How to Get the Nutrients Modern Food Misses

Published:

E266

26

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With Nick Urban of Outliyr, Episode 266

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What You’ll Learn

  • Why the “balanced diet” advice is out of date: The model behind “you don’t need supplements” is decades old, and modern food no longer carries everything your body needs. [00:46]
  • How seed selection thinned out nutrition: North America once grew over 17,000 named apple varieties. Grocery stores now stock roughly 10, bred for yield and shelf life over nutrient density. [02:24]
  • What 50 years did to the soil: Across 43 crops from 1950 to 1999, zinc fell 27 to 59% and calcium 16 to 46%, so the same vegetable delivers far fewer minerals today. [04:21]
  • Why greenhouse & hydroponic produce is weaker: UV stress drives polyphenol production, so glass-grown and soil-free produce looks great but carries fewer antioxidants. [06:32]
  • How much nutrition disappears before your plate: Fresh supermarket spinach can lose up to 50% of its vitamin C within a week of refrigeration, before any cooking. [08:08]
  • What processing strips out: Milling white flour removes 70 to 90% of B vitamins, and roughly 80% of magnesium is lost during food processing. [10:01]
  • How farm chemicals block absorption: Glyphosate was patented as a mineral chelator and later as an antibiotic, and at residue-level doses it can kill up to 54% of common gut bacteria. [12:11]
  • Which everyday foods left the modern plate: Organ-meat intake dropped about 90% since the 1970s, and over 90% of American adults fall short on choline, found mainly in liver and eggs. [15:00]
  • Why your body burns nutrients faster now: Microplastics, medications, stress, and sweat all raise demand, and 1 in 7 Americans take an acid blocker that limits B12, iron, and calcium uptake. [22:32]

Why It Matters

Mainstream health writers keep repeating that a balanced diet makes supplements pointless. Nick Urban, founder of Outliyr, walks the full chain from seed to cell and shows where modern food quietly loses its nutrients, pointing to declines like the roughly 80% of magnesium destroyed during processing. The takeaway is practical and hopeful: closing a measurable nutrient gap is one of the simplest upgrades you can make.

Who Should Listen

  • Anyone who eats clean but still feels low on energy and wonders why food alone isn’t enough.
  • Biohackers who want the science behind a smart supplement stack before they build one.
  • Skeptics who’ve read that supplements are a waste of money and want the other side of the argument.

Episode Overview

In this episode, Nick makes the case that supplementation is no longer optional in 2026. This is part one of a two-part series. Here he focuses entirely on the why, tracing every point along the chain where modern food loses the nutrients your body is built to use.

He walks through seven hidden gaps: seed selection and depleted soil, the way produce is grown, losses between harvest and your plate, industrial processing, the chemical load from products like glyphosate, the ancestral foods and mineral-rich water that left the modern diet, and the higher nutrient demand your body now carries from toxins, medications, stress, and weaker digestion. Along the way he cites concrete numbers, from a 90% drop in organ-meat consumption since the 1970s to the roughly 50% rise in microplastics found in human brain tissue between 2016 and 2024.

The turning point is simple. Once you see how many steps quietly drain nutrients, supplementation stops looking like a gimmick and starts looking like a smart, affordable way to close the gap. You walk away knowing exactly why the gap exists, ready for the next episode on how to actually pick what to take.

Score Card for This Episode

Magnesium comes up again and again in this episode, from depleted soil to processing losses to stress-driven excretion. Here is how it scores in the Outliyr BioHarmony framework.

Magnesium: 8.2/10 (Strong recommend). Read the full breakdown.

Want your own personalized scores? Take the 2-minute quiz at outliyr.com/apps/bioharmony-profile.

Key Terms Quick Reference

  • [02:24] Nutrient density: The amount of vitamins, minerals, and beneficial compounds per calorie of food. It has fallen across modern crops, so a serving today delivers less than the same serving decades ago.
  • [04:56] Mycorrhizal fungi: Soil fungal networks that plants use to pull trace minerals from deep soil. Tilling, fungicides, and glyphosate destroy them, so minerals stay locked out of reach.
  • [06:32] Polyphenols: Protective plant compounds produced as a stress response, often triggered by UV light. Greenhouse and hydroponic growing remove that stress, lowering antioxidant content.
  • [05:34] NPK fertilizer: A fertilizer that replaces only nitrogen, phosphorus, and potassium. It leaves out boron, copper, zinc, selenium, manganese, and iodine, so those stay missing from the crop.
  • [12:11] Mineral chelator: A compound that binds minerals so they cannot be absorbed. Glyphosate was originally patented as one, binding calcium, iron, copper, manganese, zinc, and cobalt.
  • [16:46] Demineralized water: Water stripped of minerals by reverse osmosis, ion exchange, or softening. It once supplied 5 to 20% of daily magnesium and calcium, now largely removed.
  • [21:03] Nutrient competition: When two nutrients share a transporter and block each other, like zinc and copper or calcium and iron. It means what you take can quietly displace something else.

Why Does Modern Food Have Fewer Nutrients?

The short answer

Nutrients are lost at every stage, starting with seeds bred for yield and shelf life, then grown in depleted soil that no longer holds the full mineral set.

What Nick found

Varietal diversity collapsed, from over 17,000 named apple varieties in North America to roughly 10 on store shelves. Soil tells the same story: across 43 crops between 1950 and 1999, iron fell 15% and riboflavin 38%, and a 2024 review found zinc down 27 to 59%. NPK fertilizers replace only three nutrients, leaving boron, copper, zinc, selenium, manganese, and iodine missing.

What to do about it

Choose the most nutrient-dense food you can, favoring field-grown, soil-grown, and seasonal produce over greenhouse and hydroponic options. Then treat targeted supplements as the simple way to refill what the soil and seed no longer provide.

“The minerals are no longer in the soil, the vitamins are processed out of the foods that we buy, and then your body burns through what’s left faster than ever.” – Nick Urban

Related: Amazing Magnesium Benefits You Should Know

How Do Farm Chemicals Affect Your Nutrients?

The short answer

Agricultural chemicals do two things that hurt nutrient status: they bind minerals so plants and people can’t use them, and they disrupt the gut bacteria that handle nutrient extraction.

What Nick found

Glyphosate, the active ingredient in Roundup, was patented in 1964 as a mineral chelator that binds calcium, iron, copper, manganese, zinc, and cobalt, and again in 2010 as an antibiotic. It shows up widely too, found in 81% of American urine samples by one CDC estimate. Fungicides, chlorine washes, and antibiotic residues add to the load on the gut microbiome.

What to do about it

Lower the chemical load where you can by choosing organic and well-sourced food, and support the gut that does the absorbing. For readers who want the research, Nick points to the work of Dr. Stephanie Seneff at MIT on glyphosate and sulfur metabolism.

“A 2022 study showed that it kills up to 54% of common gut bacteria species at residue level doses.” – Nick Urban

Related: Natural Ways to Support Cellular Detox

Why Does Your Body Need More Nutrients Now?

The short answer

Modern life raises demand. Your body spends extra nutrients clearing toxins, offsetting medications, and managing stress, while weaker digestion absorbs less of what you eat.

What Nick found

Microplastic concentration in human brain tissue rose roughly 50% between 2016 and 2024, and clearing it burns glutathione, glycine, and B vitamins. Common medications, from acid blockers to statins and metformin, deplete specific nutrients, and 1 in 7 Americans take a stomach-acid blocker that limits B12, iron, and calcium absorption. Stress, coffee, alcohol, and heavy sweating raise losses further.

What to do about it

Match your intake to your real demand. Account for medications, caffeine, alcohol, and sweat, support digestion, and use supplements to cover the extra load your body now carries.

“Microplastic concentration in human brain tissue rose roughly 50% between 2016 and 2024.” – Nick Urban

Related: Biohacker’s Ultimate Water Protocol

The Nutrient-Gap Action Plan

A practical way to close the gap before reaching for a single capsule, then fill what’s left with a smart stack.

  1. Prioritize nutrient density: Choose the highest-nutrient food you can, favoring organic, pasture-raised, and seasonal options.
  2. Bring back ancestral staples: Add liver, eggs, bone broth, and fermented vegetables to reclaim choline, retinol, and B12.
  3. Steam instead of boil: Steaming or microwaving with minimal water preserves about 80% of vitamin C versus heavy losses from boiling.
  4. Choose cold-pressed and whole: Pick cold-pressed oils and whole grains over solvent-extracted and refined versions.
  5. Upgrade your water: Remineralize reverse-osmosis water and filter chlorine, fluoride, and contaminants that displace nutrients.
  6. Account for what depletes you: Track medications, coffee, alcohol, stress, and heavy sweating that raise your needs.
  7. Close the rest with a smart stack: Where food can’t reach, add targeted supplements to fill the measurable gaps.

Common nutrient-gap mistakes

  1. Assuming “organic” means fully nutrient-dense, when depleted soil still grows depleted produce.
  2. Using supplements to excuse a junk diet, instead of letting them fill gaps around real food.
  3. Chasing influencer trends, rather than matching nutrients to your own situation.

Source: Nick Urban’s Nutrient-Gap Framework, Outliyr

Frequently Asked Questions

Do you really need supplements if you eat a healthy diet?

Even clean, organic, grass-fed food no longer carries the full nutrient set your body needs, because seeds, soil, processing, and storage all reduce nutrient density. A smart supplement stack is the simplest way to close that measurable gap.

Why is modern food less nutritious than it used to be?

Crops are bred for yield and shelf life rather than nutrition, soil is depleted of minerals, and processing strips much of what remains. Across 43 crops from 1950 to 1999, nutrients like iron and riboflavin fell measurably.

Does organic or grass-fed food fix the nutrient gap?

It helps, but it does not fully solve it. Depleted soil still grows depleted produce, and even animals depend on the nutrient content of the plants and soil in the food chain.

How does glyphosate affect nutrient absorption?

Glyphosate was patented as a mineral chelator that binds calcium, iron, copper, manganese, zinc, and cobalt, and as an antibiotic. One 2022 study found it can kill up to 54% of common gut bacteria at residue-level doses, disrupting nutrient extraction.

Which foods did the modern diet lose?

Organ meats, bone broth, fermented vegetables, raw dairy, and wild plants and herbs were daily staples. Organ-meat consumption alone dropped about 90% since the 1970s, removing top sources of choline, retinol, and B12.

Can supplements replace a healthy diet?

No. Nick is clear that supplements fill gaps around clean eating, they do not make up for a junk diet. The goal is to eat the most nutrient-dense food you can, then supplement where food falls short.

Did our ancestors take supplements?

Not in pill form, but they ate concentrated nutrient sources like liver, bone broth, and fermented foods, and traditional systems such as Ayurveda used herbs and adaptogens for thousands of years.

Products, Tools, & Resources Mentioned

Outliyr independently evaluates all recommendations. We may get a small commission if you buy through our links (at no cost to you). Thanks for your support!

Go deeper on Outliyr

Best Biohacking Supplements by Category: A category-by-category guide to building a stack, best for deciding what to actually take.

Amazing Magnesium Benefits: A deeper look at the single most-cited nutrient in this episode, best for understanding why magnesium is foundational.

Biohacker’s Ultimate Water Protocol: How to remineralize and clean your water, best for closing the water side of the nutrient gap.

People & research mentioned

Dr. Stephanie Seneff, MIT senior research scientist, for her work documenting glyphosate’s interference with sulfur metabolism and gut microbial diversity.

About Nick Urban

Nick Urban is the founder of Outliyr and host of the High Performance Longevity podcast. A self-described bioharmonizer and performance coach, he blends modern science with ancestral wisdom to decode the tools, tactics, and timeless principles of human optimization. His work spans cutting-edge biohacks and grounded lifestyle practices, with a focus on what actually moves the needle on energy, healthspan, and performance. He shares testing, protocols, and product reviews through Outliyr and the podcast each week.

Follow Nick: Website | Outliyr YouTube | High Performance Longevity

Nick Urban, founder of Outliyr

Music by Alexander Tomashevsky

Full Episode Transcript

Transcript

Nick Urban [00:00:01]:
You’re listening to High Performance Longevity, the

Nick Urban [00:00:05]:
show exploring a better path to optimal health for those daring to live as an outlier in a world of averages.

Nick Urban [00:00:13]:
I’m your host, Nick Urban, bioharmonizer, performance coach, and lifelong student of both modern science and ancestral wisdom. Each week we decode the tools, tactics and timeless principles to help you optimize your mind, body and personal performance span things you won’t find on Google or in your AI tool of choice. From cutting edge biohacks to grounded lifestyle practices, you’ll walk away with actionable insights to look, feel and perform at your

Nick Urban [00:00:46]:
best across all of life’s domains. There’s this entire genre of mainstream health advice telling you that supplements are a waste of money. You eat a balanced diet, you’re fine, you don’t need any of this stuff. I’ve been reading those takes for years and I think they’re some of the most irresponsible advice in mainstream health media. Not because the authors are stupid, not because they have any issues, but because the model that they’re working off of is decades out of date. Modern food, even the most organic, biodynamic, regeneratively cultivated, pasture raised where relevant. Grass fed and grass finished. All of these labels no longer carry exactly what your body needs.

Nick Urban [00:01:35]:
Perhaps the one exception being if you cultivate all your food at your house and you adhere to all the best practices. But very few people do that. Obviously, that’s unrealistic for the vast majority, the minerals are no longer in the soil, the vitamins are processed out of the foods that we buy, and then your body burns through what’s left faster than ever. The gap is real, it’s partially measurable, and the easiest way to close that gap is with a smart supplement stack. Today, I’m going to walk you through every place along the chain where modern food fails you. We’re not going to be covering how to pick a supplement tonight. That’s the next episode. This one is focused on the why.

Nick Urban [00:02:24]:
Why is it Even important in 2026 and beyond? Let’s go. Let’s walk through the full chain from the material inside that seed all the way to where your cells either use or don’t get the opportunity to use that nutrient. For all you holistically minded folks tuning in, you might have thought I was going to start with the soil, but it actually starts even before then, before food gets grown. The seed it comes from has been purposely selected for yield, shelf life and pest resistance, not for nutrient density. To make things even worse, we’ve collapsed the varietal diversity over the last century or so. What do I mean? There used to be over 17,000 named apple varieties cultivated in North America alone. Today the the grocery stores carry maybe 10. And that would be a high end grocery store with lots of choice.

Nick Urban [00:03:21]:
Different varieties have different nutrient profiles, different polyphenol concentrations, different mineral uptake, different shelf life, different nutrient trade offs. We specifically picked the most durable ones. We can also look at tomatoes. There were previously thousands of heirloom varieties of tomatoes, and now there are four, maybe five that dominate the supermarkets. The ones that survived were chosen for their thick skin, making shipping easier, and uniform red color, which has greater shelf appeal and therefore is more likely to be purchased not for flavor or nutrient density. For the wheat eaters, modern wheat has between 19 and 28% less zinc, iron, copper and magnesium than the cultivars from before 1965. The upside of all this is that food is now more affordable, but it has come at the cost of nutrient density. And that is the theme that you’re about to see continues on throughout.

Nick Urban [00:04:21]:
Number two. The soil is where every mineral in every item on your plate originated, including if you’re a carnivore. The soil today isn’t what it used to be. One study looked at 43 crops between the years 1950 and 1999. They documented that protein levels in the food decreased by 6%. Riboflavin down by 38%, iron down 15%. And then a follow up 2024 review found similar declines. Potassium down 16 to 19%.

Nick Urban [00:04:56]:
Calcium down 16 to 46%, zinc down 27 to 59%. If your soil is depleted of magnesium, it’s likely to grow crops with up to 40% less magnesium in them. Then you have what are called mycorrhizal fungi networks. Plants use these to extract trace minerals from soils. Then you have what are called mycorrhizal fungi networks. Plants use these to extract trace minerals from soils they otherwise could not. Tilling destroys those networks, as does the application of fungicides, one that we’ll touch on perhaps later. Glyphosate destroys them again.

Nick Urban [00:05:34]:
So even where minerals exist in deep, deep soil, the plants still can’t access them. We also have the issue of acid rain, leaching base cations from soil Calcium, magnesium and potassium specifically. This is caused because industrial sulfur and nitrogen oxides acidify rainfall, which strips minerals from forest and farm soils over decades. This has been documented for over half a century. Specifically, soils in the eastern United States and northern Europe show calcium and magnesium depletion attributed Specifically to acid deposition. Luckily, we have NPK fertilizers, which are applied to add back some nutrients into the soil. So plants do get more nitrogen, phosphorus and potassium, but that’s it. There’s no boron, copper, zinc, selenium, manganese, iodine.

Nick Urban [00:06:32]:
All the other essential nutrients are lacking. Just those three are there. Now, how the plant actually grows determines what protective compounds it makes. Many of the things that people supplement can also be obtained from food if the plant is grown in the right conditions. Ironically enough, those right conditions tend to be stressful environments for the plants. And modern industrial agriculture eliminates most of the stresses plants need to produce these substances in therapeutic quantities. Produce today is often grown in greenhouses, and greenhouses without UV stress result in less antioxidant content. That’s because UV light triggers polyphenol production in plants.

Nick Urban [00:07:15]:
Greenhouse glass blocks most of the uv. So although they might look prettier, greenhouse tomatoes are nutritionally weaker than tomatoes grown in the field. Similarly, hydroponic produce has lower mineral and polyphenol density than soil grown produce. That’s because in the hydroponic setup, there are no soil microbes, no drought stress, no pest pressure, which means that there is little to no defensive compound production. Polyphenols are the plant’s stress response. This also isn’t just limited to polyphenols or flavonoids. For example, tobacco uses nicotine as a deterrent to pests, and humans use nicotine for recreational purposes. Wild tobacco often has higher levels of nicotine as well.

Nick Urban [00:08:08]:
One area that might seem a bit strange is that rising CO2 levels actually can improve the size of produce as well. But that comes at the cost of lower nutrient density, at least According to a 2014 study I read by Lolitz et al. Even if the food was nutrient dense at the field where it was grown, what happens between harvest and your plate burns? Most of what was there? Fruits and vegetables headed to grocery stores are harvested before they’re ripened. Ripening on the vine is when peak vitamin C, polyphenols and carotenoids accumulate. Picked green food never reaches that same peak. How long does that whole process take? It can vary. Produce can spend weeks to months in cold storage. Some imported fruit travels half the world over many weeks before hitting your fridge.

Nick Urban [00:09:05]:
For example, apples can sit in storage for up to a year in a controlled atmosphere. Vitamin C and other nutrients start to oxidize and break down the moment it comes off of the tree. Now, that’s not an issue over a short time horizon. Days, maybe weeks, but as you start getting to the months level, what you receive is often very different from what is harvested. There are some great technologies here such as wax coatings and controlled atmosphere packaging and that extends shelf life by slowing respiration. Slowing respiration comes with the unfortunate trade off of also slowing the metabolic processes that produce some of the bioactives. Even, even your fresh supermarket spinach can lose up to half 50% of its vitamin C within one week of refrigerated storage. And these are with the natural foods.

Nick Urban [00:10:01]:
When it comes to the foods that receive industrial food processing, that’s where most of the remaining nutrients exit the food. Wheat is probably the most egregious milling. White flour strips 70 to 90% of B vitamins and and 50 to 80% of minerals. Thiamine drops by 90%. Vitamin B6 down 85%. Magnesium down 80%. Zinc down 70%. Vitamin E down 95%.

Nick Urban [00:10:33]:
So called enrichment puts four nutrients back out of about 30 or so lost. A 2025 review showed that around 80% of magnesium is destroyed during food processing. And this isn’t also unique to ultra processed food. Even boiling leafy greens destroys about 95 to 99% of vitamin C and about 68% of folate, according to a 2018 study. There is good news though on that front. Steaming or microwaving with minimal water preserves about 80%. Not that I recommend microwaving. So if you typically boil, try steaming with minimal water instead.

Nick Urban [00:11:16]:
Some of the others Pasteurization destroys heat sensitive vitamins and enzymes in milk, juice and other liquids. Industrial juicing removes fiber and as a result oxidizes polyphenols rapidly. Fresh pressed juiced fares much better. High heat oil extractions use solvents like hexane as well as temperatures often exceeding 200 degrees Celsius. So if you’re going to choose a product, look for something that is cold press instead of solvent extracted. This next one actually applies to supplements as well. Spray drying powders, which is a common practice used for protein powders, vitamin C products, fruit and vegetable powders that destroys most of the heat sensitive nutrients, but lets the companies market them as concentrates. Then we have the issue of agricultural chemicals.

Nick Urban [00:12:11]:
The chemicals that we spray on our foods do exactly what’s most harmful to your nutrient status. They strip minerals and kill the gut bacteria that handle nutrient extraction. One of the most common chemicals applied throughout the entire food manufacturing process is a chemical called glyphosate, also known as the active ingredient in Roundup. What you might not know about it is that it was patented in 1964 as a mineral chelator. What does that mean? It binds calcium, iron, copper, manganese, zinc and cobalt. Not just that, but it was patented again in 2010, this time as an antibiotic. A 2022 study showed that it kills up to 54% of common gut bacteria species at residue level doses. So you don’t need to be drinking the stuff to have a negative effect.

Nick Urban [00:13:06]:
Although, according to one CDC estimate, it was found in 81% of American urine samples, I think that number is vastly deflated. Even people eating fully organic diets often have high levels of glyphosate in their body. If you want to explore more about glyphosate, specifically, look into the work of Dr. Stephanie Seneff at MIT. She’s spent the last decade or so documenting glyphosate’s interference with sulfur metabolism, gut microbial diversity, glycine disruption, and a whole lot more. Then you have the other pesticides, herbicides, rodenticides, fungicides, and other biocides like atrazine paraquat, chlorpyrifos and neonicotinoids. The EU has banned a dozen of these. The US has not.

Nick Urban [00:14:00]:
You might remember from earlier when I mentioned fungicides kill mycorrhizal fungi in soil, but they can also disrupt human gut yeast balance. Two others that fly under the radar in this category include food grade antimicrobials, such as the chlorine wash they use on produce and specific washes for poultry. This is done to extend shelf life and kill the pathogens on the surface of the food. They also reach the gut and disrupt microbial diversity. Then there’s the issue of antibiotic residues in conventional meat. Now, this probably won’t cause an issue in itself, but those trace residues reach consumers and that contributes to an overall ecosystem that is disrupting the gut microbiome. Perhaps everything we’ve covered so far doesn’t really apply to you as much because you are on a strict carnivore diet. Well, there’s some things to dig into there as well.

Nick Urban [00:15:00]:
Animals raised on industrial feed produce different molecules than animals raised on what they evolved to eat. This is without the company doing anything to fortify the eggs or chicken with additional Omega 3 as well. Also, earlier I mentioned that the soil quality matters for both the omnivores, the vegans and carnivores, really for everyone. That’s because even animals must graze and eat produce at some point in the food chain. And they cannot manufacture essential nutrients out of thin air. They must get them from the produce itself, and the produce must have it, even if you aren’t actually directly eating the produce. Then there’s the issue of ancestral foods leaving the modern diet. Most of us are not consuming organ meats and other things that were staples in the earlier diets.

Nick Urban [00:15:54]:
In fact, organ meat consumption dropped about 90% since the 1970s. Beef liver alone is one of the most nutrient dense foods on earth, with among the highest levels of the bioavailable form of vitamin A as retinol and also of vitamin B12. More than 90% of American adults fail to meet the adequate intake levels for a nutrient called choline. And the highest food sources of choline are liver and eggs. Fermented foods were daily staples in nearly every traditional culture. The standard American diet has next to zero live culture fermented foods unless they’re intentionally added. The same can be said about wild plants and herbs. Dandelion, nettle and others were daily greens for most of human history.

Nick Urban [00:16:46]:
It’s not just what we’re eating though, it’s also what we’re drinking. Mineral content in water used to be a contributor to daily nutrient intake. Modern water removes a lot of that. Previously, drinking water would provide between 5 and 20% of daily magnesium and calcium. Now reverse osmosis, ion exchange, softening and modern filtration strips more than 95% of that. The World Health Organization has flagged demineralized water as a public health concern since the 1980s. Now, there are things inside our water supply that also disrupt or displace nutrients. For example, chlorine and chloramine in tap water disrupt gut bacteria when consumed in significant quantity.

Nick Urban [00:17:37]:
Fluoride is more electronegative than iodine and competitively blocks iodine uptake into the thyroid. Then there’s also the issue of heavy metals and microplastics and pharmaceutical residues in the tap water. And at the very least those pull bodily resources to neutralize them. Speaking of, modern bodies have a lot to clear that the pre industrial humans didn’t and that clearance costs nutrient stores. Let’s take the one everyone has been ranting about for the last couple years. Microplastics. Microplastic concentration in human brain tissue rose roughly 50% between 2016 and 2024. Now, those don’t come out of the body easily.

Nick Urban [00:18:24]:
The liver attempts to by burning glutathione, glycine sulfate and and B vitamins. Over 95% of tested Americans have high levels of phthalate metabolites. The higher the levels, the lower the testosterone in men. According to 2014 and Hanes Research. These are cleared through glutathione and methylation. Then you have the heavy metals cadmium, lead and aluminum. They hijack the iron and zinc transporters in the gut and iron and zinc deficiency opens that gate wider. Then there’s the issue of PM 2.5, air pollution, which depletes airway and systemic glutathione.

Nick Urban [00:19:09]:
This applies to 99% of the global population. Even if you’re indoors, you have VOCs, volatile organic compounds off gassing and those come from things like furniture and paint and cleaning products. And those create a low grade detoxification burden if you happen to have issues with mold and mycotoxins, which often come from water damaged buildings. Also from poorly stored grains and coffee, mycotoxin clearance burns, liver cofactors. All right, after all of this, there is a massive list of things that we ingest. Whether it’s other supplements, it’s over the counter medications, prescription medications, recreational substances. Many of these can also worsen the picture. Now this episode would get really long, so I’m going to leave the links in the show notes and you can also do your own research.

Nick Urban [00:20:06]:
But if you’re on any of the following, I would look into what they deplete. First of all, acid blockers or PPIs, statins, metformin, birth control, GLP1 drugs, antidepressants, broad spectrum antibiotics, diuretics, corticosteroids, chemotherapy, hormone replacement, NSAIDs, antihistamines, over the counter sleep aids, activated charcoal, specifically when taken with meals, EDTA or chelation products, high dose single nutrient supplements and then some detox greens powders that contain binders. All right. Oh, that’s a mouthful. A few more. Caffeine, alcohol, nicotine, cannabis, stimulants, mdma, psychedelics. If you take any of the following supplements, note that they compete. Zinc and copper share a transporter.

Nick Urban [00:21:03]:
Calcium and iron compete. Calcium and magnesium compete. Iron should not be taken with coffee, tea or dairy. High dose Vitamin C and B12 can degrade vitamin B12, selenium and zinc. High zinc can lower selenium status. Clearly it’s complicated. What you’re taking can displace other nutrients and make supplementation a very smart idea. I’m not a doctor.

Nick Urban [00:21:32]:
Check with your doctor because this is not medical advice and they can help guide you in this realm beyond the substances you’re ingesting. The modern lifestyle and the current metabolic state might influence what nutrients you need to obtain beyond what you get in your food. Chronic low grade inflammation consumes glutathione, selenium zinc and vitamin C. 88% of American adults are metabolically unhealthy. And if you are processing hyperglycemia, you’ll be burning through thiamine and magnesium faster. If you sweat heavily, as I do, sauna, exercise and hot climates and each of these will cause you to lose sodium, potassium, magnesium and zinc through your skin much faster if you’re stressed. Chronic cortisol promotes urinary magnesium excretion in real time. Stress not only depletes magnesium, but also zinc and selenium.

Nick Urban [00:22:32]:
According to an old 1984 study, every cup of coffee measurably increases 24 hour urinary calcium and magnesium excretion as well. If you’re a drinker, alcohol is an acute magnesium diuretic and it depletes vitamin B1, B6 and folate among others. Even if the food and the lifestyle was perfect, the digestive front has also gotten weaker. Stomach acid, bile, pancreatic enzymes all reduced today versus the pre industrial human. Currently one in seven Americans is on a stomach acid blocker. That means that every one of them has stomach acid that is intentionally suppressed. Without enough stomach acid, vitamin B12 stays bound to food protein, iron can’t ionize, and calcium absorption drops, to name a few. Now I already know someone’s going to comment below and mention yeah, but our ancestors didn’t take supplements.

Nick Urban [00:23:38]:
It’s true that nobody before 1900 was popping pills from a flashy white bottle. That’s accurate. They also did take massive amounts of what we now call supplements. Liver weekly, bone broth daily, fermented vegetables, raw dairy, fermented vegetables, raw dairy from grass fed pasture, raised cattle, organ meats, wild plants and herbs that aren’t in modern grocery stores. Their bodies were also subject to very different conditions, different stressors. Most of the issues that we’ve discussed throughout this episode were not as applicable to them when they did need them. The medical systems of the day, such as Ayurveda, Chinese medicine, those are the two that I’m most familiar with. They did have a rich materia medica.

Nick Urban [00:24:28]:
They talked about many of the currently trending supplements of today, such as many of the herbs, the adaptogens, shilajit, all of these date back at least 5,000 years for the system of Ayurveda. They certainly use them and they cherish them as well. Now none of this is a justification, an excuse to have a junk diet and think that the supplements will make up for everything in spades and flights fully optimize you. It’s not an excuse to jump on the latest trend because some influencer said so. I still recommend eating as clean as you can, choosing the highest nutrient density foods however you can, eating seasonally if you’re able to, and then where appropriate to add in the right nutrients and supplement accordingly. So this episode was a laundry list of the reasons that supplementation, as I view it, is no longer optional. The next solo soda record will be the practical companion to this one. How to actually pick a supplement that’s worth taking Brand evaluation Where to buy Beyond Amazon the industry tricks to recognize the testing you should run on yourself.

Nick Urban [00:25:39]:
First, my context lens for matching a supplement to your situation and the stack workflow I use. Subscribe so that you don’t miss it. Until next time, Be an Outlier thanks

Nick Urban [00:25:52]:
for tuning in to high performance longevity. If you got value today, the best way to support the show is to

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Updated: 06/17/2026

Episode Tags: Ancestral Health, Detox, Energy, Foundational Health, Functional & Holistic Health, Gut, Hydration, Metabolic Health, Microbiome, Nutrition, Supplements, Toxins & Toxicants, Vitamins & Minerals

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