12 Best Bioavailable Resveratrol Supplements 2025 Review

Imagine getting the benefits of caloric restriction—or even fasting—in a small pill.

It’d be a simple way to extend your healthspan, without deprivation.

Resveratrol became one of the first promising nutraceuticals to slow aging. Research showed wide-ranging benefits:

• Protecting the cardiovascular system
• Quelling oxidation and inflammation
• Enhancing blood flow and cognition
• Activating longevity pathways

Scientists lost interest due to one glaring problem…

Resveratrol is not bioavailable. Your body breaks down and excretes the molecule before does much good.

Breakthrough supplement delivery technology has mitigated this issue.

Perhaps reigniting hope for resveratrol as a miracle supplement.

In today’s post, we’ll cover the most powerful and effective resveratrol supplements on the market.

How to Make Resveratrol More Effective

Resveratrol seemed poised to revolutionize humanity and extend lifespan.

It’s regularly discussed among experts like:

• Joe Rogans’ guests
• David Sinclair
• Dr. Axe
• Rhonda Patrick

Emerging research started hinting that the body struggled to actually assimilate and use resveratrol. Some insisted that it just led to expensive pee. Others compensate for the poor absorption by using a larger dose.

Savvy manufacturers began using several strategies to get more out of resveratrol:

• Adding quercetin: a different but synergistic ingredient
• Topical delivery: transdermal application to the skin
• Liposomal encapsulation: binding the powder to tiny nano-fat particles

Quercetin works by competing with resveratrol for sulphation. This competition keeps it active in the body for longer.

Resveratrol is well absorbed through the skin and has long-lasting skin and face health benefits. Multiple studies show that this transdermal delivery works better than standard oral intake to slow down metabolism and excretion.

Liposomal encapsulation is a new supplement technology called that vastly increases absorption by allowing the body to easily identify and assimilate the nutrients. 2019 research found liposomal delivery to be a powerful option.

With the necessary background on absorption-enhancing technologies, we’ll compare the supplements.

Resveratrol Warning

I take dozens of supplements every day. In recent years, I’ve drastically cut down. This article explains the hidden dangers of supplements.

Lab testing regularly finds major issues with most supplements listed on marketplaces like Amazon. Products contain contaminants like heavy metals, other random ingredients, and even banned substances. Other times the product listed is a completely fraudulent replica; the company on the label never created the supplement.

Who knows what’s inside?

With resveratrol, manufacturers cut corners by using cheap precursors. Instead of the optimal grape skin, they use inflammatory peanut skin to save costs. Or they skimp and include the unabsorbable “cis” form.

The Top Resveratrol Products of 2023

Resveratrol is cheap to make and easy to find since ample research has investigated its uses among the healthy.

High-quality resveratrol products should be:

• Brownish in color since only synthetic resveratrol is white
• Made from grape skins

If you’re wondering where to buy resveratrol, you can use this list of the best brands and supplements to guide your research.

Best Overall: Ultra Health ResveraGEN

Overview

Dose: 300mg transResveratrol

Other ingredient doses: None

Serving size: 1 capsule

Servings: 60

Manufactured in: USA

Features: Max bioavailability, Purity

Ultra Health Store is recognized as a top innovative company that consistently follows strict standards for all of their products. They partner with FDA-approved GMP facilities and each product page features the current third-party lab test results.

This company also sets the standard for pricing.

Their ResveraGEN™ is a pharmaceutical-grade resveratrol. Ultra Health continually improves their product formulas. This one goes through a proprietary process to ensure 99.8% purity ensuring you get exactly what you pay for and nothing harmful.

This supplement also has an enteric coating which protects it from degradation by stomach acid. Taking it directly to the small intestine where the nutrients can be best absorbed by the body.

If you’re looking for a pure, well-researched, max-absorption resveratrol supplement, Ultra Health ResveraGEN will be a great choice.

Buy Ultra Health ResveraGEN

Use the exclusive Ultra Health code NC15 for 15% off

Best Anti-Aging: Ultra Health Liposomal Resvera-M

Overview

Dose: 150mg trans-Resveratrol

Other ingredient doses: 250mg beta-Nicotinamide Mononucleotide

Serving size: 1 capsule

Servings: 60

Manufactured in: USA

Features: Max bioavailability, Antioxidant

Dr. David Sinclair’s favorite longevity supplement is resveratrol. Add nicotinamide mononucleotide (NMN) to it and you have two of the most well-researched ingredients for longevity in one capsule.

Both work synergistically for cell repair and anti-aging. Resvera-M allows you to increase your NAD+ levels while also fueling antioxidant properties.

Of course, this product also passes strict standards for safety and has undergone lab testing – with Ultra Health also showing stability data of both the resveratrol and the NMN in the product.

If you’re aiming for overall longevity, Ultra Health’s Liposomal Resvera-M should be your go-to.

Buy Ultra Health Resvera-M

Use the exclusive Ultra Health code NC15 for 15% off

Renue Liposomal Trans-Resveratrol

Overview

Dose: 125mg liposomal resveratrol

Other ingredient doses: None

Serving size: 1 capsule

Servings: 90

Manufactured in: USA

Features: Potency

Renue by Science is another trusted name in maximum potency longevity supplements. They’re constantly releasing new formulas that match the latest research.

LIPO Trans-Resveratrol features Renue by Science’s proprietary liposomes to dramatically enhance absorption. With a peak particle size of <50nm, this liposomal technology maximizes nutrient bioavailability and uptake into cells.

Remember, 125mg of liposomal resveratrol is the equivalent of 4X-10X more normal resveratrol but without the side effects.

The product itself is simple. Pure liposomal trans-reveratrol. The only “other ingredients” are what’s required for liposomal tech. RBS creates these supplements in a USA-based, pristine, ISO-Certified, and cGMP-Certified facility.

As you’d expect, LIPO Trans-Resveratrol undergoes third-party lab testing for potency and purity. Certificates of Analysis (CoA) are available on each product page.

You can also get this same high-quality resveratrol in their multi-ingredient “Energizer” anti-aging supplement. It contains 65mg Liposomal Glutathione, 65mg Liposomal Resveratrol, 25mg Liposomal CoQ10 (Learn more about how extraordinary CoQ10 is in my review and unlock the healthy you), and 15mg Liposomal Apigenin.

If you’re looking for a clean and potent liposomal trans-resveratrol in capsule form, Renue by Science’s LIPO Trans-Resveratrol is the one.

Buy Liposomal Trans-Resveratrol

Alive by Science Liposomal Gels

Overview

Dose: 125mg liposomal resveratrol

Other ingredient doses: 75mg liposomal curcumin

Serving size: 2mL

Servings: 75

Manufactured in: USA

Features: Pill-free application

Alive by Science is pioneering the anti-aging field with highly effective and cutting-edge products. Their liposomal gels are no exception. Clinical studies show you only absorb ~1 percent of oral resveratrol supplements. As described in this post, liposomal technology increases the absorption of resveratrol. Giving you far stronger effects from small doses. Liposomes also solve the issue of rapid excretion.

Curcumin is another powerful antioxidant and polyphenol found in turmeric. Researchers have discovered lifespan-enhancing effects from both. Taken together in liposomal form, the two work even better. Their NMN gel came out in late 2021 and became one of the new best anti-aging products available.

Alive by Science produces all their products in the USA under strict ISO-Certified and cGMP quality control practices. This gel features pharmaceutical-grade ingredients and is third-party tested for purity and safety. Hold the gel under your tongue for 30 seconds to get the best effects.

Alive by Science LIPO gel is ideal for those that want strong, pill-free, long-lasting resveratrol.

Buy Alive by Science LIPO Gel

Best Bulk: Ultra Health ResveraGEN 300C

Overview

Dose: 300mg trans-Resveratrol

Other ingredient doses: 250mg beta-Nicotinamide Mononucleotide

Serving size: 1 capsule

Servings: 300

Manufactured in: USA

Features: Bulk purchase, max bioavailability, purity

If you intend to resale as a medical professional or simply want to secure a supply of ResveraGEN good for a few months, Ultra Health also sells in bulk packs. This makes their resveratrol even more affordable at only $.68 per serving.

It comes in a sealed mylar pouch, since again, it’s typically purchased by clinics and vitamin shops. These capsules are still enteric and you can see all the purity datasheets on the product page.

If you’re confident or like the product already, buying ResveraGEN in bulk with the 300C pack will save you a lot.

Buy Ultra Health ResveraGEN 300C

Use the exclusive Ultra Health code NC15 for 15% off

ProHealth Bulk Micronized Trans-Resveratrol

Overview

Dose: 995mg trans-resveratrol

Serving size: 1 scoop

Servings: 250

Manufactured in: USA

Features: Bulk purchase

This is another option you can take for bulk purchases.

ProHealth Longevity’s supplements come up in virtually any “best of” lists. Every few days their team of doctors and scientists publishes new articles on the state of the longevity industry.

Back of the napkin math shows the value of this product. If you standardize to the typical 500mg dose, the container comes out to 500 doses! A supply that’ll last almost 1.5 years. The star of the ProHealth product is a high-purity fermented Veri-te™️ trans-resveratrol known for stability, traceability, and reliability. This is the same patented form of resveratrol used in clinical research.

ProHealth proudly posts its safety CoA on its site, next to the product’s 4.8-star rating and recent reviews. For bulk resveratrol and a vast catalog of options, visit ProHealth.

Buy ProHealth Bulk Resveratrol

Best Combo: Life Extension Optimized Resveratrol

Overview

Dose: 250mg trans-resveratrol

Other ingredient doses: 150mg quercetin, 85mg fruit polyphenol extracts, 10mg fisetin

Serving size: 1 capsule

Servings: 90

Manufactured in: USA

Features: Great value

Life Extension is one of the larger supplement manufacturers, and for good reason. They produce a huge catalog of quality products at competitive prices. LEF Optimized Resveratrol is made from the extracts of red grapes and wild blueberries. They’ve boosted the formula with a synergistic complex of powerful anti-aging ingredients. Each capsule contains trans-pterostilbene, quercetin, and fisetin.

Unfortunately, the bottle lists several unnecessary ingredients such as maltodextrin, silica, and vegetable stearate. Note that the addition of quercetin gives the capsules a yellow tinge. It does not indicate an old or inferior product.

LES Optimized Resveratrol is a good balance between quality and price, for those looking for an all-in-one longevity supplement.

Buy LES Optimized Resveratrol

MAAC10 99% Pure Trans Resveratrol

Overview

Dose: 500mg trans-resveratrol

Other ingredient doses: 10mg Bioperine

Serving size: 2 capsules

Servings: 30

Manufactured in: USA

Features: Absorption

I discovered MAAC10 when researching a new anti-aging ingredient called NMN. From talking to manufacturers, I learned that MAAC10 buys its raw ingredients from some of them. Getting you good 99% pure trans-resveratrol at a reasonable price.

You’ll notice that each serving contains a full 500mg of trans-resveratrol and an ingredient called Bioperine to enhance absorption. They claim that the combination of Bioperine with micron-sized particles can increase bioavailability by 4-fold.

Note that the serving size is larger, requiring two capsules for the 500mg dose.

If you tolerate black pepper extract (Bioperine), MAAC10 resveratrol is a good value.

Buy MAAC10 Resveratrol

Pure Encapsulations Resveratrol

Overview

Dose: 40mg trans-resveratrol

Serving size: 1 capsule

Servings: 120

Manufactured in: USA

Features: Dosage control

Pure Encapsulations make true pharmaceutical-grade supplements. It’s one of few brands that doctors and health professionals rely on for maximum purity. None of their products contains fillers, binders, or excipients. As you’d expect, Pure Encapsulations capsules are non-GMO, certified gluten-free, dairy-free, vegetarian and vegan.

At just 40mg, the dose of each capsule is weak. Giving you finer dosage control and the ability to tweak your resveratrol intake. This was the brand Dr. Rhonda Patrick recommended in her older interviews. Since Nestle bought Pure Encapsulation, quality seems to have declined some.

I would only really consider this product if you have sensitivities or react poorly to the other products.

Buy Pure Encapsulations Resveratrol

Best Powder: Trans-Resveratrol Powder Renue™

Overview

Dose: 500mg resveratrol

Serving size: 1 scoop

Servings: 200

Manufactured in: USA

Features: Great powder option

Trans-Resveratrol provides a powerhouse of antioxidant & anti-inflammatory benefits in this crystalline powder form.  Trans-Resveratrol has shown great promise in clinical studies and is part of a group of compounds called polyphenols, which act as antioxidants to protect the body against age-related conditions.

High potency crystalline PURE Trans-Resveratrol™ provides concentrated levels of Trans-Resveratrol (99% pure) from the root of the Japanese Knotweed (Polygonum Cuspidatum).  Trans-Resveratrol is a unique antioxidant with the ability to cross the blood-brain barrier.

Buy Trans-Resveratrol Powder

Also Good: Genex Resveratrol Powder

Overview

Dose: 1000mg trans-resveratrol

Serving size: 4 scoops

Servings: 30

Manufactured in: USA

Features: Pure trans-resveratrol powder

At first glance, Genex resveratrol seems like the highest dose option. But with just 30 servings in each container, the 1000mg dose becomes less attractive. If you standardize the product to a two-scoop serving, it comes out to 60 servings of 500mg.

Genex is one of the only respected vendors that sell a true 99 percent trans-resveratrol powder. They micronized it for better blendability and absorption. Manufacturing occurs in a US-based, GMP and NSF-registered facility. If you have big fingers, you’ll want to consider another supplement. The scooper is tiny and easy to spill powder.

Buy Genex Resveratrol Powder

Cheapest: Double Wood Resveratrol 

Overview

Dose: 500mg resveratrol

Serving size: 2 capsules

Servings: 30

Manufactured in: USA

Features: Budget-friendly

Double Wood makes some of the least expensive supplements on the market. If you can overlook the dated bottle packaging, this is a great value. Each capsule contains 50 percent of the optimal trans-resveratrol form. The formula does not include any other ingredients nor technologies to enhance bioavailability. Just resveratrol and rice flour as a filler.

Double Wood claims to make this in the USA (though I have my doubts given the cost of manufacturing). These veggie capsules are gluten-free, non-GMO, and vegan-safe.

See for yourself why nearly 500 satisfied Amazon customers rate this a 4.75-star product. For the cheapest no-frills resveratrol, try Double Wood.

Buy Double Wood Resveratrol

Resveratrol Background

If you’re like me, you want to know how something works before taking it.

This guide to resveratrol will help you best understand the benefits, side effects, science, and how to use it.

What is it?

Resveratrol is a polyphenol naturally occurring in 70+ foods as a defense against toxins, predators, and microbes (bacteria, fungi, and viruses). It’s generally contained in the skin, seeds, or protective coatings of the organism.

Foods that contain resveratrol include:

• Grapes (highest concentration)
• Red wine
• Blueberries
• Peanuts

Though the minuscule dose in foods doesn’t compare to supplementation.

In humans, it acts as an antioxidant to protect the body against biological damage which would otherwise put you at higher risk for disease.

Resveratrol mimics the same molecular mechanisms and benefits of caloric restriction. In part, by activating a group of longevity genes called sirtuins. Sirtuins, an enzyme called SIRT1 in particular, control many different pathways involved in the aging process.

Not all resveratrol is the same.

Resveratrol vs Trans-Resveratrol

You’ll notice that some supplements differentiate between resveratrol and trans-resveratrol. Though the same molecule, the two have different molecular arrangements (called isomers).

Resveratrol comes in two isomers:

• Cis
• Trans

Trans-resveratrol is the superior choice, backed by more research and considered the more beneficial and absorbable of the two.

High-quality supplements generally use 50-100 percent trans-resveratrol.Clinical research funded by the keenly interested pharmaceutical industry has mostly focused on animal trials since human testing costs considerably more. Speculation by researchers and new studies suggest some of the highly touted benefits may carry over to humans if we overcome the one key obstacle.

Benefits of Quality Trans-Resveratrol

“At molecular level it targets sirtuin, adenosine monophosphate kinase, nuclear Factor-κB, inflammatory cytokines, anti-oxidant enzymes along with cellular processes such as angiogenesis, apoptosis, mitochondrial biogenesis, gluconeogenesis and lipid metabolism.”

Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases

We already know some of the mechanisms, pathways, and biological effects of this molecule. Though not studied exclusively in the context of resveratrol, many of these have wide-sweeping benefits.

Resveratrol advocates use it for:

• Hair growth and preventing hair loss
• Skin health
• Stimulating weight loss
• Pet health
• Anti-aging and longevity
• Anti-microbial
• Anti-tumor
• Heart protection
• Brain protection

The clinical trials that showed less promise in humans suffered from poor bioavailability. It’s quite possible that liposomal and other delivery technologies mentioned previously completely mitigate this sole issue preventing resveratrol from widespread use.

Immune Health

Immune. Resveratrol powerfully modulates the immune system and supports overall immunity. It does so by:

• Inhibiting the formation of biofilms
• Inhibiting all stages of uncontrolled cellular growth (anti-carcinogenesis)
• Protecting the brain and body via anti-inflammatory actions

A properly functioning immune system slows the speed of aging.

Lifespan (and Healthspan) Extension

Resveratrol has several mechanisms which confer life-enhancement to its consumers.

These include:

• Protecting the body’s organs from toxins and damage
• Activating longevity pathways (like SIRT1)
• Mimicking the effects of caloric restriction
• Boosting the anti-aging NAD+ enzyme levels
• Slowing cognitive decline according to multiple studies

Beauty and Appearance

Resveratrol was once the darling of the skincare industry. Many high-end beauty products still include it.

Applied topically, it penetrates the skin barrier and increases type III collagen.

Resveratrol’s beauty benefits:

• Improving the appearance of the skin
• Protecting skin
• Reducing inflammation and redness
• Evening the texture of skin
• Alleviates dry patches of skin
• Hydrating your skin
• Reducing acne significantly when applied via topical gel

Metabolic Health & Optimal Hormone Levels

Perhaps, most notably, resveratrol impacts the metabolism and endocrine systems.

Research supports resveratrol for:

• Enhancing exercise performance
• Improving insulin sensitivity (anti-PCOS)
• Enhancing muscle growth
• Reducing body fat and accelerating weight loss
• Boosting testosterone levels by up to 51 percent, according to this 2008 study
• Protecting against oxidative damage of free radicals and UV radiation
• Protecting mitochondria, and triggering mitochondrial biogenesis, particularly in the brain
• Protecting the liver
• Cleaning the blood via increasing flow throughout the body and brain, and reducing blood pressure
• Reducing blood glucose
• Supporting optimal heart health by reducing LDL-C, decreasing triglycerides, and improving HDL

New research continues to come out around the clock. But there’s an important distinction regarding the form of resveratrol.

Resveratrol Compared to Other Longevity Supplements

Resveratrol vs Astaxanthin

Resveratrol and astaxanthin are two popular antioxidants with different use cases and properties. Astaxanthin is a category of chemical called carotenoids. It is a red pigment that gives salmon, krill, and shrimps their color. Astaxanthin notably acts as protection against UV light and modulates the immune system. It’s also used for sports performance, promoting skin health, and reducing exercise-induced muscle soreness. Learn more about why astaxanthin made my list of the best longevity and anti-aging supplements of the future.

Resveratrol vs Quercetin

Resveratrol and quercetin are two powerful antioxidant polyphenols that work synergistically together for greater absorption and effects. Like resveratrol, quercetin is thought to promote cerebrovascular and cardiovascular health and slow the progression of neurodegenerative diseases. It also works best when encapsulated in liposomes. Many modern resveratrol formulations now include quercetin.

Resveratrol Questions & Answers

Supplementing Resveratrol Still Worth It?

Resveratrol gets full credit for igniting the longevity industry and securing billions of dollars in funding.

Resveratrol sat poised to:

• Increased lifespan
• Protect the body’s organs and notably the brain
• Enhance athletic performance, and accelerate both weight loss and muscle building
• Normalize hormones
• Activate longevity pathways
• Optimize the immune system
• Improve skin health, complexion, and overall beauty

So what happened?

Much of the hype shriveled up when scientists discovered that the body excretes the vast majority of oral resveratrol supplements. Before the molecule could exert its powerful effects.

Over the last few years, rapid advancements in supplement technology have overcome this speed bump. Using techniques like:

• Topical and other methods of delivery
• Liposomal encapsulations
• Synergistic combinations with other molecules

Certain genes and lifestyle practices (I use a powerful tool called SelfDecode to decode my genetics) can dramatically increase your need for supplementation:

• RS1319501 (NAMPT)
• RS9770242 (NAMPT)

Knowing your underlying biological needs can help you decide whether spending hundreds on resveratrol products will be worth it.

Today’s top resveratrol products reflect these recent advancements.

• Best overall: Alive by Science Liposomal Gel
• Best value: ProHealth Bulk Micronized Trans-Resveratrol
• Best all-in-one: Life Extension Optimized Resveratrol

Some researchers have dubbed this resveratrol’s “second wave”.

Have you tried any of the new formulations? What was your experience? Let us know in the comments below.