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Community-ranked biohacking, longevity & health optimization

The Outliyr Index

A living, community-ranked board of biohacking and longevity interventions, ranked by evidence and real-world results. Never by who paid.

How to read this board

Every item carries three signals side by side. Community Signal shows what the people who tried it report. Evidence pairs an independent research grade with my BioHarmony take, clearly labeled as one voice among three. Momentum shows which way attention moved this week. No placement here is sponsored or for sale. Full methodology.

Scout leaderboard: who called it first

This week’s movers

Rising

  1. SLU-PP-332 ↑ Trend Up +27 pts this week
  2. Polyphenols (Dietary) ↑ Trend Up +27 pts this week
  3. Spermidine ↑ Trend Up +25 pts this week

Falling

  1. Shilajit ↓ Trend Down -41 pts this week
  2. Urolithin A ↓ Trend Down -33 pts this week
  3. Orforglipron (Foundayo) ↓ Trend Down -29 pts this week

Movers track attention, never evidence. How momentum works.

Proven 46

The research and the results agree. Start here.

  1. Astaxanthin
    Proven Evidence C ▲ 45.6%
    Call it Weigh in
  2. Blood-Flow Restriction Training
    Proven Evidence A ▼ 34.2%
    Call it Weigh in
  3. BPC-157 In the news
    Proven Evidence B ▼ 23.4%
    Call it Weigh in
  4. Bromantane (Ladasten)
    Proven Evidence C ▲ 34.8%
    Call it Weigh in
  5. Coenzyme Q10 (CoQ10 / Ubiquinol)
    Proven Evidence C ▲ 34.8%
    Call it Weigh in
  6. Collagen Peptides
    Proven Evidence B ▲ 43.4%
    Call it Weigh in
  7. Creatine Monohydrate
    Proven Evidence A ▼ 31.9%
    Call it Weigh in
  8. Electrolytes
    Proven Evidence A ▼ 30.3%
    Call it Weigh in
  9. Essential Amino Acids
    Proven Evidence A ▼ 33.8%
    Call it Weigh in
  10. Full-Body EMS
    Proven Evidence C ▲ 32.4%
    Call it Weigh in
  11. GHK-Cu
    Proven Evidence B ▲ 41.9%
    Call it Weigh in
  12. Glycine
    Proven Evidence C ▲ 49.1%
    Call it Weigh in
  13. Grass-Fed Whey Protein
    Proven Evidence A ▲ 34.8%
    Call it Weigh in
  14. HRV Biofeedback
    Proven Evidence B ▼ 32.1%
    Call it Weigh in
  15. Infrared Sauna
    Proven Evidence C ▲ 40.2%
    Call it Weigh in
  16. KPV (Lys-Pro-Val)
    Proven Evidence C ▲ 34.8%
    Call it Weigh in
  17. L-Theanine
    Proven Evidence B ▼ 39.5%
    Call it Weigh in
  18. Lactoferrin
    Proven Evidence B ▲ 48.4%
    Call it Weigh in
  19. Lion's Mane
    Proven Evidence B ▲ 48.1%
    Call it Weigh in
  20. Magnesium
    Proven Evidence A ▼ 16.5%
    Call it Weigh in
  21. Melatonin
    Proven Evidence A ▼ 32.3%
    Call it Weigh in
  22. Molecular Hydrogen
    Proven Evidence C ▼ 34.1%
    Call it Weigh in
  23. NAC (N-Acetylcysteine)
    Proven Evidence B ▲ 43.1%
    Call it Weigh in
  24. Neurofeedback
    Proven Evidence B ▲ 46.0%
    Call it Weigh in
  25. Norwegian 4x4
    Proven Evidence A ▼ 29.9%
    Call it Weigh in
  26. PEMF (Pulsed Electromagnetic Field Therapy)
    Proven Evidence C ▼ 6.3%
    Call it Weigh in
  27. Phosphatidylserine
    Proven Evidence C ▼ 32.5%
    Call it Weigh in
  28. Polyphenols (Dietary)
    Proven Evidence C ▲ 33.1%
    Call it Weigh in
  29. Red Light Therapy
    Proven Evidence B ▼ 17.5%
    Call it Weigh in
  30. Rucking (Weighted Walking)
    Proven Evidence C ▲ 34.8%
    Call it Weigh in
  31. Saffron
    Proven Evidence A ▼ 34.1%
    Call it Weigh in
  32. Semax
    Proven Evidence C ▲ 30.6%
    Call it Weigh in
  33. Shilajit
    Proven Evidence C ▼ 24.1%
    Call it Weigh in
  34. Spermidine
    Proven Evidence C ▲ 56.8%
    Call it Weigh in
  35. Spirulina
    Proven Evidence C ▼ 27.8%
    Call it Weigh in
  36. Taurine
    Proven Evidence B ▼ 29.1%
    Call it Weigh in
  37. TB-500 (Thymosin Beta-4 Fragment)
    Proven Evidence C ▲ 34.8%
    Call it Weigh in
  38. Thymosin Alpha-1
    Proven Evidence B ▼ 16.1%
    Call it Weigh in
  39. Thymosin Beta-4 (Tβ4)
    Proven Evidence B ▼ 34.8%
    Call it Weigh in
  40. Tongkat Ali
    Proven Evidence C ▲ 42.8%
    Call it Weigh in
  41. Traditional Sauna (Finnish Dry-Heat)
    Proven Evidence B ▲ 34.8%
    Call it Weigh in
  42. Vagus Nerve Stimulation
    Proven Evidence B ▼ 34.1%
    Call it Weigh in
  43. Vitamin C (Ascorbic Acid)
    Proven Evidence B ▼ 27.9%
    Call it Weigh in
  44. Vitamin D3 + K2
    Proven Evidence A ▲ 34.8%
    Call it Weigh in
  45. Whole-Body Vibration
    Proven Evidence B ▲ 35.0%
    Call it Weigh in
  46. Zone 2 Cardio
    Proven Evidence A ▲ 33.9%
    Call it Weigh in

Promising 68

Real signal with real gaps. Worth a spot in your stack when the fit is right.

  1. Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga)
    Promising Evidence D ▲ 34.8%
    Call it Weigh in
  2. AHK-Cu (Copper Tripeptide)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  3. Aniracetam
    Promising Evidence C ▼ 35.0%
    Call it Weigh in
  4. Apigenin
    Promising Evidence C ▲ 32.7%
    Call it Weigh in
  5. ARA-290 (Cibinetide)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  6. Ashwagandha
    Promising Evidence B ▲ 34.4%
    Call it Weigh in
  7. Berberine
    Promising Evidence C ▲ 28.8%
    Call it Weigh in
  8. Ca-AKG (Calcium Alpha-Ketoglutarate)
    Promising Evidence D ▲ 34.8%
    Call it Weigh in
  9. Cagrilintide (AM833)
    Promising Evidence B ▲ 34.8%
    Call it Weigh in
  10. Celebrex (Celecoxib)
    Promising Evidence A ▲ 32.2%
    Call it Weigh in
  11. Cerebrolysin
    Promising Evidence C ▼ 33.0%
    Call it Weigh in
  12. Chlorella
    Promising Evidence D ▼ 33.5%
    Call it Weigh in
  13. CJC-1295 No DAC (Mod GRF 1-29)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  14. Cold Plunge
    Promising Evidence C ▲ 44.4%
    Call it Weigh in
  15. Colostrum
    Promising Evidence C ▼ 27.4%
    Call it Weigh in
  16. DSIP (Delta Sleep-Inducing Peptide)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  17. Dynamine (Methylliberine)
    Promising Evidence D ▲ 31.3%
    Call it Weigh in
  18. Earthing
    Promising Evidence D ▼ 32.8%
    Call it Weigh in
  19. Epitalon
    Promising Evidence C ▲ 38.5%
    Call it Weigh in
  20. Ergothioneine
    Promising Evidence D ▼ 37.7%
    Call it Weigh in
  21. Exogenous Ketones
    Promising Evidence D ▲ 43.9%
    Call it Weigh in
  22. Fisetin
    Promising ▲ 48.8%
    Call it Weigh in
  23. Fucoidan (Brown Seaweed Polysaccharide)
    Promising Evidence D ▲ 34.8%
    Call it Weigh in
  24. Full-Spectrum Hemp (CBD)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  25. Glutathione (GSH)
    Promising Evidence D ▼ 32.7%
    Call it Weigh in
  26. GlyNAC (Glycine + N-Acetylcysteine)
    Promising Evidence D ▲ 34.8%
    Call it Weigh in
  27. Gonadorelin (GnRH)
    Promising Evidence B ▲ 33.8%
    Call it Weigh in
  28. High-Dose Melatonin
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  29. Hyaluronic Acid
    Promising Evidence C ▼ 34.5%
    Call it Weigh in
  30. Hyperbaric Oxygen Therapy
    Promising Evidence B ▲ 37.0%
    Call it Weigh in
  31. Ipamorelin In the news
    Promising Evidence C ▲ 45.8%
    Call it Weigh in
  32. Kava (Piper methysticum)
    Promising Evidence B ▲ 33.9%
    Call it Weigh in
  33. Ketogenic Diet
    Promising Evidence A ▲ 40.6%
    Call it Weigh in
  34. Kisspeptin-10
    Promising Evidence C ▼ 31.3%
    Call it Weigh in
  35. Melanotan I (Afamelanotide)
    Promising Evidence B ▲ 34.8%
    Call it Weigh in
  36. Metformin
    Promising Evidence A ▼ 34.0%
    Call it Weigh in
  37. Methylene Blue
    Promising Evidence B ▲ 50.3%
    Call it Weigh in
  38. Modafinil
    Promising Evidence B ▲ 38.5%
    Call it Weigh in
  39. MOTS-c
    Promising Evidence D ▲ 37.7%
    Call it Weigh in
  40. NMN (Nicotinamide Mononucleotide)
    Promising Evidence D ▼ 32.0%
    Call it Weigh in
  41. NR (Nicotinamide Riboside)
    Promising Evidence D ▲ 33.8%
    Call it Weigh in
  42. Omega-3
    Promising Evidence B ▲ 34.2%
    Call it Weigh in
  43. Orforglipron (Foundayo)
    Promising Evidence B ▼ 37.2%
    Call it Weigh in
  44. Oxiracetam
    Promising Evidence C ▲ 33.6%
    Call it Weigh in
  45. Oxytocin (Intranasal)
    Promising Evidence C ▲ 33.0%
    Call it Weigh in
  46. Paraxanthine (Enfinity)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  47. Pinealon (Glu-Asp-Arg)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  48. Piracetam (Nootropil)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  49. Quercetin
    Promising Evidence C ▲ 34.4%
    Call it Weigh in
  50. Quinton Marine Plasma (Seawater Minerals)
    Promising Evidence D ▲ 34.8%
    Call it Weigh in
  51. Rapamycin
    Promising Evidence C ▲ 39.7%
    Call it Weigh in
  52. Sabroxy (Oroxylum indicum Extract)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  53. Selank
    Promising Evidence C ▼ 35.2%
    Call it Weigh in
  54. Semaglutide
    Promising Evidence B ▲ 42.2%
    Call it Weigh in
  55. Senolytics
    Promising Evidence D ▲ 32.5%
    Call it Weigh in
  56. Sermorelin (GHRH 1-29)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  57. SNAP-8 (Acetyl Octapeptide-3)
    Promising Evidence C ▼ 34.8%
    Call it Weigh in
  58. Sprinting (Sprint Interval Training)
    Promising Evidence B ▲ 36.6%
    Call it Weigh in
  59. SS-31 (Elamipretide)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  60. Sulforaphane
    Promising Evidence C ▲ 48.2%
    Call it Weigh in
  61. Tesamorelin
    Promising Evidence A ▼ 27.1%
    Call it Weigh in
  62. Thymalin
    Promising Evidence C ▲ 34.5%
    Call it Weigh in
  63. Thymulin (Zinc-Thymulin)
    Promising Evidence C ▲ 41.1%
    Call it Weigh in
  64. Time-Restricted Eating
    Promising Evidence B ▲ 36.1%
    Call it Weigh in
  65. Tirzepatide
    Promising Evidence B ▲ 50.1%
    Call it Weigh in
  66. TUDCA (Tauroursodeoxycholic Acid)
    Promising Evidence C ▲ 31.3%
    Call it Weigh in
  67. Vilon (Lys-Glu)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in
  68. VK2735 (Viking Therapeutics)
    Promising Evidence C ▲ 34.8%
    Call it Weigh in

Experimental 76

Early data and early adopters. Test carefully and track your own response.

  1. 5-Amino-1MQ
    Experimental Evidence E ▲ 40.3%
    Call it Weigh in
  2. Amanita Muscaria (muscimol)
    Experimental ▲ 0.0%
    Call it Weigh in
  3. Amygdalin (Vitamin B17 / Laetrile)
    Experimental ▲ 0.0%
    Call it Weigh in
  4. Anti-Gray Hair Serum
    Experimental ▲ 0.0%
    Call it Weigh in
  5. AOD-9604
    Experimental Evidence E ▲ 38.1%
    Call it Weigh in
  6. Aromatase inhibitor / estradiol management
    Experimental ▲ 0.0%
    Call it Weigh in
  7. Blue-Light-Blocking Glasses
    Experimental ▲ 37.9%
    Call it Weigh in
  8. Boswellia Serrata
    Experimental ▲ 40.4%
    Call it Weigh in
  9. BPC-157 / TB-500
    Experimental ▲ 0.0%
    Call it Weigh in
  10. Breathwork In the news
    Experimental ▲ 32.6%
    Call it Weigh in
  11. C15 (Pentadecanoic Acid)
    Experimental Evidence E ▲ 34.8%
    Call it Weigh in
  12. CagriSema (Cagrilintide + Semaglutide)
    Experimental Evidence C ▲ 34.8%
    Call it Weigh in
  13. CJC-1295
    Experimental Evidence D ▼ 26.2%
    Call it Weigh in
  14. CJC-1295 DAC
    Experimental Evidence C ▼ 31.3%
    Call it Weigh in
  15. Continuous Glucose Monitor (CGM) In the news
    Experimental ▲ 0.0%
    Call it Weigh in
  16. Creatine In the news
    Experimental ▲ 42.2%
    Call it Weigh in
  17. Dihexa
    Experimental Evidence D ▲ 33.2%
    Call it Weigh in
  18. Electrolytes (LMNT)
    Experimental ▲ 0.0%
    Call it Weigh in
  19. Ephedrine
    Experimental Evidence B ▼ 28.2%
    Call it Weigh in
  20. Exogenous Ketones (R3HBG)
    Experimental ▲ 0.0%
    Call it Weigh in
  21. FOXO4-DRI
    Experimental Evidence E ▼ 30.9%
    Call it Weigh in
  22. Fulvic/Humic Acid Minerals
    Experimental ▲ 0.0%
    Call it Weigh in
  23. GHRP-2 (Pralmorelin)
    Experimental Evidence C ▼ 31.3%
    Call it Weigh in
  24. GHRP-6
    Experimental Evidence C ▼ 34.5%
    Call it Weigh in
  25. GLP-1 agonists (microdosed)
    Experimental ▲ 0.0%
    Call it Weigh in
  26. Hair Tissue Mineral Analysis In the news
    Experimental ▲ 0.0%
    Call it Weigh in
  27. Hair-mineral-analysis mineral balancing
    Experimental ▲ 0.0%
    Call it Weigh in
  28. Hiya kids multivitamin In the news
    Experimental ▲ 0.0%
    Call it Weigh in
  29. Humanin
    Experimental Evidence D ▲ 38.3%
    Call it Weigh in
  30. Hyperbaric Oxygen Therapy (HBOT)
    Experimental ▲ 0.0%
    Call it Weigh in
  31. LL-37 (Cathelicidin)
    Experimental Evidence D ▲ 38.4%
    Call it Weigh in
  32. Marine Phytoplankton
    Experimental ▲ 55.7%
    Call it Weigh in
  33. Mazdutide (IBI362)
    Experimental Evidence C ▲ 42.0%
    Call it Weigh in
  34. Melanotan II
    Experimental Evidence C ▼ 28.5%
    Call it Weigh in
  35. MK-677 (Ibutamoren)
    Experimental Evidence C ▲ 34.8%
    Call it Weigh in
  36. Molecular hydrogen therapy (Brown's Gas)
    Experimental ▲ 0.0%
    Call it Weigh in
  37. NAD+ In the news
    Experimental ▲ 42.8%
    Call it Weigh in
  38. NAD+ (Direct)
    Experimental Evidence D ▼ 29.8%
    Call it Weigh in
  39. NAD+ / NMN precursors
    Experimental ▲ 0.0%
    Call it Weigh in
  40. Nootropics In the news
    Experimental ▲ 41.7%
    Call it Weigh in
  41. NOVOS (biological age test + longevity supplement)
    Experimental ▲ 0.0%
    Call it Weigh in
  42. NOVOS Core In the news
    Experimental ▲ 41.4%
    Call it Weigh in
  43. Omega-3 (fish oil) In the news
    Experimental ▲ 0.0%
    Call it Weigh in
  44. OS-01 peptide (OneSkin)
    Experimental ▲ 0.0%
    Call it Weigh in
  45. Ozone Therapy
    Experimental Evidence C ▲ 33.1%
    Call it Weigh in
  46. P21 (P021)
    Experimental Evidence E ▼ 42.5%
    Call it Weigh in
  47. PE-22-28
    Experimental Evidence E ▲ 35.5%
    Call it Weigh in
  48. Pentosan Polysulfate (Elmiron)
    Experimental Evidence B ▲ 34.8%
    Call it Weigh in
  49. Peptide bioregulators In the news
    Experimental ▲ 0.0%
    Call it Weigh in
  50. Peptides (Follistatin/Klotho/Ipamorelin)
    Experimental ▲ 0.0%
    Call it Weigh in
  51. Phenylpiracetam (Phenotropil)
    Experimental Evidence C ▲ 34.8%
    Call it Weigh in
  52. Phospholipid Membrane Support (TUDCA/butyrate)
    Experimental ▲ 0.0%
    Call it Weigh in
  53. Pine Pollen
    Experimental Evidence D ▼ 36.3%
    Call it Weigh in
  54. PT-141 (Bremelanotide)
    Experimental Evidence B ▲ 34.8%
    Call it Weigh in
  55. Resistance training
    Experimental ▲ 43.4%
    Call it Weigh in
  56. Resistance training + protein protocol (40+)
    Experimental ▲ 0.0%
    Call it Weigh in
  57. Resveratrol
    Experimental Evidence E ▲ 46.7%
    Call it Weigh in
  58. Retatrutide
    Experimental Evidence C ▼ 35.4%
    Call it Weigh in
  59. Semaglutide (GLP-1)
    Experimental ▲ 0.0%
    Call it Weigh in
  60. Semax & Selank
    Experimental ▲ 0.0%
    Call it Weigh in
  61. Sleep
    Experimental ▲ 39.0%
    Call it Weigh in
  62. Sleep supplements (magnesium / glycine / melatonin)
    Experimental ▲ 0.0%
    Call it Weigh in
  63. SLU-PP-332 In the news
    Experimental Evidence D ▲ 53.6%
    Call it Weigh in
  64. Structured/cellular hydration protocol
    Experimental ▲ 0.0%
    Call it Weigh in
  65. Sunlight / circadian light exposure (blue-light blocking)
    Experimental ▲ 0.0%
    Call it Weigh in
  66. Survodutide (BI 456906)
    Experimental Evidence C ▲ 34.8%
    Call it Weigh in
  67. Tadalafil (Cialis / PDE5 inhibitors)
    Experimental ▲ 0.0%
    Call it Weigh in
  68. Tesofensine
    Experimental Evidence B ▼ 32.7%
    Call it Weigh in
  69. Testosterone (TRT) In the news
    Experimental ▲ 34.6%
    Call it Weigh in
  70. Topical exosome serum In the news
    Experimental ▲ 0.0%
    Call it Weigh in
  71. TRT (Testosterone Replacement Therapy)
    Experimental Evidence A ▲ 40.2%
    Call it Weigh in
  72. VIP (Vasoactive Intestinal Peptide)
    Experimental Evidence C ▲ 36.0%
    Call it Weigh in
  73. Vitamin B12 (methylcobalamin)
    Experimental ▲ 0.0%
    Call it Weigh in
  74. Vitamin K2 + D3
    Experimental ▲ 42.0%
    Call it Weigh in
  75. Whole-food herbal supplements
    Experimental ▲ 0.0%
    Call it Weigh in
  76. Zinc (lozenges) In the news
    Experimental ▲ 21.9%
    Call it Weigh in

Overhyped/Fading 2

The claims outrun the evidence, or the moment already passed.

  1. C60 (Buckminsterfullerene)
    Overhyped/Fading Evidence E ▼ 25.0%
    Call it Weigh in
  2. Urolithin A
    Overhyped/Fading Evidence D ▼ 6.4%
    Call it Weigh in

Missing something?

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