Interested in a fountain of youth?
Researchers have long sought molecules able to halt aging. They’ve made serious progress.
Discovering of importance of NAD is one of the biggest longevity breakthroughs of my lifetime.NAD, a molecule heavily involved involved in the aging process, has gone from the fringe to mainstream in no time. Click To Tweet
Even those completely uninterested in health have taken notice of this newly understood molecule.
I understand why.
Top scientists around the world praise NAD as the next big thing.
It looks like they’re onto something. As a new product on the market, it’s quite expensive and individual formulations have little scientific backing. Most people don’t need to take NMN or NR. Before you spend potentially hundreds on a monthly recurring supply of products, make sure you’re doing the other things right to boost NAD naturally.
What is NAD and Why Does it Matter?
Biochemistry isn’t exactly simple, as exemplified by NAD.
NAD is a family of indispensable coenzymes that power most metabolic processes in your body. It’s made up of NAD+, NADH, NADP+, and NADPH. They help your mitochondria generate fuel, make nutrients, DNA & RNA, hormones, and quell free radicals.
My favorite form, NADPH, recharges your body’s antioxidants. That’s right, without the recharging electrons NADPH donates, your vitamin C, vitamin E, and glutathione antioxidant supplements run out of power. Only once they are recharged can they return to neutralizing free radicals roaming your body.
Long-term health requires high levels of NAD. You re-generate NAD naturally, but due to modern lifestyle, not nearly enough. To keep it high we have three options: recycling what you already have (salvage pathway), creating it from scratch (de novo synthesis), or minimizing NAD-lowering processes.
Filling the NAD Leak
I don’t supplement NAD boosters.
You see, without addressing underlying lifestyle factors that deplete NAD, you can only increase it so much.
It’s like filling a leaky tire with more air. Sure, it works in the short-term, but eventually it goes flat again. The real solution is to patch the tire, stop all leaks, and re-inflate.
Once you do that the air stays.
Such is the case with NAD. Dr. Mercola’s book EMF*D taught me lifestyle optimizations to make before moving on to NMN or NR.
Anything that protects your DNA, RNA, and genetic material will help keep your NAD topped off.
1. Minimizing EMF exposure
EMF exposure drains NAD. Fast.
A DNA repair molecule called PARP voraciously consumes NAD. Indeed, PARP sucks energy molecules from NAD+.
How much? PARP uses 150–200 molecules of NAD+ just to repair each DNA break.
Electromagnetic radiation exposure also activates another consumer of NAD+ called NOX (bear with me through all these acronyms). Other things like infection also activate NOX. Too much NOX impairs NAD.
It’s virtually always overlooked, but few things deplete your NAD levels as effectively as EMFs.
2. Skip the Evening Snack
Yet another reason to compress your feeding window (my favorite phrase for eating dinner earlier).
Converting excess calories to body fat costs you doubly:
- You gain body fat.
- Your NADPH levels drop significantly.
Thankfully, the fix is easy.
Eat fewer calories so the fat conversion doesn’t take place in the first place. Or consume those calories earlier in the day.
How much earlier?
Mercola recommends eating your last meal three to four hours before you go to sleep.
3. High-Intensity Exercise
Another win for exercise.
To sweeten things further, it seems that any form will do.
Both aerobic and resistance training increase NAMPT, and as a result, NAD+ too.
Above all, my favorite form of exercise to improve NAD+ & NAMPT is blood flow restriction training. BFRT is the best travel-friendly workout, portable, and effective.
Add Cheap Precursors
Niacin is dirt cheap. And effective.
If you want to avoid DNA damage or unstable chromosomes, deficiency is no laughing matter.
Niacin increases NAD+ levels inside cells. That’s not all. It is especially effective at increasing NAD+ in the brain.
There are a lot of products on the market, and at all kinds of doses. Full-flush, non-timed release Niacin at a dose of 25 milligrams works best. Remember, more isn’t always better.
Wonder what NAD stands for?
Nicotinamide adenine dinucleotide. Notice any similarities?
Your body breaks down NAD+ into this molecule.
It’s not nearly as effective as niacin in raising intracellular NAD+ levels. Niacinamide reduces activity of the longevity pathway SIRT1, so most experts caution against its use.
I’d only consider it if the niacin flush bothered me too much. At 25mg, the niacin flush should be virtually non-existent though.
6. Molecular Hydrogen
The smallest molecule in the universe, molecular hydrogen is another trendy supplement.
Molecular hydrogen doesn’t carry a charge, so it easily enters your cells.
When it does, it lowers oxidative stress, quells free radicals, and fuels NAD-hungry PARP.
If that wasn’t enough, molecular hydrogen also protects your genetic material, proteins, cells, and mitochondria from damage.
Finally, it fixes excessive NOX levels. Restoring NOX also frees up NAD.
I believe that everyone should supplement magnesium.
Nearly everyone’s deficient, it’s safe in massive quantities, it activates more than 600 enzymes, and even protects you from EMFs by acting as a natural calcium channel blocker.
Magnesium is virtually free of side effects, an effective relaxer, and inexpensive.
It’s great for maintaining cell stability, RNA and DNA synthesis, and helping repair cells. There are countless forms of the mineral.
One form in particular, magnesium glycinate, also helps increase NADPH. Magnesium belongs in all NAD boosting stacks.
8. Fruits & Vegetable Phytonutrients
Quality of life matters, right? The NRF2 phytochemical pathway regulates healthspan, so you’ll live quality years.
NRF2 activates hundreds of genes related to antioxidants and stress.
It boosts NAD by increasing NADPH and also NQO1.
Best of all, you don’t need any fancy supplements to activate the NRF2 pathway:
- Dark chocolate
- Red wine
If supplements are your thing, vitamin D and molecular hydrogen also stimulate NRF2.
Alternative NAD Boosting Strategies
Most people don’t need supplemental NMN or NR.
We don’t all have gallon buckets of the stuff sitting around like anti-aging researcher David Sinclair.
And that’s completely fine.With commonly recommended lifestyle strategies (sleep, exercise, healthy diet, smart supplementation, meal timing, and reducing toxin exposure) we can naturally and effectively maximize our NAD levels. Click To Tweet
Thanks to Dr Mercola for providing great resources on NAD & PARP in his book EMF*D.
What’s your favorite way to naturally boost NAD?