Supplements & Ingredients

15 Top Trustworthy Supplement Brands (That You Should Use)

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By:Nick

Updated:

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Best Dietary Supplement Brands & Companies
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Until recently, I started my day with a mountain of pills, powders, and capsules.

One day I ran out of a product and bought a new brand. The product had the same dose but the capsule doubled in size. I investigated.

Each new capsule contained fillers, excipients, and plenty of other inactive ingredients. The first product didn’t have them, so surely the second cheaper brand didn’t need them either.

It turns out that not all supplement brands or products are the same. Choosing reliable brands ensures that you receive a product with the actual active ingredients inside, no questionable fillers, and most importantly, no contaminants.

In this post I will present the best supplement brands that meet the highest purity, safety, and trustworthiness standards:

  • Certified by one of more regulatory agencies
  • Vigorous safety testing
  • Trusted by medical practitioners
  • Minimal filler
  • Products mostly made in the USA
The Best Major Supplements Brands of 2025

Biohacker Favorite: BiOptimizers

Peptides: LVLUP Health

Whole-Food Based: Paleovalley

Ingredients: Qualia Life

The Wrong Supplement Manufacturer Are Worse Than Useless

Dietary supplements do not fit into the category of either food or drug, so the FDA turns a blind eye. Manufacturers notoriously cut corners whenever possible for a leg up on their rivals.

Filling this need, third-party companies evaluate products for effectiveness and safety.

Every year new headlines come out about contaminated supplements. The results of many such tests are dismal.

A study on athletes found that supplement users unintentionally consumed products adulterated with banned substances. This devastated the career of Olympic swimmer Jessica Hardy. And Jessica was proactive. Before buying she had contacted the company for safety and purity information on their products. Not an athlete?

Smart drugs, or brain-enhancing nootropics have similar issues with purity. Memory supplements contained little to no active ingredients, yet substantial contamination.

One of the larger tests of 138 common dietary supplements found worrisome levels of toxic molds, yeast, and fungi.

Another more recent 2018 study identified unapproved pharmaceutical ingredients in a staggering 776 dietary supplements. What kind of products? Those marketed for sexual enhancement, weight loss, or muscle building. From that same report:

“157 products (20.2%) contained more than 1 unapproved ingredient.”

It still happens today.

In June 2019 the FDA seized 300,000 containers of contaminated products.

Due to widespread product contamination and new untested brands bombarding store shelves, choosing a safe and reliable supplement brand is critical to your health and wellbeing.

The Best Honest Supplement Companies

My research on the below companies comes mostly from their own websites along with personal testing and third-party evaluation.

Note that I haven’t included all supplement vendors below, rather only the biggest and most popular.

These online supplement sellers don’t stock everything. For niche supplements, check out these posts:

  • Where to buy quality therapeutic peptides online
  • Reputable bioregulator peptides sellers
  • Where to buy brain boosting nootropics online

You’ll find many other high-quality lab-tested supplement brands in my online shop.

BiOptimizers

BIOHACKER’S FAVORITE
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If you’ve taken supplements for any period of time, you’ve likely come across BiOptimizers. They have among the lowest return rate of any supplement company. That’s because they extensively research how to best solve their own problems and those of their clientele (pro athletes, CEOs, etc).

Using the highest-quality, most bioavailable forms of nutrients (often costing them 200-400% more than their competitors). If they cannot produce the best product in its category, they don’t.

They use organic ingredients wherever possible, and manufacture in the Canda-based facility. BiOptimizers products are non-GMO; free of chemical fillers, binders, soy, dairy, and gluten; vegetarian and vegan-friendly; and backed by a generous no-questions-asked money-back guarantee.

Other notes:

  • Team includes a world-class Chinese herbal expert, an elite nootropic formulator, and top enzyme scientists
  • Scientific Advisory Board includes Dom D’Agostino; Monia Avdic, PhD; Sabina Halilovic, PhD
  • They work with the Burch University in Sarajevo
  • BiOptimizers has their own probiotics lab with multiple PhDs
Visit BiOptimizers

Use the BiOptimizers exclusive promo code URBAN to save 10%

LVLUP Health

BEST pEPTIDES
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LVLUP Health delivers advanced peptide and nutraceutical formulations designed to support the body’s innate healing capacities.

It sets itself apart by using only clean, functional fillers and formulating some of the most potent stacks on the market.

Founded by naturopath Kyal Van Der Leest in 2020, the company blends modern ingredients for fast-acting results with time-tested botanicals to support long-term health.

Just note that some of LVLUP’s products are for research purposes only. Regardless, their commitment to purity and quality encompasses all their products.

Kyal refuses to compromise on quality, and only releases products that he (and his family) personally take.

I still use their pre-workout, testosterone formula, metabolic optimizer, longevity formula, and more.

Ingredients: Pure, clinically-dosed ingredients free from common allergens.

Testing:

  • HPLC testing and third-party verification (MZ Biolabs) for purity, potency, and contaminants
  • Certificates of Analysis available on their website

Other notes:

  • Practitioner-formulated supplements
Visit LVLUP Health

Use the exclusive LVLUP Health code URBAN for 15% off

Activation Products

BEST NATURE-BASED FORMULAS
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Activation Products is a nature-based supplement brand emphasizing pure, plant-derived nutrients and superfoods. Focusing on supporting the body’s innate ability to heal itself.

It harnesses the wisdom of nature and intelligently applies technology to retain maximum bioactives and beneficial substances in each of their products.

The company was founded by Ian Clark as a result of his successful quest to resolve simultaneous life-threatening conditions.

Activation Products emphasizes transparency and quality control. For example, their Oceans Alive® uses photobioreactor-grown marine phytoplankton to eliminate ocean pollutants and ensure strain purity.

Manufacturing is performed in US-based facilities (Salt Lake City, UT), following rigorous processes.

Ingredients: 100% plant, mineral, and superfood-based.

Other notes:

  • Emphasis on simplicity and authenticity for natural health seekers.
  • Family-owned business
  • Team includes industry experts from the USA, Canada, Germany, Spain, Greece, & Australia
  • 60-day return policy
Visit Activation Products

Use Activation Products discount code NICK to save 15%

Paleovalley

BEST WHOLE-FOOD BASED
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Paleovalley is a whole‑food supplement brand dedicated to nourishing the body with nutrient-dense, minimally processed superfoods. It was co-founded by a Doctor of Holistic Nutrition, Dr. Autumn Smith.

Their supplements are based on extensive research and a strong understanding of the natural synergy of whole foods.

They also offer the cleanest possible snacks and are widely considered the premium supplier of natural supplements.

Paleovalley upholds strict purity measures, and their products undergo gentle processing methods like freeze-drying.

While not all products carry formal third-party certifications, their transparency, consumer reviews, and inclusion in ConsumerLab evaluations reflect a trusted reputation.

Ingredients: Grass-fed, pasture-raised, wild-caught or organic whole‑food sources. No synthetic vitamins, additives, preservatives, allergens, GMOs, and flow agents.

Testing:

  • ISO-certified and third-party lab testing for pesticides, contaminants, and nutrient integrity
  • Detailed reports for select products like bone broth protein

Certifications:

  • Strict no‑GMO, gluten-free, soy/dairy-free labeling
  • Produced in U.S. facilities under cGMP/FDA compliance
  • Some products evaluated by ConsumerLab
Visit Paleovalley

Click the button above to save 15% on Paleovalley products

Thorne

CLEAN & LARGE CATALOG
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Trusted by 12 U.S. National teams and many professional sports teams, Thorne research provides safe, effective products free of contamination. If you can’t (or don’t want to) risk accidentally consuming banned substances, Thorne’s got you covered.

They’ve been in business for decades, have great evidence-based formulas, and are one of my go-to brands.

Ingredients: Free of the common magnesium stearate filler or other unwanted absorption-inhibiting ingredients.

Testing:

  • They test for 760 contaminants to verify the identity, potency, and purity of each ingredient on their labels
  • Throughout the production process, each product undergoes four rounds of testing
  • Thorne has an outstanding reputation among third-party certifications

Certifications:

  • Current Good Manufacturing Practices (cGMP)
  • NSF-Certified products available
  • A1 rating from Australia’s ultra-strict Therapeutic Goods Administration (TGA)
  • Their manufacturing facility, warehouses, and shipping centers are regularly inspected and have passed every inspection without the issuance of an FDA Form 483

Other notes:

They have over 40 products in clinical trials around the world

Thorne produces ecologically and culturally responsible products

Visit Thorne

Performance Lab

BEST NOOTROPIC FORMULAS
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Performance Lab is a clean‑label, plant‑based supplement company focused on ultramodern formulations engineered for peak daily performance.

It offers the world’s first universal nootropic (Mind Lab Pro®) that enhances all facets of cognition in all types of people. It’s also the best-selling nootropic of all time.

Performance Lab was founded by David Wright, after his fascination with smart drugs led him to discover that those supplements weren’t so clean.

This led him to formulate cleaner and smarter nootropics without the downsides.

Now, the company formulates ultra-clean, high-performing supplements for different health needs. Utilizing a proprietary nature-identical process for manufacturing ingredients.

It combines research-backed nutrition technologies like NutriGenesis® lab-grown vitamins and minerals and vegan-delivery NutriCaps®/NutriGels®.

Each product is crafted based on the latest science and continuously refined with input from global academic research (including University of Leeds).

They are proudly non-GMO, vegan-certified, and packaged in recyclable or PCR-based materials.

Ingredients: 100% plant-based ‘nature-identical,’ highly-bioavailable nutrients through NutriGenesis® technology. Uses premium-grade, research-backed ingredients with no fillers, allergens, GMOs, synthetic colors, or additives.

Testing:

  • Multi-stage QA/QC including in-house and third-party ISO-certified testing for purity, potency, and label accuracy

Certifications:

  • FDA-registered manufacturing,
  • NSF
  • cGMP
  • Natural Products Association
  • UL
  • HACCP
  • USP-compliant heavy metals
  • EU Supplement Commission standards
  • B‑Corp

Other notes:

  • 30-day money-back guarantee
  • Vegan-delivery capsules infused with prebiotic fiber
Visit Performance Lab

Qualia Life Sciences

BEST INGREDIENTS
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Qualia is a science‑driven brain and longevity supplement company focused on supporting mitochondrial function, stress resilience, and long-term cognitive health.

It takes a systems biology approach to formulation, rigorously testing each product in internal clinical trials before it ever hits the shelf.

By using patented, proven ingredients, they ensure you’re getting the real deal—effective, targeted, and trustworthy.

It was founded by CEO James Schmachtenberger, Jordan Greenhall, Daniel Schmachtenberger, and Venessa Hall.

They aimed to address large-scale civilization challenges by enhancing mental and physical capacities through scientifically formulated supplements.

Qualia also adheres to high‑quality sourcing and transparency standards. All ingredients and dosages are fully disclosed so no proprietary blends. Most of their products also contain patented ingredients, the same ones used in studies, so you know you’re getting the real thing (and researched benefits).

The brand is widely trusted by healthcare professionals and enthusiasts alike.

Ingredients: Fully‑disclosed vitamins, amino acids, adaptogens, polyphenols, and mitochondrial boosters with natural and minimal excipients.

Testing:

  • Multi-stage quality assurance with third‑party lab testing for contaminants, potency, and label verification
  • Transparent Certificates of Analysis for batches

Certifications:

  • Produced in FDA‑registered, GMP‑compliant facilities
  • Non‑GMO, vegan, gluten-free
  • Follows ISO/USP standards for ingredient quality

Other notes:

  • Includes 100‑day money back guarantee
  • Ethically sourced
Visit Qualia Life

Use the exclusive Qualia promo code URBAN to save 15%

RnA ReSet

BEST MAGNESIUM
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RnA ReSet is a practitioner-designed supplement brand founded by Dr. Carolyn Dean, MD, ND, specializing in highly absorbable, liquid and capsule mineral and vitamin solutions.

Dr. Dean is the pioneering voice who first brought magnesium therapy into the spotlight. Because she realized most products on the market simply don’t deliver what they promise.

Built on over 40 years of clinical experience, RnA ReSet emphasizes pure, biochemically optimized nutrient delivery.

The brand offers ionic liquid formulas like magnesium, zinc, and B-complex in picometer-sized or nanoparticle form for enhanced cellular uptake.

Consumer feedback rates RnA ReSet highly (≈4.3–4.8★ across platforms) and emphasizes quality, value, and effective absorption.

Ingredients: No artificial colors, flavors, gluten, soy, artificial sweeteners, and GMOs.

Testing:

  • Quality control measures for purity and potency reported across product lines

Certifications:

  • cGMP-compliant manufacturing
  • Made in FDA-regulated facilities
  • Adheres to FDA labeling requirements

Other notes:

  • Transparent about formulation design
Visit RnA ReSet

Use RnA Reset exclusive code URBAN to get 10% off first orders

Healthgevity

INNOVATIVE FORMULAS
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Healthgevity is a cutting‑edge, science‑focused supplement company dedicated to unlocking the potential of bioactive peptides and longevity-enhancing nutraceuticals.

Utilizing science-backed ingredients and formulas that you won’t find inside any other product.

The brand collaborates with top medical researchers and clinicians to formulate advanced, orally bioavailable peptides, proteins, and natural compounds.

All aimed at optimizing healthspan, metabolism, cellular function, and gut health.

Products are designed for practitioners and health-conscious consumers seeking next-level nutritional innovation.

Healthgevity upholds rigorous quality standards, with their quality assurance system exceeding industry requirements.

The brand carries forward integrity with transparent supply-chain sourcing and clinical-grade R&D. Including patented ingredients like PeptiStrong with GRAS status and backed by clinical research.

Ingredients: Peer-reviewed peptides, proteins, and natural bioactives selected for oral bioavailability. Using only qualified, superior raw materials sourced globally.

Testing:

  • Internal and external QA/QC
  • Comprehensive evaluation criteria for identity, purity, quality, strength, and composition
  • Every batch analyzed for identity, potency, contaminants, heavy metals, pesticides, and microbes

Certifications:

  • Manufactured in US-based FDA-inspected facilities
  • cGMP

Other notes

  • Offers webinars and educational resources for healthcare professionals
Visit Healthgevity

Use Healthgevity discount code URBAN to save 10%

Life Extension

GREAT VALUE

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Supplement fans that want the highest quality without the cost of ultra-premium products have found their company.

A consumer favorite, Life Extension’s behind-the-scenes access to modern research ahead of the general public helps them get effective, tested products to you quickly. I use Life Extension often.

Ingredients: Raw, pure, and potent. 99% of their products are manufactured in the U.S

Testing:

  • A Certificate of Analysis (COA) is available for every product they produce
  • Voluntarily undergo Third-party ConsumerLab testing
  • International Fish Oil Standards (IFOS™) testing
  • Extensive internal testing of both active ingredient and potential contaminants

Certifications:

  • Non-GMO certified
  • Current Good Manufacturing Practices (cGMP)

Other notes:

  • They have a Super Sale every November with the best deals of the year. I like to stock up then
  • You can request the COA of any product to verify its safety
  • A #1 pick on ConsumerLab’s 2020 customer satisfaction report
  • Life Extension offers complimentary health counsel and guides to treating a number of conditions
  • A full year, no-hassle return policy
Visit Life Extension

Jarrow

GREAT VARIETY
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Often a choice behind Life Extension, Jarrow offers cutting-edge formulations in line with the latest research.

Their decades of stellar industry reputation help me get past my initial concern of not finding specific ingredient sourcing information online.

Ingredients: I could not find much information about their ingredients online.

Testing:

  • Raw materials and finished products both tested for contaminants of any kind
  • Products tested to confirm label accuracy and safety

Certifications:

  • Quality Assurance International (QAI)
  • Current Good Manufacturing Practices (cGMP)
  • USDA organic
  • California Department of Public Health Organic Processed Product
  • Non-GMO
  • Certified Kosher

Other notes:

  • They fund research studies on many of their products
  • Jarrow products have won dozens of industry awards over the last two decades
  • Their staff of scientists and health professionals are actively involved in clinical studies and continually work with researchers from universities and institutes around the world
  • One of the more established brands, Jarrow has produced supplements for nearly 43 years
Visit Jarrow

Swanson

BEST DEALS
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51 years on the market, Swanson is one of the oldest names in the industry. For those looking to get into supplements affordably, Swanson offers some of the best promos. Search just about any grocery store carrying supplements and Swanson products will turn up.

Ingredients: I could not find much information about their ingredients online. I did see some fillers in their products.

Testing:

  • Ingredients are tested for purity and potency at multiple stages throughout the production process
  • Voluntarily undergo Third-party ConsumerLab testing

Certifications:

  • Current Good Manufacturing Practices (cGMP) since 2001

Other notes:

  • They produce products in tailored quantities to reduce storage time, ensuring your supplements haven’t degraded by the time you use them
  • Swanson offers an “Absolute Satisfaction, 30-Day 100% Money-Back Guarantee”
Visit Swanson

Gaia Herbs

BEST HERBS
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Gaia brings 33 years to producing quality herbal supplements the right way. The herbal industry is rife with contamination. Not Gaia.

From biodynamic compost to advanced regenerative farming practices, you can feel safe knowing their herbs are among the most nutritionally dense options available. Their website provides complete transparency into Gaia practices.

Ingredients: Gaia grows and tests their own ingredients.

Testing:

  • Rigorous in-house testing for contaminants
  • DNA testing to verify that what you read on the label is what you will find in the bottle

Certifications:

  • Certified Organic through Oregon Tilth — one of the nation’s most stringent organic certifiers
  • Current Good Manufacturing Practices (cGMP)

Other notes:

They have a strong commitment to sustainability

An active partner of 11 herbal organizations

I love their handy herb reference guide to give you background on every plant

Their patented technology increases the absorption of concentrated plant extracts.

Gaia cares about people and the planet. They have all kinds of other certifications: Certified B Corp, Certified Monarch Waystation, Certified United Plant Savers Botanical Sanctuary

Visit Gaia Herbs

Standard Process

PRACTITIONER FAVORITE
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Standard Process understands that whole-foods supplements are only as good as the soil quality and inputs that go into producing the raw ingredients. They vertically integrate and rigorously test each batch of products for purity, safety, and consistency.

Standard Process goes the extra mile to actually work with practitioners and ensure that their patients get results.

For over 90 years, they’ve been deeply committed to sustainability, transparent manufacturing, nutrition research, and organic whole foods.

“Whole foods are the best natural source of vitamins. The key to the highest quality is the manufacturing process.” – Dr. Royal Lee, founder of Standard Process Share on X

Ingredients: Standard Process grows their ingredients in the rich soil of their organic farm. All ingredients undergo testing.

Testing:

  • In-house active ingredient testing
  • FTIR, HPTLC, HPLC, and wet chemistry testing
  • Raw materials and finished product quality testing

Certifications:

  • Certified Organic
  • Regenerative Farming
  • Current Good Manufacturing Practices (cGMP)
  • Green Tier

Other notes:

  • Extreme environmental responsibility
  • Preserves delicate nutrients for maximum natural potency and efficacy.
  • Uses whole foods-based ingredients whenever possible.
  • Nutrition Innovation Campus sponsors the latest nutrition research
  • Plants are harvested less than two miles from their production facility
Visit Standard Process

Designs for Health

GOOD CONSIDERATION
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Designs for Health has been a source trusted by healthcare professionals since 1989. From their leadership team to the formulation scientists they have extensive experience producing ultra-high-quality supplements.

They commit to putting science first. Designs for Health has a massive catalog of supplements for virtually any need.

Ingredients: Designs for Health ingredients are sourced from select heavily-scrutinized vendors.

Testing:

  • Raw materials testing
  • Finished product testing
  • Testing throughout manufacturing for ingredient identity, purity, quality, strength, and composition

Certifications:

  • Good Manufacturing Practices (GMP)
  • NPA
  • NSF
  • TGA
Visit Designs For Health

There are lots of other great supplement brands and manufacturers. These are the ones I have the most experience with.

Supplement Brands I Stopped Recommending

While many top manufacturers used to create high-quality products, as in all industries, ownership often changes.

Pure Encapsulations

As their name implies, people chose Pure Encapsulations (PE) for their extreme attention to both safety and quality. You knew exactly what you get from Pure products. If you have lots of allergies, sensitivities, or concern over quality look no further.

I stopped recommending them because they were purchased by Nestle and we have little to no insight if any of their formulas or processes have changed (as they often do when companies are sold).

Garden of Life

Another company purchased by Nestle years ago, that was once known for whole-food-based nutrition. I’ve examined the labels of a number of their products and was unimpressed to now find all kinds of excipients, flow agents, binders, and other unhealthy (and unnecessary) additives.

How To Verify Supplement Quality

No matter what company you choose, give their products a thorough evaluation. There are a few criteria that all quality supplement companies have in common.

Quality Control Certification

Manufacturers should test the raw ingredients before they produce their formulation. Look for a third-party inspection certification. The best common supplement certifications include USP and NSF.

Certain products like fish oil have their own certifications. In the case of fish oil, look for IFOS.

Reputable companies will often provide you with Certificates of Analysis (CoAs) of their final product when asked.

Check The Ingredients Label

Capsule and pill fillers can unnecessarily interfere with absorption, and cause reactions in sensitive individuals. High-quality products minimize or do not contain “inactive ingredients”.

Passes Third Party Testing

Labdoor and ConsumerLab both independently test products for purity and safety. They purchase the supplements themselves and run unbiased testing.

ConsumerLab subscribers can access thousands of reports but they also publish some for free. Labdoor, on the other hand, publicizes its rankings of products across 36 supplement categories.

You can find the two here:

  • ConsumerLab
  • Labdoor

Which Supplement Brand Will You Choose Next?

Brands change fast in the supplement world, which is why I prefer the ones with a long, proven track record. Their products have stood the test of time and have raving fans.

The more products you add, the more opportunity for contamination. Choosing from the above quality brands reduces that risk so you don’t have to worry.

What do you think? Who do you like for supplements?

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Post Tags: Recommendations, Supplements

6 thoughts on “15 Top Trustworthy Supplement Brands (That You Should Use)”

  1. I am worried about companies I used to trust that have been bought out. I just found out today that companies I buy from like Garden of Life and Pure Encapsulations where bought out by Nestle and it is not a recent transfer.

    Jarrow Formulas was bought out by New Mountain Capital. Swanson Health was bought out by Swander Pace Capital. Not sure about the others, but it does concern me that they no longer control what goes into their products and how they are manufactured. Perhaps they did not change, but how do we know? I absolutely don’t trust Nestle after finding out what they did on some of their own products. I prefer to buy from private companies, not these huge corporations.

    Please let me know your thoughts on this topic.

    Thanks!

    Reply
    • Hey Deborah, thanks for writing in!

      I’m with you on that. Based on their track records, I don’t really trust a lot of the major corporations with human health. The issue is, we really don’t know what (if any) changes they make. There are some exceptions. Companies that truly prioritize health and product quality. Some that advance the industry by publishing independent third-party lab testing reports. I wrote this post a long time ago and it really needs some updating.

      Reply
  2. I have been using Extend-Life Total Balance Unisex for several years and am completely satisfied with the
    results. I am 84 and in good health, partly, maybe, due to this supplement. I am an engineer by education
    and am a skeptic.
    Mostly, I believe my good health is due to working out hard with weights for the last 60+ years…no
    “muscle toning”, fairly good diet and sound sleep.
    What do you think?

    Reply

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