Methylene blue supplements were among the hottest topics at both the Health Optimisation Summit and Biohacking Conferences in 2025.
For good reason…
Methylene blue was called a 'magic bullet' for its ability to eradicate pathogens without harming human cells Share on XIt’s claimed to improve:
- Energy & metabolic health
- Oxygen utilization
- Mood & mental health
- Neuroprotection
- Cognition & memory
- Immunity
- Nitric oxide levels
- Longevity
With the rising popularity of this “cellular supercharger,” there are now more products on the market than ever. But it’s not all equal.
Purity ranges from toxic fish tank cleaner, up to pharmaceutical grade. Some products also combine other ingredients with it for a synergistic effect.
In this article, I’ll guide you through the best methylene blue supplements of 2025, and my reviews of each.
Overall: LVLUP Health Mito Blue
Cognition: MitoZen Satori™ Bars
Relaxation: BioLight BioBlue Calm
Sustained Release: BioBlue (SR)
Skincare: BioLight BioCream
What is Methylene Blue?
Methylene Blue (MB) is a fascinating, rediscovered compound that’s gaining immense popularity in the health optimization world.
It started out over a century ago as a blue dye. Later, as a medical treatment for conditions like malaria and a rare blood disorder (methemoglobinemia).
Then, doctors, biohackers, and nootropic enthusiasts noticed something: MB enhances brain function, mental clarity, and cellular energy.
Now, a substantial and growing body of robust, peer-reviewed research shows that MB supports mitochondria, protects the brain, and even slows aging.
Organs with disproportionately high mitochondrial density (brain, heart, eyes, skin, muscle, liver, kidneys, genitals, etc) are most protected by methylene blue Share on XWant to learn more about how methylene blue works and how a blue dye turned out to be a miracle molecule? Read my guide on methylene blue benefits, uses, and science.
The Best Methylene Blue Supplements
I’ve used MB intermittently since around 2017, testing different forms, doses, and frequency.
It’s now one of the tools in my BioHarmony toolkit for focus, mood, longevity, cellular energy, and performance—without the crash.
This comparison table will help you quickly compare and choose what works best for you.
| Product 🧠 | Intended For 🔍 | Form 💊 | Net Content ⚖️ | MB Only Or Blend* ⚗️ | MB Dosage Per Serving 🧪 | Servings Per Container🥄 | Cost Per Serving 💰 | USP Grade MB💎 | 3rd-Party Lab Tested/CoA 🔬 |
|---|---|---|---|---|---|---|---|---|---|
| LVLUP Health Mito Blue | Mitochondrial optimization | Capsule | 60 capsules | Blend | 10mg/capsule | 60 | $1.65 | ✅ | ✅ |
| SwissChems Methylene Blue Solution | Research | Liquid, 0.05% solution** | 1fl.oz (30ml) | MB | 5mg/ml | 30 | $0.53 | ❌ | ✅ |
| MitoZen Satori™ Bars | Learning & memory | Bar | 30 bars | Blend | 5mg/¼ bar | 120 | $1.04 | ✅ | ❌ |
| Mitozen Lumetol Blue™ | Enhanced light therapy benefits | Bar | 30 bars | Blend | 10mg/¼ bar | 120 | $0.75 | ✅ | ❌ |
| BioLight BioBlue | Longevity | Liquid, 1% solution** | 2fl.oz (59.2ml) | Blend | 10mg/ml | 59 | $1.51 | ✅ | ✅ |
| Troscriptions Just Blue | Cellular revitalization | Troche | 4 troches | MB | 4mg/¼ troche | 16 | $1.69 | ✅ | ✅ |
| Biolight BioBlue Calm | Relaxation & serenity | Liquid, 1% solution** | 2fl.oz (59.2ml) | Blend | 10mg/ml | 59 | $1.85 | ✅ | ✅ |
| Wizard Sciences MitoBlue RX | Clarity, cognition, focus, & energy | Capsule | 60 capsules | Blend | 2.5mg/capsule | 30 | $3.33 | ❌ | ❌ |
| BioLight BioBlue (SR) | Sustained release | Liquid, 1% solution | 2fl.oz (59.2ml) | Blend | 5mg/ml (MB); 5mg/ml (LMB)§ | 59 | $2.19 | ✅ | ✅ |
| BioLight BioCream | Skin integrity | Cream | 1.7oz (50ml) | Blend | Unspecified | 100‡ | $1.09 | ✅ | ❌ |
| Bluelene Night Cream | Affordable skin care | Cream | 1fl.oz (30ml) | Blend | Unspecified† | 60‡ | $0.73 | ❌ | ❌ |
** 1% solution: Every 100ml solution contains 1g of pure methylene blue dissolved in it; 0.05% solution has 500mg of pure methylene blue in 100ml
† Company (Mblue Labs™) refers to 0.5 µM (micromolar) as a scientifically proven effective concentration but does not disclose that this is the amount used in their patented formulation [R]
‡ Computed at 1 pea-sized application to be roughly 0.5ml
§ Leucomethylene blue
Let’s explore some of your best options in a little more detail.
LVLUP Health Mito Blue
Price: $99.00
Cost Per Serving: $1.65
Delivery: Capsule
Dosage: 10mg/capsule
MB Purity: USP 99%
Subscription Option: Yes, save 10%
Rating: 4.56
Pros
- Convenient
- Travel-friendly
- Not messy to take
- No staining on your tongue, skin, or belongings
- No artificial fillers
Cons
- 3rd-party testing is complete but not publicly available (yet)
- Lower bioavailability compared to troches & oral solutions [R]
- Slower onset of effects (2-2.2 hours after ingestion)
LVLUP Health is known for producing best-in-class supplement formulations. Mito Blue is a precision-formulated methylene blue supplement designed to support overall mitochondrial health & function.
I like this formula for several reasons. First, it has a high-purity but low dose of 10mg. This is a sweet spot for many people. Plus, the founder, Kyal, added other ingredients that synergize nicely with methylene blue.
Acetyl-L-carnitine (ALCAR), ubiquinol (CoQ10), and PQQ all work together to support mitochondrial and brain function.
Specifically, ALCAR drives fatty acids into the mitochondria where they’re burned for energy. The other ingredients support the energy generation process and the creation of new mitochondria.
The greater the efficiency of your cellular energy generation, the better all bodily systems function.
Though it’s a simple formula, I like that Kyal opted for the ‘activated’ (and often considered superior) form of CoQ10 called ubiquinol (instead of ubiquinone). Unlike some multi-ingredient formulas, everything in this should be well tolerated by most people.
Without the mess of powders or liquids. I’m using this one before travel or in low oxygen (hypoxic) environments.
If you want a powerful mitochondrial optimizer that supports both physical & mental performance, Mito Blue delivers a well-rounded formula at a fair price.
MitoZen Satori™ Bars with MB
Price: $125
Cost Per Serving: $1.04
Delivery: Edible bar
Dosage: 5mg/¼ bar
MB Purity: USP >97%
Subscription Option: Unspecified
Rating: 4.35
Pros
- Tasty
- Intake method avoids blue tongue
- No caffeine crash
- Stacks well with early productivity or pre-workout
- Easily customize dosage
Cons
- Requires refrigeration so not the best for travel
- Doesn’t specify 3rd-party testing
- Not ideal for late-day use
MitoZen is one of the OG methylene blue vendors. Their formulas are the brainchildren of Dr. John Lieurance, a pioneering regenerative medicine physician.
Unlike the others on this list, Satori Bars Cognition Formula with MB are fortified with caffeine’s superior cousin. A molecule called paraxanthine. Paraxanthine gives you ‘the upsides of caffeine without the downsides’.
Each full Satori bar contains 200mg paraxanthine and 20mg methylene blue, alongside other proven brain-boosting compounds and a potent Ayurvedic herbs blend. Just make sure to choose the product variation that contains paraxanthine (some do not).
An ingredient in this product called Alpha GPC increases levels of the neurotransmitter, acetylcholine, further enhancing learning and memory. Then the herbs Bacopa, Centenella, Holy Basil, Shankhapushpi and Celastus increase both oxygenation and blood flow to the brain.
Astute biohackers will notice that MitoZen added certain probiotic strains and terpenes to this formula for a unique additive effect.
If you want to feel your MB, and you’re not sensitive to caffeine, this is your top pick.
I like to take this one in the late morning/early afternoon (always before 2 PM), since it gives a nice energizing and clarity effect without disrupting sleep architecture like caffeine does.
Each Satori bar is scored into 4 smaller squares so you can personalize your dose. Just cut off the number of squares you need.
I usually put these under my tongue and let them dissolve for a slightly more powerful experience. You can also just swallow them. No blue tongue or mess either way.
MitoZen Satori Bars, enhanced with energy-boosting nootropics like paraxanthine, compliment methylene blue’s benefits on cognition and mental clarity.
BioLight BioBlue
Price: $89.00
Cost Per Serving: $1.51
Delivery: Liquid
Dosage: 10mg/ml
MB Purity: USP 99.5%
Subscription Option: Yes, save 10%
Rating: 4.31
Pros
- Bioavailable liquid format
- Works synergistically with red light therapy
- Miron violetglass preserves formula’s integrity
- Contains powerful ingredients like colloidal gold & silver, & fulvic acid
Cons
- Requires careful dosing with a dropper
- Proprietary dosing of some ingredients
- May temporarily stain mouth/teeth if not swallowed quickly
Created by Dr. Mike, BioLight is a brand that focuses on the intersection of human health and light therapy. BioBlue, as you may have guessed, is a liquid methylene blue supplement specially formulated to amplify the benefits of red light therapy.
It also works great when combined with natural full-spectrum sunlight, or even no light at all.
I came across this product for the first time at the Health Optimisation Summit in Austin, Texas. Immediately, I could tell that Dr. Mike knows his stuff.
BioBlue added ingredients like NMN, colloidal gold & silver, fulvic acid, and biophotonic water.
Combining light with MB appears to cause more powerful anti-aging & anti-inflammatory effects, stronger immune function, greater physical stamina, accelerated wound healing, and enhanced overall vitality [R].
Some research suggests that the colloids plus fulvic acid likely further enhance the benefits. This field of study is called photodynamic therapy.
Plus, this ingredient profile theoretically slightly enhances NAD+ levels and thus longevity.
If you’re considering photodynamic therapy at home, check out my comparison of the best RLT devices.
One of my favorite things about BioLight is the number of advanced MB-based formulas they offer for every goal and use case.
BioLight’s classic BioBlue formula combines USP Grade MB with longevity and light therapy enhancing ingredients.
MitoZen Lumetol Blue™ Bars+
Price: $89.95
Cost Per Serving: $0.75
Delivery: Edible bar
Dosage: 10mg/¼ bar
MB Purity: USP > 97%
Subscription Option: Unspecified
Rating: 4.22
Pros
- Utilizes photoactive properties of MB & specific polyphenols
- Boosts red light therapy benefits
- No preservatives or additives
Cons
- Can make a mess, if not careful
- Proprietary dosing of some ingredients
- Requires refrigeration so not the best for travel
- Relatively short shelf life – 6 months
This is one of the original methylene blue products on the market. But Lumetol Blue Bars+ are much more.
Formulated by a neuroscientist, this formula is infused with photoactive nutrients to enhance light therapy and specifically red light therapy sessions. Phycocyanin, curcumin, quercetin, riboflavin, EGCG, and lutein within these bars all help your body better harness light.
Lumetol Blue bars come in two distinct dosages: either 40mg or a whopping 180mg. Both USP-grade methylene blue.
If you want to use high-dose methylene blue, this product is unparalleled.
Then, MitoZen added essential oils, terpenes, vitamin C, and a proprietary probiotic blend. Very similar to Satori, but with more botanicals and no paraxanthine (similar to caffeine).
This formula has unique multi-pathway (NF-kB, TNF-A, CB2) anti-inflammatory effects. The terpenes calm the nervous system, gently support cognition and alertness, and improve mood.
Between the polyphenols, AP0-808 Probiotic Blend, and organic palm oil, Lumetol has some gut and immune modulating effects too.
Each bar is scored into quarters. ¼ bar gives you 10mg (for the 40mg bar) or 45mg MB (the 180mg bar).
Unlike troches, these bars are meant to be swallowed quickly with water to avoid staining teeth and tongue.
Lumetol Blue Bars+ marry nature’s botanical wisdom with MB and nutrients that balance the body and amplify red light therapy.
BioLight BioBlue Calm
Price: $109
Cost Per Serving: $1.85
Delivery: Liquid
Dosage: 10mg/ml
MB Purity: USP 99.5%
Subscription Option: Yes, save 10%
Rating: 4.41
Pros
- Suitable for evening use or for those sensitive to stimulants
- Miron violet glass packaging enhances shelf life & potency
- cGMP manufactured
Cons
- Requires careful dosing with a dropper
- May temporarily stain mouth/teeth if not swallowed quickly
- Proprietary dosing of some ingredients
- Pricier than average relaxation supplements
BioBlue Calm from BioLight offers a gentle yet effective alternative to their flagship BioBlue formula.
Designed for those seeking relaxation, stress relief, and better sleep, this liquid supplement combines USP-grade methylene blue with a synergistic blend of calming herbs and minerals.
Unlike the original formula, BioBlue Calm omits an energy enhancing ingredient called NMN.
Instead, they replaced it with some of nature’s top relaxing substances. Specifically, organic ashwagandha, organic valerian, passionflower, kava, and two forms of magnesium.
While still retaining the colloidal silver, colloidal gold, and fulvic acid of their original formula. Interestingly, fulvic acid likely enhances the absorption and effects of the other ingredients in this formula.
Together, these naturally reduce levels of the stress hormone cortisol while promoting activity of a relaxing brain chemical called GABA.
At the dosages in the liquid, these ingredients will relieve stress without sedation. Perfect for hard-charging Type A folks to thrive under pressure without losing their edge.
Since some people feel energized from methylene blue, if using BioBlue Calm for sleep, I wouldn’t take it too close to bed. I’d take it 2+ hours before I wanted to sleep.
Where it really shines, however, is during high-stress periods. You’ll find it a helpful to alleviate nerves and manage stress.
Whether you’re combatting daily stress or just want to take the edge off of a big day, BioBlue Calm is a well-rounded, science-informed methylene blue liquid with a unique formula.
SwissChems Methylene Blue Solution
Price: $15.99
Cost Per Serving: $0.53
Delivery: Liquid
Dosage: 5mg/ml
MB Purity: Research grade
Subscription Option: Yes, save 5-10%
Rating: 4.08
Pros
- Extreme value
- Fast absorption
- No additives or fillers
- Granular dosage control
- 3rd-party lab tested
- HPLC refund guarantee
- Free shipping (orders >$100 US, >$300 international)
Cons
- Bitter/medicinal taste (expected with MB)
- Requires dosing care
- Stains easily
SwissChems Methylene Blue Solution is a no-frills, lab-tested liquid that gives you granular dosage control. Each ml delivers 5mg of pure methylene blue.
It’s not my first pick, but if you simply want an affordable MB liquid, it’s a decent option.
They’re confident about the quality, so much that they make the following guarantee:
SwissChems will refund your full order, including shipping and the cost of your own lab test, if any licensed High-Performance Liquid Chromatography (HPLC) test results [show low quality].
Since it’s unflavored, expect a medicinal taste (that’s normal for MB). Note that this product is not intended for human consumption, and is for research purposes only.
Beginners appreciate that each bottle contains just 150mg of methylene blue… making it easier and potentially safer to dose.
SwissChems also offers a capsule version, if you prefer that over liquid.
SwissChems Methylene Blue Solution is the most affordable product, but it’s only intended for research purposes.
BioLight BioBlue (SR): 50/50 Blend
Price: $129
Cost Per Serving: $2.19
Delivery: Liquid
Dosage: 10mg/ml
MB Purity: USP 99.5%
Subscription Option: Yes, save 10%
Rating: 4.30
Pros
- Both immediate and longer-term effects
- Contains synergistic ingredients
- cGMP manufactured
- 3rd-party lab tested
- Stored in Miron violet glass – enhances bioavailability & formula
- LMB is colorless so this stains less than most liquids
Cons
- Pricey
- Still stains
- LMB is less researched than MB
BioLight takes methylene blue to the next level with BioBlue (SR). It’s a first-of-its-kind 50/50 blend of traditional MB and leucomethylene blue. Resulting in a sustained-release formula that supports cellular and cognitive support for longer while simultaneously providing immediate effects.
Leucomethylene blue (LMB) is the reduced form of methylene blue. Because your body doesn’t need to convert it, LMB is instantly bioavailable Share on XMB, on the other hand, takes longer to kick in since your body has to break it down and convert it into LMB first. You’ll usually feel the full effects around 2 hours after taking it.
LMB is at the forefront of research for its ability to rapidly protect the brain and exert anti-inflammatory benefits. Plus, it appears that it can reduce the “rusting” of fat (lipid peroxidation) and penetrate deeper into cells [R].
As with other BioLight products, this contains the same beneficial NMN, gold and silver colloids, fulvic acid, and biophotonic structured water.
Get BioBlue (SR) for dual-action immediate methylene blue effects, as well as longer-term benefits… alongside the unique BioLight formula that includes NMN, gold and silver colloids, fulvic acid, and beyond.
Troscriptions Just Blue™
Price: $27.00
Cost Per Serving: $1.69
Delivery: Buccal troche
Dosage: 4mg/¼ troche
MB Purity: USP grade > 99.95%
Subscription Option: Yes, save 15%
Rating: 4.15
Pros
- High bioavailability
- Faster onset of action
- 3rd-party testing available upon request
- Mild taste
- Established, popular and beloved
- Child-proof packaging
Cons
- Turns teeth & tongue blue
- Fairly expensive for just MB alone
Just Blue™ by Troscriptions is the other original MB product on the market. In fact, they were the ones responsible for popularizing the blue tongue on social media. Many years ago, back when this was a fringe biohacker favorite.
It goes beyond USP standards. Troscriptions rigorously tests the ingredients in all their products for contaminants, purity, and potency.
This ultra-pure MB comes as a buccal troche, to be placed between your gums and cheek until it dissolves. Why?
They explain…
The MB enters the bloodstream through the mouth lining, bypassing the digestive system and the “first-pass metabolism” in the liver. Resulting in higher bioavailability and faster onset of action
Buccal delivery reduces onset of effects to just 15-20 minutes. Alternatively, you can swallow the troche on an empty stomach and then the effects will kick in within about 60-90 minutes.
Methylene blue can be pretty bitter. It’s one of the main factors that reduce patient compliance. So I appreciate the inclusion of Bitter-Bloc™ in the Troscriptions formula. This is an advanced technology that blocks bitterness.
If you want something a little stronger, Troscriptions also offers their “BlueCannatine” nootropic that combines MB with a low dose of CBD and nitotine.
Troscriptions’ Just Blue™ is one of the original low-dose MB supplements with a unique bitterness-reducing delivery technology… commonly shared on social media.
BioLight BioCream: Anti-Aging Skincare
Price: $109
Cost Per Serving: $1.09
Delivery: Topical cream
Dosage: Unspecified
MB Purity: USP 99.5%
Subscription Option: Yes, save 10%
Rating: 4.32
Pros
- 3rd-party lab tested
- Cream base uses organic ingredients
- Protects against UV damage
- Powerful & complete ingredient profile
- Very clean overall skincare product
- Miron violetglass preserves formula’s integrity
Cons
- Non-returnable once opened
- Different effect profile likely from transdermal LMB
- LMB lacks photodynamic synergy (unlike MB)
Skincare products historically couldn’t use MB because even tiny dosages would turn the cream blue. BioLight innovated here by thinking differently. BioCream is the first topical cream to feature pharmaceutical-grade leucomethylene blue (LMB).
Since LMB is fairly colorless, it’s ideal for skincare.
But this isn’t just some low-quality cream base with LMB mixed in.
BioCream is an advanced, 100% organic formulation that nourishes, protects, and revives the skin without added fillers or preservatives. Like their other products, it’s also designed to enhance the effects of light therapy and sunlight.
Aside from the leucomethylene blue, it includes a combination of anti-aging skincare compounds like:
- C60
- Astaxanthin
- Copper peptide
- Turmeric
- Shungite
- Humic acids
- Phytodynamic amino acids; and more
Plus, many of the ingredients are organic too.
This is one of the better and more interesting skincare formulas I’ve come across, and I let them know when I talked to Don & Dr. Mike about their formulas.
Each of these ingredients alone are powerful and expensive. These days, I’m rarely excited by personal care products, and this is an exception.
The only drawback is that sales are final, for sanitary reasons.
BioCream provides a specialized formulation that combines leucomethylene blue with a suite of the best skin-enhancing ingredients, all in one.
Price: $70, 5 vials
Cost Per Serving: $0.14
Delivery: Powder
Dosing: Custom
MB Purity: USP 99%+
Subscription Option: Unspecified
Rating:
Pros
- Inexpensive
- Customize to your needed dosage
- Long shelf life
- Light-protective packaging
Cons
- Needs precise measuring
- Can be messy
- Not convenient
CZTL’s ultra-high purity MB Sure Powder delivers total control and max purity. This isn’t a ready-to-use solution. It’s pharmaceutical-grade powder (USP, 99%+ purity) made for DIY biohackers who want to craft their own methylene blue formulas.
Each pack comes with 5 vials of 1 gram each. One vial is enough to make 100ml (3.38fl oz) of 1% solution, the go-to strength for most users. For reference, a 1% solution will give you 10mg of MB per ml.
The powder comes bronze (almost dark green), but mix it with water and it takes on MB’s iconic blue.
The powder lasts up to 3 years, and when mixed properly, the solution is stable for months. Just store it in a cool, dark place, ideally at 59°F – 68 °F (15°C – 20°C).
Each batch is 3rd-party lab tested for heavy metals and harmful microbes like E. coli, salmonella, and staph. They provide a batch heavy metal analysis with every order. And the light-protective packaging keeps potency intact.
Yes, it takes a little effort.
But you get massive savings, flexible dosing, and the peace of mind that you’re working with a formaldehyde-free, ultra-pure compound.
If you’re a confident DIYer, this is a potent addition to your BioHarmonizer toolkit.
Wizard Sciences MitoBlue RX
Price: $99.99
Cost Per Serving: $3.33
Delivery: Capsule
Dosage: 2.5mg/capsule
MB Purity: Unspecified
Subscription Option: Yes, save 15%
Rating: 4.15
Pros
- Comes in convenient capsules
- Synergistic blend includes longevity compounds
- Travel-friendly
- Won’t cause staining
Cons
- Expensive
- No mention of 3rd-party lab testing
- No mention of MB purity standards
MitoBlue RX by Wizard Sciences is a synergistic mitochondrial supplement designed to address the root causes of mental fatigue, low energy, and brain fog.
Unlike stimulant-based nootropics, MitoBlue RX supports long-term cellular health and brain optimization through a curated blend of methylene blue and longevity compounds like NMN, PQQ, fisetin, apigenin, and panax ginseng.
Ian Mitchell, the founder of Wizard Sciences, explains that bioactive constituents within these additives enhance the absorption and effect profile of the primary ingredients (in this case, MB).
This formula boosts brainpower by supporting mitochondrial health, clearing “zombie” (senescent) cells, enhancing NAD+ levels, and promoting calm, focused energy. Note that it contains a lower dosage of MB.
I also haven’t come across any other products that contain a nitric oxide blend, presumably added to enhance the delivery of the ingredients throughout the body.
Overall, the formula is akin to a Swiss Army Knife, with the multi-faceted ingredient profile.
Two primary drawbacks. First, they haven’t posted any details regarding their MB quality. I know Ian, and he’s not one to take shortcuts. Nevertheless, I’d like to see info posted. Secondly, the serving cost is quite expensive.
Although you could probably get away with taking just half serving (1 capsule instead of 2).
MitoBlue RX is an ideal choice for anyone dealing with chronic stress, aging-related slowdown, or a high mental workload.
Bluelene Night Cream
Price: $44
Cost Per Serving: $0.73
Delivery: Topical cream
Dosage: Unspecified
MB Purity: Unspecified
Subscription Option: Yes, save 10%
Rating: 3.71
Pros
- Budget-friendly
- FDA-approved
- Formulated for all skin types
- Not tested on animals
- Positive customer reviews claim visible results
- Ethical sourcing & sustainability from a woman- and minority-owned company
Cons
- No visible concentration of MB specified in product details
- No mention of MB purity standards
- Likely low quality
Bluelene Night Cream by Mblue Labs offers a scientifically-backed, dermatologist-approved approach to anti-aging skincare using methylene blue. It was the first on the market.
This MB cream was developed by Dr. Kan Cao, a Professor of Cell Biology and Molecular Genetics at the University of Maryland.
Her research on human aging, particularly the rare premature aging disease, Progeria, led her to discover the anti-aging & rejuvenating effects of MB on skin health.
The result? A cream claimed to rival retinol in results, but with far less irritation.
According to research conducted using ‘3D bioprinted human skin tissues’, Bluelene Night Cream doubles collagen and elastin levels within two weeks of use [R].
Bluelene smooths fine lines, repairs wrinkles, reduces sunspots, hydrates, and evens skin tone. Additionally, MB’s antioxidant action helps repair skin damage, making Bluelene an ideal alternative to retinol, especially for sensitive skin types.
One thing to note: They list MB as “Basic Blue 9” on the ingredient list. Basic Blue 9 is the official International Nomenclature Cosmetic Ingredient (INCI) when used in cosmetics or as a dye.
It’s lower quality, and higher in contaminants than USP/pharmaceutical-grade MB. Usually Basic Blue 9 is lab-grade or industrial-grade. Personally, I’d rather use a higher quality version or a skincare product without any MB.
Bluelene Night Cream is the original and most affordable skin care product, available on Amazon, but it contains a lower quality methylene blue called Basic Blue 9.
Popular MB Products I Haven’t Tested Yet
This supplement market is growing rapidly.
I bumped into some other people recently as the Biohacking Conference and they asked about brands that I’m not familiar with (and thus cannot yet recommend).
They include:
- Meraki Blu
- Biopharm Methylene Blue
- Best 365 Labs
My friend Holly is currently running third-party lab testing on a bunch of brands. I’ll update this article when her results are available.
How to Choose the Best Methylene Blue Supplement: Critical Considerations
Not all methylene blue supplements are created equal. So, when selecting the best one for you, here are factors to scrutinize:
Purity: Look for USP grade MB. If it’s USP grade, it means it meets or exceeds the purity and quality standards set by the United States Pharmacopeia (USP). This is an independent organization that sets official standards for medicines, food ingredients, and many of the top biohacking supplements.
A percentage after ‘USP’ indicates the minimum purity of MB. For example, USP 99.95% MB means the MB is at least 99.95% pure.
3rd-Party Lab Testing: Always choose supplements that are independently verified for potency, purity, and heavy metals. Especially products that contain only methylene blue and nothing else.
Bioavailability: Form matters. Capsules, powders, liquids, troches, and bars have different absorption rates & onset speeds. Delivery forms bypassing the digestive tract & first pass liver metabolism get absorbed and take effect fastest and most effectively.
Packaging Quality: Light and air degrade MB fast. Look for UV-blocking bottles or vacuum-sealed packs. Bonus if it’s child-resistant.
Precision Dosing: Check how much active MB you’re actually getting per dose.
Brand Reputation & Transparency: You want brands that are upfront, clean, and science-backed. If you’re unsure, check out my list of the best nootropic vendors. It also includes brands to be wary of.
Price per mg of MB, Not per Bottle: Don’t get fooled by a lower sticker price. Do the math: cost per effective serving is what really matters. A $99 bottle may be effectively cheaper per mg of MB than a $49 one that has less much less mg of MB.
Customer Reviews (the real ones): What are other users saying? Look for honest feedback on energy, focus, mood, and downsides like staining or GI upset.
Checking these factors will significantly help you narrow down your choices.
Know more about choosing the right MB for you with my guide on buying MB online.
Important Considerations & Safe Usage of Methylene Blue
As with anything you put inside your body, pay close attention to several considerations to maximize the benefits of methylene blue and avoid any unwanted effects.
Some considerations are possible side effects, any medications or supplements you are taking, the state of your health for dosing purposes, and any genetic issues.
Here’s a guide to the dosage and possible side effects of methylene blue if you want to learn more.
Methylene Blue Questions & Answers
Here are answers to common questions regarding methylene blue.
What are the benefits of methylene blue?
Methylene blue can reduce fatigue, enhance brain function, and offer neuroprotective benefits. Overall, methylene blue helps protect cells and supports general cellular and cognitive health. Click here to see the full list of benefits of methylene blue.
Is methylene blue natural?
No, methylene blue is a synthetic compound first developed in the 19th century and is not naturally occurring.
How does methylene blue work?
It helps your mitochondria produce energy more efficiently and acts as an antioxidant to protect your cells from damage.
Is methylene blue FDA approved?
Yes, methylene blue is approved by the FDA for certain medical uses, and research is ongoing into its benefits for brain and cellular health. MB is also on the World Health Organization (WHO) Model List of Essential Medicines.
Is methylene blue safe to use with other supplements?
Because methylene blue can interact with some medications and supplements, it’s best to consult a doctor before combining it with other products. Especially if you’re taking psychedelics and/or serotonergic drugs such as selective serotonin reuptake inhibitors (SSRI), serotonin & norepinephrine reuptake inhibitors (SNRI), or monoamine oxidase inhibitors (MAOi).
What are the side effects of methylene blue?
Side effects can include blue or blue-green urine, mild stomach upset, dizziness, headaches (especially at higher doses), and increased sensitivity to sunlight. Serious effects are rare but can happen, so it’s important to use it under medical guidance.
Is there a way to reduce the blue stain on my tongue faster?
You can reduce the blue stain by combining methylene blue with a “reducing agent” like vitamin C, molecular hydrogen, or vinegar. Try rinsing your mouth with 1 part water and 1 part vinegar. Then, rinse your mouth with a solution of 1/4 tsp baking soda in 4fl. oz of water for a few minutes. Do this after the methylene blue has completely dissolved in your mouth.
What’s the difference between industrial-grade and USP-grade methylene blue?
USP-grade methylene blue meets strict quality, purity, and safety standards for medical use. Industrial-grade is intended for non-medical applications like dyeing and may contain impurities unsuitable for human consumption.
Choosing a Methylene Blue Supplement for Your Lifestyle & Goals
Methylene blue supplements have a wide range of benefits. Things like improving:
- Energy
- Longevity & anti-aging
- Learning, memory, & cognitive function
- Immunity
- Metabolism
- Brain protection
- Mood
It has even been called a ‘magic bullet’. Years ago, it became a favorite among expert biohackers.
Methylene blue is a century-old molecule with uses ranging from malaria treatment, to enhancing mitochondrial energy, neuroprotection, and longevity support Share on XAs a nootropic, some studies suggest this blue dye outperforms common smart drugs like modafinil
It crosses the blood-brain barrier, supports ATP production, protects organ systems, and boosts brain oxygen usage.
As you’ve seen from the list, there are now versions that come in capsules, liquid solutions, bars, and creams.
But it’s not all equal…
Much of what you’ll find on the internet is toxic fish tank cleaner. High in dangerous heavy metals and other contaminants.
You’re better off avoiding MB entirely than using a low quality product.
I’m sure there are some good ones I’m missing, too.
How about you? Have you bought an MB supplement? Share your experience in the comments below!
If you found this comparison helpful, don’t forget to share it with someone whose interested in methylene blue. Thanks!
