Despite over 100 years of successful medical use, researchers are still learning and rediscovering the many therapeutic benefits of ozone therapy.
Instead of paying $100-300 per session in a clinic, you can reap the benefits from the comfort of your home.
Whenever you want, as often as you want.
Ozone is a highly powerful and volatile compound. So equipment quality matters. And there are a ton of different ways to use it.
In this article, let’s dive into how to choose your ideal at-home ozone therapy machine and the necessary equipment for each form.
Are you new to this? Read my detailed guide on the science, benefits, and review of the best ozone therapy machines.
What is ozone therapy?
Ozone therapy is an alternative health treatment that falls under the category of oxidative medicine. It involves administering ozone (O3) into the body in order to treat specific medical conditions or diseases.
This stimulates the body’s self-regulatory processes and returns it back to homeostasis. Rather than bluntly forcing certain physiological changes as drugs do, ozone allows self-repair and healing to occur.
In fact, ozone stimulates the same cellular repair hormetic pathways as exercise and caloric restriction.
While ozone therapy has been used for over 100 years, it isn’t known outside advanced medical circles. It’s legal in the United States and is widely practiced in Europe and Latin America.
Ozone generating systems are most commonly used for air purification, but also for making ozonated water, and other medical purposes.
Avoid the ones sold for air purification. We’ll focus on water generators and medical-grade (also called pure-grade or lab-grade) generators.
Medical generators are of the highest quality and make ozone using 99% pure oxygen. To do it at home, you’ll need other parts included in the ozone kits listed below.
If that’s too much hassle, you can also buy pre-ozonated supplements, lotions, and products.
By now you might be wondering… how does ozone therapy work?
How does ozone improve health?
Despite over 100 years of successful use, researchers are still uncovering exactly how ozone stimulates healing. The chemical reactions caused by O3 appear to work as a biological response modulator.
This study sums up the current theory nicely,
“We have good reasons to believe that the therapeutic power of ozone therapy consists of simultaneously improving circulation and oxygen delivery, in enhancing the release of autacoids, growth factors and cytokines and in reducing the endogenous, chronic oxidative stress…”
Scientific and Medical Aspects of Ozone Therapy
The exact mechanisms also depend on the delivery. The major differentiator comes down to how you apply the ozone.
What types of ozone therapy exist?
The ideal ozone machine depends on your use case and whether you’re looking for full-body systemic treatment, or are just addressing a local issue.
| Systemic Treatments | Local Treatments |
|---|---|
| Longevity and anti-aging | Infections |
| Athletes | Wound healing |
| Energy | Specific pains |
| Toxic mold exposure | Dental health (cavities and gum disease) |
| Lyme disease | Skin disorders |
| Gut problems | Ulcers |
| Immune dysregulation | Joint mobility |
| General pain | Repairing injuries |
The way you administer the ozone determines whether the effects are local or systemic.
The most common at-home administration options include:
- Rectal insufflation
- Ear insufflation
- Ozonated water
- Ozonated creams and supplements
Each has distinct pros and cons.
Intravenous ozone
IV ozone has been the gold standard treatment for the best results across the widest number of conditions.
There are multiple different IV ozone protocols:
- EBOO
- 10-pass
- MaH/UBI
- HiDose
Unfortunately, it’s only available in the clinic, and expensive at over $100 per treatment.
People often pair (or replace) an intravenous ozone treatment with the following at-home therapy options.
Rectal insufflation
If you can overlook the awkwardness and taboo nature of rear-end administration, rectal insufflation is one of the top at-home modalities.
Rectal ozone is easy, pain-free, and a systemic way to oxygenate the entire body. It works immediately by increasing oxygen levels in the gut and liver.
Rectal ozone is commonly used to treat:
- Constipation (chronic)
- Hepatitis
- Ulcerative colitis
- Irritable bowel syndrome (IBS)
- Anal fissures
- Hemorrhoids
- Parasitic infections
- Asthma
- Circulatory issues
- Fibromyalgia
- Chronic inflammation
- Rheumatic disease
- Other viral diseases
- Athletic performance
- Anti-aging
- General wellness support
It’s one of few modalities with efficacy that approaches IV ozone and is generally the go-to option for at-home systemic ozone therapy.
For a plug-and-play rectal ozone setup, most beginners start with the Promolife Basic Ozone Insufflation Kit, which bundles the generator, tubing, and catheters needed to run the protocol at home.
Ear insufflation
Ear insufflation is applying ozone into the ear canal.
It’s primarily used for locally treating anything related to the head:
- Brain fog
- Hearing problems
- Cold and flu symptoms
- Ear and sinus infections
- Fungal infections
- Lyme disease
- Mold toxicity
Applying ozone to the ear can be safely performed at home, and serious complications are rare.
Ozonated water
Ozonated water is normal water saturated with extra O3.
Medically, ozone-infused water is used for:
- Dental health issues (cavities, receding gums, infections, surgical wounds)
- Skin issues (ulcers, infections, slow-healing wounds, sores)
- Gut health and digestion
It works best for conditions and infections of the skin or mouth because it works two-fold. First, it eliminates infections. Secondly, ozone water boosts the natural healing process.
Though it has a history of success dating back to World War I, ozone water has less research than other modalities.
People like it because it’s non-invasive, easy, and popular machines can produce it.
Ozonated creams, supplements & other products
Albeit the rarest form, ozone does come in pre-blended products.
You can find it compounded into creams, drops, oils, and special supplement capsules.
Most ozonated products are used for:
- Oxygenating tissues
- Immune system strengthening
- Increasing energy
- Accelerating athletic recovery
- Respiratory condition treatment
- Skin health
- Gut healing
Ozone products are also non-invasive and easy to use. Again, there’s little scientific research on this method of ozone administration.
What are the health benefits of ozone therapy?

Ozone therapy has attracted a wide audience because it restores proper cellular function, and improves the root cause.
In fact, many doctors envision a near future in which ozone treatments replace antibiotics as a common first line of defense.
From the chronically ill suffering from diseases and conditions like Lyme, cancer, anxiety, depression, skin issues, and other infectious illnesses.
Athletes use it to oxygenate their tissues, turbocharge their energy, and perform higher.
Other high-achievers use ozone to boost cognition, slow the aging process, and keep their health optimized over the long term.
Some of the most popular uses include improving:
- Pain
- Infection
- Inflammation
- Detoxification
- Wound & injury healing
Benefits often occur on the very first session. And ozone treatments are inexpensive. This accessibility explains its massive resurgence in recent years,
“It is time for a full insertion of ozone therapy within pharmaceutical sciences, responding to all the requirements of quality, efficacy and safety, rather than as either an alternative or an esoteric approach.”
Ozone: A Multifaceted Molecule with Unexpected Therapeutic Activity
The effects and outcomes do vary based upon the route of administration.
Now, let’s explore some of the benefits of ozone therapy in more detail.
If you want to see which machines actually deliver these benefits, cross-reference this list with our ozone therapy machine roundup and pick the best ozone therapy machines for home use that fit your protocol.
Anti-inflammatory
One of the chief uses of ozone is to quell inflammation. Whether from a sports injury, surgical procedure, or disease. Since inflammation is widely considered “the root of all disease”, this alone is notable.
Ozone fixes many of the mechanisms responsible for inflammation.
New papers constantly discover that it significantly improves all kinds of health conditions. Perhaps best stated here,
“The results suggest that ozonated water has anti-inflammatory properties and is a potential therapeutic option for acute inflammation.”
Anti-inflammatory effects of ozonated water in an experimental mouse model
The anti-inflammatory action applies to other routes of administration too.
Boost the immune system
Ozone improves immune health. Doctors use it for this often, and with outstanding success.
It optimizes immunity in several ways:
And via many other mechanisms.
How do we combat antibiotic-resistant microbes?
Science suggests ozone therapy kills viruses, fungi, bacteria, endotoxins, biofilms, and other parasites.
Some of the impressive antimicrobial findings include:
- Fully healing tick bite-induced infection in <48 hours
- Kills four different strains of Candida
- Helps treat Lyme disease
- Eliminates H Pylori and helps heal ulcer lesions
- Completely heals antibiotic-resistant MRSA and S. aureus infections
- Greatly reduces viral load of the most infectious pathogen
So far the evidence is clear. Ozone boosts immunity and kills all kinds of pathogens.
Reverse brain damage after a stroke or TBI
Ozone also has some neuroprotective effects. Lack of oxygen directly harms the brain.
According to multiple papers, supplying oxygen can alleviate symptoms and even reverse damage across multiple conditions:
- Boosts cognition and preserves neurons in rats with hypoxic-ischemic brain injury
- Inactivates the NF-κB signaling pathway alleviating brain injury in rats with stroke
- Improves radiation-induced brain injury
- Ameliorates the behavioral and pathological damage of Alzheimer’s in mice
Those with brain injury need this restoration of normal neurometabolic function.
A 2011 paper recaps it,
“This report supports our previous works about the effect of ozone therapy in cerebral blood flow, and it suggests the use of ozone therapy in ischemic and hypometabolic brain syndromes such as stroke or RBI.”
Brain ischemia and hypometabolism treated by ozone therapy
This is especially exciting because those suffering from brain injury have few standard options.
Reduce heart attack risk & improved cardiovascular health
Ozone plays a role in supporting cardiovascular function.
One 2017 study found a direct correlation between the duration of ozone use, how long after the injury it’s administered, and the patients’ outcome.
Several other papers have found similar cardioprotective effects. The heart also contains an extremely dense concentration of mitochondria. As described later, upregulated mitochondria could help protect the heart.
Better detoxification
The body has a natural detoxification system to keep everything running properly. Today, however, we’re inundated by toxicants from our environment and everything we touch, breathe, and ingest.
Our bodies can’t keep up.
Ozone therapy boosts the metabolism, levels of the body’s master antioxidant called glutathione, and actively detoxifies certain things we’re constantly exposed to.
It’s a staple modality employed by detox clinics.
This is one area I’d like to see more research conducted.
Injury repair, improved joint mobility & reduced need for surgery
You might not suspect that ozone has orthopedic use, but more recent research is applying it to the musculoskeletal system. This is one of the fastest-growing applications.
Current research shows ozone helps:
- Rheumatoid arthritis
- Lumbar facet joint syndrome
- Subacromial bursitis
- Carpal tunnel syndrome
- Osteoarthritis
- Hip bursitis
- Shoulder adhesive capsulitis
- Herniated disc
- Temporomandibular joint disorder
- Knee osteoarthritis
- Meniscal injuries
- Lumbar disk herniation
In the last few years, there has been an increasing focus on using ozone for spinal disc issues.
In some cases, completely alleviating the need for surgery,
“Our truncated trial showed that intradiscal ozone infiltrations decreased the requirements for conventional surgery, resulting in decreased hospitalization durations and associated costs.”
Ozone therapy versus surgery for lumbar disc herniation: A randomized double-blind controlled trial
Faster wound healing
O3 therapy is a boon for rapidly healing injuries and damaged tissues.
Ozone appears to improve wound healing in many ways. This 2020 research speculates the following mechanisms:
- Reduction of microbial infection
- Debridement effect
- Modulation of the inflammatory phase
- Stimulation to angiogenesis
- Biological and enzymatic reactions that favor the oxygen metabolism
- Improving wound cicatrization
A study on diabetics found that it effectively treats ulcerous wounds.
Another found that ulcer duration, size, and pain levels decreased faster in the group treated with ozone.
Should you need it, ozone also shows great promise in accelerating the recovery from surgery,
“Studies conducted showed that including of ozone therapy into complex surgical treatment has positive effect on wound process.”
Ozone therapy effectiveness in patients with ulcerous lesions due to diabetes mellitus
The effect of ozone on wounds is best put here,
“…it was demonstrated that subcutaneous injections of ozone accelerate and ameliorate wound repairing process.”
Effects of subcutaneous injection of ozone during wound healing in rats
And it’s not just injections. Research has found that multiple routes of ozone application effectively improve wound healing.
Pain relief
Ozone is a natural analgesic, relieving pain with little to no side effects.
Researchers speculate that the anti-pain effects come from its anti-inflammatory properties.
Some pain-related conditions that O3 improves include:
- Treatment-resistant pain
- Post-surgical pain
- Low back pain
- Dentin hypersensitivity
- Fibromyalgia
- Chronic pain
- Knee osteoarthritis
- Lumbar disk herniation pain
- Cervical pain
- Plantar fasciitis
- Carpal tunnel syndrome
And it appears to be an effective adjunctive treatment for other pain-related diseases.
Stem cell production, activation, & repair
Limited evidence hypothesizes that ozone therapy may increase your body’s release of stem cells.
Due to the mechanisms of action, some believe that it stimulates stem cell production and activation.
I didn’t find any published peer-reviewed research, so I’d take this potential benefit with a grain of salt.
Oxygenates cells
Ozone is one molecule different than oxygen. One of the primary benefits of this therapy is increased oxygen saturation of the body and brain.
This can have profound impacts on improving disease states (like tumors). Many of which thrive in low-oxygen, hypoxic environments.
Improved oxygenation also optimizes physical and cognitive performance.
Improves circulation
Ozone improves both circulation and microcirculation, delivering the blood where it belongs.
This occurs throughout the body and improves conditions characterized by poor circulation. Better circulation also leads to better nutrient delivery and greater performance. If you take nootropics, this equates to stronger effects.
Rejuvenates skin, hair, & nails
Skin health and ozone go hand-in-hand. Not only does it improve related diseases, but it also can improve the complexion and overall health of the skin.
This blog breaks down ten different ways O3 therapy leads to better skin.
Science supports the claims,
“It is a promising aesthetic therapeutic modality with efficient and safe results and high patient compliance and satisfaction.”
Efficacy of biostimulatory ozone therapy: Case report and literature review
The beauty improving benefits, however, are secondary to the others.
Gut dysbiosis
Ozone rebalanced the gut (and other) microbiomes by killing pathogens and helping the healthy species thrive.
I could only find one study done on this benefit, and it found ozone restored the gut to an optimal microbiota.
It should also help heal SIBO, SIFO, and other microbial overgrowths.
I will test this one myself.
Dental & oral health
Ozone has a rich history of use in dentistry. For all kinds of reasons.
Benefits present themselves after just a single dose.
Dental and oral uses of ozone include:
- Sterilization
- Wound healing
- Anti-pain
- Tooth whitening
- Busting biofilms
- Improving root canals
It’s nicely described in this paper,
Ozone therapy has thus far been utilized with wound healing, dental caries, oral lichen planus, gingivitis and periodontitis, halitosis, osteonecrosis of the jaw, post-surgical pain, plaque and biofilms, root canals, dentin hypersensitivity, temporomandibular joint disorders, and teeth whitening. The utility of ozone will undoubtedly grow if studies continue to show positive outcomes in an increasing number of dental conditions.
Clinical utility of ozone therapy in dental and oral medicine
I expect that standard oral treatments will eventually include ozone.
Boosts energy
Ozone increases energy in several ways. Directly improving glycolysis and leading to greater cellular energy (ATP). Also by increasing cellular oxygen efficiency.
Several trials have shown that ozone has excellent anti-fatigue effects. For this reason, it’s being considered an adjunct to standard cancer treatments.
Following a session, users often report a slight energy boost, especially in those with fatigue.
Elevates cognition and brainpower
Newer research suggests that ozone therapy may actually improve brain performance. A 2021 study found increased BDNF (dubbed ‘Miracle-Gro for the brain’), and the neurotransmitter of relaxation called GABA. Together, leading to increased sleep quality in humans.
Other research in rats shows restorations to brain function disrupted by chronic conditions.
Through the O3’s action on growth cytokines (VEGF, PDGF, EGF, FGF, IGF, TGF-β, BDNF, PI3K/AKT/mTOR signalling), O3 could improve the regeneration systems, angiogenesis, cellular proliferation, differentiation, tissue regeneration.
Molecular mechanisms in cognitive frailty: potential therapeutic targets for oxygen-ozone treatment
The relation between cognition and medical ozone is one of the latest frontiers.
Stimulates mitochondria
The mitochondria produce energy and regulate cellular metabolism.
There’s a strong link between dysfunctional mitochondria and a host of deadly health conditions.
Dr. Shallenberger’s theory of mitochondrial dysfunction blames decreasing oxygen utilization that naturally occurs with age.
By improving the body’s ability to utilize oxygen, we can preserve the health of mitochondria.
Weight loss
Can ozone therapy really increase weight loss?
Very limited evidence suggests it may.
One study split 30 adults aged 30-40 into two groups. Both followed low-calorie diets, and one also received ozone therapy. The ozone group lost more weight.
But it gets better…
This blog post compared traditional surgical liposuction against ozone. Check out the table for their detailed breakdown.
I’d surely consider ozone before undergoing a costly, minimally-effective, and side effect-prone procedure!
How to Choose The Best Ozone Therapy Machine
I use Simply O3 in our education materials because they were the winner when I researched, tested, compared, and reviewed home ozone therapy systems. I regularly use their machines.
If you choose another company, that’s fine. My goal is to help you implement ozone to optimize your health.
I’ve been studying (and using) ozone therapy for many years. I regularly consult with some of the most prestigious scientists and doctors in the industry, both internationally and domestically.
When I first started, I made some mistakes and have seen countless others do the same.
There’s an International Scientific Committee of Ozone that sets standards for machines, that the reputable brands all follow. I have had in-depth conversations with several manufacturers, including the ones that supply most of the industry.
Although I don’t personally sell any of the systems, I am affiliated with some of them. I chose to partner with them only after conducting my research and getting their systems.
I have a few important pointers for my fellow consumers, that will help you choose the right company and product for your needs.
What to look for in a therapeutic ozone machine
Ozone therapy systems may look similar, but there’s often a huge quality difference.
Some of the main factors to consider include:
- 100% ozone-compatible materials – So that you can get ultra-pure ozone without the adulterants (although some will try to make you believe otherwise)
- The two types of generator – One is suited for home set-ups while the other is more for clinical use. More on these later.
- Cold-corona discharge – The best technology because it doesn’t heat up and causes changes in concentration
What to look for in a therapeutic ozone company
Knowing a few things to check, you can easily separate top ozone therapy brands from the rest.
Some of the criteria to check include:
- Demonstrable results – The company should be able to demonstrate results with the equipment
- Return policy – A 6-month return policy with no questions asked is ideal
- Warranty – A lifetime warranty with NO fine print. Some companies add fine print to make it seem like a lifetime warranty when it’s only backing one piece of the kit that will never break
- Service – The quality of service is important. If you have questions, you need to reach someone knowledgeable and helpful. Not all companies prioritize this after you make a purchase
Simply O3 is one of the top choices because they not only meet those criteria but also give free access to ozone lectures, a free video course and protocol guide, free ozone oils with their kits, and more.
Plus, you can enjoy the convenience of getting everything you need in their bundles/kits.
Along the same vein, there are several reasons why you want to avoid buying from a cheap company. Here are some more thorough criteria for choosing the best ozone machine.
The Different Types of Ozone Therapy Generators
When you first encounter oxygen tanks and ozone gas, you’ll likely think it’s for medical use. Makes sense. They’re often seen only in hospitals and clinics.
But they’re also available over the counter.
There are two variations of ozone generators:
- Flow of gas
- Flow of gas + dial
More on those momentarily.
Medical-grade ozone generators can change the strength (concentration) of the ozone gas. Each therapy requires different ozone gas strength.
When you do ozone therapy, most of the gas is oxygen. Only a small portion is ozone (<5%). 100% ozone gas would be too strong.
The strength of ozone gas is measured in gamma — aka micrograms/milliliter (μg/ml).
A typical therapeutic dose ranges from 10–60 gamma.
You’ll change the concentration within that range, depending on your chosen therapy.
The ozone generator takes pure oxygen and converts it into ozone. Two factors alter the strength of the ozone gas.
The first factor is how fast the oxygen flows into the device.
The slower the flow of the gas, the stronger the ozone gas will be. This is because the oxygen spends a longer period in the reaction chamber (where the oxygen is converted into ozone).

The second factor is how much energy is going into the reactor. An ozone generator with a dial can alter how much energy is being produced.
Only some of the ozone systems have dials. They aren’t necessary but give you extra control.
The amount of energy influences how much oxygen gets converted into ozone.

Flow rate + amount of energy in the reactor = how much ozone is created.
You don’t need to understand all of this as long as you follow the instructions in your kit.
They’ll tell you exactly what to do. It’s quite simple when you see it for yourself.
Flow of gas generators

Most ozone generators can only change the amount of ozone by altering how fast the gas flows through it.
There’s a piece on top of the oxygen tank called an “oxygen regulator”. It has a simple knob on it that changes how fast the oxygen flows into the ozone generator.
“Flow of gas” generators are the best for most people for these reasons:
- Most simple and easy to use
- Simplicity makes it less likely to break down
- They do all the basic therapies for home applications
Flow of gas ozone machines are not good for injections and IVs because they have limited concentrations to choose from.
Here’s the concentration chart on the Simply O3’S Stratus 3.0. It tells you which setting to select for each concentration of ozone.

You change the setting on the oxygen regulator to create ozone.
For example, setting #1 = 6 gamma (ug/ml).
Here’s a picture of the regulator. This is where you change the “setting” that’s shown on the concentration chart.

Some regulators look different. They typically have fractions. The Stratus 3.0 uses whole numbers to avoid confusion.
Flow of gas + dial generators

Some ozone therapy machines have a dial to change the strength of the ozone, in addition to the flow of gas described above.
The dial is technically called a potentiometer or rheostat. It controls how much energy is applied to the oxygen, changing how much ozone is created.
The reason people choose an ozone therapy machine with a dial is because it has more concentrations to choose from. That’s it. This doesn’t matter much for ozone therapy at home.
But it’s helpful if you’re doing injections or IVs. A practitioner administering knee injections may want to increase the concentration each session slowly.
A sample progression may look like this…
10 gammas to 13 gammas to 16 gammas to 20 gammas. Same for IV ozone therapy.
Most injection and IV protocols slowly increase the concentration of ozone because starting too strong can cause discomfort to the patient.
This is how the chart looks on a Cumulus Ozone Generator.

How to choose the best ozone generator for you
Flow of gas generators are typically best for home applications.
Dial generators are for medical practitioners looking for full functionality.
Here’s the difference between Simply O3’s options.
| 💨 Stratus 3.0 Kit (~$1,799.99) | ☁️ Cumulus Kit (~$3,079.99) | |
| Good for home therapies | ✔ | ✔ |
| Good for clinics | ✖ | ✔ |
| Ultra-pure ozone | ✔ | ✔ |
| Comes with free resources | ✔ | ✔ |
| Lifetime warranty | ✔ | ✔ |
| 6-month return policy | ✔ | ✔ |
Medical professionals prefer the clinical models (Ozonette & Cumulus) simply because they have more granular concentration settings.
For example, a doctor will slowly titrate up a patient’s dose. They need more options to do that.
However, for home applications or basic therapies, the drawbacks of this specialty technology likely outweigh the benefits.
Ozone Therapies You Can Do At Home
For a more in-depth look at comparing home therapies, check out this page.
Here’s a simple chart of the potential ozone therapy protocols that you can do with each type of machine.
| 💨 Stratus 3.0 Kit | ☁️ Cumulus Kit | |
| Rectal insufflation | ✔ | ✔ |
| Vaginal insufflation | ✔ | ✔ |
| Ear insufflation | ✔ | ✔ |
| Breathing ozonides | ✔ | ✔ |
| Nasal insufflation | ✔ | ✔ |
| Limb bagging | ✔ | ✔ |
| Ozone cupping | ✔ | ✔ |
| Ozone water | ✔ | ✔ |
| Ozone sauna | ✔ | ✔ |
| Dental applications | ✔ | ✔ |
| Injections (not for home) | ✖ | ✔ |
| Intravenous ozone therapy (not for home) | ✖ | ✔ |
The 3 vital home ozone protocols
Most ozone users will never use most of those protocols.
The three most impactful and common home ozone treatments include:
Basic kits will often contain the equipment necessary for these three treatments.
You can add other treatments as the need arises. For example, you don’t need ozone limb bagging unless you have a skin infection on the limb.
What Ozone Therapy Equipment Do I Need?

All options for ozone therapy require four things:
- Oxygen Tank
- Oxygen Tank Regulator
- Medical Ozone Generator
- Accessories
Here are other accessories required for each home therapy — assuming you already have the oxygen tank, oxygen tank regulator, and ozone generator. Those are necessary for every therapy.
These will all last indefinitely unless otherwise stated.
Rectal ozone insufflation
You’ll need a basic kit used for ozone administration.
- Rectal Insufflation Kit (lasts 2 – 3 months of everyday use)
Vaginal ozone insufflation
You’ll need a kit typically comprised of an insert, a liquid trap, and an ozone destruct. The insert is placed into the area to allow for an inflow of ozone and an outflow of the gas.
The liquid trap will prevent liquid from going into the ozone destruct. And the ozone destruct will neutralize the excess ozone so it does not go into the air.
Ozone ear insufflation therapy
This requires two things. An ear set and an ozone bubbler system for humidification.
The bubbler system will have a diffuser where the gas will bubble through the liquid and exit through the ear set.
Ozone water
To make ozonated water, you’ll need a bubbler system.
The internal stem will have a diffuser at the bottom, where the gas will bubble through the liquid. Then the gas will exit the container into the desired apparatus.
Ozone limb bagging
Limb bagging requires a self-sealing ozone-resistant bag. One that’s made for exposing limbs to ozone gas.
- Limb Bag (lasts indefinitely but shouldn’t be shared between person)
- Ozone Destruct
Ozone cupping
To perform ozone cupping, you’ll need laboratory-grade glass cups. These allow you to hit isolated and difficult-to-reach areas of the body with ozone.
Breathing ozonides
For this, you’ll need a bubbler system that can be used either for ozonating oil or humidifying ozone gas.
- Oil Bubbler System
- Nasal Cannula (comes with oil bubbler and lasts indefinitely)
Ozone oil
While you can make this at home, I recommend you buy professional-grade ozone oil instead. That’s because it’s significantly stronger.
- Oil Bubbler System
Ozone sauna
Traditionally, you’d have to enter a small room for a normal sauna. For ozone saunas, however, your head must not be covered. These are the ideal equipment for that:
Nasal insufflation
Do not use a normal syringe with ozone. They’ll rapidly break down from exposure to ozone. Instead, use special ozone-resistant syringes.
- Ozone syringe (use a new one every 5 uses or so)
How Do I Get Oxygen For Ozone Therapy?
Medical ozone generators require 99.9% pure oxygen for ozone therapy.
You can’t use room air or oxygen concentrators because it’s not pure oxygen. It’ll produce harmful contaminants when put through the ozone generator.
Oxygen concentrators also do not provide the same level of purity (95% at best) as an oxygen tank (99.9%).
You need to get an oxygen tank locally. You’ll have to go to a local oxygen supplier and pick one up.
You can Google “Airgas”, “Praxair”, or “weld supply shop near me”. Then go to the store and ask for a 40 cubic foot oxygen tank.
It costs about $100–$120, weighs 13 pounds, and is 18 inches in height. The tank lasts for approximately 6 months depending on usage.
Then you can refill it for around $15-$20. Of course, prices range depending on where you live.
Types of oxygen tanks for ozone therapy
There are two different types of oxygen tanks you can get: 540 or 870.

Most people choose the 540 oxygen tank because it’s easier to get but there’s no difference in purity between the tanks.
It’s important to know which tank you should use mainly because of regulator compatibility. As the names suggest, an 870 regulator will fit into an 870 tank and a 540 regulator into a 540 tank.
Outside of this, the only other difference is how long the supply will last. 870 oxygen tanks require a prescription simply because it’s a bigger container and holds more volume.
Getting a 540 tank
Again, most people choose 540 oxygen tanks because are very easy to acquire. It’ll usually last between 6 to 12 months depending on usage.
To get a 540 commercial oxygen tank:
- Search for local Airgas, Praxair, or welding supply – Google “Airgas”, “Praxair”, or “Weld supply shop near me”.
- Go to the location and ask for a 40 cubic-foot oxygen tank
- They won’t serve you if they feel it’s for medical purposes because that makes them liable.
Getting an 870 tank
870 oxygen tanks require a prescription from a doctor. The process is a lot more difficult and you might go through some issues simply because of that. You can go to a local medical oxygen supply shop once you acquire a prescription.
To get an 870 medical oxygen tank:
- Get a prescription from your doctor for medical oxygen. If you have migraines, a prescription for migraines will cut a lot of bureaucracy.
- Search for a local medical oxygen supply – Google “medical oxygen supply near me”
- Go in and give them the prescription. Do note that may only have rental options available.
- Pay with cash, not insurance. Insurance will not cover an oxygen tank for ozone therapy.
Starting Ozone Therapy at Home
Ozone therapy has been one of the most promising practices in recent years.
While there are some downsides like the price of the machines themselves and the lack of some standardization of medical treatment protocols, it’s still a key health innovation of modern medicine.
In the long run, getting a kit (instead of expensive clinical treatments) saves you a lot of time and money. You can get all that you need for most of the protocols mentioned.
To get started, the only equipment most people need include:
- A “flow of gas” generator
- Oxygen tank
- Oxygen regulator
- Attachments for your desired protocol
Remember to check the compatibility of the oxygen regulator before you buy your tank. The 540 tank is cheaper and easier to acquire while the 870 tank lasts longer. There’s no difference in purity.
Doing home ozone therapy already? Let me know how your experience has been so far or share your top tips for those who want to get started!

