Until a few years ago, longevity was a fringe topic discussed in underground online forums and within circles of advanced biohackers.
Thanks to many of the best longevity podcasts, this information has permeated into pop culture. Many popular principles, supplements, technologies, interventions, and protocols stem from podcast episodes.
Longevity isn’t just about living longer. It’s being at your best and healthiest and thriving well into later years. Sometimes called ‘Healthspan’ or even ‘PerformanceSpan’.
Whether you’re new to biohacking or a biology optimizing veteran, podcasts are a perfect medium to stay abreast of the latest ideas, delivered in short soundbites.
I’ve curated a list of today’s best longevity podcasts. These are some of the shows that I tune into. They feature expert interviews, actionable tips, and evidence-based approaches to live a high quality of life for longer.
The Top Longevity Podcasts You Should Listen To
In a hurry? I’ve compiled the key comparisons between longevity podcasts in the below table.
| Podcast 🔊 | Host(s) 👨👩 | Focus 🔍 | Best For 🎯 | Frequency 🗓️ | Average Length ⏱️ |
|---|---|---|---|---|---|
| The Drive Podcast | Peter Attia, MD | Science of longevity | Understanding complex health concepts | Weekly | 95 mins |
| FoundMyFitness | Rhonda Patrick, PhD | Nutrition, genetics, & aging | Deep research on biology & longevity | Monthly | 77 mins |
| High Performance Longevity | Nick Urban | BioHarmonizing & PerformanceSpan | Modern methods w/ ancestral wisdom | Weekly | 60 mins |
| LONGEVITY | Nathalie Niddam | Peptides, bioregulators | Products, strategies, & research on longevity | 2X weekly | 70 mins |
| Siim Land Podcast | Siim Land | Evidence-based science w/ practical biohacking strategies | Straightforward lifestyle changes | Weekly | 55 mins |
| Longevity by Design | Gil Blander, PhD | Aging research & biomarker-driven health optimization | Personalized strategies to extend healthspan | Weekly | 60 mins |
| The Human Upgrade | Dave Asprey | Latest technology & practices to hack your biology | Control of your biology through biohacking | 3X weekly | 60 mins |
| Wild Health Podcast | Mike Mallin, MD & Matt Dawson, MD | Personalized, data-driven strategies aligning w/ your natural biology | Precision & functional medicine approaches | Weekly | 40 mins |
| Gladden Longevity Podcast | Jeffrey R. Gladden, MD | Holistic, science-backed strategies to live well beyond 100 | Holistic routes to longevity | Weekly | 45 mins |
| Health Longevity Secrets | Robert Lufkin, MD | Healing & longevity | Practical strategies to prevent & reverse chronic diseases | Weekly | 45 mins |
Now let’s go into detail for each and see which ones to listen to depending on your preferences.
The Drive Podcast by Peter Attia
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Dr. Peter Attia is a Stanford, Johns Hopkins, and NIH-trained physician. In each podcast episode, he takes a deep-dive into the science and art of living the longest, healthiest life possible.
With over 100 million downloads, The Drive covers everything from exercise and nutritional biochemistry to metabolic health, cognitive performance, and emotional well-being.
Based on his book Outlive, Dr. Attia does not understand ancient medical sciences like Ayurveda or Traditional Chinese Medicine, though.
Considered one of the most rigorous longevity podcasts, The Drive gives technical, multi-hour explorations on metabolic health, aging, and performance.
FoundMyFitness with Rhonda Patrick, PhD
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FoundMyFitness, hosted by Dr. Rhonda Patrick, explores the best strategies to boost healthspan, brain function, and physical performance.
Listen to the show if you want a deeper, research-driven understanding of how biology influences long-term health and vitality.
She focuses heavily on biochemical pathways, physical fitness, sauna, specific nutrients, and BDNF.
Rhonda Patrick uniquely blends molecular biology with practical nutrition and lifestyle, showcasing her ability to translate mechanistic research into applicable health strategies.
High Performance Longevity with Nick Urban
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The High Performance Longevity Podcast (formerly Mind Body Peak Performance) empowers you to maximize your quality of life by blending modern biohacking with ancestral wisdom.
Through this dual lens, you’ll learn which interventions have the greatest ratio of potential upside to lowest risk—a rating system he calls BioHarmony.
Each episode brings you the science & tools behind extending your PerformanceSpan, the years you stay at your peak physical and mental capacity.
Each week, host Nick Urban interviews world-class experts on longevity, biohacking, performance, resilience, mindset, and smart tech.
High Performance Longevity teaches not just living longer, but how to optimize physical and cognitive performance with the right tools to save you time, money, and energy.
LONGEVITY with Nathalie Niddam
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The LONGEVITY Podcast with Nathalie Niddam stands out for its deep exploration of cutting-edge therapies like peptides and bioregulators.
She offers you actionable insights into extending healthspan and vitality through solosodes and expert interviews.
Nathalie, a certified holistic nutritionist and epigenetic coach, does a great job rooting her guests’ commentary and making implementation practical for her audience.
Nathalie brings a focus on peptides, bioregulators, and advanced therapeutics, offering in-depth yet approachable conversations on longevity.
Siim Land Podcast
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The Siim Land Podcast stands out by blending evidence-based science with practical biohacking strategies to optimize health, performance, and longevity. He’s best known for popularizing the term ‘autophagy’.
Siim’s methodical yet easy-to-understand style, combined with his background in anthropology, offers listeners deep insights into aging, nutrition, and lifestyle habits.
I like that he sometimes goes against the grain and calls out deceptive longevity-related marketing campaigns.
Siim Land uniquely fuses biohacking with evolutionary biology, hormesis, and intermittent fasting strategies, consistently emphasizing metabolic flexibility and resilience.
Longevity by Design with Dr. Gil Blander
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Longevity by Design with Dr. Gil Blander examines personalized approaches to health and longevity through the lens of scientific innovation.
He uniquely combines the latest aging research with practical, personalized health strategies.
Produced by InsideTracker, the show utilizes real-world insights from blood biomarket testing, quantification, and more
Longevity by Design provides data-first conversations and a biomarker-driven approach to longevity, making it ideal for those who want measurable insights over theory.
The Human Upgrade with Dave Asprey
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The Human Upgrade (formerly Bulletproof Radio) uniquely blends biohacking, technology, neuroscience, and personal development to help listeners optimize mind and body performance.
Hosted by Dave Asprey, the “father of biohacking,” it features expert guests who push scientific and technological boundaries.
Dave Asprey’s show stands out for pioneering biohacking in mainstream media, delivering longevity insights through performance, anti-aging tech, and his signature personality.
Wild Health Podcast with Drs. Mike Mallin & Matt Dawson
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The Wild Health Podcast with Drs. Mike Mallin, Matt Dawson, and friends stands out by embracing a personalized, precision medicine approach that aligns with your natural biology and evolutionary roots.
Their focus is on personalized, data-driven strategies that integrate genomics, biohacking, and cutting-edge science to enhance health, performance, and longevity. This is also what they provide clients at their clinic.
The Wild Health Podcast provides a precision medicine approach, blending genomics, lab data, and personalized protocols from board-certified physicians treating real patients.
Gladden Longevity Podcast with Dr. Jeffrey Gladden & Steve Reiter
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The Gladden Longevity Podcast (formerly Living Beyond 120) explores how people can live well beyond 100 years with vitality, strength, and mental sharpness. Host Dr. Jeffrey R. Gladden, a board-certified interventional cardiologist, aims to make “100 the new 30.”
How? He claims that via focusing on optimizing health, longevity, performance, and life energy through personalized, science-based strategies.
This podcast challenges traditional aging beliefs, promotes a growth mindset, and provides actionable insights.
The Gladden Longevity Podcast blends functional medicine, personal stories, and clinical strategies aimed at extending both lifespan and healthspan through regenerative therapies.
Health Longevity Secrets with Dr. Robert Lufkin
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The Health Longevity Secrets Podcast blends expert interviews with evidence-based lifestyle modifications for longevity.
It focuses on preventing and even reversing chronic diseases through simple and accessible changes. Resulting in an improved healthspan.
It also explores biohacking and offers listeners practical tools to boost longevity and well-being.
Health Longevity Secrets challenges conventional medical thinking by emphasizing metabolic health, fasting, and ketosis.
Applying What You Learn
Listening to great longevity podcasts is a necessary start, but true transformation only occurs when you put into practice what you learn.
Take notes & implement
Jot down key takeaways, reflect on what resonates, and experiment to see what works for your body and lifestyle. Check out other longevity resources to supplement your learning.
Consult trusted professionals
While podcasts offer powerful insights, they’re not a substitute for personalized medical advice. Always check in with qualified practitioners before making big changes.
Join the conversation
Many of these shows have communities on social media or online forums. Ask questions, share your progress, and learn alongside others on the same path. Plus, the social determinants of health make a major difference to your longevity.
Adding the holistic lens
Longevity isn’t just about hacks, drugs, or protocols. It’s sleep, nutrition, stress, relationships, movement, and purpose. Addressing the full picture yields the best results.
The Top Longevity Podcasts of 2025
I just shared some of the best longevity podcasts out there, but the world of wellness is always evolving.
Top longevity experts are always learning; often exploring adjacent industries.
Here’s a list of top biohacking podcasts if you want to learn more on health optimization.
Or if you’re looking for other types of content, check out my other top biohacking resources:
- Top biohacking blogs & websites
- Must-read biohacking books
- Famous biohackers & influencers to follow
- Biohacking events, conferences, & summits
What shows have you found valuable on your journey?
Drop a comment and let us know your favorite longevity podcast so we can all keep learning, growing, and thriving together.
Thanks!
