The top all-in-one longevity supplements make a profound difference to not only your lifespan, but your quality of life (healthspan).
I’ve researched and thoroughly evaluated dozens of the most powerful, natural, and safe science-backed anti-aging ingredients.
Here’s the issue…
Pulling out separate supplements canisters, manually weighing out powders, and cleaning up spillage consume tons of time. Plus, it requires scientific expertise to combine ingredients synergistically.
What if you could toss all the powders, pills, gels, sprays, and potions, and instead use an all-in-one anti-aging formula?
No more home chemistry lab. No more guesswork. No hassle, no mess.
Well, that’s now a reality.
Several brands make thorough longevity supplement complexes. Providing everything you need in one bottle.
Overall: AEON Black Longevity Complex
Clinically Proven: NOVOS Core
Cellular Energy: Qualia NAD+
Stem Cell Focus: Healthgevity Prime Time+
Superior Formula: LVLUP Health Longevity
In this article, I will share the best all-in-one anti-aging products to help you choose the right one for you.
All-in-one supplements deliver the “entourage effect”, giving synergistic benefits of combining multiple anti-aging compounds at clinical dosages
While offering convenience, lab-tested quality, and one-bottle simplicity, at a higher price and less ability to tweak individual doses
AEON Longevity Complex Black (Perpetua.Life) delivers a strong value proposition at ~$1.97 per serving, the Black version containing 11 compounds & the White with 9
Reputable brands like NOVOS & LVLUP Health include science-backed compounds at research-level doses in just 1-2 servings per day, offering convenience without sacrificing efficacy
Instead of managing 8-20 bottles, powders, and timing regimens, you take one or two products. This reduces daily decision fatigue & increases long-term consistency
Beginners avoid the complexity of formulation; advanced users can use a complex as a “base stack” and layer on experiments
Outliyr recommends this heirarchy for choosing the best longevity cpomplex: first buy vitamins, minerals, enzymes; next, amino acids and fatty acids; then NAD+ precursors & sirtuin activators; finally, nutraceuticals that amplify effects
The Top Longevity Supplement Complexes & All-In-One Products
Getting all your longevity supplements in one product has distinct pros:
Scientific. First, you’re getting a science-based blend handpicked by expert formulators. These formulas often have a synergistic “1+1=4” kind of effect. Getting you more benefits and fewer side effects. At clinically proven dosages.
Ease. The best all-in-one anti-aging supplements are easier to use and more convenient. You just toss the one bottle in your bag and have it with you anywhere you go. Without making a mess.
Safety. Less worry about contamination, adulteration, and toxicity. The dark side of the supplement industry is that many contain more problematic ingredients than they do the active ingredient on the label. Trustworthy brands have unaffiliated third parties test their final products to ensure you’re getting exactly what you expect.
There are two main drawbacks…
Price. Formulas that contain a ton of different ingredients in their best, most absorbable forms often cost more than standalone raw powders.
Dosage. Increasing or decreasing your doses of specific ingredients isn’t possible when using a multiple-ingredients-in-one supplement.
Overall, the benefits of multi-ingredient longevity supplements greatly outweigh the drawbacks. That is, if you choose the right ones.
Below are my top picks for the best all-in-one longevity supplement complexes.
Perpetua.Life AEON Longevity Complex Black
Absorption: Liposomal
Formula: Full-spectrum NAD+ precursors with an 11-compound blend
Form: Capsule
Serving Size: 2 capsules per serving
Cost Per Serving: $1.97
Lab Tested: Yes
Rating: 4.68
Pros
- Comprehensive all-in-one formula constantly improved upon
- Budget-friendly even with the comprehensive formula
- Third-party tested quality
- User-reported vitality, skin, hair improvements
- Highly-rated among independent reviewers
Cons
- Occasional delivery or support complaints
- Should mainly be taken in the mornings because of effects in energy
If I could only choose one all-in-one anti-aging supplement formula, it would likely be AEON by Perpetua.life.
This product evolves alongside the latest research, and I’ve received excellent support that answers my every question.
From minute details such as how they landed on particular doses, to why they chose particular ingredients over others.
In fact, a while back I suggested they add a particular ingredient. Fast forward to today’s V3.0 formula and it’s now included. Same with their B vitamin complex.
I asked them to upgrade to the more expensive and superior form of activated Vitamin B6, and they did.
I’m hesitant to list each of the ingredients since the formula constantly changes. At the time of this writing, the AEON longevity supplement complex includes:
- Nicotinamide DUO™ (as 400mg NMN + 100mg NR)
- Quercetin – 250mg
- Trans-Resveratrol – 150mg
- L-Theanine – 100mg
- Fisetin – 100mg
- Astragalus – 100mg
- TMG – 85mg
- Spermidine – 10mg
- Piperine – 10mg
- Epigallocatechin gallate (EGCG) – 100mg
11 compounds all in one.
Not only is this a well-rounded ingredient profile, but they designed the product with customization in mind.
Based on your experience, you can just take one capsule. Or you can increase your dose as desired.
Plus, the product page contains their latest third-party Certificate of Analysis (CoA), showing the purity and potency of the latest supplement batch.
If you subscribe, each dose comes out to just above $1.50. Yep, for all 11 ingredients in one.
That’s why AEON has been featured in major publications like Scientific American, Inc., and Entrepreneur. It’s the hot affordable NOVOS Core alternative.
AEON Longevity Complex Black is among the most affordable comprehensive longevity supplements.
NOVOS Core
Absorption: Standard
Formula: Proprietary mix of 12–13 scientifically backed longevity ingredients
Form: Powder
Serving Size: 1 sachet
Cost Per Serving: $3.63
Lab Tested: Yes
Rating: 4.52
Pros
- Developed by scientists from Harvard Medical School, MIT, and other institutions
- Documented results
- Vegan, gluten-free, non-GMO, no added sugar or calories
- Flexible Use as you can mix with water, juice, smoothies, etc.
Cons
- Pricey
- Some users report initial stomach discomfort, though taking with food often resolves it
- Needs mixing so less convenient than capsules
Of all the top longevity supplement complexes, NOVOS Core is likely the most popular.
That’s because their product, not just individual ingredients, has the backing of actual research. Third-party research has shown that Core works.
The NOVOS science team hails from top institutions like Harvard Medical School and MIT. They formulated the product to target all the known root causes of aging.
What really sets them apart, however, is their unique approach and excellent marketing.
Since NOVOS Core comes in a powder sachet, they’re able to fit bioactive doses of more ingredients. They claim that one serving contains the “equivalent of 19 pills worth of active ingredients”.
Apparently, up to ten times more bioactive ingredients than other products.
Ingredients within the NOVOS Core supplement include:
- Glycine – 2,000mg
- Magnesium Malate – 1,700mg
- Calcium Alpha-Ketoglutarate (Ca-AKG) – 1,100mg
- GreenGrown® Glucosamine Sulfate – 1,000mg
- Rhodiola Rosea Root Extract – 300mg
- L-Theanine – 150mg
- Hyaluronic Acid – 100mg
- Fisetin – 100mg
- Organic Ginger Root Extract – 100mg
- Pterostilbene – 50mg
- Lithium Aspartate – 20mg
Overall, this is a solid formula. I like that the include the adaptogen rhodiola, Ca-AKG, magnesium, and the better resveratrol alternative, pterostilbene.
Plus, they now have a comprehensive epigenetic age test that will help you see if the changes you make to your lifestyle actually brings you closer to your health goals.
While impressive, some of the main bioactives (like glycine and magnesium malate) are cheap raw ingredients. I buy glycine by the kilogram (1,000 grams), for example, at around $50.
Depending on your purchase type, the price comes out between $2.63 to $3.63 per serving. I could DIY it for around $1.00 per serving.
Some of the biggest names in health back NOVOS. You know what you’re getting when you buy from them. Consistently, every time.
You’re paying a premium to get the exact benefits of particular ingredients, proven by the research.
If you want a true clinically proven, all-in-one product with the highest dosages of many beneficial longevity supplements, NOVOS Core is a clear (premium) winner.
LVLUP Health Longevity
Absorption: Standard
Formula: Combines 2 NNMT-inhibiting peptides, NAD+ precursors, antioxidants & sirtuin-supporting botanicals
Form: Capsules
Serving Size: 2 capsules per serving
Cost Per Serving: $5.33
Lab Tested: Yes
Rating: 4.55
Pros
- The company constantly innovates and stays on top of the research & science
- Independent testing and purity focus on ingredients
- Reported other positive side effects like better gut health & increased energy
Cons
- Expensive
- Some customers have complained about difficulty cancelling subscriptions
Founded by naturopath Kyal Van Der Leest, LVLUP Health produces some of the best, most cutting-edge supplement formulas available. Kyal stays ahead of the science so you don’t have to.
Each of his products is the equivalent of about 5-10 supplements all in one, and this is no exception.
LVLUP Health Longevity is no exception! This product features some novel ingredients you won’t find elsewhere. Including two small molecule peptides. LVLUP Longevity contains:
- 5-Amino 1MQ – 100mg
- Epitalon – 3mg
- JBSNF-000098 – 6mg
- NMN – 600mg
- NR – 75mg
- Pterostilbene – 50mg
- Quercetin + EMIQ – 200mg
- Fisetin – 120mg
- Apigenin – 60mg
Before you balk at the low dosages of NMN and NR…
You won’t find an ingredient profile anywhere like this. Epitalon is considered the king of anti-aging peptides (for telomere length and pineal gland health). 5 Amino, JBSNF, and Apigenin work together to inhibit the NNMT and CD38 enzymes which increases NAD+ levels.
Then, NMN, NR, and Pterostilbene synergize to maximize the activity of sirtuins and longevity proteins. Quercetin, EMIQ, Fisetin, and Apigenin together have anti-senolytic properties.
Not only do you address most of the hallmarks of aging with this one product, but it also dramatically boosts energy levels, cognitive and mental performance, metabolic health, and reduces body fat.
The downsides? Price. These formulas are expensive. He’s also opening a warehouse in the USA soon. But for now, it ships from Australia so it can take a week or so to arrive.
If you want the very best all-in-one longevity supplement with additional nootropic, energy, metabolic, and weight loss benefits (and don’t mind paying the premium), you can’t beat LVLUP Health Longevity.
Perpetua.Life AEON Longevity Complex White
Absorption: Liposomal
Formula: NAD & NR plus key ingredients like Curcumin & AKG in a 9-compound formulation
Form: Capsule
Serving Size: 2 capsules
Cost Per Serving: $1.97 per serving
Lab Tested: Yes
Rating: 4.60
Pros
- Reviewers emphasize its strong mix of antioxidant & anti-inflammatory agents
- Designed to support deep rest and recovery
- Vegan & easy to consume
Cons
- Sparse user reviews yet
- Insufficient research on consumption for pregnant women & children
Perpetua.Life’s AEON White is an anti-aging complex designed to work with your body’s natural nighttime repair cycle.
It’s built around a 9-compound complex, including:
- NMN & NR duo – 500mg
- Curcumin – 500mg
- Alpha-Ketoglutarate (AKG) – 300mg
- Apigenin – 100mg
- Glycine – 100mg
- Taurine – 100mg
- Astaxanthin – 12mg
- Low-dose lithium – 1mg
The key ingredients like curcumin and alpha-ketoglutarate (AKG) help calm inflammation, support mitochondrial function, and encourage restorative processes that peak during sleep.
All of these are carefully selected to reduce oxidative stress, calm the nervous system, and promote deep, restorative sleep.
So, while you rest, these compounds support autophagy, mitochondrial renewal, and DNA repair, helping your body recover at the cellular level leading to healthy aging.
That being said many people pair the White version with the AEON Black for a 24-hour longevity bundle, but you don’t need the daytime version for the nighttime complex to work.
You can get both in the Perpetua.Life AEON Black & White Bundle with the discount code below too.
Get AEON White for an anti-aging complex you can take at night to support deep sleep, cellular repair, and long-term healthy aging.
Healthgevity Prime Time
Absorption: Standard
Formula: Spermidine plus a potent mix of antioxidants & cellular-support compounds
Form: Capsule
Serving Size: 3 capsules per serving
Cost Per Serving: $4.17
Lab Tested: Unspecified
Rating: 4.39
Pros
- Includes well-researched botanicals & extracts
- Non-GMO, gluten-free, vegetarian & suitable for many dietary preferences
- Reported smoother digestion compared to other supplements w/ spermidine
Cons
- Expensive
- No mentions of third-party testing
- Focused on cellular health so may need to add a blend with (NAD, NR, NMN, etc)
Healthgevity’s Prime Time+ is a longevity formula focused on stem cell optimization to boost your body’s natural renewal processes via stem cell actions.
It is formulated to support your aging by mimicking the effects of fasting, triggering autophagy, and clearing damaged cells. It promotes healthy aging by giving your cellular health a massive boost.
The ingredients in their formula include:
- Spermidine – 10mg
- CyanthOx™ Sea Buckthorn Extract – 300mg
- StemEnhance® – 250mg
- Fucoidan from Mekabu – 250mg
- AstaReal® Astaxanthin – 6mg
- AstraGin® (Astragalus membranaceus & Panax notoginseng) – 50mg
- Alpha-ketoglutarate (AKG) – 500mg
- CyaninPlus® Blue Spirulina Extract – 250mg
- Pure Mune™ organic yeast beta 1,3 /1,6 glucan – 30mg
- Apigenin – 50mg
- Luteolin – 100mg
- Ioniplex® (Fulvic Ionic Mineral Complex) – 50mg
This is a formula that targets one of the body’s most fundamental repair systems: stem cells.
I found this multi-targeted approach makes Prime Time+ a notable contender for supporting longevity and vitality.
If you want to focus on stem cell optimization specifically, here are other supplements to increase stem cells naturally.
Healthgevity’s Prime Time+ is a meticulously designed anti-aging supplement that aims to optimize stem cell function, autophagy and overall cellular health.
Mimio Biomimetic
Absorption: Standard
Formula: 4 key compounds
Form: Capsules
Serving Size: 2 capsules per serving
Cost Per Serving: $3.33
Lab Tested: Yes
Rating: 4.22
Pros
- Uses molecules that mimic prolonged fasting benefits without needing to fast
- Simple and clean formula supported by certifications & transparency
- Users have reported renewed energy for physical activity
Cons
- Reliance on novel metabolic mimetics, meaning long-term human data is still developing
- Modest ingredient list, which might feel less comprehensive compared to multi-compound blends
Mimio Health is a newcomer to consumer longevity supplements. Although they only revealed their flagship formula two years ago, it has made waves in the industry.
Why?
Research suggests that this formula simulates the same pathways and benefits of a 36-hour fast. All while you get to enjoy eating your favorite foods.
This is the closest thing we have to fasting in a pill.
Each serving contains clinical dosages of just four ingredients:
- Niacin – 250mg
- P.E.A – 600mg
- O.E.A – 400mg
- Spermidine – 8mg
Unlike most brands, Mimio has actually studied how these ingredients work together.
Counterintuitively, they discovered that lower dosages of certain substances worked better than the typical recommendations—but only when combined.
Mimio has pioneered the first biomimetic cellular health supplement, and the results speak for themselves.
37% of customers report appetite suppression, 35% report sustained energy, 31% report improved focus, and 30% report greater endurance.
I like this unique formula because it’s distinctly different from everything else in the market. OEA and PEA are fascinating molecules that deserve more recognition.
As you’d expect, they lab test their product and back it by a 30 day money-back guarantee.
Mimio Health offers the only biomimetic formula studied to replicate the longevity (and performance) benefits of a 36-hour fast.
Qualia Mitochondria+
Absorption: Standard
Formula: Blend of 34 premium ingredients that enhance cells & mitochondria
Form: Capsule
Serving Size: 8 capsules
Cost Per Serving: $5-$5.50
Lab Tested: Yes
Rating: 4.32
Pros
- Most premium compounds in one
- Synergistic formulation developed by researchers & designed to support multiple cellular pathways
- Save a massive 50% for the first shipment by subscribing
- Flexible dosing regimen (5 days on, 2 off) for tolerance and adaptation
Cons
- Also expensive (although you can save on the first shipment when subscribed)
- Large daily serving size (although 8 capsules are not taken at one time)
The team behind the Qualia line of supplements makes some of the most comprehensive multi-ingredient products on Earth.
They take a systems biology approach to formulation, making sure to positively impact each pathway.
Qualia Mitochondria (previously called ‘Life’) is their answer to slowing biological aging. And much more, including:
- Productivity
- Sleep
- Energy
- Mitochondrial fitness
- Cellular energy
- Stress management
They achieve this by using clinical dosages of 100 different ingredients.
On the product page, Neurohacker explains how they chose each ingredient and dosage. Dare I say this is the most advanced supplement on the market?
Basically, Qualia Mitochondria is like the modern upgrade to a multivitamin/multimineral that’s specially tuned to longevity.
Plus, Neurohacker actually runs and publishes the trials behind each of their products.
They then back Qualia Mitochondria with a full 100-day money-back guarantee. All this together explains why Qualia Mitochondria is a favorite of many healthcare practitioners.
The downside?
It’s expensive, and one serving is eight capsules. I wish they turned Mitochondria into a powdered drink like NOVOS!
Qualia Mitochondria is a premium all-in-one longevity supplement that uses clinical dosages of 100 different ingredients—potentially replacing multivitamins, multiminerals, nootropics, NAD+ boosters, adaptogens, and more.
Thorne Advanced Nutrients
Absorption: Standard
Formula: A blend of compounds including vitamins A, C, D, NR, NAD+ & more
Form: Capsules
Serving Size: 8 capsules per serving
Cost Per Serving: $2.23
Lab Tested: Yes
Rating: 4.01
Pros
- High-quality manufacturing w/ NSF-certified production
- Broad foundational support, suitable as a core daily multi-nutrient supplement
- Trusted by professionals & sports organizations like the UFC
Cons
- Serving size may also feel excessive
- Ingredient transparency limited in summary, full formula details require deeper lookup
Thorne is the go-to company for those who demand maximum purity supplements.
Olympians, professional sports teams, law enforcement personnel, and those who are drug tested turn to Thorne for their quality guarantees.
Although they have a massive supplement catalog, Thorne offers very few longevity and aging products.
Thorne Advanced Nutrients is their answer. This appears to be their version of Qualia Mitochondria. Paired down significantly, and at a much more affordable price.
Thorne opted to go heavy on vitamins and minerals. In fact, all but four ingredients are these essential nutrients.
What I like about it is that Advanced Nutrients is truly an advanced multivitamin and multimineral. With a few upgrades. Most notably anti-aging ingredients include nicotinamide riboside (NR), and resveratrol.
Thorne Advanced Nutrients is the enhanced longevity multimineral and multivitamin product renowned for the brand’s attention to quality.
Qualia NAD+
Absorption: Standard
Formula: Three NAD+ precursors plus B-vitamins, Aquamin minerals & more
Form: Capsules
Serving Size: 2 capsules per serving
Cost Per Serving: $2.46
Lab Tested: Yes
Rating: 4.19
Pros
- Clinically shown to boost NAD⁺ by up to 50-67% in human users
- Includes more NAD+ precursors for robust metabolic support
- Non-GMO, vegan, gluten-free
- Save a massive 58% for the first shipment by subscribing
Cons
- More focus on NAD+ than an all-in-one blend
- Mild side effects like flushing
When researching the hottest longevity tips and supplements, you’ve likely come across the term “NAD+”. Often dubbed the body’s currency of cellular energy.
When the body has adequate energy, the entire system works better.
Some of the most common supplements used to boost NAD+ levels are called Niacin, Niacinamide, nicotinamide mononucleotide (NMN), and nicotinamide riboside (NR).
This product contains three. Plus, an additional eleven ingredients.
The entire formula was thoroughly researched, designed, and proven to increase NAD+ levels by up to 50%.
In fact, Qualia carried out a study of healthy adults using their final product. They had the following impressive results:
- Healthy Aging Score improvements in 91% of men and 100% of women
- 90% of participants would buy again
- 95% of participants rated their experience with Qualia NAD+ as “good” to “excellent”
Although I’m young and shouldn’t notice much effect, I often take a capsule or two most days. This is one of the few longevity supplements that noticeably increases my energy.
I’ve written an in-depth review on NAD+ so if you want to learn more about Qualia NAD+ and the best NAD+ supplements I recommend, check it out!
Final product testing shows that Qualia NAD+ increases levels of NAD+ effectively, plus it contain some of the most popular longevity ingredients that are great for physical and mental energy.
HOP Box Longevity
Absorption: Standard
Formula: 19-ingredient formula for cellular repair, energy, organ health, & more
Form: Capsules
Serving Size: 2 capsules per serving
Cost Per Serving: $6.63
Lab Tested: No
Rating: 4.12
Pros
- Users report positive changes in energy, skin, etc
- Broad coverage of ingredients fitting of an anti-aging complex
- Dairy-free, vegetarian, gluten-free
- cGMP, NSF, and TGA-certified
- Just $99 on the first month of subscription ($154 thereafter)
- Great educational content on website
Cons
- High cost per serving even with subscription
- Marketed for women but equally effective for men
- Some people might not want to use dihydroberberine daily
Formulated by ex ER doc, Dr. Amy Killen, HOP Box Longevity is the first daily longevity supplement complex for women.
Each box contains pre-packed AM and PM pill packets to simplify your supplement routine.
The formula includes 19 science-backed ingredients including:
- Nicotinamide Riboside (NAD+ Precursor)
- Calcium alpha ketoglutarate (CaAKG)
- Astaxanthin
- Spermidine (as Puremidine®)
- Quercetin
- Fisetin
- Apigenin
- Curcumin (as CurcuPrime®)
- Dihydroberberine (as GlucoVantage®)
- Tributyrin (as NewBiome®)
- Active B-vitamins (methylcobalamin, 5-MTHF, P5P)
- Vitamin D3 + K2-MK7
- TMG
HOP chose to use the enhanced or active forms of each ingredient for improved bioavailability.
This longevity supplement system is marketed primarily toward women, primarily with the benefits on skin, hair, glow, and aging.
I don’t see any specific tailoring of ingredients or dosages to female physiology, so the “for women” tagline appears primarily for product positioning (good news for men).
The main downside is price. This product is quite expensive. They do offer a cheaper HOP Box Mini for under $50 if you want to test it out for a week first.
Get HOP Box if you want to simplify your routine with a longevity complex that covers a wide range of synergistic ingredients.
RBS Senolytique
Absorption: Liposomal
Formula: Liposomal Quercetin, Fisetin, & Spermidine
Form: Capsule
Serving Size: 1 capsule per serving
Cost Per Serving: $0.87
Lab Tested: Yes
Rating: 3.45
Senescent cell accumulation is one of the core causes of aging. Basically, these cells go rogue and consume tons of energy and create toxins without performing their normal functions.
Depleting precious resources, causing systemic inflammation, and accelerating the biological aging process.
Activator is a Formula that combines three of the most powerful senescent cell-eliminating supplements into one.
Each capsule contains quercetin, fisetin, and spermidine precisely dosed to act as an anti-senolytic.
The ingredients are packaged into nano-sized fat droplets to help bypass degradation by stomach acid and enter the bloodstream.
Dramatically increasing absorption, benefit duration, and reducing side effects… all with much lower than normal dosages.
This formula also activates AMPK, shifting the body into repair mode. At the same time, this supplement indirectly increases levels of NAD+ And even boosts the creation of new mitochondria.
This helps reduce body fat accumulation and increasing the body’s energetic reservoir.
Interestingly, this is one of those products that’s often recommended to pulse. Rather than using it daily, I prefer a version of the “hit-and-run” protocol often used in clinical research.
3-7 days of daily use followed by a break for the rest of the month.
After about age 50, using a high-quality senolytic supplement complex like Activator can significantly improve quality of life and potentially lifespan.
Life Extension Mix
Absorption: Standard
Formula: High-potency multivitamin/mineral blend with fruit, vegetable, & botanical extracts
Form: Capsule
Serving Size: 12 capsules per serving
Cost Per Serving: $0.16
Lab Tested: Yes
Rating: 3.38
Pros
- Affordable per-serving cost, especially at scale
- Strong testing transparency and certifications
- Extensive nutrient coverage as with other formulations
Cons
- Large serving protocol can be extremely impractical
- Not specifically targeted for longevity pathways like NAD⁺ or senolytics
Of all the massive supplement conglomerates, Life Extension usually has my favorite products.
They have a shockingly MASSIVE inventory of supplements, and entire teams dedicated to science and formulations.
Life Extension Mix is their all-in-one, providing vitamins, minerals, and phytonutrients from fruits & vegetables.
Overall, the blend is very comprehensive. It contains the “kitchen sink” of key nutrients as well as beneficial longevity ingredients. Some of which are in their optimal, most bioavailable forms.
Although you can get 360 capsules for around $45, note that each serving consists of a whopping 12 capsules. Making a 360-pill bottle last only 30 days.
Interestingly, Life Extension does sell its mix in several different forms.
With extra niacin, without copper, and as a powder too. But the powder is far less popular. Probably because you’ll need a blender to thoroughly mix it.
Life Extension mix contains a wide variety of vitamins, minerals, and fruit and vegetable nutrients, but each serving consists of an entire 12 capsules and each ingredient individually isn’t the most effective (due to the form and dosing).
The Ultimate Longevity Protocol

Longevity supplements can get confusing:
Are you wasting money?
Is there significant overlap (and also gaps) in the pathways the supplements activate?
Is the product making a difference?
What if you can simplify your life, take fewer products, and get better effects?
This is all possible, and it comes down to this…
A well-designed longevity stack.
Ideal formulations contain multiple ingredients. Each targets and improves different facets of biological aging.
Keeping you looking and feeling younger and performing optimally.
Together, a multi-supplement formula is more effective than the sum of the parts. This is called the entourage effect, and it’s best understood as the “1+1=3 effect”. And, this powerful ingredient biosynergy often comes with fewer side effects.
So I designed a simple “Longevity Upgrade Cheatsheet” to summarize the benefits of 30+ popular longevity supplements as well as provide my universal essentials. Download it here…
The Best Complete All-In-One Anti-Aging Supplements Ranked
Longevity supplement complexes are among the best biohacking tools for upgrading your health. But finding the right longevity stack gets tricky.
- Which ‘super ingredients’ do they contain?
- Do they include the appropriate dosages of each?
- Are they lab-tested for purity and potency?
- Will they fit into your budget?
Your unique lifestyle and goals will help determine those.
The most important fundamental longevity supplements will address your core nutrient needs. If you’re deficient in vitamins, minerals, or enzymes, many bodily systems will suffer.
Similarly, if you don’t consume enough amino acids or dietary fats, you’re missing raw materials needed to efficiently power cellular processes.
Then, you’ll need to provide the body with ample cellular energy. Master protection proteins called sirtuins require lots of NAD+ to work properly.
When you lack NAD+ or sirtuin activation, degeneration ensues and biological aging accelerates Share on XFinally, we have the flashy anti-aging individual ingredients. The food-derived nutraceuticals and other powerful compounds.
These can amplify the effects of everything else and make a big difference in the way you look, feel, and perform.
The products mentioned in this article help take the guesswork out of supplementation to slow biological aging. Making it easier, more convenient, and sustainable.
These are just some of the ones I like most. Give them a try.
Alternatively, you can also build out a custom longevity supplement stack personalized for yourself.
What about you?
Do you use an all-in-one longevity supplement complex (or multiple)? Let me know in the comments below and we’ll make this a conversation!
Have You researched Nuchido Time+? I’m wondering how they compare to Aeon.
Regards,
Michael
Hey Michael!
I have. I actually put that in a different article on the top NAD+ supplements.
Hope that helps,
Nick