Longevity scientist David Sinclair has focused most of his career on nicotinamide mononucleotide (NMN).
Five years ago, his book Lifespan brought widespread attention to this powerful anti-aging supplement.
The molecule promises to improve cellular health and slow the biological aging process.
By restoring proper energy balance throughout the body, you stay younger.
You naturally get trace quantities through diet and lifestyle, but only supplements cause robust health benefits. Unfortunately, some NMN brands do more harm than good.
In this review, we will cover everything you need to know about NMN. The best dose, the science-backed benefits, potential side effects, and how to choose the best NMN supplement for your unique lifestyle.
This was one of the internet’s first NMN guides, and I constantly update it as new products/research emerge.
In a hurry?
Best Overall – Ultra Health Liposomal NMN
Best I.V. Alternative – MitoZen NAD+ Max
Best Value – Wonderfeel Youngr
Best Bulk NMN (White Label) – Ultra Health 30C
By the end, you know if you should take a nicotinamide mononucleotide supplement and which is right for you.
The Best NMN Supplements, Products & Brands for Anti-Aging
As mentioned below, products with labels that claim to contain “NMN” are not all equal. This list, however, is a roundup of all the very best brands.
Your ideal NMN product depends on your goals and budget:
- Liposomal formulations give you maximum absorption (as described later) and are best for most people
- Intranasal spray is best for those looking to combat neurodegeneration and boost cognitive energy (and mitochondrial health)
- Normal powder used sublingually is the best value for budget-conscious folks
Before we get started…
Am I missing a product? Be sure to check the comments below where we’re having an ongoing discussion about other and new brands.
Best Overall: Ultra Health Liposomal NMN
Overview
NMN Dose: 250 mg
Contents: 60 capsules
Serving Size: 1 capsule
Specialty: Meets highest standards for safety and efficacy
Features: Max bioavailability, No additives
UltraHealth specializes in the highest quality, pharmaceutical-grade longevity products. Their line of powders and capsules regularly rank among the highest-quality NAD+ products. While best known for their Nicotinamide Riboside, they offer two different NMN products which are also top choices.
One is Ultra Health’s Liposomal NMN. From many conversations with their CTO, Bret Lee, I’ve determined that this is quite possibly the best quality liposomal NMN available.
Their proprietary lipid polymer coating helps capsules bypass the harsh environment of stomach acid and get efficiently absorbed. Since it is a high-quality liposome, the benefits last a long time.
Plus, Ultra Health’s unique manufacturing process lets them completely avoid additives or excipients.
If you’re looking for a clean, best-absorbing, and relatively budget-friendly NMN capsule for its price, definitely consider Ultra Health Liposomal NMN.
Use the exclusive Ultra Health code NC15 for 15% off
This post contains affiliate links, which means Outliyr gets a small commission if you buy (at no cost to you). Thanks for your support!
Best Targeted Delivery: Ultra Health PUR™ 60B Pharmaceutical-Grade
Overview
NMN Dose: 250 mg
Contents: 60 capsules
Serving Size: 1 capsule
Specialty: Purity
Features: No excipients or additives, 3-stage proprietary synthesis
Ultra Health’s PUR NMN line nicely features both unparalleled purity as well as decent price. This product comes in a pharmaceutical-grade form called PUR NMN.
PUR NMN specifically undergoes a three-stage synthesis process for maximum bioavailability. Aside from the one mentioned above, it’s the only 100% pure NMN product on the market. Their complete CoA and HPLC purity datasheet is posted on their product page.
Ultra Health PUR™ 60B is another popular choice if you prioritize products that meet strict purity and safety standards.
Use the exclusive Ultra Health code NC15 for 15% off
Activated NMN Formula: Wonderfeel Youngr™
Overview
NMN Dose: 900 mg
Contents: 60 capsules
Serving Size: 2 capsules
Specialty: Patented blend of antioxidants and sirtuin activators
Features: cGMP-certified lab, non-GMO, vegan-friendly
Endorsements: Dr. Andrew Salzman
Born out of Harvard University’s Dr. Andrew Salzman, created a novel (and patented formula) of NMN with some of the most popular longevity ingredients available. Dr. Salzman is a drug inventor with over 50 patents. He’s also involved in NAD research.
Suffice it to say, Dr. Salzman knows what he’s doing, and his Youngr formula reflects that.
Each capsule contains:
- 450 mg Nicotinamide Mononucleotide
- 2 mg Ergothioneine
- 50 mg Trans Resveratrol
- 25 mg Olive fruit Extract (40% hydroxytyrosol)
- 10 mcg Vitamin D3 (Cholecalciferol)
By combining the NMN with a decent dosage of sirtuin activators (resveratrol and olive fruit extract), you provide the raw materials your body needs to best use the NMN. Ergothioneine is another interesting and powerful semi-essential nutrient that most of us benefit from supplementing.
I really like that they designed this with sustainability in mind. Your initial order comes in a glass bottle, and subsequent orders arrive in a 100% recyclable & biodegradable refill pouch. Plus, you can save 17% when you subscribe.
NMN I.V. Alternative: NAD+ Max
Overview
NMN Dose: 250 mg
Contents: 10
Serving Size: 1
Specialty: Potency
Features: Powerful formula with liposomal, slow-release, and nano lipospheric technologies
Dr. John Lieurance is one of the world’s authorities on regenerative cellular medicine. He created the rapidly-growing brand MitoZen to share his first-of-a-kind formulas with the world.
One of MitoZen’s standout products is their NAD+ Max Bullet. What sets it apart is its formulation. The NAD+ Max Bullet includes plant-based polyphenols and terpenes. These powerful antioxidants work synergistically with NMN.
Each “bullet” is packed with:
- 500mg of NAD+
- 250mg of NR (Nicotinamide Riboside)
- 250mg NMN (Nicotinamide Mononuceoside)
- Fisetin, Ginkgo Biloba, EGCG, Lutein, Quercetin, Curcumin, & Resveratrol
- Alpha Pinene, Beta Pinene, Delta 3 Carene, & Alpha Phellandrene
- AP0-808 Probiotic
MitoZen takes pride in their ingredients. They use a proprietary method to stabilize NAD+, ensuring maximum absorption through Nano Lipo-Spheric Technology (NLT NAD+™). This allows for clean and complete absorption of NAD+ and polyphenols, thanks to their patented SRT™ Slow-Release Technology.
What’s most unique about this product, however, is its capability.
According to Dr. Lieurance, this delivery system has the same effects and benefits of an NAD+ I.V. (but without the suffering). The contents release into the bloodstream over a 5-7 hour peroid.
There’s one major catch that will be a dealbreaker to many. To get the maximum effects, unfortunately, you must use it as a suppository.
Biohackers demanding the ultimate NAD+ solution, as powerful as an intravenous (IV) infusion, use the Max Bullet for its biosynergistic formulation and proven effectiveness.
Use the MitoZen exclusive promo code URBAN to save 5%
Best Antioxidant Combo: Ultra Health Liposomal Resvera-M
Overview
NMN Dose: 250 mg (+ 150mg trans-resveratrol)
Contents: 60 capsules
Serving Size: 1 capsule
Specialty: Strong antioxidant
Features: Purity, anti-inflammatory, anti-aging effects
If you’re looking for a top NMN supplement fortified with Dr. David Sinclair’s favorite longevity supplement, resveratrol, look no further.
While NMN is a great precursor to increase your NAD+ levels, you can also add resveratrol for its anti-inflammatory and antioxidant functions. Resveratrol is one of the two most popular sirtuins activators. You can think of NAD+ as the fuel that powers the “engine” of sirtuins. On top of their individual benefits, both work synergistically to support cell repair and fight aging.
Similar to their main NMN products, this undergoes lab testing and passes strict standards for quality and safety. They show all the details on the product page as well, from the chemical Certificate of Analysis to the stability data. Of both NMN and resveratrol in the product.
Pick up Ultra Health’s Liposomal Resvera-M if you want a great 1-2 combo of NMN (”gas”) with resveratrol (”engine”).
Use the exclusive Ultra Health code NC15 for 15% off
Guaranteed Potent NMN Powder: Do Not Age
Overview
NMN Dose: 500 mg
Contents: 2000 servings
Serving Size: 500 mg
Specialty: Potency guaranteed to your door
Features: GMP-Certified, ISO9001-Certified, vegan-friendly
Do Not Age, appropriately abbreviated “DNA”, is a popular longevity supplement vendor known for regularly publishing their third-party lab testing results. In order to determine which products to create, Do Not Age both follows the latest research as well as listens to customer wants.
DNA’s Scientific Advisory Board features the esteemed longevity researcher Vera Gorbunova. Check out their Science page for a simple research-backed primer on the most recommended supplements and lifestyle interventions.
The major difference with Do Not Age’s NMN is that they guarantee the potency of the product at your doorstep. After third-party testing, many manufacturers store their products in sub-optimal conditions. By the time you receive your package, exposure to light, oxygen, humidity, and harsh environmental conditions have degraded the NMN. From their UK headquarters, DNA ships worldwide, going the extra mile to make sure you receive exactly what you pay for.
You can choose between NMN capsules or bulk powder available in 100 grams, 183 grams, or even an entire kilogram (1000 grams). Then add on their TMG for methylation support and their SIRT6 activator or spermidine for a comprehensive longevity stack.
Use the exclusive Do Not Age code URBAN or OUTLIYR for 10% off
Highly Stable NMN: ProHealth NMN Pro 300
Overview
NMN Dose: 300 mg
Contents: 60 capsules
Serving Size: 2 capsules
Specialty: Stability
Features: Uthever NMN, long shelf life, dual testing
Each capsule of ProHealth’s formula includes 150mg of Uthever’s patented stabilized, ultra-pure, pharmaceutical-grade NMN. Uthever’s research team is led by U.S. doctors from the pharmaceutical giant GlaxoSmithKline. This NMN is tested both in-house by Uthever and then batch-tested again by ProHealth to verify authenticity and purity.
Painstaking attention to quality and purity has led to findings that ProHealth NMN remains intact and stable for up to two years. Pro 300 gets rave reviews, often beating popular products like Genex. Pay attention to price, however, as I’ve seen it fluctuate by nearly $50. I’ve also noticed that there isn’t a GMP-certified logo on the bottle itself. If you want a shelf-stable NMN that lasts, ProHealth Pro 300 is a top choice.
Original Lipo NMN: QuickSilver Scientific
Overview
NMN Dose: 50 mg
Contents: 100 mL
Serving Size: 2.5 mL
Specialty: First liposomal NMN product
Features: Liposomal, highly absorbable, synergistic blend
QuickSilver Scientific is known for ultra-potent supplements that get great results from small doses. Their NAD+ Platinum line is no exception. At its core is the original (October 2020) liposomal delivery technology. Pioneered by the father of liposomal technology (Dr. Christopher Shade) himself. Tiny 50-100nm particles easily absorb into the bloodstream and cells. QuickSilver’s unique technology mimics the body’s built-in NMN transport system.
To redeem for its low NMN dose, the formulation team included a synergistic blend of other NAD-boosting ingredients (TMG, vitamin B2, vitamin B12, resveratrol, quercetin). Some experts recommend taking NMN and resveratrol together, so this could be a winning combo. Liquid NAD+ Platinum has become their most popular, all-in-one longevity formula. Activating anti-aging sirtuins, methylation pathways, and increasing NAD.
Popular Liposomal NMN: LIPO NMN Capsules
Overview
NMN Dose: 250 mg
Contents: 90 capsules
Serving Size: 1 capsule
Specialty: Strongest pure NMN
Features: FDA Inspected, ISO-Certified, cGMP certified lab, non-GMO. 100% free of preservatives, artificial colors, flavors, and sweeteners
Endorsements: Dr. Andrew Huberman (on Joe Rogan)
Liposomal delivery technology vastly increases the potency and deliverability of active ingredients into cells. For a long time, QuickSilver Scientific produced the only Liposomal NAD booster. It came in liquid. Renue By Science (re-branded from Alive By Science in February 2022) released the first powder-based liposomal NMN.
Compared to liquid, research shows that powdered liposomal products may be up to 6 times more bioavailable [R]. Nutraceuticals often have problems with liver toxicity at high doses. Liposomes sidestep these issues.
Liposomal technology is more economical, highly effective, and gentle on the body.
I’ve taken nearly 100 doses of this very product. Do note that RBS NMN products often go out of stock.
Best Sublingual NMN (Tablets): Renue By Science
Overview
NMN Dose: 125 mg
Contents: 240 capsules
Serving Size: 1 capsule
Specialty: Sublingual tablets
Features: FDA Inspected, ISO-Certified, cGMP certified lab, non-GMO. 100% free of preservatives, artificial colors, flavors, and sweeteners
Endorsements: Dr. Andrew Huberman (on Joe Rogan), Many MDs
Renue By Science (RBS) is the largest manufacturer of NAD+ products. Since 2017, they’ve innovated with new formulations and delivery mechanisms. Most NMN capsules get degraded (and wasted) by strong stomach acid. Though these tablets contain only 125mg of NMN, you’ll get 3-10 times greater absorption via their unique sublingual tablets. Sublingual delivery bypasses NAMT, the enzyme responsible for breaking down NMN.
In addition, Renue By Science also offers the most different forms of NMN. Including liposomal, transdermal, sublingual, and intranasal products. You can buy it in powder or capsule. As the NAD industry has boomed, manufacturing prices have dropped. In June 2021, this company passed savings on to us by slashing prices by 15 percent.
These tablets are naturally stable and dissolve in the mouth quickly. Renue By Science follows best safety practices. Each batch of Renue By Science NMN undergoes 4 rounds of pharmaceutical-grade purity testing. Resulting in certificates of analysis (CoA) for every product. This is a great value NMN product designed for sublingual use.
This post contains affiliate links, which means Outliyr gets a small commission if you buy (at no cost to you). Thanks for your support!
Bulk NMN (White Label): Ultra Health PUR™ 300C Pharmaceutical-Grade
Overview
NMN Dose: 250 mg
Contents: 300 capsules
Serving Size: 1 capsule
Specialty: Purity
Features: Enteric coating, no excipients or additives, 3-stage proprietary synthesis
In addition to NR, UltraHealth makes one of the best and most popular lines of NMN available. I’ve talked to Bret, their CTO many times about their manufacturing process. He’s well-versed in the latest NAD/longevity research and is an honest guy. This particular product makes NMN affordable, at just under $0.87 per (250mg) serving. The latest version is enteric-coated, helping it resist degradation by stomach acid to exert more beneficial effects.
Vitamin shops, doctors, and clinics commonly purchase 300C. Since this line is intended for resale by medical professionals, it comes in a sealed mylar pouch.
All PUR NMN undergoes a proprietary three-stage synthesis for maximum bioavailability. They’re one of few companies to post their complete CoA and HPLC purity datasheets.
If you’re looking for a great deal on the same high-quality NMN used in medical research and clinical studies, UltraHealth PUR™ 300C is your option.
Use the exclusive Ultra Health code NC15 for 15% off
NOVOS Boost
Overview
NMN Dose: 250 mg
Contents: 60 capsules
Serving Size: 2 capsules
Specialty: Bargain
Features: Established company, manufactured in USA, GMP & NSF Certified Facility, vegan-friendly, sugar-free, gluten-free, non-GMO
Founded by a team of world-renowned longevity scientists and doctors hailing from the most prestigious universities, NOVOS has become a noteworthy anti-aging supplement brand, mostly for their foundational 19-ingredient formula called NOVOS Core.
NOVOS Boost is their NMN product. Just NMN. It’s designed for use alongside Core, but that’s optional. Boost contains 250 mg of high-quality, 3rd-party tested NMN in each serving, ensuring purity and potency. The NMN in NOVOS Boost is a highly stable spherical crystalline form, backed by the world’s top aging experts from Harvard Medical School, MIT, and other top institutions.
NOVOS is also one of few supplement companies that actually run research studies on their products.
As you can imagine, it’s a high-quality, high-purity, and highly stable NMN, tested by independent third-party labs.
Overall, this is a fairly standard oral NMN product. I’m not sure why each serving is two capsules yet only 250mg of NMN. With NOVOS Boost, you’re paying a premium for brand name. Although when you subscribe, you can save up to 27%.
They mostly justify this with claims that their products are cleaner and absorb better due to “next-generation” NMN technology.
Boost NMN is expensive because it’s backed by a prestigious brand name, but it’s still a decent option for their customers already using their NOVOS Core product.
Use the exclusive NOVOS code URBAN5 for $5 off
Best Value NMN: Nootropics Depot Enteric Coated Tablets
Overview
NMN Dose: 125 mg
Contents: 60 capsules
Serving Size: 1 capsule
Specialty: Value
Features: Enteric coating, dual testing, lot tracking
Nootropics Depot is one of the biggest names in high-quality nootropics. Many popular supplement companies source their raw materials from Nootropic Depot due to their purity and potency. Their NMN tablets are rigorously tested both in-house and by third-party laboratories.
This is one of few products where I’ve actually heard people complain of feeling the energy-boosting effects too strongly. One friend commented that he had to find a way to offset the energy rush.
Enterically coating nicotinamide mononucleotide helps it survive harsh stomach acidity. On the Nootropic Depot site, you can often find additional coupons. I’ve seen their tablets priced as low as $0.61 each. For the best value in terms of purity, and stability, and affordability, Nootropics Depot NMN is my top choice.
Cheapest Sublingual NMN (Powder): Pure NMN Powder
Overview
NMN Dose: 500 mg
Contents: 200 servings
Serving Size: 500 mg
Specialty: Price
Features: FDA Inspected, ISO-Certified, cGMP-certified lab, non-GMO. 100% free of preservatives, artificial colors, flavors, and sweeteners.
Endorsements: Dr. Andrew Huberman (on Joe Rogan), Many MDs
Renue By Science makes the list again, this time for their bulk sublingual NMN powder. Sublingual is the delivery method of choice for a quick energy boost. and to actually feel your supplement. Sublingual administration also gets more NMN into your bloodstream for systemic effects.
Though prices have dropped significantly in recent years, NMN supplementation gets expensive. Major 2023 update! This product contains over a years-worth for about $89. By far the cheapest NMN available.
Like all Renue by Science products, here you get pharmaceutical-grade purity testing and a certificate of analysis (CoA) for safety. If you don’t mind powder and want the absolute best deal possible, look no further.
Best Intranasal NMN: NeuroNAD Vertical Spray
Overview
NAD Dose: 100 mg/mL
Contents: 20 oz (2,000 mg NAD+)
Serving Size: 2 sprays
Specialty: Intranasal spray
Features: ISO-Certified, FDA Inspected, cGMP certified lab, non-GMO, free of preservatives, artificial colors, flavors, and sweeteners
Endorsements: Dr. John Lieurance
Looking to supercharge your energy levels, enhance brain function, and optimize your overall well-being? Mitozen is a cutting-edge brand that specializes in incredibly thorough and novel formulations.
NMN and other NAD+ precursors have systemic, whole-body enhancing effects. Intranasal technology, however, can bypass the blood-brain barrier to exert benefits on the brain. Something other forms of NMN do not. Researchers hypothesize that intranasal NAD will increase NAD levels in the brain more than any other delivery method. Intranasal delivery acts quickly, targets the brain, and because it requires a lower dose, reduces potential side effects.
MitoZen’s NeuroNAD Vertical Spray+ is a gamechanger to deliver NAD+ to the brain. Where it boosts mitochondrial function, promotes cellular repair, and enhances brain health. The formula contains a proprietary blend of:
- Pure NAD+
- Plant-based polyphenols
- Potent terpenes
- Bio Ocean minerals
It’s cutting-edge. Few companies have released NAD+ sprays that target the brain, and this one goes a step further. It uses proprietary GelTech™ technology to absorb better than other nasal NAD products.
These include Fisetin, Ginkgo Biloba, EGCG, Lutein, Quercetin, Curcumin, and Resveratrol. Polyphenols work synergistically with NAD+ to support overall health and well-being.
The NeuroNAD Vertical Spray+ is perfect formula for biohackers and anti-aging enthusiasts that want a potent, complete, and fast acting formula.
Notes: NAD+ works better than NMN in nasal sprays. In order to access any of their products, MitoZen requires a one-time fee of $10 to join their Private Members Association (PMA).
Use the MitoZen exclusive promo code URBAN to save 5%
MAAC10 NMN
Overview
NMN Dose: 125 mg
Contents: 30 capsules
Serving Size: 1 capsule
Specialty: Bargain
Features: Manufactured in USA, GMP & NSF Certified Facility
MAAC10 has sold NMN capsules since 2015. Few companies can sell these boosters at under $1 per dose. As you’d expect, this product is non-GMO, and free of common contaminants (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy, and preservatives).
Manufacturing occurs in a GMP-certified facility and a CoA posted on Amazon shows that the recent lot exceeded the 125mg specified on the label. The product itself isn’t anything special. No unique delivery mechanisms. Just NMN packed into ordinary capsules. Make sure to count the pills, as some users report getting only 28 or 29 instead of 30. If you’re looking for no-frills affordable NMN pills, look into MAAC10.
Also Good: Double Wood Stabilized NMN
Overview
NMN Dose: 250 mg
Contents: 60 capsules
Serving Size: 2 capsules
Specialty: Sales
Features: Nothing notable
If you can get past the old look, Double Wood Stabilized NMN is beloved by thousands. Each pill contains 125mg of NMN packed into a capsule made of gelatin.
Double Wood products are made, tested, and produced in a cGMP facility in New York.
This was once the cheapest option on the market at $19.99 per 60 capsules. It’s risen significantly since then and is no longer my favorite budget pick. I also don’t like that the ingredients list contains unnecessary Rice Flour. And the CoA listed online is from 2019. Buy Double Wood NMN when it’s on sale.
Dangers of Most NMN Supplements
Recently, I cut severely back on my supplement intake. This is why.
Firstly, third-party reports regularly find high levels of supplement contamination. Heavy metals, impurities, and other banned substances lurk in innocent products.
Then there’s fraud. Some products don’t even contain ANY of the primary ingredients! Instead, they fill capsules with whatever cheap materials they can find.
Commercial NMN is relatively new. Researchers like Dr. Sinclair create a surge in demand, and manufacturers can’t match the supply. Stores have become littered with fake, adulterated, (and expensive) products.
Update: Massive Fake NMN Supplement Scam
I’ve long warned about the lack of regulatory oversight of NMN products.
And it’s far worse than I thought.
A shocking third-party investigation uncovered tens of thousands of fake supplements sold on Amazon. Many of these included NMN.
A few of the dozens of fake brands include:
- Komprocha
- NMN Max
- NMN Plus
- Energecko
- Vitablossom
- Mistacy
- ChriBubble
- Glorifikation
Many of which are the “best sellers” in their respective categories.
You can see the references and lab CoA data for yourself here.
Keep in mind that this is only one recent discovery. Likely just the tip of the iceberg.
Don’t fall victim to NMN scams.
On the other hand…
The brands I trust (listed below) have mostly either been directly used in clinical studies or undergone strict third-party testing.
Today, I regularly talk to the best-informed minds in longevity. This is my regularly updated list of the best nicotinamide mononucleotide products I’m coming across.
2023 Update: The NMN Ban
Beginning in November 2022, you may have heard the major NMN news. A legal battle instigated by a large biotech company caused the FDA to revoke NMN’s status as a dietary supplement.
For months, everything continued as normal.
Then Amazon warned β-nicotinamide mononucleotide vendors that they would yank their products from shelves on March 13th. All products that do not contain a National Drug Code (NDC) on the label. Amazon is full of fraudulent supplements, so I view this as a net positive. Hopefully, other regulators will not follow suit.
Certain vendors have assured me that, for legal reasons, their NMN supplements will be exempt from the potential ban.
If, however, regulatory agencies successfully NMN across the board, you still have other options. See this new post for a list of free habits and other great NMN alternatives that also increase NAD+.
Prefer video?
How NMN & NAD+ Work (Simple Science)
Nicotinamide mononucleotide builds a critical energy-generating molecule called NAD. You’d drop dead in 30 seconds without it. Every cell throughout the body relies on it. 500+ enzymes wouldn’t work without it. Vital roles of NAD include:
- Slowing aging by activating anti-aging proteins called sirtuins
- Increasing energy (Krebs Cycle)
- Repairing damaged DNA (PARP1)
- Creating hormones
- Facilitating muscle-building
- Enhancing recovery
Leading scientists get excited by things that bolster the body’s built-in defense mechanisms. Sirtuins do exactly that, but only if you have adequate NAD.
The natural aging process slowly degrades NAD. A 50-year-old has roughly half the levels of a 20-year-old. Though you’ll live with low NAD, you’ll accelerate the aging process and reduce your healthspan.
That’s where NMN helps.
NMN is a synthetically produced nucleotide and a direct precursor to nicotinamide adenine dinucleotide. NMN is a key component to proper cell functioning.
Listen to David Sinclair’s multiple explanations on the Joe Rogan Experience Podcast.
Best Forms of NMN (Delivery Technologies)
The strongest NMN in the world doesn't make a difference if you cannot absorb it Share on XBefore comparing brands and products, you should know one other vital detail that may change your top pick.
The NMN delivery method can change the effects you feel, the potency, the side effect profile, and the price.
| Pure NMN | Sublingual NMN | Intranasal NMN | Liposomal NMN | |
|---|---|---|---|---|
| 🩸 Absorption | Low | Medium | High | High |
| ⏱️ Duration | Short | Medium | Short | Up to 24 hours |
| 💥 Onset | Slow | Fastest | Fast | Fast |
| ⚖️ Dose Required | High | Medium | Low | Low |
| 🎯 Target | Muscle | Systemic | Brain | Systemic |
| ✅ Feature | Convenience | Noticeable energy boost | Neuroprotective, relieves brain fog | Extended-release into bloodstream, highest bioavailability |
| 💰 Price | Cheapest | Moderate | Moderate | Expensive |
| 🤔 Value | Low | Low | Medium | Best |
Normal Pure NMN Powder
Typical NMN powders are the cheapest and the most researched. Most products on the market fall into this category. Unfortunately, it’s also the least absorbed.
Stomach acid degrades unprotected NMN and NR into NAM (nicotinamide) before it can reach the most important tissues. Huge doses of NAD boosters to combat low absorption disproportionately increase NAM. Excess NAM has health consequences, such as inhibiting sirtuins (a vital family of proteins responsible for cellular health and longevity) [R].
Therefore, simply increasing the dose of a typical low-bioavailability NMN powder won’t work well.
Sublingual NMN
Sublingual delivery is NMN dissolved under the tongue. Some companies use special technologies to bypass the liver, rapidly diffusing into the bloodstream, resulting in greater absorption. Usually, it costs more than ordinary powders. Users of sublingual NMN report quickly feeling a big surge of energy and rush.
So far, however, there is little research on exactly how much more bioavailable sublingual powder is compared to oral.
Wondering if your supplements actually do anything or are a waste of money? Feeling the effects of sublingual NMN will convince you.
Intranasal NMN
Intranasal is the latest upcoming NMN delivery method. Only nasal administration can bypass the blood-brain barrier and first-pass metabolism to increase NAD levels in the brain [R, R].
This paper summarized the science nicely (emphasis mine),
“…drugs administered using nasal route have usually higher bioavailability, less side effects and result in higher brain exposure at similar dosage than the oral drugs.”
Evaluation of intranasal delivery route of drug administration for brain targeting
Compared to oral use, nasal administration requires far lower doses, has fewer side effects, and has a greater brain impact. Additionally, early research is showing promise in restoring energy after traumatic brain injury.
Due to limited supply, intranasal NMN is also more expensive.
Liposomal NMN
Liposomal supplements absorb faster, more efficiently, and without breaking down in your gut (compared to the typical oral forms). This is true for many supplements. Liposomes also make the NMN sustained release, continuing to increase NAD over a 24-hour period.
Simply put, liposomes are tiny fatty “shells” resembling a human cell membrane. This prevents breakdown by stomach acid and greater use throughout the body. They’ve been used since the 1960s, and some supplement formulators have proclaimed liposomal technology the biggest breakthrough in decades.
Researchers, however, are divided over the difference liposomal technology makes for NMN.
Work by Dr. Christopher Shade suggests liposomes generally increase supplement absorption by 3-10 fold. Giving you better value by requiring a smaller dose. Unfortunately, it’s also the most expensive due to the difficult manufacturing process.
Latest Nicotinamide Mononucleotide Human Health Benefits
Supplementing the NAD+ molecule itself works, but only in certain bodily systems. NMN, on the other hand, boosts cellular NAD systemically. It restores energy to aging tissues that need it most.
Benefits come from both the molecule itself and increasing NAD+ levels. Scientists are still uncovering new health effects daily.
NMN is best known for its anti-aging benefits, but it does so much more.
Some of the health & longevity benefits of NMN include:
- Boosts energy metabolism
- Improves insulin sensitivity and cholesterol and glucose metabolism [R, R]
- Protects against diabetes, fatty liver disease, and obesity
- Rejuvenates mice
- Fixes brain cells resistant to autophagy [R]
- Promotes cognition in Alzheimer’s patients
- Defends against neurodegeneration
- Improves memory
- Reduces fat mass
- Strengthens grip and walking speed [R]
- Increases lean mass
- Radically increases NAD+
- Improve immune function
- Restores and protects kidney function [R]
- Promotes cardiometabolic health (cholesterol, blood pressure, blood vessels) [R, R, R]
- Up to 75% reduced blood triglycerides when given via IV [R]
- Resistance to microbes and immunodeficiency
- Better blood flow
- May improve hormone levels [R]
- Accelerates recovery from viral illness [R]
- Old mice died 30% less from viral infection [R]
- Confers benefits of calorie restriction
- Protects the heart
- Enhancing human performance
- Boosts physical endurance and aerobic capacity [R, R, R]
- Re-establishing mobility in the elderly
- Potentially useful in treating COVID
- Restores fertility
- Mitigates frailty [R]
- Improves mitochondrial health
- Greater wellbeing
- Protects skin from UV damage [R, R]
- Reduces biological age [R, R]
- Promotes DNA repair
- Enhanced sleep quality [R]
- NAD allows the DNA-protective Sirtuin protein family to work properly
That last one is especially important. NAD is a required cofactor for the sirtuin family of proteins to exert their protective & anti-aging benefits.
Taking nicotinamide mononucleotide helps protect your body and brain. Emerging research finds that NMN optimizes NAD and helps restore organ systems to a healthy state.
I’ve written a guide on all the best NAD+ supplements you can find on the market if you want an even deeper dive into the topic.
But before buying expensive supplements, I suggest going the natural route.
How to Boost NAD+ Naturally
You can increase NAD levels through two primary ways:
- Adding specially formulated boosters
- Optimizing the NAD+ recycling process (salvage pathway)
You’ll get better, longer-lasting results from the latter.
Natural ways to boost your NAD levels without NMN include [R]:
- Raw honey
- Fermented foods
- Sauna sessions
- Pau D’ Arco tea
- Fasting
Eating more of certain foods that contain trace amounts of NMN:
- Broccoli
- Cucumber
- Cabbage
- Avocado
- Tomato
- Edamame
But you won’t get appreciable amounts from these foods alone.
I wrote a mega-guide to naturally boost your NAD.
After you’ve mastered the simple boosting strategies, you’re ready for the top products.
The Complete Longevity Supplement Stack (NMN & More)
Longevity supplements can get confusing:
Are you wasting money?
Is there significant overlap (and also gaps) in the pathways the supplements activate?
Is the product making a difference?
What if you can simplify your life, take fewer products, and get better effects?
This is all possible, and it comes down to this…
A well-designed longevity stack.
Ideal formulations contain multiple ingredients. Each targets and improves different facets of biological aging.
Keeping you looking and feeling younger and performing optimally.
Together, a multi-supplement formula is more effective than the sum of the parts. This is called the entourage effect, and it’s best understood as the “1+1=3 effect”. And, this powerful ingredient biosynergy often comes with fewer side effects.
So I designed a simple “Longevity Upgrade Cheatsheet” to summarize the benefits of 30+ popular longevity supplements as well as provide my universal essentials. Download it here…
Common NMN Questions and Answers
NMN vs NR: which is better?
NMN is more stable than NR and this stability confers additional health benefits. To use NR, first, your body must convert it into NMN. If the conversion enzyme NRK isn’t working well, NR won’t increase NAD levels. Many longevity researchers favor NMN over NR.
How can I tell if an NMN supplement works?
If you want proof that your NMN is high-quality and working, I suggest either doing an intracellular NAD test, or measuring your “biological age”. Take it before supplementation and again after six months. For more information and science on how this works, check out my InsideTracker review.
Is NMN safe?
NMN is considered safe in animals. Human trials so far show impressive safety. Follow-up studies have found similar results. NMN has so far been shown to be safe and not toxic, even at high concentrations. Make sure to purchase high-quality, contaminant-free products from reputable vendors.
What is the best NMN dosage?
Research suggests that the ideal dose for nicotinamide mononucleotide is anywhere between 100mg to 1,500mg daily, depending on the form. For normal NMN, the best results are seen at 900-1,250mg per day [R, R]. Although minimal, side effects do increase with larger doses.
Are there side effects of NMN?
Studies have reported no clear side effects from supplementing NMN within the recommended dosage. Nicotinamide riboside, on the other hand, may impair athletic performance. Athletes especially should consider NMN over NR.
Should I Take Trimethylglycine (TMG) with NMN?
I recommend taking an amino acid called betaine (or TMG) with NMN to support the body’s natural methylation process. TMG is believed to reduce any potential side effects. Especially when using oral NMN powder over the long term. TMG is likely less necessary for liposomal and sublingual NMN.
Will MIB-626 replace NMN?
MIB-626 is a novel and stable NAD booster produced by David Sinclair’s MetroBiotech. MIB-626 is under investigation for preserving muscle mass, improving cognitive performance, and slowing aging. Since it is “novel”, it’ll be patented and will make Metro huge profits. There’s virtually zero research on MIB626 compared to thousands of studies on NMN.
Why take NMN instead of NAD?
Counterintuitively, directly supplementing normal NAD powder isn’t effective. The molecules are too large and quickly get broken down. Liposomal and intranasal NAD supplement technology overcomes this barrier and works well.
The Best High-Bioavailability NMN Brands & Products to Slow Biological Aging
Without adequate NAD, we’d die within seconds.
You’re reading this, so that’s not the issue.
Partial depletion of this cellular “gas”, results in us unknowingly living below our potential.
That’s why many of the world’s top anti-aging and longevity researchers love nicotinamide mononucleotide:
- Dr. David Sinclair
- Dr. Axe
- Dr. Berg
- Dr. Hyman
- Dr. Rhonda Patrick
- Dr. Peter Attia
NMN is arguably the top NAD-boosting supplement available.
Users often report profound energy and overall health changes.
I always recommend starting with the cheap NAD+ boosting precursors.
Certain genetic variations and lifestyle habits, however, can dramatically increase your need for supplementation:
See my review of a powerful tool called SelfDecode I use to understand genetics and help folks personalize their ideal longevity protocols.
Alternatively, you can use one of these top biological age tests to get a real-time snapshot of your status. Then test again 3-6 months after supplementing. That’s one way to make sure you’re getting the real, unadulterated molecule.
Knowing your underlying biological needs can help you decide whether spending hundreds on NMN will be worth it.
Fake and adulterated products have flooded the NAD supplements scene. Many do not contain any NMN at all. Waste of money aside, using a contaminated NMN product does more harm than good. Choose one of the products above to slow aging, boost energy, and feel your best.
Questions or comments about any of this? Let me know your experience in the comments below!
Any news on Aeon?
I have tried it for 1 month and felt a big difference in my daily wellbeing. Got more energy and my stamina improved. I’m 46.
Hey Andreas! I’ve actually been talking to their team a lot and have tested some of their products. They are super transparent with me, and open to feedback. I like the way they conduct business. They even asked if I have a preferred third-party lab to test their products.
Anyway, I like the AEON formula. Haven’t included it in this list yet because the formula has changed 3 times since I first looked into them. Once they stick with a formula, I’ll add them here. Otherwise it will prompt too many questions. I did include them in this roundup of the best all-in-one longevity supplements though.
Glad to hear that formula is working for you!
Nick
Hey Nick,
I’ve come across NMN and resveratrol from Megaresvaratrol. Do you know this brand and/or endorse? Have also read people on the Renue by science forum are taking it. But apart from that I dont find much information from 3rd parties, media, blogs etc so if you have some intel I’d be more than happy.
Hey Nils, I don’t recall coming across that one before, and at this point I’ve seen hundreds of longevity supplement brands. I looked through some of their claims and either they don’t update the website, or are intentionally deceiving users. For example, they claim to be “The ONLY Resveratrol that is…” and list a bunch of factors. But I can think of several other products off the top of my head that meet all those same criteria. I personally wouldn’t use them.
Hello Nick,
Any update about Hansen ? They claim to have a NMN more pure than Renue to justify their price.
If you don’t recommend them, do you know an other Europe-based NMN producer (Renue stopped in Europe) ?
Thanks !
Hi! I haven’t heard anything back from them in a long time. I’m not sure how they figure theirs is purer. Unless they’re referring to the ingredients Renue uses for their liposomes. But in that case, “more pure” isn’t at all the same as more bioavailable. Their 100g NMN, for example, is also more than double the price. I prefer DoNotAge over Hansen for the EU. Are you able to find credible third-party data/quality reviews on Hansen? I’m interested in learning more.
Hi Nick,
Could you please advise further or Aeon Perpetua life?
Any experience if this is a good product?
It seems to good to be true.
Thank you for your advice and all you do!
Hi Eva,
Yes! I have been talking to their team quite a bit, and so far they seem like a credible and well-intentioned company. They are likely going to reformulate due to the pending NMN ban, but I plan on testing our AEON specifically and doing a more thorough evaluation once they send it. Basically, NMN is the main expensive ingredient in the stack. I like the ingredient profile. I actually made a few formula suggestions that I believe they plan to incorporate.
Once I receive my shipment, I plan to hop on a call with them to manually verify lab testing results and to further scrutinize everything. Then I can report back!
Nick
Hi Nick and thank you for a helpful site.
I also went and bought a supply of AEON from Perpetua.life and later have second thoughts about the ingredients in their product.
Their capsules weigh in at half the claimed weight, based on stated ingredients, and when I confronted them with this they claimed to have changed their formula. And gave me a new list of ingredients corresponding with my findings regarding weight, claiming reduced weight owing to customers complaining about size of capsules…The dosage of NMN was the same, they claimed. But their labels and their web-page does not update with this information.
I’m starting to worry what I’m ingesting.
Do you have updated information on this company?
Thank you,
-Morten
Hey Morten,
They used to be a crowd favorite. Hard to say right now (April 2023). I heard that they just recently reformulated and removed NMN to comply with the current regulations. Does the label on the products you received not match what they sent you? I’ve been emailing back and fourth with them for several months now. I was supposed to have a 1-1 call and get a product to check out myself. The man I was emailing seemed trustworthy, although I haven’t heard back since they mentioned potentially changing the formula. And I’ve followed up once or twice too. Just my $0.02.
Nick
Hi Nick,
Have you heard of CalerieHealth’s SOD+NMN, together with its other so-called healthcare supplements, such as hydrogen and probiotics? Some friends of mine claim they find the products effective, but I’m skeptical because they sell with MLM type direct-selling.
Will appreciate your input. Thanks!
Hi Helen,
I hadn’t heard of it, but just did a quick glance. It wouldn’t be in my top choices. First, they don’t show an ingredient label on the product page which is ALWAYS a major red flag for me. Second, they list 10,000 mg of NMN. Is that in the bottle? Seems like it’s just trying to capitalize on the “more is better” mindset since most people compare the dosages between bottles. Third, I am very cautious of MLM-style companies.
Hope that helps!
Nick
Hi Nick,
Thanks for all the great info. I am in the process of researching the different NMN Brands, trying to figure out which is best. I was curious to see if you had the chance to check out and review Life Force, I see they have some big names attached but I haven’t seen or heard any customer reviews as of yet. Hoping you could shed some light on this brand.
Thank you! Dave
Hi Dave,
You’re welcome! You’re right about Life Force. The company itself is indeed backed by big names. Seems like the Life Force NMN product is high quality, but the dose is quite low. Especially per capsule and the expensive price tag of the bottle. Wouldn’t be my first pick.
Nick
Happy Wednesday Nick. I really enjoyed your article. I just recently came across toniiq products. They even have a 1200 mg NMN product. They seem to have all the third-party tested results. Have you done any research on them? Curious your thoughts on this product’s bioavailability.
Link: https://www.toniiq.com/collections/all-products
Thank you for your time.
Hey there! I have come across them before. I’ve read and heard lots of negative things about their QC and questionable testing. Other folks in the industry have told me about their cut-throat practices designed to damage competitors. I won’t go into detail, but with so many other great options I am not a fan of this company.
Hello, I am surprised by the absence of comment/articles concerning the FDA investigation and its consequences on our consumption.
Nick, can you please enlighten us ?
Thanks !
Hi Seb,
I wrote a post last year as soon as I heard about the pending ban of alternative ways to increase NAD+ without NMN. It might still be sold, but as a “research chemical not intended for human consumption”. This is just a legal stunt to protect manufacturers. Same thing, different label.
Hi Nick,
Great article and really well put together web site with lots of useful info.
Do you have a recommendation for testing NAD levels?
My partner and I are about to start taking NMN and I feel that testing our NAD levels pre NMN dosing would make sense.
Thank you, Neil! I’ve used Renue by Science’s NAD IC tests previously. Although I’m not the biggest fan of NAD+ blood testing, because it’s notoriously unstable and inaccurate, unfortunately.
Hi Nick,
I have been reading the comments and your reviews on NMN and was wondering what would suit me best.
I’m 38yo female taking high blood pressure meds. My energy levels are very low and I’m usually under a lot of stress due to work, exercise strength twice a week and walk every second day. Healthy diet and started fasting a couple of weeks ago.
In my case is there any products from your list that would make more sense to take?
Appreciate any help.
Thank you
Hey Aline,
Of course, none of this is medical advice or prescriptions of any kind. While I certainly get the allure of NMN, if I were in your shoes, I would look into a class of safe, proven, and effective supplements called adaptogens. These bring the body back into balance and help buffer against stress. Some of the classics in this category are ashwagandha, ginseng, rhodiola, and functional mushrooms like cordyceps, lion’s mane, or reishi.
Hope this helps!
Nick
Thank you Nick for the prompt response.
I started taking the Jarrow Formulas Ashwagandha a month ago and am hoping to get the benefits of it soon.
Cheers
Aline
Hi Nick, are you aware of NOVOS Boost?
Hi,
I am aware of NOVOS Boost. It’s a decent product. Not my favorite. It’s just normal NMN (at a low dose) and fairly expensive for what you get. Although subscriptions make it far more affordable. I like their CORE product better, and would rather stack that with a different NMN or NAD+ precursor product. That said, I am a partner of theirs, so the code URBAN5 will get you an additional 5% off your order.
Hi Nick-
You might want to check out and review Peak NMN By Lifeforce. This has both NAD+ and 375 mg of NMN.
I second this. Looks like they have an impressive roster on their board of directors, and the ingredients seem promising:
Berberine HCL – 660mg
NMN – 375mg
White Mulberry Extract (as Reducose) – 200mg
Spermidine – 5.7mg
Lithium (as Lithium Orotate) – 450mcg
I just recently started using this brand. Hoping it is a good one. Hopefully Nick will look into it. I really don’t know if it’s doing anything, but I am hoping.
Hi Nick
thank you for all the info. Have you heard of a directly marketing company called ‘ihealth’ promoting their own brand of NMN? would like to know if you have come across them and what you think of them and their NMN product?
Hi Jack! I was actually just recently asked about them. Here are my thoughts from some very light research:
I just looked into Ihealth and I absolutely would avoid this supplier. Everything about them screams scam. They use endorsements which I highly doubt they have permission to. I couldn’t find the certifications they mentioned in all those “quality guarantee” logos on their home page. I did see the certificate by ConsumerLab and also the FDA “Certificate of Free Sale”. Even this one analysis is suspicious. Very little information about the actual testing, no data about safety (heavy metals and contaminants), no mass spec/HPLC graph, etc. Even the ConsumerLab sheet says “100mg of NMN claimed”. Yet the label says 150mg! Very deceptive. Plus it has two unnecessary supplement additives ingredients that I avoid.
Even if this was legit, 150mg NMN is low and inadequate. To top it off, these products aren’t cheap. You’re better off buying elsewhere.
Hi Nick,
Very helpful article as I am a newbie to NMN , I am looking at the Renee liposomal or the Ultra Health Pur 30C ( is this liposome ? ) , heard that NMN has to be stored nicely in order to be effective , do I need to keep them in the fridge ?
Thx !
Gilbert
Hi Gilbert,
Thank you and also good catch! I just noticed that they updated their product catalog and 30C is now the upgraded “NMN 300C ENTERIC”. The enteric coating helps it bypass stomach acid. Better than traditional, but not the same as liposomal.
NMN storage is very important. Especially between manufacturing and arrival at your home, since packages are often subject to extreme temperatures and light. If your home is air conditioned and you use the NMN frequently, it’s not essential. Overall, it’s a best practice though.
Hi Nick,
Thx for you reply and I’m trying to re-order on Black Friday deal , found out there isn’t any expiry date with Renue Liposomal , did email them but no response so far , any idea on their shelf life ?
Gilbert
Hi Gilbert! Great question. It lists the manufacturing date on the bottom of the bottle. I’d recommend using it within a year if you store it well. Since it’s liposomal, it might last longer.
Hi, Rick:
I am taking Tru Niagen (NR) for the past 3 months and I am beginning to see subtle improvements. Have you heard from anyone taking them?
Hi Vivian! I’ve heard of people getting good results from many of the natural NAD+ boosting lifestyle habits as well as other boosting supplements (like NR). For a long time, Tru Niagen was the dominant name in this market.
Thx for the feedback Nick!
Hi Nick,
I discovered your blog a few weeks ago. I am currently reading David Sinclair’s book on NMN and your comparison is super useful when come the time to choose a correct NMN brand.
The problem is that I live in the European Union (Belgium) and there is tooo much restrictions on such products. I’ve ordered some bottles from Renue by Science but I don’t know if I’ll be able to receive them (customs, health protection service, etc.).
By any chance, have you found some good producers of NMN within the European Union?
Thanks a lot and continue your great job 🙂
Sébastien
Hi Nick,
I have the same problem as Sébastien.
I would like to purchase NMN within the European Union. I found Hansen Supplements (Poland) but I’m not sure of their products are pure. I’ve seen that You had contact with this company a while ago by mail? Can You give me some more information please?
@sebastien: did You receive Your NMN from Renue by Science?
Thank You!
Hey Thomas,
Great question. They did answer a few of my questions via email. They assured me that the University of Wroclaw in Poland (Department of Chemistry) tests and approves all batches. But they didn’t provide a CoA. It still wouldn’t be my first choice. I am not sure if packages from the UK arrive easier than the USA, but DoNotAge is another option. I’ll keep my eyes peeled for a quality EU supplier.
Hi Nick,
I recently purchased 2 bottles of ProHealth NMN Pro 500 and am planning to try to deal with my recent physical quality issue ( since a year ago I found myself very difficult to recover from the exercise and after running/jogging. Additionally my sleeping problem made this getting worse and this already influence everything.. ) I am note sure if it is due to aging problem – I am a 43 guy – or I was overtraining.
Yet, I read an article from below link about Uthever nmn which ProHealth is using and it sounds this nmn is not workable.
https://www.nmn.com/news/uthever-nmn-nad-endurance
Do you have any advice for me? Should I get another brand of nmn?
Thanks for your time!
Hey Tung,
Thanks for sharing that! Unfortunate news. Two separate things here: Uthever nmn, and your situation.
If that result is replicated, I would be curious to see other brands. Several issues I see with that study: 300mg is a fairly low-dose, 60-days is a very short trial (even 90-days would be too short from what I’ve read), and the 31-person sample size is quite small. I would also want to see more details about the batch, since NMN is notoriously unstable and breaks down rapidly. That’s another reason I prefer liposomal NMN/NAD precursors.
For your case, was there a particular incident (injury, sickness, high-stress, etc) that led to your inability to recover? From your description, it sounds more like general under-recovery, which is multifactorial. You’ll want to focus on increasing anabolism in the short-term. NMN may help, but not as much as quality rest, essential amino acids, “working in” movements, de-stressing, etc. Of course, this is what I would do and certainly not medical advice.
Feel free to email me if you want personal help.
Dear Nick what’s your opinion on pulsing polyflavonols as senolytics/anti-inflammatory with nmn as nad boosters. As we get older we accumulate senescent cells and diseases such as autoimmune and even cancer which would do badly with unopposed nad boost. One option is to delay nad boost until after 40s and start with senolytics, another is to pulse intermittently. I know there’s no research here but what’s your gut feeling considering you are clearly widely read on the subject?
Many thanks
Nebil.
Hey Nebil! Very late here (just seeing a bunch of old commments I missed), but I think it’s a great idea! This is actually the protocol I recommend. Senolytics and anti-inflammatories first, then increasing NAD+. If you haven’t seen it already, you can check out my article on senolytic therapy.
Hi Nick,
Thanks for this helpful article! I was wondering if you had heard about Ascuoli brand. They sell “Resveratrol and NMN 1500mg Blend” on Amazon. The description says that the product is third party tested, but no further information is given. I was wondering if the brand is reputable and the product is legit. Thank you!
Hi! Appreciate you weighing in. I do not trust that product for several reasons.
– The bottle says third-party testing, but the description does not reference a Certificate of Analysis (CoA) or any other details.
– Second, the Amazon description says “Organic” in the title. No ingredients in the Nutrition Facts are organic. Nor does it have any organic certification.
– 50mg is a HUGE bioperine dose. Most are between 5-15mg. Not 50mg. While black pepper extract can increase the absorption of certain ingredients, it does so by modifying metabolism indiscrimenently. This can have all kinds of other side effects.
It is great to be part of your educative platform.I ordered two bottles of Lipo NMN+ today before I found your site .
Grateful for the information download . The world needs people like you you in their thousands.
Thanks, Samuel! Hope it helps you
Hi Nick!
Thank you for such a good comprehensive review about NAD/NMN. I was wondering if you had any thoughts on IV NAD therapy?
Hi Jeri, happy it helped you! Some people swear by it and say that they feel great after a few sessions. Far more than any supplement. Personally, I don’t do them for two reasons.
1. Value. They’re fairly expensive, take time, and the benefits are transient.
2. Unknown safety. NAD is a signaling molecule in the body. So I don’t love the idea of injecting it.
One potential idea would be to get the IV and then extend the effects via supplementation.
I do a lot of lifestyle things to keep NAD high and recently have also been supplementing Renue’s NAD Complete (I think it’s called).
Hi, Nick:
What is your opinion on RevGenetics? When I received the 3 x 1000mg bottles I check the address and it was a house! I then asked them where was their NMN manufactured and they told me that they could only provide that information to the FDA. I need help with this. I spent $242 and I can’t afford buying more at this time. I wish I had the money to take it to a lab and get it tested.
Hey Vivian, I hadn’t heard of them but just looked them up.
From their product page alone, I’m suspicious. A lot of little things. At one point they say “since 2017 when we first provided NMN to the public.” Two columns over they say “We have tested every batch of Advanced NMN for your safety since 2016”. Their CoA also claims 100% purity which no supplement can achieve. They also don’t use the usual high-quality lab I’m used to seeing (they also changed labs since their 2016 CoA).
Their response is also indicative of a low-quality product, I hate to say. Overall I wouldn’t recommend. Can you return it?
Thanks for your reply!
I have been experimenting and researching supplementation for years, but you are way ahead and this is great news.
Your feedback was very helpful. You confirmed my feeling about Toniiq. The resveratrol controversy you showed was important and Dr. Brad Stanfield seems unbiased and trustworthy. The only thing I can say is that Dr. Sinclair seems to honestly believe that it makes sense to take resveratrol – which is why he has been taking it for years. So, despite the controversy, he still has a reason to believe it might work. He also looks very well for his age, so whatever he is doing, it seems to work for him.
What supplements would you suggest for methylation support and bioflavonoids, and in what dosages? For the latter, I like Life Extension’s Optimized Quercetin (https://www.lifeextensioneurope.com/optimised-quercetin-250-mg-60-vegetarian-capsules) as well as NOW’s Quercetin with Bromelain (https://www.nowfoods.com/products/supplements/quercetin-bromelain-veg-capsules). Speaking of NOW, what are your thoughts on the company? It wasn’t listed in your top recommended brands, but I have been interacting with their staff recently (on Omega 3-s) and their attention to detail and just the time they have given me in their responses is impressive.
And while on the topic of anti-aging supplements, there are couple of more floating around that I would like to hear your opinion on:
– Metformin/Berberine, and
– Sulforaphane.
Your input is much appreciated.
Best regards,
Christo
He does believe it. But he’s also the one that’s done or consulted virtually all the research. I’m skeptical whether it really works like he claims. I’ve never heard him mention taking liposomal resveratrol or other forms with higher bioavailability. The research I’ve read critical of resveratrol has often highlighted the inability for humans to absorb it. As with many polyphenols. I get your argument, but we also don’t know if he looks young because of the resv, or in spite of it. A lot of people have been taking resveratrol for years and I haven’t seen reports of it changing any lives.
I like TMG, but creatine, choline, SAM-e, and a bunch of others support methylation. To avoid giving medical advice, I’ll just recommend the dosages listed on the products 🙂
The other bioflavonoids suffer from the same low-bioavailability problem as resveratrol. When I take them, it’s usually in liposomal form. What’s your goal with them? They have different purposes.
I actually like a lot of those large companies. They have a reputation to protect, so they tend to contain what they say. My issues with them is that they’re 1) often not using the most absorbable forms of ingredients 2) usually adding excipient, binders, flow agents, and other additives to cut costs.
I use berberine on occasion, on rest days when I’m eating high-carb (not very often). Dihydroberberine and liposomal berberine work better according to testing with my continuous glucose monitor. I don’t love metformin for the reasons I describe in that article.
I sometimes eat sprouts, and particularly broccoli sprouts, to get sulforaphane. Sulforaphane is volatile and not stable enough for supplements. The high-quality ones are expensive. I’d rather get it from sprouts because then I’m getting the other synergistic ingredients that research hasn’t identified yet.
Hello, Nick,
Thank you for this great article, it was immensely helpful.
Could you please give me your opinion on the Toniiq brand and especially their ElixR NMN+Resveratrol product? https://www.toniiq.com/collections/longevity/products/elixr-98
And while on the subject, what is your take on the necessity to take NMN in combination with resveratrol in order to improve the efficiency of NMN? This is according to David Sinclair.
Kind regards,
Christo
Christo, happy it helped! I’m not a fan of Toniiq in general. They’re a dirty player in the supplement industry. Engaging in practices like bashing competitors without trying the product, and getting fake reviews of their own products. I’ve heard this from several credible and honest supplement vendors. The website Fakespot.com also confirms the same.
I’m undecided about resveratrol. The more I learn about the studies, the less convinced I become. Dr. Brad Stanfield’s videos highlight major flaws with the research. After all, GSK spent $720 million to acquire the rights and later dropped development. You don’t scrap such an expensive project without good reason.
I think taking methylation support and a bioavailable bioflavonoid with NMN is better than resveratrol. Just my $0.02.
Hi Nick!
Thanks for the information you provided on your blog. Placed an order of the Liposomal NMN today using your link but later did i know its not Liposomal NMN its Sublingual NMN after paying. I’ll order again Liposomal NMN soon but kindly check and update your links.
Thanks!
Manuel
Hi Manuel,
Sorry about that! I just checked their link (https://renuebyscience.com/product/lipo-nmn-powdered-liposomal-nmn/) and it redirects to the wrong product. I fixed the link in my article, so it should work properly now. Appreciate you flagging that for me.
Hi Nick,
I’ve bought some of the Alive by Science Liposomal NMN Capsules, and have a question I’m trying to work out – they suggest a daily dose of 250mg. Meanwhile David Sinclair’s suggestion is 1 gram per day. From what I read on the Alive By Science website the liposomal delivery gives better efficiency of uptake, and so I had the idea that this was why 250mg is recommended rather than up to 1 gram. Do you have a view on this and whether I might consider increasing my daily intake to more than 1 250mg capsule? Am wary that when taking too much it can have adverse affects on the liver. Would be good to hear your views. Received my shipment a bit over a week ago and have been doing 250mg daily, all good so far, no noticeable effects, but I’ve been doing a number of other things for about a year – just turned 51, have pretty close to a full plant based diet with avoidance of processed foods, am into some breathwork that I find awesome, plenty of good and varied exercise, plus recently have started some fasting (15-16 hour spaces between meals, that are generally two within a window of 8 hours maximum), so I imagine NMN is just another thing that should make another incremental improvement. I did contact Alive by Science to ask the same question, but their answer didn’t really confirm to me a straightforward answer one way or another.
Thoughts much appreciated.
Gary
Hey Gary,
Totally understand where you’re coming from! NMN dosing in general is still “best guess”, with 1,000mg of the normal powder seeming to be a common recommendation. You are correct that liposomal delivery usually results in better uptake, and thus a significantly lower dose. I sometimes take two of their lipo capsules and my routine bloodwork shows no elevation of liver enzymes or anything worrisome. There’s little research comparing typical oral powder versus lipo NAD products, so I’d be surprised if they had a clear answer.
This isn’t medical advice, but I see a few options:
1) Take 1 capsule of lipo and 250mg of normal powder
2) Get baseline bloodwork/IC NAD tested and compare after taking 2 capsules
3) Take a second capsule every other day or so since liposomal supplements last longer in the body
But overall, happy to see that you’ve taken care of diet, movement, breathwork, and are trying fasting! No silver bullets, but incremental improvements as you mentioned.
I hope that this is semi-useful!
Nick
Dear Nick,
I read enthusiastically your “Best NMN Supplements 2021 Review” article, also I browse your extra articles.
I am 66, 174cm/72kg, healthy no drugs, do aerobic(running), vegetarian take long list of food supplements(vitamins, minerals, herbs, bee products, probiotics WHEY arginine, creatine L-carnitine and some longevity: Super Miraforte, Metformin, quercetin, resveratrol).
For longevity and Iifespan, I would like to receive your recommendation for extra best:
A. Supplements in the way that they will not disturb each other and when to take them (before/during/after meal and how many times per day).
B. Treatments.
I wish to have the best supplements/treatments no (almost) matter the cost.
Thanks in advance,
Zeev zeev@cos.co.il
Hey Zeev. Sounds like you’re already doing a lot. Since this pertains to your situation, I’ll go ahead and email you.
Hi there,
I was wondering if any of you have any experience with AEON from perpetua life? It seems too good to be true imo
Also, a bit scammy? The first image you’ll see on their page is their product with a pic of 1300 trust pilot like reviews. I wasn’t able to find any reviews anywhere on their product though.
What are your thoughts about this?
Thanks!
Martin, I haven’t personally used them but know people that have. First, the ingredients list looks suspiciously amazing, as you mentioned. I am very skeptical that it actually contains the listed dosages of each of those ingredients. I’d like to see third-party analysis of AEON.
I haven’t done diligence on the company yet. I always talk to the science/formulation team to see if they know what they’re doing. If you’re able to find more about them, please let us know. Unless you’re willing to be their guinea pig, for now, I’d recommend going elsewhere.
Hey, I’ve just come across AEON myself…the list looks Great…adding Vit K2 would be the best thing I can find for Longevity and Protection from Alzheimer’s due to APOE4/4 I can currently find.
Would love to hear if someone can verify ingredients.
Thanks,
Julian.
I’ve tried a few NMN supplements and I recently picked up AEON at Kroger. It seems ok as it gives me that same tingling feeling that I got when I did the NAD shots from Ageless which I highly recommend. I’m going to keep sampling, and I do appreciate this list. Very helpful.
I like the ingredients in that complex. For boosting NAD+ specifically with NMN, it wouldn’t be my choice as it’s not absorbed as well as many of the others.
Hi Nick thank you do much for all your amazing wisdom! I’ve just purchased AEON before finding your article. I can see on website that AEON have a COA attachment under testing section on their product page.
What are your thoughts on this safety/purity etc after taking a look at this. I like this combo of ingredients – does seem too good – so I want to get your thoughts on if it is legit before start taking.
I’m new to NMN and sometimes sensitive to new supplements in general (nausea etc).I primarily like the formulation for longevity and also good ingredients (quercetin, fisetin)for those with mast cell issues (like me!). I saw your comment about the NMN not being the most absorbable in this formulation – but thought this might be good if just starting out with NMN?
Any additional comments on purity/testing/safety and general due diligence you’ve come across would be amazing.
Many thanks in advance!
Appreciate you for asking, Cath!
I’ve heard about AEON and been asked about them several times. I have a few questions about their testing methodologies and about some of the results and why they choose particular labs, etc. I really do like the formulation of a bunch of powerful longevity ingredients in one single product.
You’re correct about the NMN not being in the most absorbable form. It’s not my top pick for NMN specifically, but seems like a great all-on-one longevity product. I do wonder about the safety of taking high doses of senloytic supplements (fisetin & quercetin) on a daily basis. I’m coordinating a call with their Science Team to discuss the methodologies and testing they do to ensure it’s as high quality as they claim. If so, I’ll add it to this list!
Nick
Hi nick,
Let us know once you have an answer 🙂 really keen to understand if they trustworthy !
Hey Max!
I’ve actually talked to the founder several times now and he shared a lot of their private data with me under NDA. Including testing, manufacturing, and business info. I’m a fan of AEON and actually have a few bottles at my house.
Nick, sorry for jumping the gun before reading up on what you previously been writing. I found your comments on Niagen, including this comment “Tru Niagen is the gold-standard, proven to increase NAD+ levels by 40-50%.” That sounds great to me. However, reading your earlier comments, listening to Attia, sinclair etc I hear that you all prefer NMN because of the body’s need to convert to NR to NMN (as I understand it) before it becomes NAD. 40-50% sounds very good. Is the thought that NMN would be even more effective then?
No problem. That’s the general consensus. NR has more human research on it, and Tru Niagen leads the way in terms of track record. Right now, the evidence suggests that NMN is more effective. Only time will tell. To be honest, however, I think that most people are best off making sure they do the cheap/free things to boost NAD first. These improve multiple different pathways involved in healthspan. I personally take NMN and have NR that’s just sitting around collecting dust.
I just clicked both your links for Liposomal NMN Capsules and they’re no longer available for pre-ordering. Do you know why? Meanwhile, I’ll try the nasal spray.
Hi Christina,
Looks like they’ve sold out of Liposomal NMN caps, unfortunately. They’re in extremely high demand.
Thank you for all the great information! What do you think about Niagen (truniagen.com) by Chromadex? Would that be less effective because it has to be converted into NMN first? Do you know about the manufacturer? My husband just started taking it. I’m going to order Liposomal NMN Capsules for myself after reading this and listening to Attia.
Hi Nick…how would you rate Komprocha Brand NMN & Resveratrol 1150 Mg (2x day)???
The actual NMN in each tablet is 250; Trans-Resveratrol in each tablet is 300 mg. Black Pepper Extract of each tablet is 25 mg. Am 75 woman, in excellent health, but would like to keep brain activity at healthy as possible. Many thanks!!
Hey Jamie, that’s another one I hadn’t heard of. I looked for the brand’s website to research their process, and nothing turned up on my initial search (and if they do have a website and it doesn’t appear via a search, that’s also worrisome). Since all I could find is an Amazon listing, I cannot comment on the quality/purity — which is the entire point of choosing a high-quality product! Keep in mind that anything with Bioperine/Black Pepper Extract will increase absorption of ANYTHING that goes through that same P450 pathway. Good or bad.
The biggest issue with resveratrol is also absorption. It’s why many longevity scientists abandoned the compound. If you want to use resveratrol, I suggest looking into liposomal supplements. Alive By Science makes a liposomal NMN + Resveratrol, for example.
ConsumerLab reports the Chromadex Study (Tru Niagen maker) showing Komprocha with basically nothing in it in the NMN study. I bought 240 caps. Most in the study showed little or none. Bought Tru Niagen just now on sale. So, NR until I decide on a bonafide NMN. Shame on Amazon.
Sorry to hear that. I hadn’t heard of Komprocha, but I do know that, sadly, many companies “fairy dust” their products with NMN or omit it entirely. Be very careful if buying supplements (especially NAD products) on Amazon. Often times they’re actually counterfeits sold by third parties. Who knows what you’re really getting.
Avoid, it actually doesn’t contain any NMN. Check this video: https://www.youtube.com/watch?v=LmQHGUUQ2oc
Hey nick thanks for the great article!
I recently got a product call the real NAD+ From my naturopathic doctors office who’s pretty up on stuff. It’s sublingual. Just wondering if u have heard anything about it cause I really can only find stuff about it on the website. It’s not nmn but they claim it raises nad+ blood levels.
I was also wondering if something called oligonol has gotten on your radar it has amazing benefits for skin, metabolic syndrome, visceral fat etc. I don’t know a ton about exactly why david Sinclair recommends resveratrol but I know oligonol also works on the sirt1 pathway.
Would love your thoughts!
Shana
Hi Shana!
Thank you. I haven’t heard of that product in particular. Do you have a link to it?
The jury is out on NAD+. Some claim it effectively raises NAD levels (especially in the brain), while others say that it’s mostly broken down in the liver. I use the AliveByScience NAD+ Nasal Spray which, due to the administration method, likely has a greater impact on brain NAD levels.
I’ve heard of Oligonol, but still waiting on some more research. There are just too many promising compounds to take! The biggest issue with most SIRT1 activators is bioavailability. Seems like liposomal supplement tech (resveratrol & quercetin) partially solves this.
If you decide to try Oligonol, let me know how it goes!
Hi, I’ve been taking NMN for the past month, I bought it online from a company called AEON the website is perpetua.life. I don’t feel any difference yet, I was just wondering if you heard about it and if it is a legit product.
Hi Ariela, I’m not familiar with that brand. I can look into it. From a precursory scan of their website, here are a few of my thoughts.
1) I like the formulation. They don’t use the most absorbable forms of the ingredients, but those are all promising for longevity.
2) I don’t see a CoA or any indication of safety/purity/stability testing. You’ll want to get that from them.
Just so you know, many people don’t feel NMN at all. Some people do feel a slight energy buzz from sublingual NMN though.
Hey Nick,
Just came across this post and was thinking the same as Ariela. Have you had chance to have a more in depth look at the AEON product?
Hey Jonny! Just responded to Eva who had a similar question to you. Overall, I’ve been talking to their team and it seems like a solid product. Still waiting on my shipment to arrive so that I can investigate further and determine quality.
Curious too.
Hi, I am an 87 year old woman still in reasonably good health. I am active and belong to a hiking club. I just completed my first jar of double wood powder NMN. Is there another brand that is less expensive? Is it even effective to be starting this at my age? I also take resveratrol. Would you recommend any other supplements related to reducing biological age?
Thanks Betty
Hi Betty, glad to hear that you’re still active! Impressive that you’re on top of this science. I don’t think that there are many brands cheaper than that. Though there will be for Black Friday! Actually, it becomes more important as you age. So yes, NMN makes sense. Note that it might take a while to feel the effects.
This won’t be as exciting of an answer, but do you have routine bloodwork done? Are you getting ample vitamins, minerals, trace minerals, and amino acids? That’s a great place to start.
Awesome!!!! I’m not all that far behind you. I am 69 and am in the gym working hard building muscle on every inch of my body. I started at about 55 with ME/CFS.
I went from gentle Pilates to working out five days a week at an athletic performance training center one hour in the weight room and one hour on the turf. Then I had to have a hip replacement and then Covid ….haven’t been able to get back to that level.
How would you rate the NMN from Revgenetics?
Hadn’t heard of them, but I wouldn’t go with them due to the dosing alone. 50mg of NMN in 2 capsules. 1 bottle ($38) contains just 1,500mg of NMN. There’s more inactive ingredient than NMN
Hello Nick,
In your July 4th 2021 post you said you were testing Alive By Science Lipo NMN.
A little over 3 months later what would say about that Lipo NMN supplement ?
How many Lipo NMN 250mg capsules do you take daily ?
How many Lipo NMN 250mg capsules a day would you advise to people in their mid 40s and mid 50s ?
Thanks for your time.
Have a nice day.
Hi Hemmet,
Correct. I’ve tested their lipo, sublingual, and nasal spray. I’ve used their sublingual most (only because I have the most of it). Though their lipo and nasal sprays are supposed to be more effective. To be completely transparent, I stopped taking NMN daily because I am young (26), already use other precursors, and engage in lifestyle practices that support high NAD levels.
When I do, I take just 250mg of lipo NMN. When I take sublingual, I take 500mg to feel a slight energy boost for my workouts. I’d stick to 250mg – 500mg of lipo. It’s a good idea to consume alongside a methyl donating supplement like choline, creatine, or TMG.
Hi Nick,
Thanks for this wonderful blog and sharing your insights. I was wondering if you could recommend a preparation that combines these methyl donating supplements or if there is another preparation thats is good for taking either of these choline, creatine or TMG. Should people only take one of these or are they ever combined as well when taking with NMN? I am asking for an older woman (in her late 70s).
Thanks, Swati
Hi Swati!
Happy you found it helpful. None of those are considered dangerous. You can even get them from diet. I don’t think it’s necessary to take them all. TMG is the typical recommendation, but any will do.
I’m curious as to how you feel about reservatrol and tmg, which some sites sell as an essential accompaniment to NMN…
Hey Joe!
Great questions. I think that both are interesting ideas but for different reasons. Using TMG alongside NMN is for its methyl group donating properties. Basically synergizing to make sure that taking large doses of NMN doesn’t deplete the body and so that it works best. For methylation support, there are several great options:
– Choline (as CDP choline or alpha-GPC) which also benefits learning, memory, and movement
– Creatine which is a nootropic, improves nutrient delivery, and enhances physical performance
– TMG increases nitric oxide and may have several other benefits
I personally prefer using either choline or creatine.
I like resveratrol, but for other reasons. It’s another longevity-promoting supplement (SIRT activator). But most supplements are poorly absorbed and don’t have much effect. As I explained in my post on buying resveratrol, you should look for certain formulations that make it work better.
Hope this helps you.
hello! I am new to this and I am desperate for an advice.I bought NMN, resveratrol and TMG from Hansen supplements. From their website it seems they are legit but I can not find any review and I am worried that they may be harmful. Do you know anything for this brand?
Hello! I wrote you a long comment, but it looks like it never posted for some reason.
Anyway… I was recently asked the same question and I exchanged emails with Hansen. They started selling NMN out of personal necessity when they couldn’t find other suppliers (back in the early days of David Sinclair’s book Lifespan). Apparently, the University of Wroclaw in Poland verifies the purity of each batch. I’m a little hesitant to recommend them as I’ve heard virtually nothing about them and they claim to be one of the oldest vendors in the space. Plus, their products are no longer cheaper than the most trusted recommendations.
If you’re worried, I suggest you get blood labs done. Pay particular attention to liver enzymes. That’ll at least help you determine if they’re contaminated (but that won’t tell you anything about effectiveness). Feel free to shoot me an email (nick@outliyr.com) and I’ll help you out however I can.
Do you have more
Information about Hansen Supplements after these years?
Hi! Just responded to another comment on Hansen supplements. I haven’t heard back from them in a while. I also haven’t used them or found very much third-party data. Out of curiosity, what do you like about them? It’s entirely possible that they’re a great company. But with the state of the supplement industry (and all the fraud), I err on the side of caution.
They are legit and Hansen have their NMN tested in Europe (Warschau University )
Hello, have you found out anything new about Hansen suppliments? I bought NMN and Resveratrol from them and started using them about 7 months ago. It’s the first time I’m using these suppliments but I can’t see any results by now. I’ve read that it is supposed to feel extra energy after NMN but I really can’t feel anything
Hi and thanks. I just tried another brand, GeneX. Only took half dose, 125 mg. I had positive all day results. I’m healthy, 110# female. Probably will try to reduce my next dose and do not wish to take every day. I want to say GeneX may be made in China, not sure. I would give what I took the Wow factor. Over 60 yo. Thank you. I do want to order the Alive by Science, noticed the caps are 300 mg, pretty sure that would overload my system. What do you think of taking the capsule and dosing it out somehow? Guess I’d have to eyeball it. Nothing on the label of what I have indicates liposomal, did seem to be time released. Thanks so much.
That’s great to hear. GeneX is another good option. It is made in China, but ingredients should be pre-tested before they go into production (if their cGMP is any good).
I’m younger, so my NAD levels are naturally higher and I don’t feel anything less than 500mg.
If the label doesn’t specifically mention that it’s liposomal, it isn’t. Liposomal is far more difficult and expensive to manufacture. Aside from sublingual and nasal spray, most that forms that I’ve tried take a while to produce a noticeable effect.
The sublingual tablets are 250mg and can easily be broken into smaller pieces. Of course, you wouldn’t get exactly 125mg. Capsules are a little more difficult. But I believe it shouldn’t be a problem.
Hi, I am trying to use the discount URBAN for Ultra Health but it doesnt seem to work.
Can you check and let me know a code that works?
Thanks!
Raul
Hi Raul,
Sorry about that! I talked to Ultra Health and it is up and running on my end. Can you try again?
Hello
I am trying to purchase the nmn liposamal capsules x 90 however when I press purchase it comes up as 100 ml tonic
Can you please advise?
Michele
Hi Michele,
You’re right. The table was inaccurate. QuickSilver only produces the liquid, so I updated the post to reflect that. Sorry! If you’re able to wait for the public release in a few weeks, Alive by Science makes a great LIPO NMN powder product that I’m testing. Added it to the post