Is dry fasting the ultimate biohack to reverse biological aging and health conditions or an unsafe fad?
Will it really cause a natural surge in stem cell activity?
What are the other benefits and use cases of dry fasting?
How does it compare to more traditional water fasting?
Perhaps most importantly, what should I know about how to dry fast?
After reading a book called The Phoenix Protocol, conducting extensive research, and consulting with some of the world’s leading experts, I’ll share some of what I’ve discovered about the forgotten health protocol that is dry fasting.
What is Dry Fasting?
Dry fasting is the intentional practice of completely abstaining from consuming any food or drinks for a predetermined amount of time in order to reap physical, mental, emotional, and spiritual benefits.
Proponents use it to:
- Activate stem cells and the process of autophagy (cellular component recycling for longevity)
- Reverse biological aging
- Rejuvenate the body
- Burn fat
- Rebalance organ systems
- Fix a wide range of health conditions
One of the best resources to learn about dry fasting is The Phoenix Protocol.
In it, author Dr. August Dunning describes two types of dry fasting:
- Soft dry fasting which allows you to bathe and wash your hands/face
- Hard dry fasting which prohibits any contact with any water whatsoever
Most practitioners advocate soft dry fasting only.
He also explains the two key tenets that must be maintained throughout a fast to be healthy:
- Keeping blood glucose levels steady to fuel the brain and red blood cells [R, R]
- Protecting key proteins in the heart and skeletal muscles [R, R]
Water fasting violates these cardinal rules but dry fasting does not.
How does it work differently?
How dry fasting works
Dry fasting causes all kinds of powerful physiological changes.
The mechanisms change depending on the duration. Some of the core processes that underlie all dry fasting include:
- Depleting glycogen
- Upregulating micro-autophagy, macro-autophagy, and chaperone-mediated autophagy
- Increasing blood solids
- Increasing growth hormone release protects bodily proteins from being digested by gluconeogenesis
Russian doctors discovered that drinking water (through the mouth) stimulates gastric juices.
It also prevents a part of the brain called the hypothalamus from activating the body’s built-in water generation system (endogenic/metabolic water) via osmo receptors.
This is because drinking water prevents the blood from concentrating sufficiently.
Then, the pituitary gland releases anti-diuretic hormone (ADH) and growth factors which bypass gluconeogenesis and preserves lean tissue (muscle and organs).
Increasing ADH stimulates the release of epinephrine, which in turn activates lipase at the fat cells. Accelerating the breakdown of fat tissue and helping the body excrete toxins.
By day three of dry fasting, levels of Protein Kinase A (PKA) decline. This results in systemic stem cell regeneration.
You also get to enjoy improved paracrine signaling and mitochondrial efficiency.
Dry fasting vs water fasting
If even a single drop of water enters your mouth, you engage the digestive system and break your dry fast.
What 📝 | Dry Fast 🍽 | Water Fast 💧 |
---|---|---|
Definition | No food or liquids | Consuming only water |
Hydration | No water intake | Regular water intake |
Physical stress | Higher | Lower |
Metabolic effects | Rapid ketosis | Gradual ketosis |
Potential benefits | Max | Moderate |
Detoxification | Greater | Slower |
Weight loss | Faster, potentially resets body weight set point | Minimal weight loss |
Source of weight loss | Fat | Muscle & lean tissue |
Energy levels | Decreases quickly | More stable |
Safety | Medical supervision recommended | Medical supervision recommended |
Popularity | Less common | More common |
Spiritual/Religious benefits | Greater | Less |
Impact on exercise routine | Not recommended | Possible |
Either way, consider working with a healthcare professional, especially for prolonged fasting periods.
Medical dry fasting has actually been used since the 1990s Share on XModern scientific uses
Virtually all the research and clinical usage of dry fasting comes from Russia.
Four doctors and researchers have contributed most:
- Dr. Leonid A. Shchennikov
- Dr. Sergei I. Filonov
- Dr. August Dunning
- Eduard Gavrilov
Dr. Shchennikov extensively researched the effects of dry fasting (both on himself and supervised thousands of his patients) and patented his method in 1993.
He advocated for the 11-day dry fast for the best results and to cure many conditions I’ll list below.
Dr. Filonov also researched and experimented with dry fasting and developed his own protocol.
His style focused on nature immersion and applying cold water to the body (WITHOUT ingesting it orally).
Dr. Dunning popularized dry fasting in the west. He’s synthesized most of the Russian research into two books and many videos on his YouTube channel.
Eduard Gavrilov is another Russian researcher who investigated how the body responds to periods without food and water. His work is less known in Western scientific communities.
The potential conditions treated or reversed by the above dry fasting experts include:
- Manic-depression
- Obsessive states
- Hereditary mental disorders
- Severe head trauma and severe concussion (short courses of 1-3-5 days)
- Encephalitis
- Toxoplasmosis
- Inflammatory diseases of the central nervous system
- Cerebral palsy
- Cerebral tumors
- Hypothyroidism and thyrotoxicosis
- Chronic diseases of the cardiovascular system
- Hepatitis
- Bronchial asthma
- Angina pectoris
- Diseases of the nervous system
- Epilepsy
- Schizophrenia
- Condition after chemotherapy and radiotherapy
- Acute infections of the kidney
- Hemophilia
- Thrombophlebitis
- Grade III heart failure
- Diseases of the inner ear
- Ovarian cysts
- Uterine fibroids
- Endometriosis
- Infertility
- Mastitis
- Hot flashes
- Yeast infection
- Parasite infection
- Viral infection
- Bacterial infection
- Benign tumors
- Rheumatoid arthritis
- Osteoarthritis
- Psoriasis
- Interstitial cystitis
- Chronic pyelonephritis
- Prostatitis
- Prostate adenoma
- Inflammation
- Gangrene
- Atopic dermatitis
- Chronic urticaria
- Eczema
- Ankylosing Spondylitis
- Asthma
- Chronic pneumonia
- Pulmonary Sarcoidosis
- Atherosclerosis
- Hypertension
- Sciatica
- Herniated disk
- Brain injury
- Migraine headaches
- Gastritis and disorders
- Stomach ulcer
- Duodenal ulcer
- Pancreatitis
- Cholecystitis
- Ulcerative colitis
- Irritable bowel syndrome
- Hemorrhoids
- Non-insulin dependent diabetes
As you can see, it’s a very long list.
The history of dry fasting dates back even longer.
History
Religious literature throughout the world either directly mentioned or alluded to dry fasting.
For example:
- Christianity: In the Bible, the Gospel of Matthew (Matthew 4:1-2) describes Jesus fasting for 40 days and 40 nights in the wilderness. It’s often interpreted as a complete fast from both food and drink by some Christian traditions. Esther 4:16 also mentions a three-day fast from both food and water undertaken by Queen Esther and the Jews of Susa
- Eastern Orthodox Christianity: The Typikon (a book providing instructions for services) includes guidelines for fasting, including the Great Lent, where some people abstain from both food and water… though this is more tradition than explicit commandment
- Judaism: The practice of dry fasting is directly linked to the Yom Kippur and Tisha B’Av. The Torah, in Leviticus 16:29-31, instructs Israelites to “afflict their souls” on Yom Kippur… which is traditionally understood to include abstaining from both food and water
- Islam: Hadith literature (sayings and traditions of the Prophet Muhammad) sometimes references stringent forms of fasting. For example, there are Hadiths where Muhammad engaged in forms of dry fasting, particularly during times of deep spiritual reflection or need
Let’s explore some of the many proposed benefits of dry fasting.
Dry Fasting Health Benefits Timeline (Day by Day Stages)
So what exactly can this therapy do for you?
Lots.
“I believe, that when properly administered, the Phoenix Protocol [dry fasting] can extend lifespan by 25 years or more”
Dr. August Dunning
Benefits appear to accrue the longer and more frequently it is performed (to an extent).
I’ll share what happens from the beginning throughout your fasting, as well as the day by day changes.
Throughout the entire process
Autophagy: Increased recycling of damaged cellular components and the regeneration of new, healthy cells.
Autophagy is strongly activated after 2 to 3 days of dry fasting and has a profound impact on healing and longevity Share on XIt aids the removal of senescent cells, damaged proteins, and cellular debris, improving cellular function and potentially extending lifespan.
The following autophagic functions occur while dry fasting:
- Aggrephagy: The degradation of protein aggregates
- Lipophagy: The breakdown of lipid droplets
- Ferritinophagy: The processing of iron complexes
- Mitophagy: The removal of damaged mitochondria
- Pexophagy: The degradation of peroxisomes
- Reticulophagy: The turnover of the endoplasmic reticulum
- Ribophagy: The recycling of ribosomes
- Xenophagy: The selective autophagic degradation of intracellular pathogens
- Zymophagy: The degradation of zymogen granules in the pancreas
Stem cell activation: Stimulates the release and activation of stem cells, enhancing tissue repair and rejuvenation. Without glucose and insulin, the Protein Kinase A (PKA) signal, which keeps stem cells dormant, is turned off.
Once activated, stem cells then multiply and transform into various cell types.
Detoxification: Releases and eliminates toxins stored in fat cells and tissues. Dry fasting initiates a detox process, removing toxins and improving overall health.
The absence of external water forces the body to produce its own endogenous water, which is free from external contaminants.
This detox cleanses the blood and lymph, improving overall health and reducing the risk of diseases.
Immunity: Boosts immune cell production, including immunoglobulins and T-cells, enhancing your immune system’s efficiency and disease resistance.
Fat loss: Dry fasting primarily burns fat as your body shifts to ketosis. It also improves metabolic health by lowering insulin levels and enhancing fat metabolism.
Reported to help reset the body’s weight set point to enable life-long weight loss.
Psychological & spiritual health: Participants report improved mental clarity, emotional stability, personal resilience, and spiritual well-being during and after a dry fast.
Cardiovascular improvements: Cleans cholesterol plaques from blood vessels, reduces high blood pressure, and may improve myocardial infarction.
Cleanses organs: Helps the body work as it should to use diseased cells, dissolve stones in the kidneys and gallbladder, and improve lymphatic system health
Beauty. Appears to help improve the complexion and health of the skin, digestive tract, and elimination pathways. Anecdotally, dry fasting is the only intervention to remove loose skin.
Now, let’s explore what happens on each day.
Day 1: adaptation
- The body begins to deplete glycogen stores in the liver and muscles and starts transitioning to fat metabolism
- 4 hours of no food, macro-autophagy begins
- 6-7 hours later, micro autophagy activates
- 10 hours later, chaperone-mediated autophagy (CMA) starts
- Energy levels stay fairly stable
- Clarity and focus heighten
- Zero to minimal bathing required
- 1kg of weight loss mainly from water
Day 2: ketosis begins
- The body starts entering ketosis, where fat becomes the primary energy source
- Early stages of immune system regeneration begin as cells clean out damaged components
- Although still mostly water weight, weight loss starts to become noticeable and the body begins to burn fat for fuel
- 1kg of weight loss, still mostly from water but some fat too
Day 3: deep ketosis
- You reach full ketosis, a major transition with significant fat-burning. Signals the beginning of the first acidotic crisis. Detoxification ramps up
- Stem cells are released to facilitate repair and regeneration
- Fat cells may release new stem cells, promoting cellular repair in the vascular system. Blood pressure may shift
- 1kg of weight loss, with more of it coming from body fat
Day 4: accelerated detoxification
- Accelerated metabolism with more aggressive detoxification and the beginning of healing
- New lysosomes form, which help degrade old proteins into amino acids for new cell production
- Energy levels, body temperature, and blood pressure often fluctuate as the body works hard metabolically
- Symptoms of hidden diseases can start to arise and the body begins to address infection
- Autophagy rises significantly
- Take more cold showers or baths to address fluctuating body temperature
- If you continue, stem cell activation occurs
- 1kg of weight loss, with much of it coming from body fat
Day 5: healing phase
- Regenerating stem cells and replacing senescent cells take place
- Fatigue, body temperature, and blood pressure fluctuations are common
- Pain in unhealthy organs can arise
- Symptoms of hidden diseases intensify
- Prioritize downtime and recovery due to increased metabolic activity and healing
- 1kg of weight loss is common, with people often reporting losing around 12 pounds up to this point
Day 6: genetic repair & functionality
- Body prioritizes demethylating cells back to youthful functionality
- Cellular function and protein synthesis improve
- Mental clarity heightens and brain function often improves
- Emotional state and energy markedly improve
- Sense of smell sharpens
- Restlessness is common
- Spend more time in moist environments (morning and evening walks, bathing)
- 1kg of weight loss, with most of it coming from body fat
Day 7: rejuvenation & immune boost
- Immune function sharply improves while stem cells actively repair tissues and organs
- Major rejuvenation occurs
- Bodily functions stabilize and participants often report feelings of relief and lightness
- Urine contains high levels of toxins and the color becomes dark brown
- 1kg of weight loss, with most of it coming from body fat
Day 8: optional extension causes second wave of detox
- Many protocols advocate ending after 7 days, only experienced dry fasters should continue
- On day 8, the body goes through a second acidotic crisis and cleansing symptoms return
- Another wave of detoxification, deep cellular regeneration, and the fixing of chronic issues occur
- New symptoms like bitter saliva and irritability can appear
- 1kg of weight loss, with most of it coming from body fat
Day 9: symptoms intensify & blood purifies
- The body reaches a new point where it focuses on renewing and purifying the blood specifically
- New symptoms arise again, including cold extremities and increased heart palpitations
- Again, spend ample time cooling the body
- 1kg of weight loss, with most of it coming from body fat
Day 10: healing continues & boredom arises
- Second acidotic crisis ends, cleansing continues and the boredom of fasting intensifies
- Nothing much else to note
Day 11: the end
- Longer duration dry fasts require meticulous planning and preparation to gradually reintroduce (the right) foods
How to Dry Fast Safely & Effectively
By now, you might be wondering if dry fasting is safe and how to do dry fasting successfully.
Like water fasting, the premise is simple… Completely abstain from putting anything in your mouth. With this one, including water.
Dry fasting is biologically stressful and you should certainly know a few things before considering a protocol Share on XStart small
With the help of your healthcare professional, you should plan to work your way up to a multi day dry fast.
If you’ve never dry fasted before, start small. Here’s the progression I recommend:
- 24 hours
- 2 days
- 3 days
- 5 days
- 7 days
First, try a 24-hour fast several times before going longer.
The longer your dry fast, the more time between sessions. I wouldn’t do a three-day dry fast more often than monthly. I wouldn’t do a five-day (or longer) more than twice per year.
Also, unlike water fasting, when you end it matters significantly.
Strategic supplementation
The way you supplement before and after dry fasting can boost your results.
The Phoenix Protocol advocates the use of several supplements:
- Fisetin (pre-fasting) as one of several senolytic supplement ingredients to help remove “zombie” cells. Take daily for the week before dry fasting
- Quercetin supports demethylation, and NAD+ optimization. Take it often between fasts.
- Polyphenols (post-fasting) help neutralize free radicals and build bodily resilience. Take low dosages daily between fasts for powerful synergy
- Resveratrol (post fasting) to activate sirtuins, support demethylation, and boost NAD+ (although I believe pterostilbene is a similar but superior options). Take daily between fasts
- Multi-minerals, electrolytes, & multivitamins provides your body with key nutrients depleted during fasting. Take daily for two weeks after fast
Perhaps even more effectively, you can use Joel Greene’s amplified fasting protocol before fasting.
Aside from fisetin, you should use all other nutraceuticals after the fast.
Time properly
Russian researchers discovered that the duration of your water fasting matters immensely.
You either want to go:
- 3 days or less
- 5 days
- 7 days
When you dry fast for four days or more, you cause a massive release of stem cells throughout the body. This is great for bodily regeneration and helps prevent stem cell senescence.
At the same time, over-activation via too frequent dry (or longer) fasts can cause stem cell exhaustion.
So as a rule of thumb, stick to shorter three-day dry fasts, occasionally extending to five or seven days.
Bathe in filtered water
Although paradoxical, you’ll want to bathe in clean water often.
The Russian doctors advocated this too.
That’s because bathing in water helps flush the lymphatic (toxin drainage) system without activating the digestive system.
To avoid reintroducing and absorbing toxins, you’ll want to use clean filtered water.
Ending the dry fast properly
The way you end your fast matters so that you don’t negate the benefits of all your hard work.
Here are the essential tips to end a dry fast properly:
- Replenish electrolytes immediately after ending the fast, by mixing 1/2 teaspoon of baking soda into an 8 ounce glass of water. Sip it slowly over an hour to replenish sodium. Gradually build up to 6-8 glasses of liquid daily to rehydrate. This can include water, carbonated mineral water, coconut water, and bone broth. Just avoid acidic drinks like citrus or vinegar
- Slowly nourish by getting enough electrolytes like sodium, magnesium, phosphorus, and potassium before reintroducing food. Take magnesium and potassium supplements daily during your recovery period and add key minerals with upgraded water
- Gently restart digestion by avoiding overeating and particularly avoiding sugar and carbohydrates for the first few days. Instead, slowly consume water and broths like bone broth
- Make smart food choices with a clean whole food diet and avoid processed foods, sugar, and sugary drinks. Choose easy-to-digest foods like steamed veggies, soups, salads, yogurt, and kefir
- Prioritize physical recovery because your new body will be taxed after an extended dry fast. Avoid strenuous work while prioritizing getting ample recovery
That’s the core.
Consuming sugar too close to the end of a fast will tax your pancreas and likely cause weight regain Share on XIf you’re able, consider the following:
- Use sun protection since you just created new skin cells. Minimize damage for the first month or so by wearing a hat and protective clothing
- Post-fast enema on the 2nd or 3rd day after the fast to help rid waste products in the colon that occurred during the detox process. Recommended by Dr. Dunning.
Side Effects & Symptoms
Dry fasting does have its share of unpleasant side effects and symptoms.
Partially caused as a result of detoxification, as thirst reaches unfamiliarly high levels.
Some of the potential side effects include:
- Dry mouth
- Blood pressure changes
- Pulse changes
- Nausea
- Weakness and fatigue
- Discolored urine
- Dizziness
- Pain
- Body temperature changes
- Chills
- Fever
- Headache
- Sleep issues
- Foul taste/smell in mouth
- Bad
- Irritability and emotional sensitivity
Although unpleasant, many of these symptoms can be signs of beneficial change. Of course, work with your medical provider to ensure safety.
Questions & Answers
Won’t I die without water for multiple days?
The body has various mechanisms for coping with dehydration. It breaks down triglycerides into fatty acids and glycerin to provide energy, with the liver converting these fatty acids into ketone bodies—an energy source for many tissues, particularly the brain. Proper pre-fast nutrition helps you prime your body to manage dehydration effectively.
Who should not dry fast?
People with heart problems, those exposed to intense heat, or those who work outdoors should generally avoid dry fasting. Individuals with kidney problems should only attempt this under professional guidance. If you’re chronically stressed mentally or physically, wait until you’re in a better state before attempting dry fasting.
How long is the recovery period?
Doubling the time of the fast is a good rule of thumb. For example, if you fasted for 2 days, you should take 4 days to recover. Gradually introduce food to your system while adding electrolytes, multivitamins, and similar key nutrients
Why do I pee a lot when dry fasting?
When you start dry fasting, you might urinate more frequently because your body is naturally releasing large amounts of water and salt.
Can I exercise while dry fasting?
Yes. Most healthy people can exercise during any type of fast. But when you’re doing a longer dry fast (more than 24 hours) or you’re still inexperienced, it’s best to keep your body well-rested
Conclusion
Is dry fasting the cure-all panacea?
No.
Done properly, dry fasting appears to be one of the most powerful available interventions to regenerate the body, slow biological aging, and promote healthspan Share on XDr. August Dunning refers to it as the pathway to “Functional Immortality”.
Before trying it, work with a professional to make sure you do it right. As you can see, there are a number of considerations to maximize the benefits.
Definitely start lightly. Short dry fasts have a cumulative beneficial effect over time.
This is one of few therapies that, anecdotally, can reset your fat body fat set point. Meaning you can lose weight and keep it off.
I’m gradually working up to a five day dry fast. I plan to test my biological age before and after to see what exactly this therapy can do.
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And if you’ve tried dry fasting, I’d love to hear your experience. Drop a comment below and let me know!