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11+ Top BiOptimizers Supplement Reviews: Honest Truth

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BiOptimizers Supplements Review
BiOptimizers Supplements Review

“Supplements don’t do anything”.

“They’re nothing but expensive urine”.

“If supplements worked, they’d be regulated as drugs”.

I hear these all the time. Here’s the thing…

It’s true.

Many health and fitness supplements do virtually nothing. Or worse. Due to dangerous fillers and toxic contaminants, some even have a net negative impact.

This is why, every week, I turn down all kinds of supplements offered to me for free.

I only use products I’ve thoroughly vetted.

A company called BiOptimizers perfectly matches my own mission…

Helping humans shift from a sick unhealthy condition into a peak biologically optimized state Share on X

Whether you’re looking to sleep deeper and/or longer, enhance your brain using nootropics, unlock more food nutrients using enzymes, or optimize your body, mind, and soul, BiOptimizers has you covered.

In this post, I’m reviewing BiOptimizers supplements and other products I’ve used. I’ll help you understand the science behind them, how they compare and contrast, as well as my real-world experience. If you want to test any of them yourself, BiOptimizers has arranged a generous discount code for Outliyrs.

What is BiOptimizers & What Makes Their Supplements Special?

bioptimizers longevity vitality performance

BiOptimizers is a nutrition company founded by Matt Galant and Wade Lightheart in 2004 to solve their own needs. Both as fitness professionals. Wade, a 3X Canadian natural bodybuilding champion, and Matt as a professional strength and conditioning coach.

Their mission is to help humans go from just getting by, to a superhuman biologically optimal state.

BiOptimizers only creates products if they will become best-in-class. Otherwise, they won’t touch it. Over the years I’ve used thousands of dollars worth of BiOptimizers supplements. Because they just work. Exactly as expected, every time.

In alignment with ancient medical systems like Ayurveda, they first focused on creating products to improve digestion. Better digestion means unlocking more nutrients within foods. This company has since expanded its offerings to include:

  • Dual use enzymes
  • Digestive aids for every kind of diet
  • Sleep and dreaming enhancers
  • Maximum absorption protein products
  • Protection against blood sugar spikes and leaky gut induced by foods
  • Brain enhancing nootropics

Soon, BiOptimizers is releasing lines for hormone optimization, sexual health, adaptogenic stress support, and much more.

My favorite is their powerful cognitive enhancement products, which I detailed in a separate Nootopia review.

BiOptimizers is clearly doing something right, as you’ll hear them favorably mentioned on many of the world’s largest health & wellness platforms.

They also received a prestigious mention as an Inc. 5000 honoree in 2022, are the 3rd fastest growing supplement company in the USA, and 245th fastest-growing across all industries on the Inc. 5000 list.

With their 365-day money-back guarantee, stackable deals & sales, and outstanding customer service team, BiOptimizers products provide what you need to live a fully optimized life.

Next, I’ll share my experiences and review each BiOptimizer product.

How BiOptimizers Consistently Creates Supplement Breakthroughs

Although they’ve sold nutrition products for nearly two decades, BiOptimizers is rapidly growing and thus able to unveil new formulations at record-breaking speed.

Last I talked to Matt, he mentioned that they have 30+ products slated for release in 2023 alone.

Without sacrificing quality.

Most supplement companies just focus on an ingredient or one particular pathway. Some advanced products combine a few.

BiOptimizers takes a systems biology approach to product formulation, thoroughly researching all the cofactors and nutrient synergies and consulting with the world’s foremost experts across:

  • Chinese herbalism
  • Probiotics
  • Formulation
  • Plant extraction
  • Nootropic brain supplement stack design

They start with fresh ingredients and put each through rigorous quality and purity testing. They’re deeply partnered with Burch University and employ multiple PhDs all working to create next-generation supplements.

Like good bioharmonizers, the million-dollar BiOptimizers lab is constantly researching, testing, and improving all of their formulas.

Where other companies just blindly combine ingredients and sell the same product for decades, BiOptimizers puts products through dozens of iterations before releasing them to the world. One recent release first underwent 55+ prototypes before unveiling to the public.

This is the secret to BiOptimizers’ record-breaking 8.95/10 average product rating across their ENTIRE inventory.

BiOptimizers Product Reviews From Personal Experience

I use BiOptimizers products daily and continue turning to them because they just work. Consistently.

This isn’t one of the countless supplement companies that slyly swap out the top ingredients for inferior forms. Instead, BiOptimizers continues to invest in R&D and upgrades.

Below, I will share my experiences with some of the top BiOptimizers’ supplements.

MassZymes Review

BiOptimizers MassZymes Supplement


For: Digestion, injury repair, increasing nutrient absorption, amplifying fasting benefits

Form: Capsules

Ingredients: Tri-phase protease, enzyme blind

Bulk Discount: Save 32% on 5 bottles

An intricate web of enzymes and biochemical processes make life possible. Unfortunately, many of life’s pleasurable activities and just everyday living reduce our ability to create adequate enzymes. Using the right systemic enzymes can help.

While digestive enzymes improve your ability to utilize food and other nutrients, systemic (proteolytic) enzymes have an additional role. These travel throughout the body, breaking down proteins, scar tissue, and other unwanted waste products. You take them with food to get the digestive benefits, or on an empty stomach to break down waste.

MassZymes is a dual-use proteolytic blend of 17+ enzymes made “for the masses”. It contains the highest quality protein degrading enzymes (each capsule contains an industry-leading 100,000 units of protein-digesting enzymes) and their proprietary all-natural plant compound called AstraZyme™. This extract from Panax ginseng and Astragalus further improves the formulation for an impressive array of benefits:

  • Increase your absorption of the vital amino acids arginine (key for blood flow, “pump” and testosterone) by up to 66.7%
  • Increase your absorption of the amino acids citrulline (critical for fat-burning) by 45%
  • Increase your absorption of the amino acids tryptophan (essential for sleep, GH, and recovery) by 52.5%
  • Increase your absorption of vitamins, like folate, by up to 50%
  • Increase the joint-protecting benefits of glucosamine absorption by 42%
  • Increase your glucose absorption by 55%, speeding muscle recovery
  • Increase repair of intestinal wall damage, which is where most absorption problems occur
  • Increase your overall energy level by as much as 18%

Again, I take this one almost every morning and on an empty stomach. It’s a natural way to accelerate my recovery from intense workouts; to break down proteins naturally occurring in my blood so that I can get into autophagy faster and amplify the benefits of my fasts; extract more amino acids, vitamins, minerals, and other nutrients from my foods; slightly improve energy, clarity, and focus; and support optimal digestion.

I notice that it helps normalize my ravenous appetite, reduces post-meal “protein bloat”, facilitates putting on muscle, and according to recent bloodwork, has normalized a number of key optimal health biomarkers.

This is unlike any other enzyme formula available, and if I could only pick one, it would be MassZymes hands down. Indeed, it’s another of the few supplements that I travel with.

Masszymes are the “Massively Beneficial” and often overlooked supplement first-time users fall in love with.

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Stress Guardian Review

bioptimizers stress guardian review


For: Buffering stress, cognition, clarity, wellbeing, immune optimization, amplifying fasting benefits

Form: Capsules

Ingredients: Comprehensive adaptogenic ingredient blend (listed below)

Bulk Discount: Save 32% on 5 bottles

For the last decade, I’ve used a unique category of supplements religiously. Adaptogens are a special category of natural substances that help rebalance your body your body and mind. You enter your optimal state.

If you experience stress (HPA Axis Overload) regularly in any form (physical, mental, emotional, chemical), adaptogens are incredible tools.

I used to buy these powders in bulk and mix my own. On top of the time hassle and inconvenience, this was a massive mistake. Adaptogens bought in health food stores or even online are notoriously contaminated and often lack the very active ingredients listed on the label!

So I was thrilled to find a high-quality all-in-one solution.

BiOptimizers Stress Guardian formula includes a potent combination of 14 highly prized adaptogenic substances designed to shield you against stress:

  • Eleutherococcus senticosus (Siberian Ginseng)
  • Astragalus Membranaceus (Huang Qi)
  • Ganoderma Lucidum (Reishi Mushroom)
  • Polygonum Multiflorum (He Shou Wu/Fo-Ti)
  • Lycium Barbarum (Goji Berry)
  • Glycyrrhiza Uralensis (Licorice Root)
  • Schisandra Chinensis (Wu Wei Zi/Schisandra Berry)
  • Panax Ginseng (Asian Ginseng)
  • Panax Notoginseng (Tienchi Ginseng)
  • Salvia Miltiorrhiza (Dan Shen/Chinese Salvia)
  • Pueraria Lobata (Kudzu Root)
  • Paeonia Lactiflora (White Peony Root)
  • Cordyceps Militaris (Cordyceps Mushroom)
  • Rhodiola Rosea (Rhodiola)

You won’t find as comprehensive of a stress-relieving adaptogen formula anywhere. This breakthrough formula unlocks greater stress resilience and helps optimize the root causes.

This is a new formula of theirs and already becoming one of my favorites.

Stress Guardian is the ultimate 14-adaptogens-in-one supplement to build personal resilience and easily overcome stress.

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P3-OM Review

Bioptimizers P3OM Supplement


For: Gut health and repair, immunity and microbiome protection

Form: Capsules

Ingredients: Lactobacillus plantarum OM

Bulk Discount: Save 32% on 5 bottles

P3-OM is BiOptimizers super probiotic. It’s a strain unlike anything else I’ve tried. It was also one of their original products. It works by shifting the gut microbiome into a better state. A “magic bullet” for all kinds of seemingly unrelated things. From improving sleep to accelerating athletic recovery, marginally boosting energy, enhancing nutrient partitioning (faster muscle gain), and strengthening the immune system.

I take this one every morning on an empty stomach. It is full-body, systemic protection, particularly great for strengthening the gut barrier. Resulting in less inflammation and better nutrient absorption and assimilation.

P3-OM combines nicely with BiOptimizers’ other enzymes and nutrients. This one always goes in my carry-on while traveling or anytime I will be exposed to questionable foods. When people in my group had Montezuma’s Revenge, this supplement reversed it quickly. Not only that, but it dramatically helps with gas and bloating too.

P3-OM is a beloved universally beneficial probiotic, nicknamed “The Navy SEALs of probiotics”.

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Kapex Review

BiOptimizers Kapex Supplement


For: Energy, digestion, cognition, stress while on keto or low-carb

Form: Capsules

Ingredients: Tri-phase protease, lipa4 lipase, l-carnitine powder, innoslim, astrazyme, betaine HCL, dandelion root powder, ubiquinone, trace mineral

Bulk Discount: Save 32% on 5 bottles

The ketogenic diet has exploded in popularity because it promises to provide peak health, near-effortless weight loss, unparalleled mental acuity, and longevity… all while followers enjoy many of the most pleasurable foods. Since studying health optimization and cellular nutrition, I’ve regularly used something similar to great results.

While you can go keto without any supplements, the right ones can make it much easier to maintain, and improve the way look, feel, and perform. They can also help offset many of the side effects and symptoms of keto that cause people to quit before it naturally gets easier. Things like the “keto flu” and digestive problems. Finally, there are also concerns about the ketogenic diet’s long-term effects on lipids, cholesterol, hormones, and nutrient imbalances.

One of my go-to solutions is KAPEX. With his 26+ years following the diet, the CEO of BiOptimizers specially designed this to support those using keto, low-carb, and paleo. It works on many pathways to help your body perform better. Dandelion root protects the liver and stimulates bile flow to break down fat. Improved mitochondria and fat-burning pathways give your brain and body more fuel to use. Then the trace minerals protect you from crashing and burning. You have the blend of full-spectrum proteases and lipases to easily break down and assimilate nutrients within keto-friendly foods. Innoslim activates the longevity pathway, AMPK, which enhances the benefits of fasting and boosts energy.

I use this one when I expect to consume high-fat, high proteins meals. Especially during my yearly one-month keto/carnivore metabolic reset. It makes the entire process much easier and also more effective.

I also take KAPEX along with omega-3-rich fish oil and nootropics to dramatically amplify their mind-enhancing effects. The mitochondrial support complex noticeably stabilizes my energy throughout the day. Then the patented Astrazyme acts as an adaptogen to mitigate stresses from the day, including switching to burning fat as fuel.

Anyone going low carb, especially athletes and beginners, will feel significantly better from KAPEX.

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Magnesium Breakthrough Review

bioptimers magnesium gifts e1670554157920


For: Relaxation, sleep, recovery, mental health, full-body support

Form: Capsules

Ingredients: Vitamin B6, elemental magnesium, manganese

Bulk Discount: Save 32% on 5 bottles

Since I started using dietary supplements, I’ve taken magnesium more consistently than anything else, by a landslide. Virtually everyone is deficient, and this mineral plays a key role in 1,000+ biochemical reactions throughout the body. Deficiency increases your risk of all diseases, while also artificially limiting your performance.

Magnesium is the anti-stress mineral for deep relaxation and sleep. Stress further depletes magnesium, and magnesium plays a vital role in beating stress. Mag also improves various parameters of sleep. Not only sleep duration, but how fast you fall asleep (sleep latency), and sleep quality. It helps naturally soothe worry, fear, and the neurotoxicity of overstimulation.

Magnesium is a mental and neurological health super supplement.

As an essential electrolyte, magnesium supports the optimal function of nearly every organ and bodily system. Including, the immune system, musculoskeletal system, endocrine system (hormones), cardiovascular system, neurological system, nervous system, and circadian rhythm.

But there are some major differences between magnesium supplements. First, most products use cheap, poorly absorbed forms that don’t do much for your health. Or, they add so many synthetic additives and preservatives that these unnecessary ingredients likely outweigh any benefits. Or, they use just one kind. Magnesium comes in many different forms. Each with affinities to particular bodily systems and with particular effect profiles. Overloading one form may not reverse a deficiency. Finally, the smartest magnesium formulators know to add cofactors like vitamin B6 to maximize its powerful effects.

I personally take BiOptimizers’ Magnesium Breakthrough every morning, and night. Twice daily because it’s that important. I’ve yet to find another naturally-derived, full-spectrum magnesium supplement that supports each bodily system. Since thoroughly researching this super mineral, and reading a book called Magnesium Miracle [Amazon], it has become one of the first supplements I recommend people research due to its wide-ranging, pleiotropic benefits.

If humanity only had 15 supplements available, I’d put BiOptimizers Magnesium Breakthrough on that list because of its universal necessity and its incredible results.

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Sleep Breakthrough Review

Sleep Breakthrough Supplement


For: Sleep quality and quantity, sleep deprivation, relaxation

Form: Powder

Ingredients: Vitamin B6, magnesium, zinc, glycine, taurine, bamboo leaf extract, l-theanine, pharmaGABA

Bulk Discount: Save 40% on 3 bottles

Sleep is the unsung foundation of long-term health and high performance. The “I’ll sleep when I’m dead” crowd eventually learns that. Sleep also happens to be my Achilles’ heel. I just don’t get enough of it. Either I’m not tired, or I wake up too early. Then to top it off, I’m a light sleeper. For the last few years, I’ve been prioritizing “biohacking my sleep”.

While your unique sleeping genetics do play a role, we have lots of tools available to improve our sleep. Environmental variables play a major role. Light, temperature, noise, etc. But optimizing these can be costly, difficult, or unavailable. Or, perhaps you’ve already taken the DIY approach to building your ultimate wellness palace and just want to layer on additional strategies for even greater benefits.

I’ve tried dozens of different sleep products, ingredients, and expert formulas. Most are either ineffective or non-sustainable (nightly use discouraged). Heavy hitters like melatonin and phenibut shouldn’t be used nightly. Sustainable ingredients like l-theanine, glycine, and magnesium used in isolation help, but only minorly.

The first thing I encountered that actually works powerfully was full-spectrum hemp (non-psychoactive). It consistently knocks me out and dramatically increases my sleep quality. But I also wake up feeling groggy.

I was eager to beta test BiOptimizers’ Sleep Breakthrough product. This (naturally) neon blue elixir is the result of 55+ different formula prototypes. Unlike other sleep pills, it’s a drink that offers several key advantages. First, you get the full therapeutic dosages of each ingredient without needing to take 10 or 15 capsules. The benefit that excited me most, however, is that you can control and titrate to your unique perfect dose. For me, that’s half of a serving. My partner prefers just 1/4.

The vibrant blue color comes from one of the world’s greatest superfoods, spirulina micro-algae. Nicely sweetened with a dash of a novel zero-glycemic sweetener. BiOptimizers combines a zero-aftertaste protein called the “miracle plant” with a pinch of the highest-quality stevia.

Now, I use this one most nights. About an hour before bed, I mix up some clean water with my half serving and slowly sip on it during my wind-down routine. I start feeling it after about 30 minutes.

Sleep Breakthrough induces that same "curl-up-in-bed and knockout" feeling usually experienced after a long, physically demanding day Share on X

According to my Oura ring, my REM and Deep sleep scores significantly improve on the nights I use Sleep Breakthrough. I also see some improvements in my biomarkers of recovery. My resting heart rate drops, and my heart rate variability increases. Indicating that my nervous system, mind, and body all recover more effectively.

Here’s my favorite part. When I know I can’t sleep a full night (thanks, early morning flights), taking Sleep Breakthrough the night before helps mitigate some of the consequences of sleep deprivation. Here is also the video review on this that you can watch and learn more from it.

BiOptimizers’ Sleep Breakthrough is the delicious, sustainable yet potent sleep aid that quantifiably improves my recovery and I look forward to consuming nightly.

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Dream Breakthrough Review

Nootopia Dream Optimizer


For: Instant sleep, vivid dreams, lucid dreams, boosting REM scores, squeezing in 1-2 hours of extra sleep

Form: Spray

Ingredients: Distilled water, glycerin, low-dose melatonin, lemon essential oil, ascorbic acid, 5-HTP, citric acid, California poppy seed extract, prolong liquid 2.0

Bulk Discount: Subscribe and save 12%

While Sleep Breakthrough is a boon for increasing Deep Sleep and physical recovery, Dream Optimizer is my secret weapon to maximizing the other often-forgotten facet of regenerative sleep—Rapid Eye Movement (REM). REM is when mental and emotional processing occurs. Where your mind codifies and boosts your personal resilience. The genius stage of sleep when the brain combines novel ideas and patterns to discover novel solutions. This is also the sleep stage associated with vivid dreams.

Dream Optimizer contains a number of natural botanicals, plus some novel ingredients. Each spray contains a bioharmonic ultra-low 0.021 milligrams of melatonin. Mimicking your natural production. Most supplements use a whopping 3-10 milligrams of melatonin. When I take standard products, I wake up feeling wide awake about 2-4 hours later. Not with Dream Optimizer. The Dream Optimizer spray also contains essential oils, other supplements, California poppy seed extract, and an ingredient called prolong liquid 2.0.

Most supplement stacks focused on optimizing REM and dreams do so unsustainably. They use ingredients with long half-lives that make you wake up groggy. And they stop working over time. Dream Optimizer is a sublingual sleep spray that functions differently. By absorbing under your tongue, it escapes processing by the liver and rapidly enters the bloodstream. Requiring lower doses and without next-day lingering effects.

I generally use just 1-3 sprays. Primarily, when I wake up in the middle of the night. The effects hit me quickly, often 3 to 7 minutes after using. Boy does it work. Generally, when I wake up after 4 AM, I’m done sleeping for the night. No matter how badly I want to sleep in, I’m up. With Dream Optimizer, I effortlessly squeeze in another 2 full R.E.M cycles. This is HUGE. A total game-changer.

I’m able to take Dream Optimizer at 3-4 AM, get an additional 2 REM cycles in, and wake up fully refreshed at 6-6:30 AM. All without waking up drowsy or with a “sleep hangover”. Plus, I have the most incredible, vivid, hopefully one day lucid, dreams. I notice no tolerance or issues from daily use either.

My partner sleeps even lighter than me. The faintest noise, light, or thought will rouse her. She doesn’t take supplements, but demands we keep Dream Optimizer socked.

For anyone that wakes up in the middle of the night, is looking to boost REM, or discover vivid/lucid dreaming, Dream Optimizer is the obvious “sleep hangover”-free solution.

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Blood Sugar Breakthrough Review

Blood Sugar Breakthrough Supplement


For: Blood sugar balance, healthy restaurant food, “cheat” meals, reducing fat gain

Form: Capsules

Ingredients: Glucovantage, glycostat, cinnulin pf, innoslim, banana leaf, hippophae rhamnoides, alpha lipoic acid, quercetin, fucoxanthin, bee propolis

Bulk Discount: Save 32% on 5 bottles

We can simplify nutrition down to three things: minimizing blood sugar spikes, reducing intake of unhealthy (oxidized) fats, and attaining optimal levels of nutrients. This is the common goal of all diets. Master them, and fat loss inevitably ensues. The problem, however, is that modern meals violate one or more of these.

How do you enjoy the conveniences of enjoying your favorite foods without sabotaging your health?

Well, I occasionally eat out. I indulge in new foods and make choices I usually wouldn’t. Few restaurants match my quality standards, and I’ll choose social life over a pristine meal.

So I mitigate the damage by biohacking restaurant meals.

The easiest variable to control while dining out is the massive blood sugar swings. The right supplements can help shuttle the sugar into muscles instead of fat cells. When you do that, it offsets the consequences of large swings. The 90-minute post-meal side effects disappear. Neutralizing laziness, fatigue, irritable mood, cravings, and brain fog. This also blunts the accelerated aging caused by elevated blood glucose, keeping your cells biologically younger.

Plus, this prevents the unnecessary production of stress hormones. When foods spike your blood sugar, insulin overreacts and makes it plummet. Then, your body uses the stress hormone cortisol to bring it back up and into range. Resulting in extra stress just from eating.

I regularly pop two capsules of Blood Sugar Breakthrough before any indulgent meal. It improves carb metabolism and preferentially shuttles them into muscles to be burned as fuel. BSB also boosts a process known as mitochondrial uncoupling, burning more calories while at rest (doing nothing). Helping improve weight loss and fat loss (great for belly fat).

As I previously detailed in my article on the best natural alternatives to Metformin, I’ve tested just about every blood sugar-stabilizing strategy and quantified them with my continuous glucose monitor to see what really works. Blood Sugar Breakthrough dramatically outperformed metformin and without the side effects. In fact, it beat everything but exercise (and combining the two works even better).

When looking at the different biochemical pathways regulating blood sugar, two things stood out to me. BSB naturally increases GLP-1 (Glucagon-like peptide 1). This is the same target as the wildly popular weight loss peptide called Ozempic (semaglutide). Second, it activates both PPAR-Alpha and PPAR-Gamma. These signaling proteins are sometimes referred to as “exercise in a bottle” for their broad metabolic benefits.

Along with spirulina & chlorella micro-algae to offset the bad inflammatory fats, my restaurant kit always contains BiOptimizers Blood Sugar Breakthrough to keep my blood sugar under control.

Anyone that eats carbs or dines out should consider Blood Sugar Breakthrough to slow the biological aging process, maintain an upbeat mood, offset the post-meal energy slump, neutralize laziness, keep cravings at bay, and eliminate brain fog.

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Biome Breakthrough Review

Biome Breakthrough Supplement


For: Gut health, digestion, immunity, repairing “leaky gut”, reversing food intolerances

Form: Powder

Ingredients: IgY max, lactobacillus blend, bovine collagen, bovine bone broth

Bulk Discount: Save 32% on 5 bottles

We’re not “what we eat”, but what we absorb and assimilate into our tissues. Our modern living environments have largely compromised our gut barriers, causing (often unknown) food intolerances. Not life-threatening food allergies, but minor food intolerances that contribute to increased chronic and body-wide inflammation with every bite. My favorite way to identify and remove our “kryptonite” foods, is to follow a rotation diet where we systematically remove food groups and gauge how we feel. But it’s time-consuming and a huge hassle.

Biome Breakthrough, on the other hand, contains several powerful and patented ingredients to repair and rebuild our compromised intestinal lining. Doing so leads to less bloating and gas, better immune responses, accelerated metabolism, greater nutrient absorption, improved elimination, and elevated energy. All from simply repairing the gut lining.

The four star ingredients within this supplement include:

  • IgY Max®, the world’s only patented egg-based immunoglobulin
  • Lactobacillus rhamnosus – Natural probiotic that helps GI issues and creates overall gut balance
  • Lactobacillus gasseri – Natural probiotic with weight loss, decreased blood sugar, gut health and immunity benefits
  • Lactobacillus helveticus – Natural probiotic that helps rebalance the gut

IgY Max is especially interesting, as it specifically targets pathogenic bacteria in the digestive tract, and according to human research, reduces intestinal permeability by up to 95%. More than any other probiotic or gut health product.

I sometimes use the Carnivore Chocolate flavor in my Genius Coffee recipe for a rich taste and additional gut support. They also offer Vegetarian Vanilla. Though I’m diet agnostic, both taste quite pleasant. Like cake. Just make sure to cool your hot drinks a bit before adding. Extreme temperatures can kill probiotics.

When I’ve used Biome Breakthrough for 2-3 days straight, I do notice that I am better able to tolerate questionable foods. As for the immune benefits… well, I still haven’t gotten sick while using it.

BiOptimizers’ Biome Breakthrough is awesome for anyone with gut dysbiosis, leaky gut, poor immune function, trouble eliminating, or food intolerances.

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Protein Breakthrough Review

Protein Breakthrough Supplment


For: Muscle building, fat loss, reducing cravings, exercise recovery

Form: Powder

Ingredients: Plant protein blend, organic cocoa powder, organic erythritol, organic lucuma powder, organic mesquite powder, sunflower lecithin, organic coconut palm sugar, organic maca root powder, organic luo han guo, himalayan salt, organic vanilla flavor, organic stevia leaf extract

Bulk Discount: Save 68% on 5 bottles

Protein is the backbone of life. Tiny building blocks called amino acids comprise protein. The two most important nutrition goals are to get adequate clean fatty acids (fats), and adequate essential amino acids (protein). Without these, the body cannot regenerate or repair itself. Consuming ample protein is also the single most impactful diet tip to transform your body and fitness.

Protein is also the most satiating macro-nutrient, helping you feel full from fewer calories while also keeping cravings away. Best of all, assimilating protein costs about 30% of the calories too. So for every 100 calories of protein you consume, you only absorb about 70. Compared to 100/100 for carbs and fat.

The issue with protein is that, per quality calorie, it’s by far the most expensive macro. That, and most vegetarian protein powders taste like grainy chalk (at best). And I’ve tried a bunch. After 17 years of meticulous R&D, BiOptimizers has changed the game with Protein Breakthrough. It’s got a better texture, an impressive taste, and is one of few vegetarian proteins to contain a complete amino acid profile. They use a blend of pea protein, hemp protein, and pumpkin seed protein.

At the same time, Protein Breakthrough is low-glycemic, low-carb, easily digestible, and 97.38% organic. This one is more than a protein powder, it’s hearty like a meal replacement. Great for supporting muscle building, faster workout recovery, fat burn, and reducing cravings and other things that throw off your valiant efforts.

I personally love grass-fed whey protein and use it most often. But to avoid developing a nutrient imbalance or eventual food sensitivity, it’s smart to rotate proteins. So, I sometimes use Protein Breakthrough instead. While it’s impossible to match the deliciousness and silky nature of a quality whey, BiOptimizers’ Protein Breakthrough isn’t far behind.

Before using it, I compared the amino acid profile to my whey, and it holds its own. I sometimes use it by itself, and other times mix it into a concoction in my blender. Either way, it keeps me full for hours. Nevertheless, I am still waiting on their carnivore/non-vegetarian protein powder.

For vegetarians, vegans, and those looking to balance heavy animal-product consumption, BiOptimizers Protein Breakthrough is the only protein powder worth considering.

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CogniBiotics Review

CogniBiotics Supplement


For: Mood, memory, learning, supports an optimally balanced brain

Form: Capsules

Ingredients: Probiotic blend, prebiotic complex, Chinese herbal blend

Bulk Discount: Save 32% on 5 bottles

Most brain supplements focus on altering neurochemicals, neurohormones, and other metabolic processes within the brain. While this is a noticeable and powerful strategy, there’s a safer way that also produces impressive results. Though “all health begins in the gut” has become trite, it holds true. This includes mental health and performance.

BiOptimizers’ original nootropic is a special blend that works differently. It contains a synergy of 17 different mood, resiliency, and cognition-enhancing herbs, as well as 10 similarly beneficial bacteria strains. Improving the whole gut-brain-microbiota axis. Combining the power of two favorite formulas of expert Traditional Chinese Herbal Scientists with cognitive enhancing probiotics. This is also a natural way to produce postbiotics like Butyrate.

Like most good nootropics, CogniBiotics accelerates the production of brain-enhancing proteins. Aiding neuroregeneration and neuroplasticity to promote learning, mood, and memory. The two chief proteins improved by this supplement include the highly coveted “Miracle-Gro for the brain” — brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF).

Their research shows CogniBiotics can reduce brain fog, help beat procrastination, promote relaxation and blunt stress, improve brain chemical balance (acetylcholine, serotonin, GABA, and dopamine), support optimal brain blood flow, protect against damage, and help heal from an injury like TBI.

I use this one on an empty stomach (to maximize absorption), several mornings per week. Since I already take specific nootropics, adaptogens, and probiotics, it’s less essential than my other supplements. If I were to suffer any form of brain or gut damage, I’d immediately implement this into my routine. The biggest effect I feel is a solid mood boost. Comparable to the other heavy-hitting mood-altering compounds.

A few hours after taking it, I just feel happy and upbeat for no particular reason. I also notice that BiOptimizers’ CogniBiotics amplifies the effects of any other brain-enhancing nootropics. While exercising, I’m also slightly stronger and perform better.

CogniBiotics is a solid product to strengthen the mind-gut connection, as a standalone mild natural cognitive enhancer, and amplify the effects of other nootropics/brain supplements.

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Gluten Guardian Review

Gluten Guardian Supplement


For: Diary and gluten-containing foods, gut health, digestion

Form: Capsules

Ingredients: Enzyme blend, trace minerals

Bulk Discount: Save 32% on 5 bottles

Most of our favorite foods contain one of two nearly universally problematic ingredients: gluten or dairy. Historically, neither was too problematic for humans. Hybridization and processing technologies, however, concentrate the gut irritants and degrade the most important nutritional qualities of these two. Here’s the thing… both dairy and gluten harm those without any allergies via different mechanisms.

In 100 percent of all humans, gluten (and other prolamin proteins found in wheat and some grains) temporarily increase intestinal permeability. Allowing heavy metals, pesticides, herbicides, insecticides, and other toxins to freely pass through the gut lining into your bloodstream. Increased toxic burden also leads to the development of new food intolerances, leaky gut, and immune dysfunction. Of course, celiacs and those that have decoded other problematic genetic variants fare far worse.

Likewise, the relatively newer process of pasteurizing dairy destroys key delicate constituents that allow humans to best assimilate it. Pasteurized dairy is “dead”, devoid of key enzymes, probiotics, prebiotics, and with denatured fatty acids, denatured proteins, destroyed vitamins, and more. Plus, up to 80% of the protein within dairy consists of inflammatory and difficult-to-digest casein.

Dairy and gluten are the two most common sensitivities and intolerances. Since they’re in virtually all restaurant foods and everything with a barcode at grocery stores, it helps to have another line of defense. Biome Breakthrough certainly works. But BiOptimizers’ Gluten Guardian is specifically designed to help with dairy and gluten. It’s a formula of 6 plant-based proteolytic enzymes clinically proven to improve the breakdown of gluten and also starches and sugars.

I personally don’t consume much dairy or gluten, so I rarely use Gluten Guardian. Every once in a while, however, I’m at a restaurant (they add wheat to everything) or want to indulge. I usually remember to bring Gluten Guardian or Biome Breakthrough. When I take it before a high-carb meal, I feel significantly better (lighter) afterward, and avoid some of the lethargy that often hits me 24-72 hours later. If you do “cheat meals”, this is a solid way to help partition the food into muscle tissue rather than derailing your progress.

Think of Gluten Guardian like MassZymes but specifically formulated to offset junk food binges.

Gluten Guardian helps protect the body from the two nearly universal (yet often unknown) food intolerances while also mitigating the damage that comes from consuming high-carb junk foods.

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BiOptimizers Supplements Review Final Verdict: Worth The Expense?

BiOptimizers is a nutrition company helping humans go from sub-optimal to thriving.

As the most ancient health sciences suggested, they began by focusing on digestion.

Digestion is our internal "furnace" that helps us transmute foods (nutrients) into cellular fuel Share on X

Restricting delicious foods is unsustainable. That which we resist, persists. BiOptimizers takes the opposite approach. They’re helping us mitigate the downsides of enjoying many of the finer things in life.

BiOptimizers won’t even consider creating a new product unless they can make it the undisputed best on the market. What I like most about these products is that you know you’re getting quality.

And it shows…

More than any other brand, I regularly hear glowing reports from other folks using these supplements.

My favorite BiOptimizers supplements are currently:

  • Stress Guardian
  • MassZymes
  • Magnesium Breakthrough
  • Sleep Breakthrough
  • Dream Optimizer

Click those links to give one of those a try and make sure to use the exclusive BiOptimizers code URBAN to save 10%.

I continue coming back to these time and time again. They’re core parts of my stacks.

BiOptimizers’ supplements are certainly more expensive than your grocery store generics, but they actually work exactly as expected. Every time.

Here’s the other thing…

I take nearly 100 capsules/powders/elixirs per day.

From a bunch of different companies. I’ve discovered the hard way that many of them secretly change their formulas to cheaper versions. Or water down the beneficial active ingredient. Or add toxic fillers. All to save cost and to the detriment of my health.

BiOptimizers is one of the few trustworthy supplement companies with ethics.

They personally spend thousands of hours researching before creating their formula. Then, they test, analyze, and tweak the formula—sometimes up to 55 times—before releasing version one to the world.

Where most companies sit on their laurels and move on, they continue iterating years (and even a decade) later.

Have you used BiOptimizers’ supplements or Nootopia’s nootropics? Let me know your comments and experience in the comments below!

BiOptimizers Supplements Review

With the numerous number of supplement to choose from, BiOptimizers are definitely on top of the list to consider. In this review you will learn the difference between each of their supplements and choose what suits your needs

Product Brand: BiOptimizers

Editor's Rating:


  • Powerful
  • Highest-quality supplements
  • Zero fillers
  • 365-day satisfaction guarantee
  • Great customer support
  • Bulk bundle discounts
  • Endorsed by top health professionals
  • Fast shipping


  • Expensive
  • Limited options
  • Not available in stores
  • Heavy marketing
  • Uses proprietary formulas

Post Tags: Brain & Cognition, Recovery & Resilience, Review, Supplements, Vendor

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