I’ve spent years biohacking my way to better health, and stem cells pose one of the exciting frontiers of longevity science.
Aging is a condition of progressive degeneration and these remarkable cells act as your body’s repair crew. Constantly fixing damage and keeping your entire body (and mind) operating younger and better.
Yet as we age, they become exhausted and less effective.
The good news? You can naturally increase your stem cell activity through simple, science-backed practices.
No need for $10,000 injections or controversial treatments.
In this post, we’ll go over how stem cells work, lifestyle habits to improve stem cell production, the best supplements, food sources, and more.
Stem cells are capable of both self-renewal & differentiation into various types of specialized cells
By age 65, humans will only have 12% of the stem cell pool they had in their 20s
Nutrition, fasting, exercise, sleep, & stress management naturally boost stem cell health
Avoid alcohol, tobacco, chronic stress, and environmental toxins to protect stem cells
Biohacks like molecular hydrogen, peptides, RLT, LifeWave X39, & HBOT support stem cell health
Specialized stem cell supplements target pathways that stimulate stem cell function & provide an environment for stem cells to flourish
What Are Stem Cells & How Do They Work
Stem cells are special cells in the human body that can develop into many different other types (differentiation) including muscle cells, brain cells, blood cells, and more.
They also have the capability to self-renew, meaning they can divide and produce more stem cells, maintaining their population over time (self-renewal).
Stem cells work by carefully balancing self-renewal to maintain their population and differentiation to replace or repair tissues.
In short…
Stem cells are like your body's Swiss Army knife for repair and regeneration Share on XSadly, your stem cell reserves naturally decline with age.
Research shows that by age 65, you only have 12% of the stem cells you had in your 20’s (World J Exp Med).
This decline contributes to:
- Slower healing
- Reduced tissue function
- Increased susceptibility to age-related diseases
The solution isn’t just maintaining what you have. It’s actively boosting your stem cell production and function.
By the end of this article, you’ll know how to do just that!
Types of Stem Cells
Stem cells are categorized in 2 ways:
Origin-based classification describes where the stem cells come from.
Potency or differentiation potential-based describes what the stem cells can become.
Scientists use both because each system highlights different important aspects of stem cells.
Differentiation potential-based classification
Classification by differentiation refers to the types of other cells that stem cells can mature into (ordered from broad to specific):
- Totipotent develops into any cell type in the body and extra-embryonic tissues like the placenta (example: the zygote and very early embryonic cells)
- Pluripotent becomes almost any cell type in the body but not extra-embryonic tissues (embryonic stem cells and induced pluripotent stem cells fall into this category)
- Multipotent differentiates into several related cell types within a group (example: blood stem cells can become red blood cells, white blood cells, or platelets, but they can’t become brain cells or skin cells)
- Oligopotent differentiates into fewer, closely related cell types (a narrower subset of multipotent)
- Unipotent can produce only 1 cell type but retain the ability to self-renew (example: muscle stem cells)
These all end in ‘-potent,’ signifying the power each has to turn into other cell types.
Origin-based classification
Origin-based classification considers three types of stem cells:
- Adult stem cells
- Embryonic stem cells
- Induced pluripotent stem cells
Adult stem cells help maintain and repair tissues throughout life.
They’re found in various tissues like bone marrow, brain, skin, and liver (i.e., liver stem cells will only produce liver cells).
They are usually multipotent or unipotent, meaning they generate only certain types of cells related to the tissue they originate from.
Embryonic stem cells come from early-stage embryos (unused embryos from in vitro fertilization donated for research). They’re pluripotent, developing into almost any cell type in the body.
Induced pluripotent stem cells (iPSCs) are adult cells genetically reprogrammed in the lab to behave like embryonic stem cells. They have the potential to become many cell types but their full capabilities are still under study.
Where are stem cells located?
Stem cells are found throughout the human body but tend to concentrate in particular tissues or “niches.”
They remain mostly dormant until needed for tissue maintenance or repair.
Key locations include:
- Bone marrow: Contains hematopoietic stem cells (HSCs) that produce blood and immune cells, as well as mesenchymal stem cells (MSCs) that can become bone, cartilage, and fat cells
- Umbilical cord blood and tissue: Rich in stem cells collected at birth, useful for regenerative medicine
- Dental pulp: Inside teeth, containing MSCs
- Fat (adipose) tissue: Contains MSCs that can be harvested for therapies
- Placenta and amniotic fluid: Sources of perinatal stem cells
- Other tissues: Brain, blood vessels, skeletal muscles, skin, liver, and heart also harbor adult stem cells in small numbers
Critical functions of stem cells
Stem cells have a variety of uses and critical functions throughout the body.
| Function 🎯 | Description 🔍 |
|---|---|
| Self-renewal | Make more stem cells to maintain the stem cell pool |
| Differentiation | Transform into specialized cell types as needed by the body |
| Tissue maintenance | Replace cells lost through normal wear & tear, injury, or disease |
| Regeneration | Repair & regenerate damaged tissues & organs |
| Therapeutic potential | Used in treatments for blood disorders & explored for other diseases |
They’re fundamental to the development and lifelong maintenance of the body.
They’re also the future of regenerative medicine.
Symptoms of ‘Exhausted’ Stem Cells
Stem cell exhaustion is one of the 12 currently recognized hallmarks of aging. Exhaustion refers to the reduced ability of stem cells to regenerate and repair tissues.
| Symptom 🔍 | Stem Cell Exhaustion Mechanism ⚙️ |
|---|---|
| Slow healing of injuries, fractures, muscle fibers | Reduced tissue repair & regeneration |
| Muscle weakness | Compromised muscle regeneration |
| Chronic fatigue | Systemic exhaustion of stem cells |
| Brain fog & increased neurodegenerative disease susceptibility | Impaired stem cell function in neural tissues (Stem Cells & Aging) |
| Sagging skin and poor recovery | Reduced proliferation & impaired differentiation of skin & MSCs |
| Frequent infections | Reduced production & diversity of immune cells due to exhaustion & functional decline of HSCs |
| Premature aging | Reduced regenerative function cause senescent stem cells to release a harmful mix of inflammatory molecules (SASP), contributing to the diseases & decline associated with aging |
| Anemia & blood disorders | HSC exhaustion (Stem Cell Exhaustion) |
| Osteoporosis | MSC exhaustion in bone marrow |
If you are grappling with these symptoms, consider the natural and powerful ways to increase your stem cells.
How to Naturally Boost Stem Cells
You have the power to naturally boost your stem cells through simple lifestyle behaviors like fasting, eating right, and exercising.
Avoid stem cell-depleting habits and substances
Minimize (or better yet get rid of) chronic alcohol use, smoking, excessive sugar & processed food, and more.
Get your nutrition right
Start eating more anti-inflammatory foods and take your hydration seriously.
Do a fast
Multiple studies support the benefits of fasting to stem cell health. Even more so when proper re-feeding is done after the fast.
Break a sweat
Exercise promotes stem cell activation, resulting in better tissue regeneration, resulting in stronger bones & muscles.
Get your sleep right
Let your body maximize its rest and recovery mode. Make sure you’re getting enough quality sleep every single day.
Take the right supplements
Stem cell supplements help you fill in any minor gaps you’ll unknowingly miss with proper diet, physical activity, and sleep.
Now, let’s discuss in detail these effective, science-backed ways to naturally activate your body’s regeneration system.
Nutrition
When it comes to boosting your stem cells, an anti-inflammatory diet is your best friend.
Chronic inflammation is a major enemy of stem cells, quietly wearing down their ability to regenerate and repair.
I use this approach myself by focusing on foods that not only calm inflammation but also activate key cellular pathways.
| Food group 🥕 | Mechanism ⚙️ | Sample Sources 🔍 |
|---|---|---|
| Polyphenol-rich foods | Activate pathways such as SIRT1 & Nrf2, crucial for maintaining stem cell health & longevity | • Berries like blueberries, raspberries, and goji berries • Dark chocolate (70%+ cocoa) • Green tea • Turmeric • Pomegranate |
| Omega-3 Fatty Acids | Reduce inflammation & support the integrity of your cell membranes | • Fatty fish (salmon, mackerel, sardines) • Flaxseeds • Chia seeds • Walnuts |
| Cruciferous Vegetables | Contains sulforaphane, which plays a key role in detoxification & activating stem cell pathways | • Broccoli • Kale • Cauliflower • Brussels sprouts |
| Garlic & onions | Contain sulfur compounds with powerful anti-inflammatory & antioxidant effects, protecting stem cells from oxidative stress & inflammation | • Garlic (all types) • Onions • Shallots • Leeks • Scallions, spring onions |
| Leafy greens & colorful vegetables | Supply vitamins A, C, and E, & antioxidants, nourishing cells | • Beet greens, dandelion Greens • Endive, escarole, lettuce microgreens • Parsley (flat-leaf, curly) • Spinach (flat-leaf, savoy, baby) • Sorrel • Swiss Chard • Beets, bell peppers, tomatoes • Carrots, pumpkin, sweet potatoes • Beetroot, zucchini, celery |
| Mushrooms | Contain immune-boosting polysaccharides that support stem cell function | • Shiitake • Maitake • Reishi |
Finally, don’t forget proper hydration. Water is essential for every cellular process, including stem cell activity.
A good rule of thumb is to drink half your body weight in ounces daily. For example, I am 200 pounds, so I should aim to consume at least 100 ounces of water every day.
Fasting
Fasting is perhaps the most powerful stem cell regeneration tool available.
A 2020 research found that fasting increases the percentage of stem cells with long telomeres (Aging). Telomeres are “protective caps” at the end of chromosomes, preventing them from deteriorating.
This same study further found that fasting also increases the maximum telomere length. In flatworm (planarian) stem cells, anyway. But this opens up more understanding of stem cell aging and regeneration.
Meanwhile, MIT researchers discovered that mice fasting for 24 hours dramatically improved intestinal stem cells’ ability to regenerate (Cell Stem Cell).
During fasting, intestinal stem cells (ISCs) switch from burning glucose to burning fat, which triggers a metabolic shift that enhances their regenerative capacity (Cell Stem Cell).
However, there’s a downside. Regeneration also increased the risk of developing intestinal tumors when cancerous mutations happened during the regenerative period (Nature).
But here’s the interesting part:
The refeeding cycle matters more to increase stem cells than the fasting protocol itself Share on XColumbia Stem Cell Initiative researchers found that the combination of fasting followed by refeeding rejuvenates old blood stem cells (HSCs) (Cell Stem Cell).
This makes them nearly as effective as young stem cells at creating new blood cells.
This 24-hour fasting-refeeding cycle activates your body’s cellular cleanup process (autophagy). Autophagy removes damaged components and resets stem cell function (Nature).
You can get more out of your fast with amplified fasting, or explore more challenging practices like dry fasting.
Exercise
Exercise promotes tissue regeneration primarily through stem cell activation and proliferation (J Tissue Eng Regen Med).
When you move your body, you activate and multiply mesenchymal stem cells (MSCs). These are the stem cells that differentiate into bone, cartilage, fat, and muscle cells.
University of Illinois researchers found that MSCs proliferate during exercise, contributing to stronger bones and muscle structures (MSSE J).
Another study also shows exercise shifts MSC differentiation away from fat and toward stronger musculoskeletal tissues instead (Sign Transd Tgt Ther).
| Exercise Type 💪 | Impact on Stem Cells 🧬 |
|---|---|
| Aerobic exercise | Helps stem cells differentiate into bone & muscle, rather than fat |
| Resistance training | Stimulates the release & activation of stem cells, particularly in muscle & bone tissue |
| High-Intensity Interval Training (HIIT) | Further enhances stem cell mobilization |
| Gentle movement/low impact activities | Mobilizes HSCs & MSCs from bone marrow into circulation, supporting formation of new blood vessels (angiogenesis) (JMDH, J Ayur Int M) |
But don’t overtrain.
Chronic stress from overtraining negatively affect stem cells and potentially lead to their dysfunction or death. Impairing your body’s ability to repair and renew itself.
So, balance is key.
Vary and combine your workouts with proper rest. You’ll then be properly supporting your body’s natural healing and regeneration.
Sleep
Quality sleep is non-negotiable for stem cell health because it regulates their production and activity.
Research reveals that sleep regulates the bone marrow environment where stem cells are produced (Stem Cell Res Ther).
During sleep, your body:
- Promotes stem cell wound healing & regeneration (Life Sci).
- Enhances stem cell proliferation & migration
- Maintains circadian rhythms that control stem cell activity
- Reduces inflammatory markers that damage stem cells
Poor sleep disrupts the body’s internal biological environment, leading to increased inflammation and reduced stem cell function.
In fact, sleep deprivation damages stem cells and reduces their ability to migrate to proper locations by up to 50% (Nature Communications).
Optimize sleep with:
- Blackout curtains
- Blue light blockers
- Magnesium
- Consistent bedtimes
Track your sleep with wearables like the Ultrahuman Ring to know where to start and how to adjust.
Learn how to biohack optimal sleep.
Stress management
Chronic stress kills stem cells, reduces growth of new ones, and makes the existing less effective.
When you’re under constant pressure, your body pumps out cortisol. That elevated cortisol suppresses neural stem cell growth and increases stem cell death.
Research shows that chronic stress reduces the regenerative capacity of various stem cell populations throughout the body (WI Rev Dev Biol, Mol Psychiatry)
Mitigate the effects of stress on your stem cells with these easy strategies:
Meditation
Meditation significantly influences telomere length and stem cell activity through stress reduction and inflammation modulation (Int J Res Med Sci).
Studies suggest 7.8 Hz theta frequencies may stimulate stem cell production. These frequencies correspond closely to the Schumann Resonance, the Earth’s natural electromagnetic frequency.
Achieve this by listening to binaural beats tuned to 7.8 Hz. Use headphones for maximum effectiveness.
Try using neurofeedback and brain entrainment tech like the Muse Athena headband and BrainTap headset during meditation for better results.
Explore other neurofeedback devices to elevate your meditation for that stem cell boost.
Breathwork
Various breathing techniques balance or relax your nervous system.
Basically, exhaling longer than inhaling signals your nervous system to relax. So does nose breathing.
Try this simple 4-7-8 breathing technique: Inhale for 4 seconds, hold for 7, exhale for 8. Do 4 rounds Share on XAlso try box breathing which Navy SEALs use for calming and centering. Then there’s alternate nostril breathing from Ayurveda.
More importantly, breathe the right way to reap the most benefits from simply breathing.
Nature exposure & earthing
Aim for spending 20 minutes minimum in natural settings. You will markedly notice the almost immediate effect on your stress levels as soon as you step foot in nature.
The Japanese call it “Shinrin-yoku.” Literally “forest bath”—bathing in the atmosphere of the forest. It has proven to be so therapeutic that forest bathing is now an important part of preventative healthcare in Japan (EHPM).
Better yet, go barefoot to have direct contact with the grass or soil. This is called grounding (or earthing) and has been shown to have antioxidant effects, taming inflammation (J Inflamm Res).
Discover more science-backed stress busters in my biohacking stress guide.
Minimize stem cell depleters
Certain substances accelerate stem cell aging and reduce their activity.
Adopting lifestyle practices that support stem cell health does wonders for your body’s repair and regenerative functions.
It works even better when you avoid stem cell depleters.
| Avoid 🚫 | Why 🧐 |
|---|---|
| Chronic alcohol use | Actively destroys vital liver stem cells, accelerating aging at the cellular level |
| Tobacco smoke | Accelerates stem cell aging & reduces their activity |
| Pollution | Creates oxidative stress, impairing regeneration of stem cells |
| Excess UV radiation | Acts like internal accelerants to stem cell aging |
| Processed foods | Creates inflammatory environments detrimental to stem cells |
| Excessive sugar, refined carbs | Impairs stem cell function |
| Vegetable seed oils, commercial red meat | Pro-inflammatory, impairing stem cell function |
| Chronic stress | Elevates cortisol levels leading to inflammation, blunting stem cell activity |
Medications deserve a mention as there are some that adversely affect stem cells.
It’s worth discussing alternatives with your doctor if you’re concerned about stem cell health.
| Medication 💊 | Impact on stem cells 🧬 |
|---|---|
| Quinolone antibiotics (Cipro, Levaquin) | Can damage stem cells & tendon cells (Pharmaceuticals, Cureus) |
| High-dose NSAIDs | May interfere with stem cell activity (Exp Ther Med, Medicina) |
| Statins | Potential negative effects on stem cell function (Ajpcell, Arch Med Sci) |
The Best Stem Cell Supplements
Stem cell supplements can amplify the results of your protocol and dramatically increase levels without any injections.
Get your health foundations right, then supplement.
I found the following supplements to be the best at boosting stem cells. They support mechanisms that activate endogenous stem cells.
I expect this supplement vertical to grow tremendously over the next decade.
STEMREGEN Release
Benefits: Stem cell release & migration, protect organ health, improve vitality, support healthy aging
Servings: 60 capsules
Serving Size: 2 capsules
Cost Per Serving: $6.30
Lab Tested: Yes
Rating: 4.31
Pros
- Research-backed & clinically-tested
- Natural ingredients
- Minimal excipients
- Save $4-5 each month when you subscribe
Cons
- Expensive
- No discount for bundles
- Proprietary formula
STEMREGEN was founded by Christian Drapeau, a stem cell scientist and neurophysiologist who spent 20 years researching solely stem cells.
His research led him to discover natural, potent plant-based ingredients that effectively enhance stem cell function.
Using these powerful ingredients, he formulated STEMREGEN Release, their foundational product. Release is designed to tap into and activate your body’s innate capability to repair and renew itself.
It’s a clinically-tested and proprietary blend that significantly increases the release of adult stem cells from the bone marrow into circulation.
Key ingredients of Release include:
- Aphanizomenon flos-aquae (AFA) extract – supports stem cell release from bone marrow & significantly increases circulating stem cells (Cardiovasc Revasc Med)
- Fucus vesiculosus extract – anti-inflammatory & increases the baseline number of circulating stem cells over time (Mar Drugs)
- Panax notoginseng extract – increases both stem cell proliferation & release from bone marrow (Neural Regen Res)
- Sea buckthorn berries extract (Stemberry™) – triggers stem cell release & increases circulating stem cells by 40% (Clin Interv Aging)
- Stemaloe™ – supports the proliferation of stem cells in bone marrow & stem cell release from the bone marrow (Odontology, J Stem Cell Res Ther)
- Beta-glucan 1-3 – supports stem cell proliferation, release from the bone marrow, & migration into tissues (Clin Vaccine Immunol, Stem Cells)
Drapeau has designed a total of 4 proprietary and clinically-tested formulas (including Release) that target specific aspects of stem cell function.
The 4 STEMREGEN formulas are:
| STEMREGEN Formula | Benefits | Price | Form | Count | Price per serving |
|---|---|---|---|---|---|
| Release | Promotes natural stem cell release & migration for enhanced repair, renewal, & healthy aging | $189 | Capsules | 60 | $6.30 |
| Signal | Enhances stem cell precision by reducing inflammatory noise & optimizing cellular signaling | $134 | Tablets | 120 | $4.47 |
| Mobilize | Supports efficient stem cell delivery through enhanced blood flow, capillary health, & microcirculation | $164 | Stick packs | 30 | $5.47 |
| Sport | Colostrum-free (replaced with adermosilbene), NSF-certified formula supporting stem cell recovery & repair; ideal & safe for professional athletes; NO performance-enhancing compounds & ingredients considered doping agents | $189 | Capsules | 60 | $6.30 |
You can take each formula on its own, depending on your goal. Or you combine them to form 2 distinct STEMREGEN protocols:
- STEMREGEN Maintenance & Repair – For everyday wellness, this protocol consists of STEMREGEN Release, Signal, & Mobilize. It promotes daily stem cell release, optimizes cellular signaling, & improves blood flow for better stem cell circulation.
- STEMRGEN Recovery Support – Consists of STEMREGEN Sport, Signal, & Mobilize. Designed for athletes & active individuals to guide stem cells where they’re needed most. Resulting in faster recovery, decreased post-exercise fatigue, & sustained performance.
Both STEMREGEN protocols powerfully support endogenous stem cell mobilization (ESCM) but for different needs. The protocols are available as bundles though with no discount.
Rigorously researched and tested formulas make STEMREGEN a stem cell supplement brand you can fully trust.
Healthgevity Prime Time+
Benefits: Stem cell release & migration, boosts autophagy, modulates inflammatory responses
Servings: 90 capsules
Serving Size: 3 capsules
Cost Per Serving: $4.17
Lab Tested: Yes
Rating: 4.26/5
Pros
- No proprietary blends
- Science-backed
- Formulated by top researchers & clinicians
- Every batch analyzed for potency, contaminants, heavy metals, & microbes
Cons
- No discount when you subscribe
- Expensive
Prime Time+ is a longevity formula that boosts your body’s natural renewal processes via stem cell actions. It’s from Healthgevity, 1 of my most trusted supplement brands.
It delivers 10mg of spermidine per serving. This helps mimic fasting, trigger autophagy, and clear damaged cells to support healthy aging. All while rejuvenating your stem cells.
The following are other notable ingredients in Prime Time+ that promote stem cell function:
- Spermidine – stimulates autophagy, slows aging, reduces severity of age-related illnesses, supports health span, & increases lifespan
- CyanthOx™ Sea Buckthorn Extract – stimulates 3 types of stem cells
- StemEnhance® (Aphanizomenon flos-aquae concentrate(AFA)) – stimulates the production & release of adult stem cells
- Fucoidan from Mekabu – anti-inflammatory, regulates autophagy, & mobilizes stem cells
- AstaReal® Astaxanthin – promotes autophagy, supports stem cell health & vitality, fosters a healthy environment for stem cells
- Epigallocatechin-3-gallate (EGCG) from green tea – supports & maintains stem cell health
- AstraGin® (Astragalus membranaceus & Panax notoginseng) – boosts stem cell activity, stimulates stem cell proliferation
- Alpha-ketoglutarate (AKG) – supports healthy aging by optimizing cellular energy, regeneration, & metabolic function
- CyaninPlus® Blue Spirulina Extract (Phycocyanin >30%) – provides potent antioxidant & anti-inflammatory, protect cells, enhances immune function, & promote overall vitality & longevity
- Pure Mune™ organic yeast beta 1,3 /1,6 glucan – enhances immune defense by activating key immune cells, balancing inflammation, & reducing infection risk for optimal immune resilience
- Apigenin – protects cells from oxidative stress & inflammation while preserving NAD+ levels, supports healthy aging & cellular vitality
- Luteolin – fights oxidative stress to protect cells & tissues, promoting long-term cellular health & resilience
- Ioniplex® (Fulvic Ionic Mineral Complex) – enhances nutrient absorption & mitochondrial function, optimizes cellular energy production & supports detoxification for overall vitality
Prime Time+ also promotes stem cell release and movement for tissue repair and cellular renewal, helping restore organs and improve vitality.
The formula aids fasting benefits and supports cellular regeneration and immune health.
It helps protect the inside lining of your blood vessels (endothelial glycocalyx) and controls inflammation. It also supports epigenetic aging, plus skin and eye health.
Backed by research, Prime Time+ advanced formula solidly supports your body’s innate healing and long-term wellness through stem cell optimization.
Powerful Herbs & Ingredients That Increase Stem Cells
These powerful herbs, natural ingredients, and a few simple supplements (and 1 drug) can boost stem cell production and support the body’s healing abilities.
| Ingredient 🍽️ | Benefit ✅ | Sources & Notes 📝 |
|---|---|---|
| Panax ginseng & panax notoginseng | Aids the proliferation and differentiation of neural and mesenchymal stem cells | Herb & root, supplements |
| Carica papaya leaf extract | Increases thrombocyte counts in human and rat models, indicating its role in promoting stem cell health | Supplements |
| Omega-3 fatty acids | Reduces inflammation, supports stem cell health (J Tissue Eng Regen Med) | Fish oil, algae oil, fatty fish |
| Sulforaphane | Enhances detox enzymes, suppresses cancer stem cells (Cancer Prev Res) | Broccoli, kale, cauliflower, Brussels sprouts, supplements |
| Chlorella | Promotes stem cell proliferation and supports mesenchymal stem cells (Front Bioeng Biotechnol) | Algae-based, supplements in powder or tablets |
| Coffee berry fruit extract | Stimulates stem cell production | Found in specialty supplements |
| Colostrum | Boosts stem cell activation and immune activity (J Sci Food Agric) | Bovine source supplements; check for allergies |
| Matcha green tea | Activates multiple stem cell types and targets cancer stem cells (Aging) | Powder; daily cup recommended |
| Blueberries | Increases totipotent stem cells 6–10x | 1 cup/day for 30 days; or supplements in capsules, powder or softgel form |
| Seabuckthorn berry | Increases circulating stem cells (Clin Interv Aging) | Fresh & dried fruit, supplement in capsules, softgels, liquid, oil, extract |
| Aphanizomenon Flos-Aquae | Significantly increases circulating stem cells | Blue-green algae |
| Stemaloe™ | Supports stem cell release from bone marrow; increases the number of circulating stem cells | Proprietary blend of a unique extract of aloe from Madagascar; ingredient used in supplements |
| Fucus vesiculosus (bladderwack) | Boosts circulating stem cell numbers | Edible brown algae (seaweed) extract |
| Beta-Glucan 1-3 | Supports stem cell function | Oats, mushrooms, supplements |
| Vitamin D3 | Crucial for overall cellular function, promotes stem cell proliferation & differentiation, Supports stem cell growth and activity (Int J Mol Sci) | Sunlight, supplements (get your 25(OH)D levels tested), cod liver oil, salmon, mackerel, sardines, |
| Resveratrol | Activates longevity pathways (SIRT1) & enhances stem cell pluripotency (Cell Death Dis), suppors MSC differentiation | Grapes, supplements |
| Curcumin | Potent anti-inflammatory & antioxidant, enhances bone marrow stem cells & neurogenesis | Turmeric (add some black pepper for better absorption), supplements |
| Metformin | Improves function of aged stem cells (Stem Cells) | Oral drug |
| N-acetylcysteine (NAC) | Promotes development MSCs to bone cells (Front Cell Dev Biol); protects stem cells from apoptosis (Front Dent Med); induces pluripotent stem cells (iPSCs) (Int J Dev Biol) | Supplements |
| Glutathione | Rejuvenates aged stem cells (Cell Metab); maintains stem cells’ ability to self-renew & proliferate (Ch J TER, SciAdv) | Most bioavailable forms: s-acetyl glutathione, liposomal glutathione, and sublingual glutathione |
Incorporate these ingredients in your daily diet for stronger and healthier stem cells.
Biohacks to Boost Stem Cells
Certain biohacks can naturally enhance stem cell function, supporting tissue repair and overall health. These methods stimulate the body’s regenerative processes.
The following accessible biohacks, and an advanced one, have been shown to support stem cell function.
Molecular hydrogen
Molecular hydrogen has numerous benefits for your health, including your stem cells.
According to research, H2 stimulates early proliferation of stem cells, including MSCs, helping them divide and expand more rapidly (Antioxidants).
Molecular hydrogen safeguards stem cells from programmed cell death and inflammatory damage (MDPI).
It’s also important that you choose only the best molecular hydrogen supplements to ensure that you receive the intended health benefits while minimizing potential risks.
The effectiveness of molecular hydrogen tablets depends on the concentration of dissolved hydrogen they produce, measured in parts per million (PPM).
A minimum of 4–10 PPM is needed for optimal benefits but many low-quality tablets deliver only 1–3 PPM, which may be insufficient for noticeable effects.
Premium tablets are formulated to consistently provide higher H2 concentrations and are free from unwanted additives or impurities.
I have a guide on hydrogen tablets vs bottles vs machines as well if you’re already deciding among the three.
Peptides
Certain peptides boost stem cells primarily by acting as signaling molecules that enhance stem cell survival, proliferation, and differentiation.
They help stem cells migrate to injured areas and begin healing. Some also guide stem cells to become specific cell types, like skin or neurons, for targeted regeneration.
Additionally, peptides enhance stem cell lifespan and function by reducing stress and damage. This leads to stronger tissue and more effective regeneration.
GHK-Cu and BPC-157 are 2 longevity peptides that powerfully support stem cell health. Here’s how.
GHK-Cu
GHK-Cu boosts stem cells by promoting their growth and guiding their differentiation into mature cells. It helps balance stem cell renewal and tissue repair effectively (Biomolecules).
This peptide also regulates genes that support regeneration and reduce inflammation.
GHK-Cu is available as liquid serums, creams, foams, pure powder, subcutaneous injectables, liposome-encapsulated liquid formulations.
BPC-157
BPC-157 is a promising peptide for regenerative medicine and stem cell activation.
It supports stem cell activity by reducing inflammation and accelerating tissue repair, especially in muscles, tendons, and ligaments (Molecules).
It interacts with stem cells in vivo, facilitating communication that promotes stem cell-mediated tissue repair and regeneration (Yale J Biol Med).
BPC-157 comes in oral capsules, tablet, and liquid forms. Also as subcutaneous and intramuscular injections.
Lifewave X39
LifeWave X39 is a phototherapy patch that boosts stem cells by stimulating endogenous GHK-CU production. This peptide activates stem cells and promotes tissue repair and regeneration.
The patch, strategically placed over specific energy points, does this by reflecting your body’s infrared heat back into the skin. This stimulates nerve endings, triggering increased production of GHK-Cu.
X39’s mechanism enhances stem cell activity by improving gene expression related to healing and anti-aging. It supports collagen production, skin health, and reduces inflammation and pain.
Read my experience in my LifeWave X39 review and learn how phototherapy patches work in more detail.
Red light therapy
Red light therapy (RLT) boosts stem cells by activating mitochondria, increasing cellular energy (ATP) production.
This energy surge improves stem cell survival, proliferation, and function, supporting tissue repair and regeneration (J Clin Med).
The most effective wavelengths are around 600-700 nm, which penetrate tissues and stimulate key cellular processes. Enhancing the behavior and therapeutic potential of MSCs (Photomed Laser Surg).
RLT also enhances stem cell migration, directing them to damaged areas for faster healing. It promotes stem cell differentiation, helping cells develop into needed tissue types (Curr Stem Cell Res Ther).
Additionally, RLT reduces inflammation and oxidative stress, creating a better environment for stem cells to work effectively (Front Pharmacol).
By stimulating angiogenesis, RLT improves blood supply to regenerating tissues. This supports stem cell activity and accelerates overall tissue repair.
These combined effects make red light therapy a valuable, non-invasive tool in regenerative medicine.
If you’re looking to buy 1 for home use, see my best red light therapy devices roundup.
Hyperbaric oxygen therapy
Hyperbaric oxygen therapy (HBOT) is an advanced and fringe biohacking strategy. It involves breathing pure oxygen in a pressurized room or chamber.
This increases oxygen levels in your body, enhancing stem cell proliferation and mobilization.
Studies show that HBOT increases circulating stem/progenitor cells (SPCs), particularly CD34+ cells (HSCs). The increase is up to 8-fold after repeated sessions, improving tissue repair and regeneration (Front Neurol).
This oxygen-rich environment also promotes angiogenesis, further supporting stem cell function and healing (Front Physiol).
HBOT also reduces inflammation, creating a favorable environment for stem cells to repair damaged tissues effectively (Medicina).
HBOT also has benefits for workout recovery and TBI recovery.
Stem Cells Questions & Answers
Where do we get stem cells from?
Stem cells come from embryos, adult tissues (like bone marrow, fat, and blood), umbilical cord blood, placenta, and induced pluripotent stem cells (iPSCs) made by reprogramming adult cells.
What are the benefits of stem cells?
Stem cells regenerate damaged tissues and organs; treat blood disorders, immune diseases, & some neurodegenerative conditions; aid in wound healing & reduce inflammation; and has potential for personalized treatments & research into new therapies.
What’s the difference between stem cell therapy & stem cell supplements?
Stem cell therapy is a medical procedure using real stem cells while stem cell supplements are dietary products designed to support stem cells.
Stem cell therapy is administered by healthcare professionals and can directly regenerate or repair tissue or treat specific diseases. Stem cell supplements are sold over-the-counter and not regulated as medicine.
How quickly can I increase my stem cells with supplementation?
Measurable stem cell increase occurs within 1-6 weeks with consistent supplementation and lifestyle changes. Fasting and refeeding can boost stem cell regeneration within 24 hours (Nature).
Are stem cell supplements safe?
Yes, using approved stem cell ingredients are safe. Look for ingredients like sea buckthorn extract, aphanizomenon flos-aquae (AFA), Stemaloe™, fucus vesiculosus extract, beta-glucan 1-3, fucoidan, panax notoginseng, and astaxanthin.
Of course, as with all supplements, check with your doctor first. Especially if you have medical conditions or take medications.
Can I get enough stem cell support from food alone?
Yes, you can get enough stem cell support from food, such as blueberries & green tea, for daily upkeep and maintenance.
But if you want to get the therapeutic increases in stem cells to drive a major difference, you’ll need to use targeted stem cell supplements as well.
Do stem cell boosters help with aging?
Yes. It supports tissue repair and regeneration, which, in essence, reduces your biological age and makes you younger.
Can stem cells cause tumors and cancers?
Yes, they can. IF the stem cells acquire genetic mutations, they can transform into cancerous cells and lead to tumor formation.
Because stem cells have the ability to self-renew and proliferate, mutated stem cells can drive cancer growth and recurrence. This potential risk highlights the importance of careful screening in stem cell therapies.
Healthy Stem Cells Are Key to Longevity
Stem cells are the body’s master cells or building blocks. They’re like a regeneration cheat code.
Your stem cells naturally decline with age, which is why babies and kids bounce back from injuries so quickly. Yet adults struggle.
The longer adults spend rehabilitating injury, the greater the inflammation and overall degeneration. You can see the vicious, rapid aging spiral this creates.
The ultra wealthy combat this with stem cell injections and related medical procedures.
Before that, try the natural ways to improve your stem cells.
Some of the best ways to enhance your regenerative capacity include:
- Strategic fasting
- Targeted nutrition
- Smart exercise
- Quality sleep
- Stress management
- Powerful stem cell supplements
- Simple yet powerful biohacks
The key is consistency. These interventions work synergistically over time.
If you found this guide helpful, share it with a friend considering a stem cell procedure or on social media. You’ll be helping others accelerate their recovery from injury and bulletproof their longevity. Thanks!
