest set of supporting facts around it. The potency is real: about 22.7%…
CJC-1295 is a {{bh_score}} fit for people weighing body composition, sleep quality, and recovery and repair, especially when the goal is a tracked experiment with clear endpoints.…
For CJC-1295 with DAC, its one real edge, more human mechanism data and once-weekly convenience, is outweighed by a sustained action you cannot reverse, a heavier side-effect profi…
Dihexa is a {{bh_score}} fit for experimenters looking at cognition through a high-risk research-chemical lens, not people who want a normal nootropic, not a clinically proven memo…
Eloralintide is the most interesting obesity molecule in development and one of the worst things you could actually buy right now, and both statements follow from the same fact: it…
Ephedrine is a {{bh_score}} fit for people considering body composition, energy, respiratory, endurance cardio, with the strongest case in the populations already represented by th…
FOXO4-DRI sits in Caution at 4.2 because it pairs one of the most elegant senolytic mechanisms and the most dramatic mouse result in the category with zero human evidence and grey-…
GHRP-2 lands at Neutral because it pairs genuine strengths, a strong growth-hormone pulse and a one-of-a-kind diagnostic approval, with genuine weaknesses, lower selectivity and an…
It pairs a real, fast, historically important mechanism with an empty human outcomes file and the heaviest side-effect load of its group. It is one of the original growth-hormone-r…
Humanin is one of the more biologically interesting longevity peptides on the board, and it lands at Neutral because fascinating biology cannot outrun an empty human file. It is a…
The practical verdict is simple: LL-37 is a fascinating molecule with one promising topical use and a genuine double-edge. If you are drawn to it, the only route with human evidenc…
Mazdutide earns a neutral score because the science is strong but the access and cardiac questions are not yet resolved. If your specific goal is liver fat, mazdutide posts the bes…
Melanotan II is effective enough to tempt use and risky enough to demand restraint. It reliably tans skin, blunts appetite, and drives libido, but it does all of that by activating…
MK-677 sits at a {{bh_score}}, {{bh_tier}} score because it is the best-evidenced growth-hormone secretagogue you can name and still not a clear win, which is an unusual place to l…
NAD+ (Direct) sits at the bottom of Neutral because it pairs an undisputed, central biology with a nearly empty direct-delivery evidence file and a real IV burden. The molecule mat…
Ozone Therapy is a {{bh_score}} fit for people weighing acute pain, chronic pain, and wound healing, especially when the goal is a tracked experiment with clear endpoints. The stro…
It pairs the cleanest, broadest rodent neurogenesis-and-tau dataset of any grey-market neurogenic peptide with a completely empty human file and a failed independent replication of…
It pairs one of the cleaner mechanisms in the grey-market peptide world with a completely empty human file. The TREK-1 to depression link is real and well-characterized, the rodent…
It pairs a genuinely approved, trial-backed drug with a modest, contested benefit and a serious eye toxicity that can be partly permanent. If you have interstitial cystitis, it is…
Phenylpiracetam is the most stimulating member of the racetam family, and it earns a middling score because the effect is real but narrow, fades fast with use, and rides on thin in…
Pine pollen is neutral at 5.7 out of 10: a cheap, low-risk, nutrient-dense whole food with a long traditional record, weighed against a famous testosterone claim that no human evid…
It pairs the best evidence base in the peptide world with a modest payoff and a heavy nausea burden. If you are a premenopausal woman with diagnosed low desire who wants the one FD…
Resveratrol may be worth a trial for postmenopausal women focused on modest cognitive or cerebrovascular gains and for high-risk adults who need a cheap, low-effort supplement to s…
Retatrutide is a {{bh_score}} fit for people following obesity, diabetes, liver-fat, or cardiometabolic drug development under medical supervision, because retatrutide has unusuall…
SLU-PP-332 may provide modest increases in mitochondrial oxidative capacity and treadmill endurance for highly controlled self-experiments, yet the evidence is limited to rodent mo…
Survodutide lands at neutral because it pairs a genuinely exciting liver mechanism with an unfinished, investigational file and a grey-market-only supply. The practical read: if yo…
It pairs genuinely strong Phase 2 weight loss with a cardiovascular signal that stalled its own development and a regulatory record that never crossed the finish line. The efficacy…
TRT (Testosterone Replacement Therapy) is a {{bh_score}} fit for people weighing hormonal, libido, and energy, especially when the goal is a tracked experiment with clear endpoints…
VIP lands at Neutral because it pairs a genuine, well-mapped anti-inflammatory and immune mechanism, and a larger registered-trial footprint than most grey-market peptides, with a…
Berberine is a {{bh_score}} fit for people considering blood sugar, metabolic health, cardiovascular, liver detox, with the strongest case in the populations already represented by…
MOTS-c is a {{bh_score}} fit for people considering mitochondrial, metabolic health, blood sugar, energy, with the strongest case in the populations already represented by the evid…
Selank is a {{bh_score}} fit for people weighing anxiety, mood, and stress resilience, especially when the goal is a tracked experiment with clear endpoints. The strongest evidence…
The practical verdict on sulforaphane is that it is a reasonable food-level intervention for cruciferous vegetable enthusiasts and a selective supplement for metabolic-health and p…
Time-Restricted Eating is a {{bh_score}} fit for people using metabolic health, blood sugar, and body composition as a measured experiment, not a belief-based staple. The best anch…
Early scout calls are locked in Results publish as calls resolve.
The Outliyr Index, Edition 11 (Week 2026-W36). Outliyr, 2026. https://outliyr.com/health-optimization-index/2026-W36
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Each edition is a versioned, immutable, content-hashed dataset snapshot, structured for archival deposit (e.g. a Zenodo DOI per edition) at public launch.