9 Best Cutting-Edge Resveratrol Supplements [2021 Review]


Imagine getting the benefits of caloric restriction—or even fasting—in a small pill.

It’d be a simple way to extend your self-sufficient life, without deprivation.

Resveratrol became one of the first (and most widely used) promising nutraceuticals to slow aging. Researchers have extensively studied its many effects:

  • Protecting the cardiovascular system
  • Quelling oxidation and inflammation
  • Enhancing blood flow and cognition
  • Activating longevity pathways

Many scientists lost interest due to one glaring problem.

Resveratrol is not bioavailable. Your body breaks down and excretes the molecule before it can do much good.

Breakthrough supplement technology has mitigated this issue. In today’s post, we’ll cover the most powerful and effective resveratrol supplements on the market.

Top Resveratrol Products of 2021

Best overall for anti-aging: Alive by Science Liposomal Gel
Best value: ProHealth Bulk Micronized Trans-Resveratrol
Best all-in-one: Life Extension Optimized Resveratrol
Best powder: Botany Bio Resveratrol Phytosome
Best for skin and face: Renue™ Transdermal Products

How to Make Resveratrol Work Best

Resveratrol seemed poised to revolutionize humanity and extend lifespan.

It’s regularly discussed among experts like:

  • Joe Rogans’ guests
  • David Sinclair
  • Dr Axe
  • Rhonda Patrick

Emerging research started hinting that the body struggled to actually assimilate and use resveratrol. Some insisted that it just led to expensive pee. Others compensated for the poor absorption by using a larger dose.

Savvy manufacturers began using several strategies to get more out of resveratrol:

  • Adding quercetin: a different but synergistic ingredient
  • Topical delivery: transdermal application to the skin
  • Lipsomal encapsultion: binding the powder to tiny nano fat particles

Quercetin works by competing with resveratrol for sulphation. This competition keeps it active in the body for longer.

Resveratrol is well absorbed through the skin and has long-lasting skin and face health benefits. Multiple studies show that this transdermal delivery works better than standard oral intake to slow down metabolism and excretion.

Liposomal encapsulation is a new supplement technology called that vastly increases absorption by allowing the body to easily identify and assimilate the nutrients. 2019 research found liposomal delivery to be a powerful option.

With the necessary background on absorption-enhancing technologies, we’ll compare the supplements.

Word of Caution on Resveratrol

Resveratrol supplement dangers

I take dozens of supplements every day. In recent years, I’ve drastically cut down. This article explains the hidden dangers of supplements.

Lab testing regularly finds major issues with most supplements listed on marketplaces like Amazon. Products contain contaminants like heavy metals, other random ingredients, and even banned substances. Other times the product listed is a completely fraudulent replica; the company on the label never created the supplement.

Who knows what’s inside?

With resveratrol, manufacturers cut corners by using cheap precursors. Instead of the optimal grape skin, they use inflammatory peanut skin to save costs. Or they skimp and include the unabsorbable “cis” form.

The Top Resveratrol Products of 2021

Resveratrol is cheap to make and easy to find since ample research has investigated its uses among the healthy.

High-quality resveratrol products should be:

  • Brownish in color since only synthetic resveratrol is white
  • Made from grape skins

If you’re wondering where to buy resveratrol, you can use this list of the best brands and supplements to guide your research.

Best Anti-Aging Complex: Alive by Science Liposomal Gels

alivebyscience resveratrol gel

Overview

Dose: 125mg liposomal resveratrol

Other ingredient doses: 75mg liposomal curcumin

Serving size: 2mL

Servings: 75

Manufactured in: USA

Absorption: Max

Alive by Science is pioneering the anti-aging field with highly effective and cutting-edge products. Their liposomal gels are no exception. Clinical studies show that you only absorb ~1 percent of oral resveratrol supplements. As described in this post, liposomal technology increases the absorption of resveratrol. Giving you far stronger effects from small doses. Liposomes also solve the issue of rapid excretion.

Curcumin is another powerful antioxidant and polyphenol found in turmeric. Researchers have discovered lifespan-enhancing effects from both. Taken together in liposomal form, the two work even better. Their NMN gel is coming out in late 2021 and will likely become the new best anti-aging product available.

Alive by Science produces all their products in the USA under strict ISO-Certified and cGMP quality control practices. This gel features pharmaceutical-grade ingredients and is third-party tested for purity and safety. Hold the gel under your tongue for 30-seconds to get the best effects.

Alive by Science LIPO gels are the strongest, longest-lasting and easiest to take.

Use the exclusive Alive by Science coupon code GVQCUKN6 for 10% off.

Best Resveratrol for the Skin & Face: Alive by Science Transdermal Renue™

Alive by Science Transdermal Resveratrol for Face & Skin Health

Overview

Dose: Unknown

Other ingredient doses: 150mg NAD+ Complex

Serving size: 3mL

Servings: 75

Manufactured in: USA

Absorption: Max

Pharmaceutically formulated and dermatologist tested. I prefer to get my anti-aging products here when possible. As described below, resveratrol quickly and readily absorbs through the skin. Improving skin health and complexion as it enters the bloodstream.

Renue™ is an advanced formulation that includes the latest skin health technologies. Ingredients include NAD+, NMN, Apocynin, Alpha-Lipoic Acid (ALA), Hyaluronic Acid (HLA), and of course, Resveratrol. Delivered via nanoliposome technology, Renue™ restores youthfulness by improving the skin’s texture, firmness, and dermal matrix. Suitable for every type of skin.

TheRenue™ line is produced in anISO-Certified and cGMP-Certified facility and undergoes rigorous third-party testing for both strength and purity.

Those using resveratrol for beauty and aesthetics will love theRenue™ line of longevity products.

Use the exclusive code GVQCUKN6 for 10% off.

Best Combo: Life Extension Optimized Resveratrol

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Overview

Dose: 250mg trans-resveratrol

Other ingredient doses: 150mg  quercetin, 85mg fruit polyphenol extracts, 10mg fisetin

Serving size: 1 capsule

Servings: 90

Manufactured in: USA

Absorption: Low

Life Extension is one of the larger supplement manufacturers, and for good reason. They produce a huge catalog of quality products at competitive prices. LEF Optimized Resveratrol is made from the extracts of red grapes and wild blueberries. They’ve boosted the formula with a synergistic complex of powerful anti-aging ingredients. Each capsule contains trans-pterostilbene, quercetin, and fisetin.

Unfortunately, the bottle lists several unnecessary ingredients such as maltodextrin, silica, and vegetable stearate. Note that the addition of quercetin gives the capsules a yellow tinge. It does not indicate an old or inferior product.

LES Optimized Resveratrol is a good balance between quality and price, for those looking for an all-in-one longevity supplement.

MAAC10 99% Pure Trans Resveratrol

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Overview

Dose: 500mg trans-resveratrol

Other ingredient doses: 10mg Bioperine

Serving size: 2 capsules

Servings: 30

Manufactured in: USA

Absorption: Low

I discovered MAAC10 when researching a new anti-aging ingredient called NMN. From talking to manufacturers, I learned that MAAC10 buys its raw ingredients from some of them. Getting you good 99% pure trans-resveratrol at a reasonable price. You’ll notice that each serving contains a full 500mg of trans-resveratrol and an ingredient called Bioperine to enhance absorption. They claim that the combination of Bioperine with micron-sized particles can increase bioavailability by 4-fold. Note that the serving size is larger, requiring two capsules for the 500mg dose.

If you tolerate black pepper extract (Bioperine), MAAC10 resveratrol is a good value.

Cleanest: Pure Encapsulations Resveratrol ir?t=outliyr038 20&language=en US&l=li3&o=1&a=B008S90RCQ

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Overview

Dose: 40mg trans-resveratrol

Serving size: 1 capsule

Servings: 120

Manufactured in: USA

Absorption: Low

Pure Encapsulations make true pharmaceutical-grade supplements. It’s one of few brands that doctors and health professionals rely on for maximum purity. None of their products contains fillers, binders, or excipients. As you’d expect, Pure Encapsulations capsules are non-GMO, certified gluten-free, dairy-free, vegetarian and vegan.

At just 40mg, the dose of each capsule is weak. Giving you finer dosage control and the ability to tweak your resveratrol intake. This was the brand Dr. Rhonda Patrick recommended in her older interviews. Since Nestle bought Pure Encapsulation, quality seems to have declined some.

I would only really consider this product if you have sensitivities or react poorly to the other products.

Also Good: Genex Resveratrol Powder ir?t=outliyr038 20&language=en US&l=li3&o=1&a=B084ZVL82H

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Overview

Dose: 1000mg trans-resveratrol

Serving size: 4 scoops

Servings: 30

Manufactured in: USA

Absorption: Low

At first glance, Genex resveratrol seems like the highest dose option. But with just 30 servings in each container, the 1000mg dose becomes less attractive. If you standardize the product to a two-scoop serving, it comes out to 60 servings of 500mg.

Genex is one of the only respected vendors that sell a true 99 percent trans-resveratrol powder. They micronized it for better blendability and absorption. Manufacturing occurs in a US-Based, GMP and NSF registered facility. If you have big fingers, you’ll want to consider another supplement. The scooper is tiny and easy to spill powder.

Cheapest: Double Wood Resveratrol 

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Overview

Dose: 500mg resveratrol

Serving size: 2 capsules

Servings: 30

Manufactured in: USA

Absorption: Low

Double Wood makes some of the least expensive supplements on the market. If you can overlook the dated bottle packaging, this is a great value. Each capsule contains 50 percent of the optimal trans-resveratrol form. The formula does not include any other ingredients nor technologies to enhance bioavailability. Just resveratrol and rice flour as a filler.

Double Wood claims to make this in the USA (though I have my doubts given the cost of manufacturing). These veggie capsules are gluten-free, non-GMO, and vegan-safe.

See for yourself why nearly 500 satisfied Amazon customers rate this a 4.75-star product. For the cheapest no-frills resveratrol, try Double Wood.

Botany Bio Resveratrol Phytosome

Science Bio Resveratrol Product

Overview

Dose: 250mg resveratrol

Serving size: 1 scoop

Servings: 40

Manufactured in: USA

Absorption: Low

I buy most of my supplements through Science Bio and their partner site, Botany Bio. In my Science Bio review, I broke down their impressive quality control process. Each product has a verifiable lot and batch number associated with a Certificate of Analysis (CoA) proving safety and efficacy. They supply most of the ingredients used in clinical studies.

The resveratrol phytosome is more of a full-spectrum product. Without needing any additional technology, it’s up to four-fold more potent than standard oral supplements. It contains 33 percent trans-resveratrol, 66 percent lecithin, along with other naturally occurring ingredients.

This is pure stuff. No other ingredients, additives, fillers, binders, or preservatives. Should you want pure trans-resveratrol, they sell it at a great price.

ProHealth Bulk Micronized Trans-Resveratrol

Bulk Micronized Trans-Resveratrol (250 grams) by ProHealth Longevityimage 9104887 15015353

Overview

Dose: 995mg trans-resveratrol

Serving size: 1 scoop

Servings: 250

Manufactured in: USA

Absorption: Low

ProHealth Longevity’s supplements come up in virtually any “best of” lists. Every few days their team of doctors and scientists publishes new articles on the state of the longevity industry.

Back of the napkin math shows the value of this product. If you standardize to the typical 500mg dose, the container comes out to 500 doses! A supply that’ll last almost 1.5 years. The star of the ProHealth product is a high-purity fermented Veri-te™️ trans-resveratrol known for stability, traceability, and reliability. This is the same patented form of resveratrol used in clinical research.

Should you want a different quantity, or pills instead of powder, you’ll find many different variations listed on their website.

ProHealth proudly posts their safety CoA on their site, next to the product’s 4.8-star rating and recent reviews. For bulk resveratrol and a vast catalog of options, visit ProHealth.

Resveratrol Background

Foods that contains resveratrol: peanuts, wine, grapes, blueberries

If you’re like me, you want to know how something works before taking it.

This guide to resveratrol will help you best understand the benefits, side effects, science, and how to use it.

What is it?

Resveratrol is a polyphenol naturally occurring in 70+ foods as a defense against toxins, predators, and microbes (bacteria, fungi, and viruses). It’s generally contained in the skin, seeds, or protective coatings of the organism.

Foods that contain resveratrol include:

  • Grapes (highest concentration)
  • Red wine
  • Blueberries
  • Peanuts

Though the minuscule dose in foods doesn’t compare to supplementation.

In humans, it acts as an antioxidant to protect the body against biological damage which would otherwise put you at higher risk for disease.

Resveratrol mimics the same molecular mechanisms and benefits of caloric restriction. In part, by activating a group of longevity genes called sirtuins. Sirtuins, an enzyme called SIRT1 in particular, control many different pathways involved in the aging process.

Not all resveratrol is the same.

Resveratrol vs Trans-Resveratrol

You’ll notice that some supplements differentiate between resveratrol and trans-resveratrol. Though the same molecule, the two have different molecular arrangements (called isomers).

Resveratrol comes in two isomers:

  • Cis
  • Trans

Trans-resveratrol is the superior choice, backed by more research and considered the more beneficial and absorbable of the two.

High-quality supplements generally use 50-100 percent trans-resveratrol.Clinical research funded by the keenly interested pharmaceutical industry has mostly focused on animal trials since human testing costs considerably more. Speculation by researchers and new studies suggest some of the highly touted benefits may carry over to humans if we overcome the one key obstacle.

Benefits

“At molecular level it targets sirtuin, adenosine monophosphate kinase, nuclear Factor-κB, inflammatory cytokines, anti-oxidant enzymes along with cellular processes such as angiogenesis, apoptosis, mitochondrial biogenesis, gluconeogenesis and lipid metabolism.”

Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases

We already know some of the mechanisms, pathways, and biological effects of this molecule. Though not studied exclusively in the context of resveratrol, many of these have wide-sweeping benefits.

Resveratrol advocates use it for:

  • Hair growth and preventing hair loss
  • Skin health
  • Stimulating weight loss
  • Pet health
  • Anti-aging and longevity
  • Anti-microbial
  • Anti-tumor
  • Heart protection
  • Brain protection

The clinical trials that showed less promise in humans suffered from poor bioavailability. It’s quite possible that liposomal and other delivery technologies mentioned previously completely mitigate this sole issue preventing resveratrol from widespread use.

Immune Health

Immune. Resveratrol powerfully modulates the immune system and supports overall immunity. It does so by:

A properly functioning immune system slows the speed of aging.

Lifespan (and Healthspan) Extension

Resveratrol has several mechanisms which confer life-enhancement to its consumers.

These include:

Beauty and Appearance

Resveratrol was once the darling of the skincare industry. Many high-end beauty products still include it.

Applied topically, it penetrates the skin barrier and increases type III collagen.

Resveratrol’s beauty benefits:

Metabolic Health & Optimal Hormone Levels

Perhaps, most notably, resveratrol impacts the metabolism and endocrine systems.

Research supports resveratrol for:

New research continues to come out around the clock. But there’s an important distinction regarding the form of resveratrol.

Resveratrol Compared to Other Longevity Supplements

Alternatives to Resveratrol Supplements for Longevity: Quercetin & Astaxanthin

Resveratrol vs Astaxanthin

Resveratrol and astaxanthin are two popular antioxidants with different use cases and properties. Astaxanthin is a category of chemical called carotenoids. It is a red pigment that gives salmon, krill, and shrimps their color. Astaxanthin notably acts as protection against UV light and modulates the immune system. It’s also used for sports performance, promoting skin health, and reducing exercise-induced muscle soreness. Learn more about why astaxanthin made my list of the best longevity and anti-aging supplements of the future.

Resveratrol vs Quercetin

Resveratrol and quercetin are two powerful antioxidant polyphenols that work synergistically together for greater absorption and effects. Like resveratrol, quercetin is thought to promote cerebrovascular and cardiovascular health and slow the progression of neurodegenerative diseases. It also works best when encapsulated in liposomes. Many modern resveratrol formulations now include quercetin.

Resveratrol Questions & Answers

What is the best resveratrol dose?

The best dose of resveratrol depends on the desired health benefits and form of the product. Typical doses range between 100mg and 2000mg taken every day. For longevity and lifespan extension, the generally recommended resveratrol dose is 250mg – 400mg.

When should I take resveratrol?

Resveratrol is best taken twice per day, with meals low in fat. Because it is an antioxidant, it’s ideally taken away from bouts of intense exercise.

What are the side effects of resveratrol?

Several studies have investigated the safety of resveratrol and found it well tolerated by the health.

Large resveratrol doses thin the blood and can interfere with medications like blood thinners and NSAIDs by increasing the risk of bleeding.

Like other antioxidants, when taken too close to exercise, it may blunt adaptation (gains) to exercise.

Although rare, some users report additional side effects of resveratrol: diarrhea, headaches, insomnia, and blood pressure changes. Check with your doctor before taking resveratrol.

Resveratrol Still Worth It?

Resveratrol gets full credit for igniting the longevity industry and securing billions of dollars in funding.

Resveratrol sat poised to:

  • Increased lifespan
  • Protect the body’s organs and notably the brain
  • Enhance athletic performance, and accelerate both weight loss and muscle building
  • Normalize hormones
  • Activate longevity pathways
  • Optimize the immune systeme
  • Improve skin health, complexion, and overall beauty

So what happened?

Much of the hype shriveled up when scientists discovered that the body excretes the vast majority of oral resveratrol supplements. Before the molecule could exert its powerful effects.

Over the last few years, rapid advancements in supplement technology have overcome this speedbump. Using techniques like:

  • Topical and other methods of delivery
  • Liposomal encapsulations
  • Synergistic combinations with other molecules

Today’s top resveratrol products reflect these recent advancements.

Some researchers have dubbed this resveratrol’s “second wave”.

Have you tried any of the new formulations? What was your experience? Let us know in the comments below.

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Nick Urban

Nick Urban is the Founder of Outliyr, an expert biohacker of 10+ years, Data Scientist, Certified CHEK Practitioner, host of the Mind Body Peak Performance Podcast, and a High-Performance Coach.

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